{"id":"https://openalex.org/W135140100","doi":null,"title":"Superovulation with buserelin and gonadotropins dramatically improves the success rate of intrauterine insemination with husband's washed semen.","display_name":"Superovulation with buserelin and gonadotropins dramatically improves the success rate of intrauterine insemination with husband's washed semen.","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W135140100","mag":"135140100","pmid":"https://pubmed.ncbi.nlm.nih.gov/2128158"},"language":"en","primary_location":{"id":"pmid:2128158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2128158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Europaea fertilitatis","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102921304","display_name":"Adolfo Allegra","orcid":"https://orcid.org/0000-0001-9942-7810","observed_orcids":["https://orcid.org/0000-0001-9942-7810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Allegra","raw_affiliation_strings":["Centro Andros, Medical Center for the Diagnosis and Treatment of Infertility, Palermo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Andros, Medical Center for the Diagnosis and Treatment of Infertility, Palermo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109078898","display_name":"Aldo Volpes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Volpes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038267009","display_name":"Francesco Coffaro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Coffaro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032817829","display_name":"S Guida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Guida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035577275","display_name":"R Francofonte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Francofonte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.01183536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"21","issue":"4","first_page":"191","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superovulation","display_name":"superovulation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/buserelin","display_name":"buserelin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.9559999704360962},{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.9810000061988831},{"id":"https://openalex.org/keywords/intrauterine-insemination","display_name":"intrauterine insemination","score":0.972000002861023},{"id":"https://openalex.org/keywords/male-subfertility","display_name":"male subfertility","score":0.7609999775886536},{"id":"https://openalex.org/keywords/unexplained-infertility","display_name":"unexplained infertility","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cervical-factor-infertility","display_name":"cervical factor infertility","score":0.796999990940094},{"id":"https://openalex.org/keywords/clomiphene","display_name":"clomiphene citrate","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pregnancy-rate","display_name":"pregnancy rate","score":0.8259999752044678},{"id":"https://openalex.org/keywords/follicular-development","display_name":"folliculogenesis","score":0.5889999866485596},{"id":"https://openalex.org/keywords/estradiol-levels","display_name":"estradiol levels","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2777230143","wikidata":"https://www.wikidata.org/wiki/Q414745","display_name":"Buserelin","level":4,"score":0.7945913076400757},{"id":"https://openalex.org/C2776537878","wikidata":"https://www.wikidata.org/wiki/Q7239894","display_name":"Pregnancy rate","level":3,"score":0.6710578799247742},{"id":"https://openalex.org/C2780853582","wikidata":"https://www.wikidata.org/wiki/Q25556","display_name":"Anovulation","level":5,"score":0.655288815498352},{"id":"https://openalex.org/C2777005246","wikidata":"https://www.wikidata.org/wiki/Q1379223","display_name":"Insemination","level":3,"score":0.6423419713973999},{"id":"https://openalex.org/C2778610407","wikidata":"https://www.wikidata.org/wiki/Q207122","display_name":"Artificial insemination","level":3,"score":0.5864744782447815},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.5696118474006653},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5597509741783142},{"id":"https://openalex.org/C2778580812","wikidata":"https://www.wikidata.org/wiki/Q686627","display_name":"Unexplained infertility","level":4,"score":0.5336974859237671},{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.5293337106704712},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.4906812906265259},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.474680632352829},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4541094899177551},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.39625799655914307},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.38560622930526733},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35125911235809326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32773953676223755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2964089810848236},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.1355818510055542},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12911880016326904},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.1259632706642151},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.07359001040458679},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002064","descriptor_name":"Buserelin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002996","descriptor_name":"Clomiphene","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006062","descriptor_name":"Gonadotropins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007317","descriptor_name":"Insemination, Artificial, Homologous","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008525","descriptor_name":"Medroxyprogesterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013480","descriptor_name":"Superovulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2128158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2128158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Europaea fertilitatis","raw_type":"Journal Article"},{"id":"mag:135140100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2128158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967809510","https://openalex.org/W2333023845","https://openalex.org/W2013183948","https://openalex.org/W2010376111","https://openalex.org/W2401013134","https://openalex.org/W2399159553","https://openalex.org/W2405085825","https://openalex.org/W2410593106","https://openalex.org/W2083045841","https://openalex.org/W2412454197"],"abstract_inverted_index":{"The":[0,108,122,192],"purpose":[1],"of":[2,10,24,125,157,209,221],"this":[3],"study":[4,82],"was":[5,78,113,131,151],"to":[6],"determine":[7],"the":[8,70,81,98,155,222],"effectiveness":[9],"intrauterine":[11,196],"insemination":[12,197],"with":[13,39,198,214,218,225],"husband's":[14],"washed":[15,199],"semen":[16],"during":[17,201],"stimulated":[18,202],"cycles":[19,148,204],"using":[20],"a":[21,149,206],"combined":[22],"treatment":[23],"GnRH":[25],"agonist":[26],"(buserelin)":[27],"and":[28,41,45,115,135,146,164,174,186],"gonadotropins.":[29],"47":[30],"infertile":[31],"couples":[32,36,213],"were":[33,37,59,86,95],"studied;":[34],"25":[35],"treated":[38],"buserelin":[40],"gonadotropins":[42],"(study":[43],"group)":[44,48],"22":[46],"(control":[47],"received":[49],"clomiphene":[50],"citrate":[51],"alone.":[52],"Indications":[53],"for":[54],"treatment,":[55],"in":[56,75,97,211],"both":[57,76,161],"groups,":[58],"male":[60],"subfertility,":[61],"cervical":[62],"factor":[63],"or":[64,224],"unexplained":[65],"infertility.":[66],"For":[67],"sperm":[68,200],"preparation,":[69],"same":[71],"swim":[72],"up":[73],"technique":[74],"groups":[77],"used.":[79],"In":[80],"group,":[83],"15":[84],"pregnancies":[85,94],"achieved":[87,96],"(pregnancy":[88,101],"rate:":[89,102],"60%)":[90],"whereas":[91],"only":[92,153],"5":[93],"control":[99],"group":[100],"22.7%)":[103],"(p":[104,118,140],"less":[105,119,141,183,188],"than":[106,120,142,184,189],"0.01).":[107,121],"pregnancy":[109],"rate":[110],"per":[111,127,162,165],"cycle":[112,128,163],"17.6":[114],"4.8":[116],"respectively":[117,139],"mean":[123],"number":[124],"follicles":[126],"(+/-":[129],"SEM)":[130],"3.6":[132],"+/-":[133,137,168,172,176,180],"0.2":[134],"1.7":[136],"0.07,":[138],"0.0005).":[143],"Comparing":[144],"successful":[145,207],"unsuccessful":[147],"difference":[150],"observed":[152],"among":[154],"levels":[156],"17":[158],"beta":[159],"E2,":[160],"follicle/cycle":[166],"(1075":[167],"165.4":[169],"vs":[170,178],"721":[171],"57.6":[173],"319.8":[175],"42.6":[177],"219.9":[179],"17.8;":[181],"p":[182,187],"0.01":[185],"0.0005":[190],"respectively).":[191],"authors":[193],"conclude":[194],"that":[195],"superovulatory":[203],"is":[205],"mode":[208],"therapy":[210],"all":[212],"infertility":[215],"not":[216],"associated":[217],"anatomic":[219],"damage":[220],"adnexa":[223],"chronic":[226],"anovulation.":[227]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}