{"id":"https://openalex.org/W134691243","doi":null,"title":"Review on pathophysiology and treatment of diabetic kidney disease.","display_name":"Review on pathophysiology and treatment of diabetic kidney disease.","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W134691243","mag":"134691243","pmid":"https://pubmed.ncbi.nlm.nih.gov/21280541"},"language":"en","primary_location":{"id":"pmid:21280541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21280541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005694183","display_name":"Bancha Satirapoj","orcid":"https://orcid.org/0000-0002-8881-0942","observed_orcids":["https://orcid.org/0000-0002-8881-0942"]},"institutions":[{"id":"https://openalex.org/I4210087968","display_name":"Phramongkutklao Hospital","ror":"https://ror.org/007h1qz76","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210087968"]},{"id":"https://openalex.org/I4401726974","display_name":"Phramongkutklao College of Medicine","ror":"https://ror.org/04md5yc36","country_code":"TH","type":"education","lineage":["https://openalex.org/I4401726974"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Bancha Satirapoj","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand. satirapoj@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand. satirapoj@yahoo.com","institution_ids":["https://openalex.org/I4210087968","https://openalex.org/I4401726974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005694183"],"corresponding_institution_ids":["https://openalex.org/I4210087968","https://openalex.org/I4401726974"],"apc_list":null,"apc_paid":null,"fwci":2.696,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88668404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"93 Suppl 6","issue":null,"first_page":"S228","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":1.0},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8420000076293945},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9340000152587891},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.7889999747276306},{"id":"https://openalex.org/keywords/polyol-pathway","display_name":"polyol pathway","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hemodynamic-changes","display_name":"hemodynamic changes","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8259999752044678},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8889999985694885},{"id":"https://openalex.org/keywords/renin-angiotensin-system-blockade","display_name":"renin-angiotensin system blockade","score":0.9620000123977661},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.6919999718666077},{"id":"https://openalex.org/keywords/multifactorial-intervention","display_name":"multifactorial intervention","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cardiovascular-complications","display_name":"cardiovascular complications","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9099786877632141},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6443263292312622},{"id":"https://openalex.org/C2776997535","wikidata":"https://www.wikidata.org/wiki/Q2556837","display_name":"Advanced glycation end-product","level":4,"score":0.5987773537635803},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5815790295600891},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.5685688257217407},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5028057098388672},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.4868678152561188},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.44782933592796326},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4455655813217163},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.41273725032806396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3981459140777588},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33791792392730713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013785","descriptor_name":"Thailand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21280541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21280541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},{"id":"mag:134691243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21280541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W240958350","https://openalex.org/W1970733045","https://openalex.org/W1971213885","https://openalex.org/W1971823155","https://openalex.org/W1982610111","https://openalex.org/W1983678974","https://openalex.org/W1984061204","https://openalex.org/W1985941010","https://openalex.org/W1986639245","https://openalex.org/W1988763377","https://openalex.org/W1994887713","https://openalex.org/W1998378885","https://openalex.org/W2001933911","https://openalex.org/W2003510810","https://openalex.org/W2006013310","https://openalex.org/W2011211981","https://openalex.org/W2011906273","https://openalex.org/W2014050006","https://openalex.org/W2017604361","https://openalex.org/W2023362855","https://openalex.org/W2031484324","https://openalex.org/W2039893332","https://openalex.org/W2042206937","https://openalex.org/W2042646534","https://openalex.org/W2044773944","https://openalex.org/W2045161455","https://openalex.org/W2045790461","https://openalex.org/W2051159435","https://openalex.org/W2055801973","https://openalex.org/W2056976690","https://openalex.org/W2057439688","https://openalex.org/W2061202476","https://openalex.org/W2070474257","https://openalex.org/W2074391878","https://openalex.org/W2074527199","https://openalex.org/W2075518213","https://openalex.org/W2075787199","https://openalex.org/W2076563855","https://openalex.org/W2084343172","https://openalex.org/W2085050051","https://openalex.org/W2086315976","https://openalex.org/W2091216428","https://openalex.org/W2091754751","https://openalex.org/W2092576380","https://openalex.org/W2093734846","https://openalex.org/W2099971031","https://openalex.org/W2100409734","https://openalex.org/W2101417448","https://openalex.org/W2108192985","https://openalex.org/W2111478784","https://openalex.org/W2115000187","https://openalex.org/W2118932957","https://openalex.org/W2118987172","https://openalex.org/W2119088528","https://openalex.org/W2127674042","https://openalex.org/W2130479018","https://openalex.org/W2134293572","https://openalex.org/W2135960771","https://openalex.org/W2136898798","https://openalex.org/W2137178544","https://openalex.org/W2139634859","https://openalex.org/W2140773214","https://openalex.org/W2143154009","https://openalex.org/W2144516376","https://openalex.org/W2145027776","https://openalex.org/W2145632481","https://openalex.org/W2147056242","https://openalex.org/W2148959930","https://openalex.org/W2153816764","https://openalex.org/W2154685498","https://openalex.org/W2156121263","https://openalex.org/W2156825907","https://openalex.org/W2157606645","https://openalex.org/W2157677292","https://openalex.org/W2160201851","https://openalex.org/W2161624379","https://openalex.org/W2162154857","https://openalex.org/W2163106864","https://openalex.org/W2163914595","https://openalex.org/W2165325650","https://openalex.org/W2166453795","https://openalex.org/W2170271198","https://openalex.org/W2317521667","https://openalex.org/W2330121013","https://openalex.org/W2337454357","https://openalex.org/W2340171512","https://openalex.org/W2403048016","https://openalex.org/W2769264260","https://openalex.org/W4237181509","https://openalex.org/W4256636055","https://openalex.org/W4300987630"],"related_works":["https://openalex.org/W2791990516","https://openalex.org/W2948520814","https://openalex.org/W4401750975","https://openalex.org/W2001045885","https://openalex.org/W3128594661","https://openalex.org/W2557298839","https://openalex.org/W4414011776","https://openalex.org/W1481277481","https://openalex.org/W4413255647","https://openalex.org/W3199976355"],"abstract_inverted_index":{"Diabetes":[0],"is":[1,13,52],"the":[2,11,14,63,82,127,185],"leading":[3],"cause":[4,17],"of":[5,18,37,50,72,79,81,95,120,126,175,184],"chronic":[6],"kidney":[7,29,96],"disease,":[8],"which":[9],"in":[10],"Thailand":[12],"most":[15],"common":[16,138],"end":[19,117],"stage":[20],"renal":[21],"disease":[22,30,83],"(ESRD)":[23],"requiring":[24],"dialysis.":[25],"Patients":[26],"with":[27,46,68,143,207],"diabetic":[28],"(DKD)":[31],"are":[32,90],"at":[33],"a":[34,136,208],"higher":[35],"risk":[36],"mortality,":[38],"mostly":[39],"from":[40],"cardiovascular":[41,196],"complications,":[42],"than":[43],"other":[44],"patients":[45],"diabetes.":[47],"The":[48],"development":[49,80],"DKD":[51,74,172],"determined":[53],"by":[54,202],"environmental":[55],"and":[56,70,84,87,124,149,166,180,189],"genetic":[57],"factors.":[58],"This":[59],"review":[60],"focuses":[61],"on":[62],"latest":[64],"published":[65],"data":[66],"dealing":[67],"mechanisms":[69],"treatment":[71],"DKD.":[73],"has":[75],"several":[76],"distinct":[77],"phases":[78],"hyperglycemia-induced":[85],"metabolic":[86],"hemodynamic":[88,144],"pathways":[89,100],"recognized":[91],"to":[92,134],"be":[93,135],"mediators":[94],"disease.":[97],"Multiple":[98,192],"biochemical":[99],"have":[101],"been":[102],"postulated":[103],"that":[104,113],"explain":[105],"how":[106],"hyperglycemia":[107],"causes":[108],"tissue":[109],"damage:":[110],"nonenzymatic":[111],"glycosylation":[112,116],"generates":[114],"advanced":[115],"products,":[118],"activation":[119],"protein":[121,190],"kinase":[122],"C,":[123],"acceleration":[125],"polyol":[128],"pathway.":[129,139],"Oxidative":[130],"stress":[131],"also":[132],"seems":[133],"theme":[137],"These":[140],"derangements,":[141],"along":[142],"changes,":[145],"activate":[146],"various":[147],"cytokines":[148],"growth":[150,156,159],"factors":[151],"such":[152],"as":[153,198,200],"vascular":[154],"endothelial":[155],"factor,":[157],"transforming":[158],"factor-beta2":[160],"Interleukin":[161],"1":[162],"(IL":[163],"1),":[164],"IL-6":[165],"IL-18.":[167],"Current":[168],"renoprotective":[169],"treatments":[170],"for":[171],"include":[173],"optimization":[174],"glycemic,":[176],"blood":[177],"pressure,":[178],"lipid":[179],"weight":[181],"control":[182],"blockade":[183],"renin-angiotensin":[186],"system,":[187],"salt":[188],"restriction.":[191],"intensive":[193],"interventions":[194],"reduce":[195],"events":[197],"well":[199],"nephropathy":[201],"about":[203],"half":[204],"when":[205],"compared":[206],"conventional":[209],"multifactorial":[210],"treatment.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
