{"id":"https://openalex.org/W134529920","doi":null,"title":"Le NAADP, un messager lib\u00e9rant du calcium : \u00e9tude de l'implication des r\u00e9serves acides et r\u00f4le de CD38 dans la voie de synth\u00e8se","display_name":"Le NAADP, un messager lib\u00e9rant du calcium : \u00e9tude de l'implication des r\u00e9serves acides et r\u00f4le de CD38 dans la voie de synth\u00e8se","publication_year":2007,"publication_date":"2007-06-27","ids":{"openalex":"https://openalex.org/W134529920","mag":"134529920"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/797500","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/797500","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-00159587","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020798507","display_name":"Alexis Menteyne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153407","display_name":"Laboratoire de Neurobiologie Cellulaire et Mol\u00e9culaire","ror":"https://ror.org/0452rtt80","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210153407"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Alexis Menteyne","raw_affiliation_strings":["Laboratoire de neurobiologie cellulaire et mol\u00e9culaire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de neurobiologie cellulaire et mol\u00e9culaire","institution_ids":["https://openalex.org/I4210153407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020798507"],"corresponding_institution_ids":["https://openalex.org/I4210153407"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naadp","display_name":"NAADP","score":0.9940000176429749},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8109999895095825},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cyclic-adp-ribose","display_name":"cyclic ADP-ribose","score":0.7300000190734863},{"id":"https://openalex.org/keywords/ip3","display_name":"IP3","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lysosomal-calcium","display_name":"lysosomal calcium","score":0.7059999704360962},{"id":"https://openalex.org/keywords/zymogen-granules","display_name":"zymogen granules","score":0.9700000286102295},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9599999785423279},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.984000027179718},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.6240000128746033},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7549095153808594},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4996912479400635},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.38878095149993896},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.18636703491210938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05997675657272339}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/797500","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/797500","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-00159587v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00159587","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biologie cellulaire. Universit\u00e9 Paris Sud - Paris XI, 2007. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:134529920","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/tel-00159587v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:tel-00159587v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00159587","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biologie cellulaire. Universit\u00e9 Paris Sud - Paris XI, 2007. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":286,"referenced_works":["https://openalex.org/W12865270","https://openalex.org/W110320370","https://openalex.org/W131012821","https://openalex.org/W154904764","https://openalex.org/W182201330","https://openalex.org/W199220195","https://openalex.org/W334810105","https://openalex.org/W1263387749","https://openalex.org/W1488869774","https://openalex.org/W1503015871","https://openalex.org/W1517921781","https://openalex.org/W1518576018","https://openalex.org/W1522944859","https://openalex.org/W1529341137","https://openalex.org/W1536803321","https://openalex.org/W1544601757","https://openalex.org/W1559286577","https://openalex.org/W1560040722","https://openalex.org/W1562797648","https://openalex.org/W1564587827","https://openalex.org/W1564829038","https://openalex.org/W1566643819","https://openalex.org/W1580586916","https://openalex.org/W1587138541","https://openalex.org/W1588036636","https://openalex.org/W1589002191","https://openalex.org/W1593385535","https://openalex.org/W1598963691","https://openalex.org/W1601185542","https://openalex.org/W1604805265","https://openalex.org/W1605251585","https://openalex.org/W1615545200","https://openalex.org/W1650401181","https://openalex.org/W1658019904","https://openalex.org/W1768196376","https://openalex.org/W1784820495","https://openalex.org/W1791904161","https://openalex.org/W1795554797","https://openalex.org/W1828920282","https://openalex.org/W1859398825","https://openalex.org/W1884656506","https://openalex.org/W1888295889","https://openalex.org/W1918267618","https://openalex.org/W1930917734","https://openalex.org/W1946056901","https://openalex.org/W1963403501","https://openalex.org/W1963869670","https://openalex.org/W1967329828","https://openalex.org/W1967411995","https://openalex.org/W1967431831","https://openalex.org/W1967924763","https://openalex.org/W1967940275","https://openalex.org/W1969246107","https://openalex.org/W1969637387","https://openalex.org/W1969774551","https://openalex.org/W1970093299","https://openalex.org/W1971534715","https://openalex.org/W1971696344","https://openalex.org/W1973391847","https://openalex.org/W1973524650","https://openalex.org/W1975551314","https://openalex.org/W1976269779","https://openalex.org/W1977231617","https://openalex.org/W1979002457","https://openalex.org/W1980166477","https://openalex.org/W1980550706","https://openalex.org/W1980828399","https://openalex.org/W1980997572","https://openalex.org/W1981753053","https://openalex.org/W1982199817","https://openalex.org/W1983078818","https://openalex.org/W1984082491","https://openalex.org/W1984172303","https://openalex.org/W1984369622","https://openalex.org/W1985018205","https://openalex.org/W1986192509","https://openalex.org/W1986684354","https://openalex.org/W1988187116","https://openalex.org/W1991692667","https://openalex.org/W1993551565","https://openalex.org/W1993624419","https://openalex.org/W1993783817","https://openalex.org/W1997018082","https://openalex.org/W1997119596","https://openalex.org/W1997308033","https://openalex.org/W1997816574","https://openalex.org/W1997874647","https://openalex.org/W1998942070","https://openalex.org/W1998969662","https://openalex.org/W2000334213","https://openalex.org/W2000845667","https://openalex.org/W2001155424","https://openalex.org/W2001695130","https://openalex.org/W2003108264","https://openalex.org/W2004249539","https://openalex.org/W2004307693","https://openalex.org/W2004773321","https://openalex.org/W2006190060","https://openalex.org/W2006577689","https://openalex.org/W2007219916","https://openalex.org/W2008326644","https://openalex.org/W2009225669","https://openalex.org/W2009667219","https://openalex.org/W2011366275","https://openalex.org/W2011680705","https://openalex.org/W2013032388","https://openalex.org/W2013191030","https://openalex.org/W2014993252","https://openalex.org/W2015820951","https://openalex.org/W2015942983","https://openalex.org/W2016417523","https://openalex.org/W2017817071","https://openalex.org/W2018417695","https://openalex.org/W2018510333","https://openalex.org/W2018973124","https://openalex.org/W2019636677","https://openalex.org/W2020223826","https://openalex.org/W2020795276","https://openalex.org/W2021779926","https://openalex.org/W2022182177","https://openalex.org/W2026571586","https://openalex.org/W2029146584","https://openalex.org/W2031463920","https://openalex.org/W2031663339","https://openalex.org/W2032970890","https://openalex.org/W2033250952","https://openalex.org/W2033570433","https://openalex.org/W2035805790","https://openalex.org/W2036028191","https://openalex.org/W2036287496","https://openalex.org/W2037286164","https://openalex.org/W2037388166","https://openalex.org/W2037665823","https://openalex.org/W2038404316","https://openalex.org/W2038658125","https://openalex.org/W2039043166","https://openalex.org/W2039757972","https://openalex.org/W2040352872","https://openalex.org/W2040664792","https://openalex.org/W2041690080","https://openalex.org/W2041740826","https://openalex.org/W2042439603","https://openalex.org/W2043183187","https://openalex.org/W2044787178","https://openalex.org/W2045106617","https://openalex.org/W2045405389","https://openalex.org/W2045523357","https://openalex.org/W2045692472","https://openalex.org/W2046196975","https://openalex.org/W2047044502","https://openalex.org/W2047350789","https://openalex.org/W2047510863","https://openalex.org/W2048160331","https://openalex.org/W2048596172","https://openalex.org/W2049491065","https://openalex.org/W2050376414","https://openalex.org/W2051815180","https://openalex.org/W2052347872","https://openalex.org/W2052964194","https://openalex.org/W2053432866","https://openalex.org/W2054225000","https://openalex.org/W2055221223","https://openalex.org/W2056575537","https://openalex.org/W2057665893","https://openalex.org/W2057872722","https://openalex.org/W2059010267","https://openalex.org/W2059354304","https://openalex.org/W2059794282","https://openalex.org/W2059893490","https://openalex.org/W2059931045","https://openalex.org/W2061189653","https://openalex.org/W2061613974","https://openalex.org/W2061645562","https://openalex.org/W2062230584","https://openalex.org/W2063348606","https://openalex.org/W2063679416","https://openalex.org/W2065292112","https://openalex.org/W2065368005","https://openalex.org/W2065462781","https://openalex.org/W2066030442","https://openalex.org/W2067107527","https://openalex.org/W2067202204","https://openalex.org/W2067688604","https://openalex.org/W2068412376","https://openalex.org/W2069945478","https://openalex.org/W2070062499","https://openalex.org/W2070253406","https://openalex.org/W2070518369","https://openalex.org/W2072276106","https://openalex.org/W2072922837","https://openalex.org/W2072929605","https://openalex.org/W2073706613","https://openalex.org/W2074858432","https://openalex.org/W2075250269","https://openalex.org/W2075984067","https://openalex.org/W2078189165","https://openalex.org/W2078303408","https://openalex.org/W2078391920","https://openalex.org/W2080350670","https://openalex.org/W2081375348","https://openalex.org/W2082066176","https://openalex.org/W2082127635","https://openalex.org/W2082340361","https://openalex.org/W2082588556","https://openalex.org/W2082625926","https://openalex.org/W2083988323","https://openalex.org/W2086217063","https://openalex.org/W2086561251","https://openalex.org/W2086669662","https://openalex.org/W2087479677","https://openalex.org/W2087510642","https://openalex.org/W2088209808","https://openalex.org/W2089307581","https://openalex.org/W2089988685","https://openalex.org/W2091204852","https://openalex.org/W2091368852","https://openalex.org/W2092613581","https://openalex.org/W2092639019","https://openalex.org/W2093364468","https://openalex.org/W2095289942","https://openalex.org/W2095319998","https://openalex.org/W2096626380","https://openalex.org/W2098510657","https://openalex.org/W2100629398","https://openalex.org/W2100680004","https://openalex.org/W2102834181","https://openalex.org/W2104397667","https://openalex.org/W2105630800","https://openalex.org/W2108191968","https://openalex.org/W2108277395","https://openalex.org/W2108578589","https://openalex.org/W2109234448","https://openalex.org/W2111698016","https://openalex.org/W2116839542","https://openalex.org/W2117158748","https://openalex.org/W2117472172","https://openalex.org/W2120156727","https://openalex.org/W2125745779","https://openalex.org/W2127594071","https://openalex.org/W2128498401","https://openalex.org/W2128635872","https://openalex.org/W2129307413","https://openalex.org/W2130682692","https://openalex.org/W2132020713","https://openalex.org/W2132274419","https://openalex.org/W2133411368","https://openalex.org/W2133555256","https://openalex.org/W2133772521","https://openalex.org/W2134173596","https://openalex.org/W2134903200","https://openalex.org/W2135224653","https://openalex.org/W2136369816","https://openalex.org/W2136392779","https://openalex.org/W2137229430","https://openalex.org/W2137258759","https://openalex.org/W2137565449","https://openalex.org/W2138870554","https://openalex.org/W2139052757","https://openalex.org/W2140673749","https://openalex.org/W2140924908","https://openalex.org/W2141188578","https://openalex.org/W2141913307","https://openalex.org/W2144344199","https://openalex.org/W2146528056","https://openalex.org/W2150057093","https://openalex.org/W2159178484","https://openalex.org/W2160385558","https://openalex.org/W2161432643","https://openalex.org/W2162006028","https://openalex.org/W2163529058","https://openalex.org/W2163678596","https://openalex.org/W2163760215","https://openalex.org/W2164558002","https://openalex.org/W2169614568","https://openalex.org/W2171403233","https://openalex.org/W2171863507","https://openalex.org/W2184516036","https://openalex.org/W2188098210","https://openalex.org/W2221736702","https://openalex.org/W2267416220","https://openalex.org/W2285926521","https://openalex.org/W2309027821","https://openalex.org/W2416156032","https://openalex.org/W2431713845","https://openalex.org/W2438981934","https://openalex.org/W4313325039"],"related_works":["https://openalex.org/W2060483995","https://openalex.org/W2087510642","https://openalex.org/W1615545200","https://openalex.org/W629534652","https://openalex.org/W2144344199","https://openalex.org/W1968004900","https://openalex.org/W4415603193","https://openalex.org/W2061962091","https://openalex.org/W1992728455","https://openalex.org/W2088892777"],"abstract_inverted_index":{"Dans":[0],"les":[1,7,19,124,127,182],"cellules":[2],"acineuses":[3],"du":[4,22,57,84,119,141],"pancr\u00e9as":[5],"exocrine,":[6],"agonistes":[8,131],"ac\u00e9tylcholine":[9],"(ACh)":[10],"et":[11,25,29,31,40,56,86,110,140],"Chol\u00e9cystokinine":[12],"(CCK)":[13],"d\u00e9clenchent":[14],"des":[15,60,72,100,130],"oscillations":[16,73],"calciques":[17,74,129],"via":[18],"messagers":[20,39,125],"lib\u00e9rant":[21],"calcium":[23],"IP3":[24],"cADPR":[26,32],"pour":[27,33,176],"l'ACh,":[28,95],"NAADP":[30,80,153],"la":[34,48,77,134,147,155,177,189],"CCK.":[35],"L'existence":[36],"de":[37,41,45,53,63,70,87,94,102,136,150,152,159,166,191],"plusieurs":[38,42],"r\u00e9serves":[43,62],"intracellulaires":[44],"Ca2+":[46,83,99],"pose":[47],"question":[49],"d'une":[50],"possible":[51],"coop\u00e9ration":[52],"ces":[54],"messagers,":[55],"recrutement":[58],"s\u00e9lectif":[59],"diff\u00e9rentes":[61],"Ca2+.":[64],"Notre":[65,143],"travail":[66,144],"montre":[67,145],"que":[68,90,123,146,180],"lors":[69],"l'initiation":[71],"induites":[75],"par":[76,112],"CCK,":[78],"le":[79,82,92,98,113,170,185],"recrute":[81,97],"lysosome":[85],"l'endosome,":[88],"tandis":[89],"dans":[91,169,181],"cas":[93],"l'IP3":[96],"granules":[101],"zymog\u00e8ne.":[103],"Cette":[104],"r\u00e9ponse":[105],"calcique":[106],"est":[107,157],"ensuite":[108],"maintenue":[109],"amplifi\u00e9e":[111],"r\u00e9ticulum":[114],"endoplasmique":[115],"(RE)":[116],"sous":[117],"contr\u00f4le":[118],"cADPR.":[120],"Nous":[121],"proposons":[122],"d\u00e9terminent":[126],"signatures":[128],"en":[132],"contr\u00f4lant":[133],"contribution":[135],"chaque":[137],"r\u00e9serve":[138],"acide":[139],"RE.":[142],"principale":[148],"enzyme":[149,165],"synth\u00e8se":[151,167,190],"chez":[154],"souris":[156],"l'antig\u00e8ne":[158],"surface":[160],"CD38,":[161],"bien":[162],"qu'une":[163],"autre":[164],"existe":[168],"cerveau.":[171],"Nos":[172],"r\u00e9sultats":[173],"montrent":[174],"aussi":[175],"premi\u00e8re":[178],"fois":[179],"muscles":[183],"squelettiques,":[184],"monoxyde":[186],"d'azote":[187],"inhibe":[188],"NAADP.":[192]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}