{"id":"https://openalex.org/W134462624","doi":null,"title":"Atypical teratoid/rhabdoid tumor of the CNS: cytopathology and immunohistochemistry of insulin-like growth factor-II, insulin-like growth factor receptor type 1, cathepsin D, and Ki-67.","display_name":"Atypical teratoid/rhabdoid tumor of the CNS: cytopathology and immunohistochemistry of insulin-like growth factor-II, insulin-like growth factor receptor type 1, cathepsin D, and Ki-67.","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W134462624","mag":"134462624","pmid":"https://pubmed.ncbi.nlm.nih.gov/10229502"},"language":"en","primary_location":{"id":"pmid:10229502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10229502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076818447","display_name":"Shuji Ogino","orcid":"https://orcid.org/0000-0002-3909-2323","observed_orcids":["https://orcid.org/0000-0002-3909-2323"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Ogino","raw_affiliation_strings":["Institute of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021873304","display_name":"Mark L. Cohen","orcid":"https://orcid.org/0000-0002-9678-5521","observed_orcids":["https://orcid.org/0000-0002-9678-5521"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M L Cohen","raw_affiliation_strings":["Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018592399","display_name":"Fadi W. Abdul\u2010Karim","orcid":"https://orcid.org/0000-0002-4096-6120","observed_orcids":["https://orcid.org/0000-0002-4096-6120"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F W Abdul-Karim","raw_affiliation_strings":["Case Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center","institution_ids":["https://openalex.org/I4390039247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6103,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.64738094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"4","first_page":"379","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.25929999351501465,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-teratoid-rhabdoid-tumor","display_name":"atypical teratoid/rhabdoid tumor","score":0.996999979019165},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":1.0},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7670000195503235},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.6549999713897705},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6300213932991028},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5329960584640503},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5281389355659485},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.5150718092918396},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5091862082481384},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5006601810455322},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4825005531311035},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47687774896621704},{"id":"https://openalex.org/C2779069268","wikidata":"https://www.wikidata.org/wiki/Q14874349","display_name":"Insulin-like growth factor 2","level":4,"score":0.43647894263267517},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.435421347618103},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31885766983032227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16434574127197266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013724","descriptor_name":"Teratoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013724","descriptor_name":"Teratoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018335","descriptor_name":"Rhabdoid Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018335","descriptor_name":"Rhabdoid Tumor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10229502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10229502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Case Reports"},{"id":"mag:134462624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10229502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W113555068","https://openalex.org/W2137566380","https://openalex.org/W2041221267","https://openalex.org/W2987452154","https://openalex.org/W2001172791","https://openalex.org/W2145685090","https://openalex.org/W2082959291","https://openalex.org/W2130314501","https://openalex.org/W2163467983","https://openalex.org/W2040807236"],"abstract_inverted_index":{"Insulin-like":[0],"growth":[1,7,168],"factor":[2],"(IGF)-II":[3],"is":[4],"a":[5,12],"potent":[6],"factor,":[8],"normally":[9],"controlled":[10],"by":[11,35,169,182],"number":[13],"of":[14,33,60,69,73,88,91,166,200],"other":[15],"factors,":[16],"including":[17],"IGF":[18,22,34,37,43,104,128,156],"binding":[19,23,38,44],"proteins":[20],"and":[21,110,123,132,145,155,195],"protein":[24,45],"proteases.":[25],"In":[26,93],"general,":[27],"the":[28,31,58,67,74,161,183],"latter":[29],"increase":[30],"bioavailability":[32],"cleaving":[36],"proteins.":[39],"Cathepsin":[40,179],"D":[41,180],"(an":[42],"protease)":[46],"was":[47,55,79],"also":[48,187],"implicated":[49,56],"in":[50,57,66,176,190],"tumor":[51,72,184,192],"invasion.":[52],"Although":[53],"IGF-II":[54,154,170],"pathogeneses":[59],"various":[61],"childhood":[62],"neoplasms,":[63],"its":[64],"significance":[65],"pathogenesis":[68,199],"atypical":[70],"teratoid/rhabdoid":[71],"central":[75],"nervous":[76],"system":[77],"(ATRT-CNS)":[78],"not":[80],"studied":[81],"to":[82,203],"date.":[83],"We":[84,147],"present":[85],"clinicopathologic":[86],"features":[87],"two":[89],"cases":[90],"ATRT-CNS.":[92],"addition,":[94],"formalin-fixed,":[95],"paraffin-embedded":[96],"tissue":[97],"sections":[98],"were":[99,143],"stained":[100],"immunohistochemically":[101],"for":[102,119,127,136],"IGF-II,":[103,120],"receptor":[105,129,157],"type":[106,130,158],"1,":[107,159],"cathepsin":[108,137],"D,":[109],"Ki-67.":[111],"Both":[112],"tumors":[113],"demonstrated":[114],"diffuse":[115,121,133],"strong":[116],"cytoplasmic":[117,122,134],"positivity":[118,126,135],"focal":[124],"membranous":[125],"I,":[131],"D.":[138],"The":[139,197],"Ki-67":[140],"labeling":[141],"indices":[142],"10.0%":[144],"1.4%.":[146],"conclude":[148],"that":[149,163],"ATRT-CNS":[150,177,201],"cells":[151,185],"express":[152],"both":[153,191],"supporting":[160],"hypothesis":[162],"autocrine/paracrine":[164],"stimulation":[165],"cell":[167,193],"might":[171,186],"be":[172,188,204],"one":[173],"mechanism":[174],"involved":[175,189],"tumorigenesis.":[178],"expressed":[181],"invasion":[194],"growth.":[196],"exact":[198],"remains":[202],"elucidated.":[205]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
