{"id":"https://openalex.org/W13431249","doi":null,"title":"Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.","display_name":"Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W13431249","mag":"13431249","pmid":"https://pubmed.ncbi.nlm.nih.gov/2181380"},"language":"en","primary_location":{"id":"pmid:2181380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2181380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109834052","display_name":"Tomoko Tahira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Tahira","raw_affiliation_strings":["Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017184112","display_name":"Yukihito Ishizaka","orcid":"https://orcid.org/0000-0002-1863-6096","observed_orcids":["https://orcid.org/0000-0002-1863-6096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ishizaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109325065","display_name":"Fumio Itoh","orcid":"https://orcid.org/0000-0003-3411-0278","observed_orcids":["https://orcid.org/0000-0003-3411-0278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Itoh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105501776","display_name":"Takashi S\u00fcgimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sugimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111795584","display_name":"Minako Nagao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Nagao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6919,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.93474324,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"1","first_page":"97","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ret-proto-oncogene","display_name":"RET proto-oncogene","score":0.9670000076293945},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.6940000057220459},{"id":"https://openalex.org/keywords/alternative-polyadenylation","display_name":"alternative polyadenylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/transcript-isoforms","display_name":"mRNA isoforms","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cdna-clones","display_name":"cDNA clones","score":0.675000011920929},{"id":"https://openalex.org/keywords/neuroblastoma-cell-lines","display_name":"neuroblastoma cell lines","score":0.7049999833106995},{"id":"https://openalex.org/keywords/c-terminal-truncation","display_name":"C-terminal truncation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/transcript-size","display_name":"transcript size","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.8927928805351257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8863971829414368},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6848114132881165},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.6559059619903564},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6246958374977112},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5520704388618469},{"id":"https://openalex.org/C50724178","wikidata":"https://www.wikidata.org/wiki/Q381434","display_name":"Rapid amplification of cDNA ends","level":5,"score":0.5393310785293579},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.5340313911437988},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.494564026594162},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.4550545811653137},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.45440831780433655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39608800411224365},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2935672402381897},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1724758744239807},{"id":"https://openalex.org/C19924922","wikidata":"https://www.wikidata.org/wiki/Q408351","display_name":"Molecular cloning","level":4,"score":0.1622532308101654}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051096","descriptor_name":"Proto-Oncogene Proteins c-ret","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2181380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2181380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:13431249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2181380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413729974","https://openalex.org/W2426716536","https://openalex.org/W1977383551","https://openalex.org/W2025541400","https://openalex.org/W79816168","https://openalex.org/W4248668685","https://openalex.org/W2043091491","https://openalex.org/W2277460059","https://openalex.org/W4248713390","https://openalex.org/W2268631203"],"abstract_inverted_index":{"The":[0,52],"ret":[1,21,95],"proto-oncogene":[2,22,96],"expresses":[3],"four":[4],"major":[5],"mRNA":[6],"species":[7],"of":[8,29,54,83,93,98,119,122,127,143,151,169,187],"different":[9],"lengths":[10],"in":[11,46,108],"human":[12,31],"malignant":[13],"cell":[14],"lines":[15],"and":[16,100,111,141,160,177],"rat":[17],"tissues.":[18],"We":[19],"isolated":[20],"cDNA":[23,27,40,60,68,123,152],"clones":[24,41,61,124],"from":[25,43,71,105],"a":[26,30,66,78,167,178,185],"library":[28],"neuroblastoma":[32],"line,":[33],"Nagai,":[34],"which":[35],"over-expressed":[36],"these":[37],"mRNAs.":[38],"Four":[39],"differing":[42],"each":[44,106],"other":[45,107],"their":[47,109],"3'":[48,89,134],"portions":[49],"were":[50],"analysed.":[51],"sequence":[53,69],"the":[55,59,88,94,120,128,133,155,173],"region":[56],"common":[57],"to":[58,65],"is":[62,136],"essentially":[63],"identical":[64],"reported":[67],"derived":[70],"THP-1":[72],"monocytic":[73],"leukemia":[74],"cells,":[75],"that":[76,103,126,132,154],"encodes":[77],"protein":[79,168,186],"with":[80,125],"characteristic":[81],"features":[82],"receptor-type":[84],"tyrosine":[85],"kinase.":[86],"From":[87],"heterogeneity,":[90],"two":[91],"isoforms":[92],"product":[97],"1072":[99,170],"1114":[101,188],"residues":[102],"differed":[104],"9":[110],"51":[112],"C-terminal":[113],"amino":[114],"acids":[115],"are":[116],"predicted.":[117],"Comparison":[118],"structures":[121],"genomic":[129],"clone":[130],"showed":[131],"heterogeneity":[135],"produced":[137],"by":[138],"alternative":[139],"polyadenylation":[140],"splicing":[142],"mRNA.":[144],"Northern":[145],"blot":[146],"analysis":[147],"using":[148],"various":[149],"fragments":[150],"indicated":[153],"4.5":[156],"kb,":[157],"3.9":[158],"kb":[159,163,175,181],"possibly":[161],"7.0":[162],"transcripts":[164],"may":[165,183],"encode":[166,184],"residues,":[171],"while":[172],"6.0":[174],"transcript":[176,182],"(minor)":[179],"4.6":[180],"residues.":[189]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
