{"id":"https://openalex.org/W134285098","doi":null,"title":"The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene.","display_name":"The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene.","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W134285098","mag":"134285098","pmid":"https://pubmed.ncbi.nlm.nih.gov/20412686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2855038"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2855038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2855038","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2855038","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047789641","display_name":"Bengi Acar-Perk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bengi Acar-Perk","raw_affiliation_strings":["Clinic of Gynecology and Obstetrics, University Clinic Schleswig-Holstein, Campus Kiel, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Gynecology and Obstetrics, University Clinic Schleswig-Holstein, Campus Kiel, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046309596","display_name":"Karen Br\u00e4utigam","orcid":"https://orcid.org/0000-0001-8521-9607","observed_orcids":["https://orcid.org/0000-0001-8521-9607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Br\u00e4utigam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033799121","display_name":"Regina Grunewald","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Regina Grunewald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Andreas Schmutzler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Schmutzler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032626301","display_name":"Christian Schem","orcid":"https://orcid.org/0000-0001-8606-3077","observed_orcids":["https://orcid.org/0000-0001-8606-3077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Schem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061324093","display_name":"Norbert Arnold","orcid":"https://orcid.org/0000-0003-4523-8808","observed_orcids":["https://orcid.org/0000-0003-4523-8808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norbert K Arnold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111451713","display_name":"W. Jonat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Jonat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066649665","display_name":"J\u00f6rg Paul Weimer","orcid":"https://orcid.org/0000-0002-4528-8509","observed_orcids":["https://orcid.org/0000-0002-4528-8509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00f6rg Weimer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.00874903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"60","issue":"2","first_page":"118","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.3109999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adamts12","display_name":"ADAMTS12","score":0.878000020980835},{"id":"https://openalex.org/keywords/gene-disruption","display_name":"gene disruption","score":0.6000000238418579},{"id":"https://openalex.org/keywords/reciprocal-translocation","display_name":"reciprocal translocation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/vascularization","display_name":"vascularization","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.9549999833106995},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.7036657929420471},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6547537446022034},{"id":"https://openalex.org/C167814343","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondin","level":4,"score":0.6495972871780396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5832712650299072},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5730209946632385},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.48207908868789673},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43975698947906494},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4282555878162384},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.42521175742149353},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.3239164352416992},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.10974347591400146},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071096","descriptor_name":"ADAMTS Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019457","descriptor_name":"Chromosome Breakage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D033481","descriptor_name":"Chromosomes, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2855038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2855038","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},{"id":"pmid:20412686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20412686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Journal Article"},{"id":"pmh:oai:publications.rwth-aachen.de:185175","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/185175","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine / American Association for Laboratory Animal Science 60(2), 118-122 (2010).","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:134285098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20412686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2855038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2855038","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W245706496","https://openalex.org/W749189942","https://openalex.org/W1552162287","https://openalex.org/W1979339922","https://openalex.org/W1984731778","https://openalex.org/W1988594089","https://openalex.org/W2015354603","https://openalex.org/W2018029080","https://openalex.org/W2030705338","https://openalex.org/W2031510428","https://openalex.org/W2048470218","https://openalex.org/W2075612872","https://openalex.org/W2089943125","https://openalex.org/W2095512005","https://openalex.org/W2118632409","https://openalex.org/W2132993315"],"related_works":["https://openalex.org/W2029087704","https://openalex.org/W2560620234","https://openalex.org/W1993322814","https://openalex.org/W2026002230","https://openalex.org/W2603522895","https://openalex.org/W2018028560","https://openalex.org/W2106568932","https://openalex.org/W2032712201","https://openalex.org/W2916518677","https://openalex.org/W7100773942"],"abstract_inverted_index":{"The":[0,66,109],"mouse":[1,11,111],"strain":[2,112],"CBA/CaH-T(14;15)6Ca/J":[3,110],"carries":[4],"a":[5,43,60,81,115],"homozygous":[6],"balanced":[7],"reciprocal":[8],"translocation":[9,22],"between":[10,71],"chromosomes":[12],"14":[13],"and":[14,74,83,88,97,100],"15,":[15],"but":[16],"the":[17,37,54,105,122],"break":[18,38,55,68],"points":[19],"of":[20,47,76,107,121,124],"this":[21,89],"have":[23],"not":[24],"previously":[25],"been":[26,102],"examined":[27],"in":[28,32,40,57,94,104,127],"detail.":[29],"Using":[30],"fluorescent":[31],"situ":[33],"hybridization,":[34],"we":[35],"assigned":[36],"point":[39,56],"14qE3":[41],"to":[42,59],"200-kb":[44],"region":[45,62],"devoid":[46],"any":[48],"known":[49],"gene.":[50],"We":[51],"similarly":[52],"defined":[53],"15qA1":[58],"27-kb":[61],"containing":[63],"involving":[64],"ADAMTS12.":[65,77],"chromosomal":[67],"likely":[69,113],"is":[70,114],"exons":[72],"2":[73],"3":[75],"This":[78],"gene":[79],"encodes":[80],"disintegrin":[82],"metalloproteinase":[84],"with":[85],"thrombospondin":[86],"motifs,":[87],"product":[90],"plays":[91],"crucial":[92],"roles":[93],"both":[95],"vascularization":[96],"cancer":[98],"progression":[99],"has":[101],"implicated":[103],"development":[106],"arthritis.":[108],"suitable":[116],"model":[117],"for":[118],"further":[119],"examination":[120],"influences":[123],"defective":[125],"ADAMTS12":[126],"various":[128],"pathologic":[129],"processes.":[130]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
