{"id":"https://openalex.org/W134205010","doi":null,"title":"Synthesis And Characterization Of Brain Penetrant Prodrug Of Neuroprotective D264: Potential Disease Modifying Treatment Agent For Parkinson's Disease","display_name":"Synthesis And Characterization Of Brain Penetrant Prodrug Of Neuroprotective D264: Potential Disease Modifying Treatment Agent For Parkinson's Disease","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W134205010","mag":"134205010"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_theses-1430","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_theses/373","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1430&context=oa_theses","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Theses","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1430&context=oa_theses","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021846899","display_name":"Fahd Shamoon Dholkawala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fahd Shamoon Dholkawala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5021846899"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.7919999957084656},{"id":"https://openalex.org/keywords/brain-penetration","display_name":"brain penetration","score":0.7379999756813049},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.796999990940094},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9679999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.6639999747276306},{"id":"https://openalex.org/keywords/alpha-synuclein-aggregation","display_name":"alpha-synuclein aggregation","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7855865955352783},{"id":"https://openalex.org/C2779335537","wikidata":"https://www.wikidata.org/wiki/Q7162617","display_name":"Penetrant (biochemical)","level":2,"score":0.7745668888092041},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6539260745048523},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.5912798643112183},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.538737952709198},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.43860554695129395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40217703580856323},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4005226492881775},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3619684875011444},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.333312451839447},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.18449917435646057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10247480869293213},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06696099042892456}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:oa_theses-1430","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_theses/373","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1430&context=oa_theses","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Theses","raw_type":"thesis"},{"id":"mag:134205010","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1430&context=oa_theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_theses-1430","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_theses/373","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1430&context=oa_theses","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Theses","raw_type":"thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W134205010.pdf","grobid_xml":"https://content.openalex.org/works/W134205010.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1480429336","https://openalex.org/W1485428386","https://openalex.org/W1540470728","https://openalex.org/W1889609763","https://openalex.org/W1891591278","https://openalex.org/W1964463501","https://openalex.org/W1965778124","https://openalex.org/W1967922486","https://openalex.org/W1971210853","https://openalex.org/W1972012028","https://openalex.org/W1972509721","https://openalex.org/W1973077436","https://openalex.org/W1980977603","https://openalex.org/W1985760248","https://openalex.org/W1998858609","https://openalex.org/W2010605130","https://openalex.org/W2013512181","https://openalex.org/W2016693691","https://openalex.org/W2017549779","https://openalex.org/W2017737272","https://openalex.org/W2023158322","https://openalex.org/W2023248876","https://openalex.org/W2026395566","https://openalex.org/W2027943861","https://openalex.org/W2029695700","https://openalex.org/W2029973048","https://openalex.org/W2030876064","https://openalex.org/W2032319297","https://openalex.org/W2032381724","https://openalex.org/W2049588777","https://openalex.org/W2053066866","https://openalex.org/W2054663416","https://openalex.org/W2061736925","https://openalex.org/W2062754118","https://openalex.org/W2062781235","https://openalex.org/W2063221926","https://openalex.org/W2063985393","https://openalex.org/W2065993125","https://openalex.org/W2068327908","https://openalex.org/W2068816850","https://openalex.org/W2069632588","https://openalex.org/W2072715188","https://openalex.org/W2074773874","https://openalex.org/W2077152493","https://openalex.org/W2078578100","https://openalex.org/W2078915251","https://openalex.org/W2080194182","https://openalex.org/W2084537955","https://openalex.org/W2087155141","https://openalex.org/W2091265794","https://openalex.org/W2095374280","https://openalex.org/W2109747317","https://openalex.org/W2116766274","https://openalex.org/W2118825726","https://openalex.org/W2123431154","https://openalex.org/W2123913108","https://openalex.org/W2125211730","https://openalex.org/W2141533937","https://openalex.org/W2143959688","https://openalex.org/W2150656456","https://openalex.org/W2152440646","https://openalex.org/W2152727843","https://openalex.org/W2152858850","https://openalex.org/W2154737306","https://openalex.org/W2154761807","https://openalex.org/W2156168338","https://openalex.org/W2157678497","https://openalex.org/W2164167622","https://openalex.org/W2187524630","https://openalex.org/W2285760952","https://openalex.org/W2301404923","https://openalex.org/W2333915371","https://openalex.org/W2340192722","https://openalex.org/W2419436028","https://openalex.org/W2437948583"],"related_works":["https://openalex.org/W2304764341","https://openalex.org/W10225556","https://openalex.org/W2032381724","https://openalex.org/W4310177740","https://openalex.org/W2126005891","https://openalex.org/W2023158322","https://openalex.org/W2904304912","https://openalex.org/W2133643242","https://openalex.org/W1966545592","https://openalex.org/W2616175774"],"abstract_inverted_index":{"Parkinson's":[0,125],"disease":[1,104,126],"(PD)":[2],"is":[3,31,48,53,91,141,293],"a":[4,64,136,184,190],"complex":[5,100],"neurodegenerative":[6],"disorder":[7],"with":[8,211],"progressive":[9],"loss":[10],"of":[11,19,24,37,46,70,102,114,124,143,176,193,200,225,245,260,278,281],"dopamanergic":[12],"neurons":[13],"in":[14,67,132,151,178,205,232,247,251],"the":[15,20,44,68,82,88,103,122,172,179,207,220,243,275],"substantia":[16],"nigra":[17],"region":[18],"brain":[21,165,233,253],"and":[22,40,106,174,258,285],"accumulation":[23],"intracytoplasmic":[25],"inclusions":[26],"called":[27],"`Lewy":[28],"bodies'.":[29],"PD":[30,47,155,212],"characterized":[32],"by":[33,295],"tremors,":[34],"rigidity,":[35],"slowness":[36],"movement,":[38],"bradykinesia":[39],"postural":[41],"imbalances.":[42],"Although":[43],"etiology":[45],"not":[49],"well":[50,54],"understood,":[51],"it":[52],"established":[55],"that":[56],"oxidative":[57,208],"stress,":[58],"mitochondrial":[59],"dysfunction,":[60],"alpha-synuclein":[61],"aggregation":[62],"play":[63],"central":[65],"role":[66,199],"pathogenesis":[69,101],"PD.":[71],"Current":[72],"treatment":[73,123],"methods":[74],"are":[75],"based":[76,186,268],"on":[77],"symptomatic":[78,108],"relief":[79,109],"without":[80],"addressing":[81],"underlying":[83],"pathophysiological":[84],"factors":[85],"responsible":[86],"for":[87,121],"disease.":[89],"It":[90],"important":[92,198],"to":[93,162,169,228,241,273],"develop":[94],"therapies":[95],"which":[96,147],"can":[97],"address":[98],"these":[99],"process":[105],"providing":[107],"as":[110,189,203],"well.":[111],"Towards":[112],"development":[113],"novel":[115],"multifunctional":[116],"dopamine":[117],"D2/D3":[118],"agonist":[119],"drugs":[120],"(PD),":[127],"D-264":[128,177,187,231],"was":[129,262,271],"previously":[130],"synthesized":[131,226],"our":[133,144],"lab.":[134],"D-264,":[135],"potent":[137],"D3":[138],"preferring":[139],"agonist,":[140],"one":[142],"lead":[145],"compounds":[146],"showed":[148],"high":[149],"neuroprotection":[150],"MPTP":[152],"&":[153,234],"Lactacystin":[154],"animal":[156],"models.":[157],"However,":[158],"this":[159,215],"drug":[160],"seems":[161],"have":[163,182,218],"minimal":[164],"penetration.":[166],"In":[167,239],"order":[168,240],"further":[170],"enhance":[171],"efficacy":[173],"bio-availability":[175],"brain,":[180],"we":[181,217],"designed":[183],"cysteine":[185],"prodrug":[188,227,246,282],"substantial":[191],"amount":[192],"research":[194],"points":[195],"out":[196],"an":[197],"antioxidants":[201],"such":[202],"L-cysteine":[204],"reducing":[206],"stress":[209],"associated":[210],".":[213],"To":[214],"end,":[216],"evaluated":[219],"ex":[221],"vivo":[222,252],"hydrolysis":[223,261],"pattern":[224],"yield":[229],"active":[230],"plasma":[235],"solutions":[236],"using":[237,264],"RP-HPLC.":[238,265],"evaluate":[242,274],"efficiency":[244,259],"crossing":[248],"blood-brain":[249],"barrier,":[250],"penetration":[254],"studies":[255],"were":[256],"performed":[257,272],"quantified":[263],"Further,":[266],"DPPH":[267],"anti-oxidant":[269,276],"assay":[270],"property":[277],"prodrug.":[279],"Details":[280],"design,":[283],"synthesis":[284],"pharmacological":[286],"evaluation":[287],"will":[288],"be":[289],"presented.":[290],"This":[291],"work":[292],"supported":[294],"NS047198":[296],"(AD)":[297]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
