{"id":"https://openalex.org/W13419715","doi":null,"title":"STABILITY OF AFFINITY BASED LAYER-BY-LAYER POLYMERIC SELF-ASSEMBLIES FOR ORAL WOUND APPLICATIONS","display_name":"STABILITY OF AFFINITY BASED LAYER-BY-LAYER POLYMERIC SELF-ASSEMBLIES FOR ORAL WOUND APPLICATIONS","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W13419715","mag":"13419715"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:cme_etds-1002","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/cme_etds/3","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1002&context=cme_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Chemical and Materials Engineering","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1002&context=cme_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005020814","display_name":"Sundar P. Authimoolam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sundar P. Authimoolam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005020814"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0008282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-mucositis","display_name":"oral mucositis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/layer-by-layer-assembly","display_name":"layer-by-layer assembly","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mouthwash","display_name":"mouthwash","score":0.6299999952316284},{"id":"https://openalex.org/keywords/barrier-stability","display_name":"barrier stability","score":0.6850000023841858},{"id":"https://openalex.org/keywords/chemical-resistance","display_name":"chemical resistance","score":0.4950000047683716},{"id":"https://openalex.org/keywords/mechanical-stability","display_name":"mechanical stability","score":0.9200000166893005},{"id":"https://openalex.org/keywords/biotin-conjugation","display_name":"biotin conjugation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/polymer-molecular-weight","display_name":"polymer molecular weight","score":0.746999979019165},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.5899999737739563},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.6909074187278748},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4382639229297638},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3574216365814209},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35095757246017456},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32213103771209717},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3180369734764099},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:cme_etds-1002","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/cme_etds/3","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1002&context=cme_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Chemical and Materials Engineering","raw_type":"text"},{"id":"mag:13419715","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1002&context=cme_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:cme_etds-1002","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/cme_etds/3","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1002&context=cme_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Chemical and Materials Engineering","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W13419715.pdf","grobid_xml":"https://content.openalex.org/works/W13419715.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W12033898","https://openalex.org/W129798735","https://openalex.org/W1486369761","https://openalex.org/W1530494162","https://openalex.org/W1556673589","https://openalex.org/W1788256932","https://openalex.org/W1869883584","https://openalex.org/W1965088977","https://openalex.org/W1976677187","https://openalex.org/W1979776046","https://openalex.org/W1984335257","https://openalex.org/W1985010021","https://openalex.org/W1985482871","https://openalex.org/W1993363985","https://openalex.org/W2012005071","https://openalex.org/W2016963426","https://openalex.org/W2016994623","https://openalex.org/W2021521734","https://openalex.org/W2021815726","https://openalex.org/W2024381955","https://openalex.org/W2025969146","https://openalex.org/W2032999290","https://openalex.org/W2042324535","https://openalex.org/W2046209970","https://openalex.org/W2048874935","https://openalex.org/W2055984731","https://openalex.org/W2056010226","https://openalex.org/W2069529348","https://openalex.org/W2072444438","https://openalex.org/W2074967251","https://openalex.org/W2078320987","https://openalex.org/W2084800358","https://openalex.org/W2084850974","https://openalex.org/W2089816268","https://openalex.org/W2097640610","https://openalex.org/W2097911686","https://openalex.org/W2102681606","https://openalex.org/W2123684166","https://openalex.org/W2127673745","https://openalex.org/W2130317719","https://openalex.org/W2130512481","https://openalex.org/W2131487860","https://openalex.org/W2132364269","https://openalex.org/W2141092749","https://openalex.org/W2145063848","https://openalex.org/W2152485160","https://openalex.org/W2162596875","https://openalex.org/W2164712168","https://openalex.org/W2188188826","https://openalex.org/W2412527814","https://openalex.org/W4249281955"],"related_works":["https://openalex.org/W2107900515","https://openalex.org/W7138440693","https://openalex.org/W4388969693","https://openalex.org/W7154335084","https://openalex.org/W4308463075","https://openalex.org/W3041908825","https://openalex.org/W4411330735","https://openalex.org/W4417449909","https://openalex.org/W4312019732","https://openalex.org/W4414551977"],"abstract_inverted_index":{"Oral":[0],"mucositis":[1],"is":[2,27,55,89,159],"a":[3,34,66,168,191],"painful":[4],"and":[5,45,117,145,174],"debilitating":[6],"chronic":[7],"inflammatory":[8],"condition":[9],"that":[10,57,161],"can":[11,41,71],"result":[12],"from":[13],"chemo":[14],"and/or":[15],"radiotherapy.":[16],"While":[17],"current":[18],"treatment":[19,193],"strategies":[20],"which":[21,40],"provide":[22,43],"temporary":[23],"relief":[24],"exist,":[25],"there":[26],"still":[28],"an":[29,58,79],"unmet":[30],"clinical":[31],"need":[32],"for":[33,73],"robust":[35],"long":[36],"active":[37],"barrier":[38,63,130,155,188],"strategy":[39],"simultaneously":[42],"protection":[44],"release":[46],"drug":[47,76],"to":[48,91,108,153],"enhance":[49],"the":[50,102,110,162,179],"wound":[51,74],"healing":[52],"response.":[53],"It":[54],"proposed":[56,180],"affinity":[59,98,181],"based":[60,95,182],"layer-by-layer":[61],"self-assembled":[62],"administered":[64],"as":[65,142],"series":[67],"of":[68,104,147,164],"mouth":[69],"rinses":[70],"allow":[72],"specific":[75],"delivery,":[77],"providing":[78],"effective":[80],"regenerative":[81],"therapy.":[82],"In":[83],"this":[84],"work,":[85],"biotinylated":[86],"poly(acrylic":[87],"acid)":[88],"used":[90],"develop":[92],"LBL":[93,106,129,172],"assemblies":[94,107,150,184],"upon":[96],"biotin-streptavidin":[97],"interactions.":[99],"To":[100],"explore":[101],"ability":[103],"developed":[105],"resist":[109],"harsh":[111],"intraoral":[112],"environment,":[113],"in":[114,149,171,175,195],"vitro":[115],"chemical":[116,154],"ex":[118],"vivo":[119],"mechanical":[120,176],"tests":[121],"are":[122],"performed.":[123],"The":[124],"stability":[125,131],"results":[126],"demonstrate":[127],"significant":[128,169],"with":[132,185],"wear":[133],"resistance.":[134],"From":[135],"principal":[136],"component":[137],"regression":[138],"analysis,":[139],"factors":[140],"such":[141],"polymer":[143],"MW":[144],"number":[146],"layers":[148],"contributed":[151],"significantly":[152],"stability.":[156,177],"Also":[157],"it":[158],"observed":[160],"extent":[163],"biotin":[165],"conjugation":[166],"plays":[167],"role":[170],"development":[173],"Thus,":[178],"multilayered":[183],"their":[186],"excellent":[187],"properties":[189],"offer":[190],"modular":[192],"approach":[194],"oral":[196],"mucosal":[197],"injuries.":[198]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
