{"id":"https://openalex.org/W133997601","doi":null,"title":"A randomized clinical trial comparing radiation therapy v radiation therapy plus cis-dichlorodiammine platinum (II) in the treatment of locally advanced non-small cell lung cancer.","display_name":"A randomized clinical trial comparing radiation therapy v radiation therapy plus cis-dichlorodiammine platinum (II) in the treatment of locally advanced non-small cell lung cancer.","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W133997601","mag":"133997601","pmid":"https://pubmed.ncbi.nlm.nih.gov/2851172"},"language":"en","primary_location":{"id":"pmid:2851172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2851172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016367695","display_name":"Enzo Soresi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210094195","display_name":"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","ror":"https://ror.org/00htrxv69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094195"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Soresi","raw_affiliation_strings":["Department of Pneumology and Radiotherapy, E.O. Niguarda Ca Granda, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pneumology and Radiotherapy, E.O. Niguarda Ca Granda, Milan, Italy","institution_ids":["https://openalex.org/I2803066834","https://openalex.org/I4210094195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024287096","display_name":"Maurizia Clerici","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Clerici","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024916387","display_name":"Roberto Giuseppe Grilli","orcid":"https://orcid.org/0000-0001-9425-7170","observed_orcids":["https://orcid.org/0000-0001-9425-7170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Grilli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087076187","display_name":"Umberto Borghini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Borghini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060335065","display_name":"Roberto Zucali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Zucali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023683659","display_name":"Mario Leoni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Leoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000862070","display_name":"Marco Botturi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Botturi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031588558","display_name":"Chiara Vergari","orcid":"https://orcid.org/0009-0002-5453-8239","observed_orcids":["https://orcid.org/0009-0002-5453-8239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Vergari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008585325","display_name":"Gino Luporini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Luporini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064435203","display_name":"S Scoccia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Scoccia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6582,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.93919974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"15","issue":"6 Suppl 7","first_page":"20","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/locally-advanced-lung-cancer","display_name":"locally advanced lung cancer","score":0.8429999947547913},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.6520000100135803},{"id":"https://openalex.org/keywords/local-control","display_name":"local control","score":0.7160000205039978},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6579999923706055},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9264014959335327},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6609160900115967},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5776523947715759},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4948708415031433},{"id":"https://openalex.org/C164718446","wikidata":"https://www.wikidata.org/wiki/Q7234839","display_name":"Potentiator","level":2,"score":0.4763736426830292},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.47298988699913025},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42936745285987854},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4096105098724365},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3987649083137512},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3870672583580017},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3575042486190796},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10913628339767456}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2851172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2851172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Clinical Trial"},{"id":"mag:133997601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2851172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2008234782","https://openalex.org/W645949272","https://openalex.org/W2038463673","https://openalex.org/W2142764975","https://openalex.org/W2159577139","https://openalex.org/W2403335129","https://openalex.org/W2053888668","https://openalex.org/W1990227629","https://openalex.org/W1984781673","https://openalex.org/W4206655690"],"abstract_inverted_index":{"Cis-Dichlorodiammine":[0],"platinum":[1],"(II)":[2],"(cis-DDP)":[3],"was":[4,95,168,189],"demonstrated":[5],"to":[6,43,114,155,238],"be":[7,156,198,207,239],"a":[8,27,34,162,212],"potentiator":[9],"of":[10,26,38,55,72,91,150,165,194,204,219,227],"radiation":[11,213],"therapy":[12],"(RT)":[13],"in":[14,19,97,134,141,170,177,184,241],"experimental":[15],"tumor":[16],"models":[17],"and":[18,33,93,100,129,191,229,234],"cultured":[20],"cells.":[21],"To":[22],"assess":[23],"the":[24,56,78,98,135,142,148,151,171,178,185,192,216,225,230],"effectiveness":[25],"combined":[28,221],"modality":[29,222],"treatment":[30,223],"including":[31],"RT":[32,68,80,99,101,121,126,136,143,172,179,186],"weekly":[35],"low-dose":[36],"administration":[37],"cis-DDP,":[39],"from":[40],"January":[41],"1986":[42],"June":[44],"1987,":[45],"95":[46],"patients":[47,66,76],"with":[48,112],"unresectable":[49],"locally":[50],"advanced":[51],"non-small":[52],"cell":[53],"carcinoma":[54],"lung":[57],"(stage":[58],"IIIa,":[59],"b)":[60],"were":[61,110],"randomized":[62],"for":[63,120,125],"study.":[64],"Fifty":[65],"received":[67,77],"alone":[69],"at":[70],"doses":[71],"50":[73],"Gy;":[74],"45":[75],"same":[79],"plus":[81],"cis-DDP":[82,103,145,174,181,210,232],"15":[83],"mg/m2":[84],"IV":[85],"weekly.":[86],"An":[87],"overall":[88],"response":[89],"rate":[90],"50%":[92],"64%":[94],"observed":[96,169],"+":[102,127,144,173,180],"group,":[104],"respectively.":[105],"No":[106],"statistically":[107],"significant":[108],"differences":[109],"detected":[111],"regard":[113],"median":[115],"survival":[116],"time":[117],"(11":[118],"months":[119,124,133,140],"v":[122,138,182],"16":[123],"cis-DDP)":[128],"progression-free":[130],"interval":[131],"(7":[132],"arm":[137,175],"9":[139],"arm),":[146],"but":[147,215],"patterns":[149],"first":[152],"failure":[153],"appeared":[154],"affected":[157],"by":[158],"treatment.":[159],"In":[160],"fact,":[161],"lower":[163],"number":[164],"intrathoracic":[166],"relapses":[167],"(12":[176],"23":[183],"arm).":[187],"Toxicity":[188],"mild":[190],"feasibility":[193],"this":[195,220],"schedule":[196],"must":[197],"remarked.":[199],"A":[200],"better":[201],"local":[202],"control":[203],"disease":[205],"can":[206],"obtained":[208],"using":[209],"as":[211],"potentiator,":[214],"true":[217],"influence":[218],"on":[224],"length":[226],"survival,":[228],"optimal":[231],"timing":[233],"dosage":[235],"are":[236],"still":[237],"evaluated":[240],"further":[242],"clinical":[243],"trials.":[244]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}