{"id":"https://openalex.org/W133972983","doi":"https://doi.org/10.5980/jpnjurol1989.83.1882","title":"ESTABLISHMENT OF A NEW HUMAN RENAL CANCER CELL LINE (TC-1) AND ITS PRODUCTIVITY OF INTERLEUKIN-6 (IL-6)","display_name":"ESTABLISHMENT OF A NEW HUMAN RENAL CANCER CELL LINE (TC-1) AND ITS PRODUCTIVITY OF INTERLEUKIN-6 (IL-6)","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W133972983","doi":"https://doi.org/10.5980/jpnjurol1989.83.1882","mag":"133972983","pmid":"https://pubmed.ncbi.nlm.nih.gov/1479760"},"language":"ja","primary_location":{"id":"doi:10.5980/jpnjurol1989.83.1882","doi":"https://doi.org/10.5980/jpnjurol1989.83.1882","is_oa":true,"landing_page_url":"https://doi.org/10.5980/jpnjurol1989.83.1882","pdf_url":"https://www.jstage.jst.go.jp/article/jpnjurol1989/83/11/83_11_1882/_pdf","source":{"id":"https://openalex.org/S2752698192","display_name":"The Japanese Journal of Urology","issn_l":"0021-5287","issn":["0021-5287","1884-7110"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313616","host_organization_name":"Japanese Dermatological Association","host_organization_lineage":["https://openalex.org/P4310313616"],"host_organization_lineage_names":["Japanese Dermatological Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jpnjurol1989/83/11/83_11_1882/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113726038","display_name":"Junro Muraki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129303","display_name":"Tochigi Cancer Center","ror":"https://ror.org/03eg72e39","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junro Muraki","raw_affiliation_strings":["Department of Urology, Tochigi Cancer Center, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tochigi Cancer Center, Japan","institution_ids":["https://openalex.org/I4210129303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091371459","display_name":"Masaaki Nakazano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129303","display_name":"Tochigi Cancer Center","ror":"https://ror.org/03eg72e39","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Nakazano","raw_affiliation_strings":["Department of Urology , Tochigi Cancer Center , Tochigi Pref , Japan","\u6803\u6728\u770c\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u6ccc\u5c3f\u5668\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology , Tochigi Cancer Center , Tochigi Pref , Japan","institution_ids":["https://openalex.org/I4210129303"]},{"raw_affiliation_string":"\u6803\u6728\u770c\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u6ccc\u5c3f\u5668\u79d1","institution_ids":["https://openalex.org/I4210129303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210129303"],"apc_list":null,"apc_paid":null,"fwci":0.2186,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.53971834,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"11","first_page":"1882","last_page":"1889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cell-line-establishment","display_name":"cell line establishment","score":0.6769999861717224},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.6800000071525574},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.671999990940094},{"id":"https://openalex.org/keywords/nude-mouse-xenograft","display_name":"nude mouse xenograft","score":0.8820000290870667},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.6909999847412109},{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.7799999713897705},{"id":"https://openalex.org/keywords/autocrine-growth-factor","display_name":"autocrine growth factor","score":0.9020000100135803},{"id":"https://openalex.org/keywords/il-1alpha","display_name":"IL-1\u03b1","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.7259727716445923},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6839227080345154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5463190674781799},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5185952186584473},{"id":"https://openalex.org/C48900799","wikidata":"https://www.wikidata.org/wiki/Q1424376","display_name":"Doubling time","level":3,"score":0.4747367799282074},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33092397451400757},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5980/jpnjurol1989.83.1882","doi":"https://doi.org/10.5980/jpnjurol1989.83.1882","is_oa":true,"landing_page_url":"https://doi.org/10.5980/jpnjurol1989.83.1882","pdf_url":"https://www.jstage.jst.go.jp/article/jpnjurol1989/83/11/83_11_1882/_pdf","source":{"id":"https://openalex.org/S2752698192","display_name":"The Japanese Journal of Urology","issn_l":"0021-5287","issn":["0021-5287","1884-7110"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313616","host_organization_name":"Japanese Dermatological Association","host_organization_lineage":["https://openalex.org/P4310313616"],"host_organization_lineage_names":["Japanese Dermatological Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese Journal of Urology","raw_type":"journal-article"},{"id":"pmid:1479760","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1479760","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Hinyokika Gakkai zasshi. The japanese journal of urology","raw_type":"English Abstract"}],"best_oa_location":{"id":"doi:10.5980/jpnjurol1989.83.1882","doi":"https://doi.org/10.5980/jpnjurol1989.83.1882","is_oa":true,"landing_page_url":"https://doi.org/10.5980/jpnjurol1989.83.1882","pdf_url":"https://www.jstage.jst.go.jp/article/jpnjurol1989/83/11/83_11_1882/_pdf","source":{"id":"https://openalex.org/S2752698192","display_name":"The Japanese Journal of Urology","issn_l":"0021-5287","issn":["0021-5287","1884-7110"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313616","host_organization_name":"Japanese Dermatological Association","host_organization_lineage":["https://openalex.org/P4310313616"],"host_organization_lineage_names":["Japanese Dermatological Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W133972983.pdf","grobid_xml":"https://content.openalex.org/works/W133972983.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W157721590","https://openalex.org/W1517067629","https://openalex.org/W1939179218","https://openalex.org/W1972117642","https://openalex.org/W2005811564","https://openalex.org/W2007000374","https://openalex.org/W2058554371","https://openalex.org/W2062137913","https://openalex.org/W2089428672","https://openalex.org/W2120486924","https://openalex.org/W2123610052","https://openalex.org/W2158034263","https://openalex.org/W2158946057","https://openalex.org/W2285002277","https://openalex.org/W2409636460","https://openalex.org/W2416379485"],"related_works":["https://openalex.org/W2353944979","https://openalex.org/W2320284128","https://openalex.org/W1973455627","https://openalex.org/W2171344915","https://openalex.org/W2100462890","https://openalex.org/W2419526448","https://openalex.org/W7099377528","https://openalex.org/W2058554371","https://openalex.org/W7208690495","https://openalex.org/W2009771778"],"abstract_inverted_index":{"We":[0],"established":[1],"a":[2,11,39,43,63,72],"new":[3],"cell":[4,13,90,108,124,149,154,169,187],"line":[5,91],"(TC-1)":[6],"from":[7],"primary":[8],"site":[9],"of":[10,46,65,114,122,134,164,201,210],"renal":[12],"carcinoma":[14],"(RCC)":[15],"patient.":[16],"Its":[17],"doubling":[18],"time":[19],"in":[20,80,119,132,185,203],"tissue":[21],"culture":[22,125,194,205],"was":[23,33,52,84,92,117],"20":[24],"hours":[25],"at":[26],"45th":[27],"passage":[28],"and":[29,62,76,97,110],"mycoplasma":[30],"contamination":[31],"test":[32],"negative.":[34],"The":[35],"karyotypic":[36],"analysis":[37,158],"demonstrated":[38],"human":[40],"karyotype":[41],"with":[42,86,208],"modal":[44],"number":[45],"70.":[47],"A":[48],"consistent":[49],"chromosomal":[50],"abnormality":[51],"noted":[53],"such":[54],"as":[55,129,131,151,180],"No.":[56,59],"4":[57],"monosomy,":[58],"7":[60],"trisomy":[61],"loss":[64],"Y":[66],"chromosome.":[67],"Electron":[68],"microscopic":[69],"examination":[70],"showed":[71],"brush":[73],"border,":[74],"vacuoles":[75],"abundant":[77],"glycogen":[78],"granules":[79],"the":[81,98,103,120,147,162,168,174,186,193,204],"cytoplasm,":[82],"which":[83],"compatible":[85],"RCC":[87],"cells.":[88],"This":[89],"transplantable":[93],"to":[94,192],"nude":[95,135],"mice":[96,136],"grown":[99],"tumor":[100,139],"closely":[101],"resembled":[102],"original":[104],"tumor,":[105],"i.e.":[106],"clear":[107],"type":[109],"hypervascularity.":[111],"High":[112],"titer":[113],"interleukin-6":[115],"(IL-6)":[116],"detected":[118],"supernatant":[121,206],"TC-1":[123,148],"(approximately":[126],"5":[127],"ng/ml)":[128],"well":[130],"sera":[133],"bearing":[137],"this":[138],"(260":[140],"pg/ml).":[141],"Exogenous":[142],"IL-6":[143,165,176,202,220],"did":[144,177,217],"not":[145,160,178,218],"enhance":[146],"proliferation":[150],"determined":[152],"by":[153],"count.":[155],"Flow":[156],"cytometric":[157],"could":[159],"demonstrate":[161],"existence":[163],"receptor":[166],"on":[167],"surface.":[170],"These":[171],"results":[172],"suggested":[173],"produced":[175],"act":[179],"an":[181],"autocrine":[182],"growth":[183],"factor":[184],"line.":[188],"Additional":[189],"IL-1":[190],"alpha":[191,216],"medium":[195],"induced":[196],"3-4":[197],"times":[198],"higher":[199],"concentration":[200],"compared":[207],"that":[209],"non-stimulating":[211],"cells,":[212],"while":[213],"exogenous":[214],"TNF":[215],"stimulate":[219],"production.":[221]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
