{"id":"https://openalex.org/W133937641","doi":null,"title":"Crystalloid vs. colloid resuscitation: is one better? A randomized clinical study.","display_name":"Crystalloid vs. colloid resuscitation: is one better? A randomized clinical study.","publication_year":1979,"publication_date":"1979-02-01","ids":{"openalex":"https://openalex.org/W133937641","mag":"133937641","pmid":"https://pubmed.ncbi.nlm.nih.gov/419454"},"language":"en","primary_location":{"id":"pmid:419454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/419454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079394356","display_name":"Richard W. Virgilio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R W Virgilio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066312085","display_name":"Charles L. Rice","orcid":"https://orcid.org/0000-0002-5323-6979","observed_orcids":["https://orcid.org/0000-0002-5323-6979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C L Rice","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000684412","display_name":"David E. Smith","orcid":"https://orcid.org/0000-0001-7670-0212","observed_orcids":["https://orcid.org/0000-0001-7670-0212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D E Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D R James","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R James","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003894791","display_name":"Christopher Kristaps Zarins","orcid":"https://orcid.org/0000-0001-6179-1000","observed_orcids":["https://orcid.org/0000-0001-6179-1000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C K Zarins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043159559","display_name":"Charles F. Hobelmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C F Hobelmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064178320","display_name":"Richard M. Peters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Peters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":21.8688,"has_fulltext":false,"cited_by_count":247,"citation_normalized_percentile":{"value":0.99773499,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"85","issue":"2","first_page":"129","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.12600000202655792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crystalloid-resuscitation","display_name":"crystalloid resuscitation","score":0.953000009059906},{"id":"https://openalex.org/keywords/colloid-resuscitation","display_name":"colloid resuscitation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lactated-ringer-s-solution","display_name":"lactated Ringer's solution","score":0.9819999933242798},{"id":"https://openalex.org/keywords/balanced-salt-solution","display_name":"balanced salt solution","score":0.6909999847412109},{"id":"https://openalex.org/keywords/abdominal-aortic-surgery","display_name":"abdominal aortic surgery","score":0.8009999990463257},{"id":"https://openalex.org/keywords/colloid-osmotic-pressure","display_name":"colloid osmotic pressure","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pulmonary-capillary-wedge-pressure","display_name":"pulmonary capillary wedge pressure","score":0.9049999713897705},{"id":"https://openalex.org/keywords/intrapulmonary-shunt","display_name":"intrapulmonary shunt","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.8709999918937683},{"id":"https://openalex.org/keywords/fluid-balance","display_name":"fluid balance","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.5180000066757202},{"id":"https://openalex.org/keywords/sodium-balance","display_name":"sodium balance","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.87912917137146},{"id":"https://openalex.org/C104471311","wikidata":"https://www.wikidata.org/wiki/Q16670987","display_name":"Oncotic pressure","level":3,"score":0.7758874893188477},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.7717991471290588},{"id":"https://openalex.org/C146556889","wikidata":"https://www.wikidata.org/wiki/Q1414127","display_name":"Pulmonary wedge pressure","level":3,"score":0.7279554009437561},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5648400783538818},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5386260747909546},{"id":"https://openalex.org/C2113261","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Extracellular fluid","level":3,"score":0.5263391733169556},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.48583194613456726},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.48565375804901123},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.41496971249580383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.258750319480896},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.11252254247665405},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.11145392060279846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07043889164924622},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009997","descriptor_name":"Osmotic Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012462","descriptor_name":"Saline Solution, Hypertonic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049671","descriptor_name":"History, 18th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:419454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/419454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Clinical Trial"},{"id":"mag:133937641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/419454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W158320421","https://openalex.org/W175754229","https://openalex.org/W2004531596","https://openalex.org/W2015320013","https://openalex.org/W2026880513","https://openalex.org/W2033646103","https://openalex.org/W2042571585","https://openalex.org/W2059374868","https://openalex.org/W2061713049","https://openalex.org/W2068734467","https://openalex.org/W2069289355","https://openalex.org/W2074874516","https://openalex.org/W2076816553","https://openalex.org/W2077652148","https://openalex.org/W2085179994","https://openalex.org/W2089827321","https://openalex.org/W2094903692","https://openalex.org/W2139175387","https://openalex.org/W2145319376","https://openalex.org/W2162734895","https://openalex.org/W2172848054","https://openalex.org/W2288061679","https://openalex.org/W2336699363","https://openalex.org/W2397411062","https://openalex.org/W2411214828","https://openalex.org/W2413703377","https://openalex.org/W2417195751","https://openalex.org/W2417466313"],"related_works":["https://openalex.org/W2175631128","https://openalex.org/W196821807","https://openalex.org/W2017973849","https://openalex.org/W2047597702","https://openalex.org/W2117143036","https://openalex.org/W2417650597","https://openalex.org/W1991998656","https://openalex.org/W2411214828","https://openalex.org/W4294553798","https://openalex.org/W2049016660"],"abstract_inverted_index":{"The":[0,112,190],"effects":[1],"of":[2,136,155,264,304],"hemodynamic":[3,293],"resuscitation":[4,134,156],"with":[5,25,32,242,254,268],"protein-containing":[6,289],"or":[7,37,57,71,236],"balanced":[8,305],"salt":[9,306],"solution":[10],"were":[11,45,102,115,128,261],"studied":[12],"prospectively":[13],"in":[14,40,118,171,179,186,201,209,214,246,274],"29":[15],"patients":[16,245],"undergoing":[17],"abdominal":[18],"aortic":[19],"surgery.":[20],"Blood":[21],"loss":[22],"was":[23,138,157,173,184,220],"replaced":[24],"packed":[26],"red":[27],"cells":[28],"and":[29,76,95,98,107,126,144,163,183,207,257,271],"extracellular":[30],"volume":[31],"either":[33],"Ringer's":[34,41],"Lactate":[35],"(RL)":[36,143,162],"5%":[38],"albumin":[39],"lactate":[42],"(ALB).":[43,149,168],"Fluids":[44],"given":[46],"to":[47,56,70,197,284,297],"maintain":[48,285],"the":[49,65,77,91,153,180,187,247,275,282],"pulmonary":[50,251,265],"capillary":[51],"wedge":[52],"pressure":[53,87],"(PCWP)":[54],"equal":[55,69],"within":[58],"5":[59],"torr":[60],"above":[61],"preoperative":[62,74],"(PO)":[63],"levels,":[64],"cardiac":[66],"output":[67,79],"(CO)":[68],"greater":[72],"than":[73,177,205],"values,":[75],"urine":[78],"at":[80,152],"least":[81],"50":[82],"ml/hr.":[83],"Serum":[84],"colloid":[85],"osmotic":[86],"(COP),":[88],"CO,":[89],"PCWP,":[90],"gradient":[92],"between":[93,223],"COP":[94,172,286],"PCWP":[96],"(COP-PCWP),":[97],"intrapulmonary":[99],"shunt":[100],"(Qs/Qt)":[101],"measured":[103,113],"PO,":[104],"intraoperatively":[105],"(IO),":[106],"daily":[108],"for":[109,133],"3":[110],"days.":[111],"variables":[114],"similar":[116],"PO":[117],"both":[119,215],"groups.":[120,224],"Operation":[121],"time,":[122],"estimated":[123],"blood":[124],"loss,":[125],"transfusions":[127],"similar.":[129],"Total":[130],"fluids":[131],"received":[132],"(day":[135],"operation)":[137],"11.3":[139],"+/-":[140,146,159,165,195,199],"0.8":[141,160],"liters":[142,148,161,167],"6.2":[145],"0.4":[147],"Fluid":[150,225],"balance":[151],"end":[154,299],"8.4":[158],"3.4":[164],"0.5":[166],"Maximum":[169],"decrease":[170],"40%":[174],"(P":[175,203],"less":[176,204],"0.001)":[178,206],"RL":[181,202],"group":[182,249],"insignificant":[185],"ALB":[188,248],"group.":[189,277],"COP-PCWP":[191,237],"decreased":[192],"from":[193],"11":[194],"1":[196,200],"2":[198],"insignificantly":[208],"ALB.":[210],"Qs/Qt":[211],"increased":[212],"slightly":[213],"groups":[216],"following":[217],"operation":[218],"but":[219],"not":[221,239],"different":[222],"balance,":[226,231],"total":[227,232],"fluid":[228],"infused,":[229,234],"sodium":[230,233],"COP,":[235],"did":[238],"significantly":[240],"correlate":[241],"Qs/Qt.":[243],"Two":[244],"experienced":[250],"edema":[252,266],"associated":[253,267],"normal":[255,272],"COPs":[256,270],"elevated":[258],"PCWPs.":[259],"There":[260],"no":[262],"cases":[263],"low":[269],"PCWPs":[273],"crystalloid":[276],"These":[278],"data":[279],"seriously":[280],"question":[281],"necessity":[283],"by":[287],"using":[288],"solutions":[290,307],"during":[291],"acute":[292],"resuscitation.":[294],"When":[295],"titrated":[296],"physiological":[298],"points,":[300],"even":[301],"large":[302],"volumes":[303],"are":[308],"tolerated":[309],"well.":[310]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}