{"id":"https://openalex.org/W13385681","doi":null,"title":"Liganded VDR induces CYP3A4 via DR3 and ER6 VDREs: A potential mechanism for vitamin D-mediated cellular detoxification","display_name":"Liganded VDR induces CYP3A4 via DR3 and ER6 VDREs: A potential mechanism for vitamin D-mediated cellular detoxification","publication_year":2002,"publication_date":"2002-09-20","ids":{"openalex":"https://openalex.org/W13385681","mag":"13385681"},"language":"en","primary_location":{"id":"mag:13385681","doi":null,"is_oa":false,"landing_page_url":"https://pure.ulster.ac.uk/en/publications/liganded-vdr-induces-cyp3a4-via-dr3-and-er6-vdres-a-potential-mec-3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046892542","display_name":"Peter W. Jurutka","orcid":"https://orcid.org/0000-0002-4950-9161","observed_orcids":["https://orcid.org/0000-0002-4950-9161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter W. Jurutka","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4950-9161","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Paul D. Thompson","orcid":"https://orcid.org/0000-0002-0365-2149","observed_orcids":["https://orcid.org/0000-0002-0365-2149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul D. Thompson","raw_affiliation_strings":["Faculty Of Life & Health Sciences"],"raw_orcid":"https://orcid.org/0000-0002-0365-2149","affiliations":[{"raw_affiliation_string":"Faculty Of Life & Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109980267","display_name":"G. Kerr Whitfield","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Kerr Whitfield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062236737","display_name":"SM Myskowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SM Myskowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049256467","display_name":"Kristina R. Eichhorst","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KR Eichhorst","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002171304","display_name":"CE Dominguez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CE Dominguez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079344270","display_name":"Carol A. Haussler","orcid":"https://orcid.org/0000-0001-8360-3066","observed_orcids":["https://orcid.org/0000-0001-8360-3066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CA Haussler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032309888","display_name":"H\u00e4ussler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H\u00e4ussler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00197422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.6435999870300293,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.6435999870300293,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.2542000114917755,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.765999972820282},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.5120000243186951},{"id":"https://openalex.org/keywords/dr3","display_name":"DR3","score":0.503000020980835},{"id":"https://openalex.org/keywords/vitamin-d-response-element","display_name":"vitamin D response element","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cellular-detoxification","display_name":"cellular detoxification","score":0.878000020980835},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.8279550671577454},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.6518030166625977},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5642293095588684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5188797116279602},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49193310737609863},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4188719391822815},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3529822528362274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2754979133605957},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24665933847427368},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22255870699882507},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1792372763156891},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17758578062057495},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15671327710151672},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:13385681","doi":null,"is_oa":false,"landing_page_url":"https://pure.ulster.ac.uk/en/publications/liganded-vdr-induces-cyp3a4-via-dr3-and-er6-vdres-a-potential-mec-3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W998100"],"related_works":["https://openalex.org/W2114874915","https://openalex.org/W2339823238","https://openalex.org/W2102464054","https://openalex.org/W2368444379","https://openalex.org/W2153942370","https://openalex.org/W2932429544","https://openalex.org/W2039079930","https://openalex.org/W2134065514","https://openalex.org/W1748227957","https://openalex.org/W2026993208"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}