{"id":"https://openalex.org/W133692001","doi":"https://doi.org/10.1080/02724936.1992.11747584","title":"Serological tests in cerebrospinal fluid for congenital syphilis in Central Africa","display_name":"Serological tests in cerebrospinal fluid for congenital syphilis in Central Africa","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W133692001","doi":"https://doi.org/10.1080/02724936.1992.11747584","mag":"133692001","pmid":"https://pubmed.ncbi.nlm.nih.gov/1280042"},"language":"en","primary_location":{"id":"doi:10.1080/02724936.1992.11747584","doi":"https://doi.org/10.1080/02724936.1992.11747584","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02724936.1992.11747584","pdf_url":null,"source":{"id":"https://openalex.org/S102902149","display_name":"Annals of Tropical Paediatrics","issn_l":"0272-4936","issn":["0272-4936","1465-3281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Paediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014212479","display_name":"D Gendrel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dominique Gendrel","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Libreville, Gabon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Libreville, Gabon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062768531","display_name":"C M\u00e9fane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Mefane","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Libreville, Gabon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Libreville, Gabon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109011960","display_name":"Martine Nardou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martine Nardou","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Libreville, Gabon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Libreville, Gabon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111413999","display_name":"Jean-Luc Moreno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Luc Moreno","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Libreville, Gabon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Libreville, Gabon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031895526","display_name":"E. Engohan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edouard Engohan","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Libreville, Gabon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Libreville, Gabon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108429632","display_name":"Andr\u00e9 Moussavou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andre Moussavou","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Libreville, Gabon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Libreville, Gabon","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020779648","display_name":"C Nguemby-Mbina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Celestin Nguemby-Mbina","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Libreville, Gabon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Libreville, Gabon","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.01410006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"3","first_page":"273","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-syphilis","display_name":"congenital syphilis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-serology","display_name":"cerebrospinal fluid serology","score":0.9570000171661377},{"id":"https://openalex.org/keywords/treponema-pallidum","display_name":"Treponema pallidum","score":0.8050000071525574},{"id":"https://openalex.org/keywords/treponema-pallidum-hemagglutination-assay","display_name":"TPHA","score":0.9309999942779541},{"id":"https://openalex.org/keywords/vdrl-test","display_name":"VDRL test","score":0.8119999766349792},{"id":"https://openalex.org/keywords/false-positive-results","display_name":"false positives","score":0.5659999847412109},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.40299999713897705},{"id":"https://openalex.org/keywords/gabon","display_name":"Gabon","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780187896","wikidata":"https://www.wikidata.org/wiki/Q134745","display_name":"Treponema","level":4,"score":0.9401366114616394},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.9058353900909424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8560270667076111},{"id":"https://openalex.org/C2781232182","wikidata":"https://www.wikidata.org/wiki/Q5160454","display_name":"Congenital syphilis","level":4,"score":0.8255293369293213},{"id":"https://openalex.org/C2779882780","wikidata":"https://www.wikidata.org/wiki/Q1243869","display_name":"Treponematosis","level":5,"score":0.7564696073532104},{"id":"https://openalex.org/C2781319584","wikidata":"https://www.wikidata.org/wiki/Q7888578","display_name":"Neurosyphilis","level":4,"score":0.7385740280151367},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.7176478505134583},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.628379762172699},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5854508876800537},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47883203625679016},{"id":"https://openalex.org/C2908804808","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis Serodiagnosis","level":4,"score":0.4419771134853363},{"id":"https://openalex.org/C2909760446","wikidata":"https://www.wikidata.org/wiki/Q12198","display_name":"Sexually transmitted disease","level":4,"score":0.4100303053855896},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.34001272916793823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2643848657608032},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005681","descriptor_name":"Gabon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009494","descriptor_name":"Neurosyphilis","qualifier_ui":"Q000151","qualifier_name":"congenital","is_major_topic":true},{"descriptor_ui":"D009494","descriptor_name":"Neurosyphilis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013588","descriptor_name":"Syphilis Serodiagnosis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013590","descriptor_name":"Syphilis, Congenital","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016508","descriptor_name":"Fluorescent Treponemal Antibody-Absorption Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/02724936.1992.11747584","doi":"https://doi.org/10.1080/02724936.1992.11747584","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02724936.1992.11747584","pdf_url":null,"source":{"id":"https://openalex.org/S102902149","display_name":"Annals of Tropical Paediatrics","issn_l":"0272-4936","issn":["0272-4936","1465-3281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Paediatrics","raw_type":"journal-article"},{"id":"pmid:1280042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1280042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of tropical paediatrics","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W98365374","https://openalex.org/W1555753369","https://openalex.org/W1872932826","https://openalex.org/W1987932591","https://openalex.org/W2019089015","https://openalex.org/W2023524307","https://openalex.org/W2320103161","https://openalex.org/W2412372577","https://openalex.org/W4242782324","https://openalex.org/W4251690584"],"related_works":["https://openalex.org/W203856274","https://openalex.org/W24399693","https://openalex.org/W2413542090","https://openalex.org/W2355028064","https://openalex.org/W2019089015","https://openalex.org/W1984819629","https://openalex.org/W2083481857","https://openalex.org/W2103343468","https://openalex.org/W2045263459","https://openalex.org/W2384123827"],"abstract_inverted_index":{"Serological":[0],"tests":[1,66],"were":[2,44],"performed":[3],"in":[4,38,84,116,128,150,188],"the":[5,47,54,61,72,85,96,123,130,138,151,157],"cerebrospinal":[6],"fluid":[7],"(CSF)":[8],"of":[9,17,23,89,98,106,119,137,184],"13":[10,73],"children":[11,26,74,131],"with":[12,27,75,95,132,141,177],"active":[13,29,76,133],"congenital":[14,134,165],"syphilis":[15,30],"(presence":[16],"specific":[18,186],"IgM":[19,187],"FTA-ABS":[20,82,147,169],"antibodies)":[21],"and":[22,60,69,122,148,167],"seven":[24,78,139],"seropositive":[25],"no":[28],"(FTA-ABS":[31,67],"IgM-negative)":[32],"born":[33],"to":[34,163],"syphilitic":[35],"treated":[36],"mothers":[37],"Libreville,":[39],"Gabon.":[40],"Antibodies":[41],"against":[42],"treponema":[43,63],"measured":[45],"by":[46],"Venereal":[48],"Disease":[49],"Research":[50],"Laboratory":[51],"test":[52,91,113,125],"(VDRL),":[53],"Treponema":[55],"pallidum":[56],"haemagglutination":[57],"assay":[58],"(TPHA)":[59],"fluorescent":[62],"antibody":[64],"absorption":[65],"IgG":[68,83],"IgM).":[70],"Of":[71],"syphilis,":[77],"had":[79,144],"a":[80,145,181],"positive":[81,115,146],"CSF.":[86,152],"The":[87,111],"result":[88],"this":[90],"was":[92,114,126],"not":[93,160,191],"correlated":[94],"severity":[97],"clinical":[99],"features,":[100],"CSF":[101,107,189],"protein":[102],"levels":[103],"or":[104],"number":[105],"white":[108],"blood":[109],"cells.":[110],"CSF-TPHA":[112],"four":[117],"out":[118],"12":[120],"children,":[121],"CSF-VDRL":[124],"negative":[127],"all":[129],"syphilis.":[135],"One":[136],"newborns":[140],"mother-transmitted":[142],"antibodies":[143],"TPHA":[149,173],"These":[153],"data":[154],"show":[155],"that":[156,168],"VDRL":[158],"is":[159,190],"sensitive":[161],"enough":[162],"diagnose":[164],"neurosyphilis,":[166],"or,":[170],"at":[171],"least,":[172],"are":[174],"convenient,":[175],"sometimes":[176],"false-positive":[178],"results,":[179],"when":[180],"sophisticated":[182],"method":[183],"detecting":[185],"available.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}