{"id":"https://openalex.org/W1335424","doi":null,"title":"[Lercanidipine in diabetic patients with renal failure].","display_name":"[Lercanidipine in diabetic patients with renal failure].","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1335424","mag":"1335424","pmid":"https://pubmed.ncbi.nlm.nih.gov/15455493"},"language":"es","primary_location":{"id":"pmid:15455493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15455493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008123216","display_name":"Nicol\u00e1s Roberto Robles","orcid":"https://orcid.org/0000-0003-4984-6691","observed_orcids":["https://orcid.org/0000-0003-4984-6691"]},"institutions":[{"id":"https://openalex.org/I4210165837","display_name":"Hospital Universitario Infanta Cristina","ror":"https://ror.org/05txkk980","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210165837"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"N R Robles","raw_affiliation_strings":["Unidad de HTA, Hospital Infanta Cristina, Badajoz. nroblesp@meditex.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de HTA, Hospital Infanta Cristina, Badajoz. nroblesp@meditex.es","institution_ids":["https://openalex.org/I4210165837"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L Pastor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Pastor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069154648","display_name":"M. Manj\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Manj\u00f3n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075377643","display_name":"J Oc\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Oc\u00f3n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113515237","display_name":"F. G\u00f3mez Campder\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F G\u00f3mez Campder\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053823027","display_name":"J Herrera","orcid":"https://orcid.org/0009-0009-9018-6024","observed_orcids":["https://orcid.org/0009-0009-9018-6024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Herrera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109223212","display_name":"J. Villatoro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Villatoro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013247880","display_name":"Jordi Calls","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Calls","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110200843","display_name":"J. Torrijos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Torrijos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003907353","display_name":"I. Rodr\u00edguez Villareal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Rodr\u00edguez Villareal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M A Rodr\u00edguez Mart\u00ednez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Rodr\u00edguez Mart\u00ednez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M L M\u00e9ndez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L M\u00e9ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004525771","display_name":"Allen F. Morey","orcid":"https://orcid.org/0000-0003-1464-7131","observed_orcids":["https://orcid.org/0000-0003-1464-7131","https://orcid.org/0000-0001-9551-4888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Morey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103443781","display_name":"J.M. P\u00e9rez Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Mart\u00ednez Fern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108105747","display_name":"J. Marco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Marco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048416976","display_name":"Antonio Li\u00e9bana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Li\u00e9bana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022966800","display_name":"Bladimiro Rinc\u00f3n","orcid":"https://orcid.org/0000-0001-5323-0422","observed_orcids":["https://orcid.org/0000-0001-5323-0422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Rinc\u00f3n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075294036","display_name":"Fernando Tornero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Tornero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8699,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.76556504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"4","first_page":"338","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.19380000233650208,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lercanidipine","display_name":"lercanidipine","score":1.0},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.9179999828338623},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6439999938011169},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.8489999771118164},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.7350000143051147},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7429999709129333},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7310000061988831},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5329999923706055},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8009999990463257},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C2779283177","wikidata":"https://www.wikidata.org/wiki/Q410492","display_name":"Lercanidipine","level":3,"score":0.9572409987449646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8716402053833008},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7787004113197327},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6639606952667236},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.6499093770980835},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5913375020027161},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5848749279975891},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4819302558898926}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004095","descriptor_name":"Dihydropyridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004095","descriptor_name":"Dihydropyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15455493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15455493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia","raw_type":"Clinical Trial"},{"id":"mag:1335424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15455493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1979072447","https://openalex.org/W1988715948","https://openalex.org/W2001049748","https://openalex.org/W2003670762","https://openalex.org/W2016342558","https://openalex.org/W2027809962","https://openalex.org/W2029458168","https://openalex.org/W2035150563","https://openalex.org/W2043726802","https://openalex.org/W2044773944","https://openalex.org/W2064997656","https://openalex.org/W2074289623","https://openalex.org/W2075391935","https://openalex.org/W2106447874","https://openalex.org/W2109861453","https://openalex.org/W2114646524","https://openalex.org/W2125958513","https://openalex.org/W2139805666","https://openalex.org/W2147784554","https://openalex.org/W2149258163","https://openalex.org/W2153701973","https://openalex.org/W2161847205","https://openalex.org/W2297753288","https://openalex.org/W2401564367","https://openalex.org/W2408302261","https://openalex.org/W2414106381","https://openalex.org/W2469875272","https://openalex.org/W2615684303"],"related_works":["https://openalex.org/W2106403831","https://openalex.org/W1984697061","https://openalex.org/W2415560909","https://openalex.org/W2998067676","https://openalex.org/W2955037394","https://openalex.org/W2063161122","https://openalex.org/W2052281697","https://openalex.org/W2132777569","https://openalex.org/W1991896678","https://openalex.org/W4307842583"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,128,180,233,246],"safe":[4],"use":[5],"of":[6,170,175,280],"a":[7,132,257,267],"new":[8],"calcium":[9],"channel":[10],"blocker,":[11],"lercanidipine,":[12],"in":[13,261,285],"diabetic":[14,27],"chronic":[15],"renal":[16,281],"failure":[17],"(CRF)":[18],"patients.":[19,264],"DESIGN":[20],"AND":[21],"METHODS:":[22],"The":[23],"study":[24],"recruited":[25],"42":[26],"CRF":[28,95,263],"patients":[29,62,74,96,100,171],"(creatinine":[30],">":[31,37],"1.4":[32],"mg/dl":[33,39],"for":[34,40,94,120],"males,":[35],"creatinine":[36,43,215,229],"1.2":[38],"females,":[41],"or":[42,80],"clearance":[44,142,230],"<":[45],"70":[46],"ml/min).":[47],"Mean":[48],"age":[49],"was":[50,135,143,204,248,252],"68.2":[51],"+/-":[52,156,158,163,165,220,225,237,242],"9.1":[53],"years.":[54],"53.8%":[55],"were":[56,63,70,75,101,106,125,212,287],"males":[57],"and":[58,67,111,122,187,228,271],"46.2%":[59],"females.":[60],"Three":[61],"type":[64,71],"1":[65],"diabetics":[66,262],"39":[68],"ones":[69],"II.":[72],"All":[73],"receiving":[76],"ACE":[77],"inhibitors":[78],"(67.4%)":[79],"angiotensin":[81],"II":[82],"antagonist":[83],"(32.6%)":[84],"therapy":[85],"but":[86,245],"they":[87],"had":[88],"higher":[89],"blood":[90,123,176,182],"pressure":[91,183],"than":[92],"recommended":[93],"(130/85":[97],"mmHg).":[98,195],"No":[99,196,202],"under":[102],"diuretic":[103],"treatment.":[104],"Patients":[105],"clinically":[107],"evaluated":[108],"1,":[109],"3":[110],"6":[112],"months":[113],"after":[114],"starting":[115],"treatment":[116],"with":[117],"lercanidipine.":[118],"Samples":[119],"urine":[121,148],"examination":[124],"taken":[126],"during":[127],"examination.":[129],"When":[130],"needed,":[131],"third":[133],"drug":[134],"added":[136],"to":[137,161,210],"treatment,":[138],"excluding":[139],"diuretics.":[140],"Creatinine":[141],"measured":[144],"using":[145],"24":[146],"h":[147],"collection.":[149],"RESULTS:":[150],"BP":[151,191],"significantly":[152],"decrease":[153],"from":[154],"163":[155],"18/90":[157],"8":[159],"mmHg":[160],"134":[162],"12/77":[164],"9":[166],"mmHg.":[167],"One":[168],"half":[169],"showed":[172,199,256,272],"significant":[173],"reduction":[174],"pressure,":[177],"26.7%":[178],"reached":[179],"target":[181],"(<":[184,193],"130/85":[185,194],"mmHg)":[186],"20.0%":[188],"gets":[189],"optimal":[190],"control":[192],"one":[197],"patient":[198],"untoward":[200],"effects.":[201],"edema":[203],"detected":[205],"nor":[206,283],"adverse":[207],"effects":[208],"related":[209],"vasodilatation":[211],"found.":[213],"Plasmatic":[214],"did":[216],"not":[217,249],"change":[218],"(1.9":[219],"0.5":[221,226],"baseline":[222,239],"vs":[223,240],"1.8":[224],"mg/dl)":[227],"increased":[231],"at":[232],"end":[234],"visit":[235],"(40.1":[236],"14.5":[238],"45.4":[241],"18.2":[243],"ml/min)":[244],"difference":[247],"significant.":[250],"Proteinuria":[251],"unchanged.":[253],"CONCLUSIONS:":[254],"Lercanidipine":[255],"good":[258,268],"antihypertensive":[259],"effect":[260,274],"It":[265],"has":[266],"tolerability":[269],"profile":[270],"neutral":[273],"on":[275],"plasmatic":[276],"lipids.":[277],"Neither":[278],"impairment":[279],"function":[282],"increment":[284],"proteinuria":[286],"detected.":[288]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}