{"id":"https://openalex.org/W133463763","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.576","title":"The Jackson Laboratory Repository: New Mouse Models of Inflammation and Cancer/Immunology","display_name":"The Jackson Laboratory Repository: New Mouse Models of Inflammation and Cancer/Immunology","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W133463763","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.576","mag":"133463763"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.2_supplement.576","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.576","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.2_supplement.576","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085286041","display_name":"Jennifer Merriam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Merriam","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070104654","display_name":"Alicia Valenzuela","orcid":"https://orcid.org/0000-0001-6479-1583","observed_orcids":["https://orcid.org/0000-0001-6479-1583"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Valenzuela","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040297601","display_name":"Jeffrey P. Lake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Lake","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035248007","display_name":"David E. Bergstrom","orcid":"https://orcid.org/0000-0003-0352-5411","observed_orcids":["https://orcid.org/0000-0003-0352-5411"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Bergstrom","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053055285","display_name":"Bo Chang","orcid":"https://orcid.org/0000-0001-8259-7290","observed_orcids":["https://orcid.org/0000-0001-8259-7290"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Chang","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056698501","display_name":"LR Donahue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LR Donahue","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063656029","display_name":"Kevin C. Johnson","orcid":"https://orcid.org/0000-0003-0016-5158","observed_orcids":["https://orcid.org/0000-0003-0016-5158"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Johnson","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041935915","display_name":"Cat Lutz","orcid":"https://orcid.org/0009-0006-4797-5130","observed_orcids":["https://orcid.org/0009-0006-4797-5130"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Lutz","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111413933","display_name":"Stephen F. Rockwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Rockwood","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063586680","display_name":"Michael Sasner","orcid":"https://orcid.org/0000-0002-6612-6111","observed_orcids":["https://orcid.org/0000-0002-6612-6111"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Sasner","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor ME","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210115256"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S2","first_page":"576","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2168000042438507,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.8069999814033508},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9150000214576721},{"id":"https://openalex.org/keywords/immunology","display_name":"immunology","score":0.9950000047683716},{"id":"https://openalex.org/keywords/il-4-receptor-alpha","display_name":"IL-4 receptor alpha","score":0.7070000171661377},{"id":"https://openalex.org/keywords/ige-response","display_name":"IgE response","score":0.8069999814033508},{"id":"https://openalex.org/keywords/allergic-airway-inflammation","display_name":"allergic airway inflammation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stat5a","display_name":"STAT5A","score":0.765999972820282},{"id":"https://openalex.org/keywords/stat5b","display_name":"STAT5B","score":0.9950000047683716},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8949999809265137},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9229999780654907},{"id":"https://openalex.org/keywords/trp53","display_name":"Trp53","score":0.9739999771118164},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5799999833106995},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/p53-phosphorylation","display_name":"p53 phosphorylation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9089999794960022},{"id":"https://openalex.org/keywords/floxed-allele","display_name":"floxed allele","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5354324579238892},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4704427123069763},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.453911155462265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4165952205657959},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39741232991218567}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.2_supplement.576","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.576","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.2_supplement.576","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4502755923","display_name":"Special Mouse Strains Resource","funder_award_id":"P40RR016049","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5294418113","display_name":"Transgenic and Targeted Mutant Preservation","funder_award_id":"P40RR009781","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6206342989","display_name":null,"funder_award_id":"RR11083","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2276464397","https://openalex.org/W2312315792","https://openalex.org/W1580951798","https://openalex.org/W2908396229","https://openalex.org/W4231078194","https://openalex.org/W2326585029","https://openalex.org/W2886040148","https://openalex.org/W2319664277","https://openalex.org/W2258161491","https://openalex.org/W60340211"],"abstract_inverted_index":{"The":[0,138,158,171,176],"Jackson":[1,159],"Laboratory":[2,160],"Repository":[3,139,154,161],"serves":[4],"as":[5],"a":[6,41,49,54,79,89,99,103,116,133,141],"centralized":[7],"facility":[8],"to":[9,17,27,152],"import,":[10],"develop,":[11],"preserve,":[12],"and":[13,58,63,65,69,97,115,132,180],"distribute":[14],"mouse":[15,33],"models":[16,37],"the":[18,28,153,165],"scientific":[19],"community.":[20],"Approximately":[21],"300":[22],"strains":[23,34,151],"are":[24],"added":[25],"annually":[26],"largest":[29],"collection":[30],"of":[31,38,51,82,101,105,119,124,135],"characterized":[32],"available.":[35],"Mouse":[36],"inflammation":[39],"include:":[40],"spontaneous":[42],"mutation":[43,81,92],"in":[44,95],"Sharpin":[45],"(chronic":[46],"proliferative":[47],"dermatitis),":[48],"variant":[50],"Il4ra":[52],"developing":[53],"heightened":[55],"IgE":[56],"response":[57],"amplified":[59],"allergic":[60],"airway":[61],"inflammation,":[62],"Stat5a":[64],"Stat5b":[66],"signal":[67],"transducer":[68],"transcription":[70],"activator":[71],"targeted":[72,80,91],"mutations":[73,110],"(BALB/cJ":[74],"background).":[75],"Recent":[76],"additions":[77],"include":[78],"Il8rb":[83],"with":[84,107],"impaired":[85],"wound":[86],"healing/angiogenesis/tumor":[87],"growth,":[88],"Trp53":[90,106],"abolishing":[93],"apoptosis":[94],"thymocytes":[96],"causing":[98],"range":[100],"malignancies,":[102],"knock\u2010in":[104],"phosphorylation":[108],"site":[109],"which":[111],"stops":[112],"p53\u2010dependent":[113],"apoptosis,":[114],"floxed":[117],"allele":[118],"Sfpi1":[120],"(PU.1)":[121],"for":[122],"studies":[123],"T":[125],"cell":[126],"lymphoma,":[127],"acute":[128],"myelogenous":[129],"leukemia":[130],"(AML),":[131],"variety":[134],"other":[136],"cancers.":[137],"maintains":[140],"searchable":[142],"on\u2010line":[143],"resource":[144],"(":[145],"www.jaxmice.jax.org/query":[146],").":[147],"Researchers":[148],"can":[149],"submit":[150],"at":[155],"www.jax.org/grc":[156],".":[157],"is":[162],"supported":[163],"by":[164],"NCRR":[166],"(RR09781,":[167],"RR11083,":[168],"RR16049),":[169],"NIA,":[170],"Howard":[172],"Hughes":[173],"Medical":[174,178],"Institute,":[175],"Ellison":[177],"Foundation":[179],"donations":[181],"from":[182],"private":[183],"charitable":[184],"foundations.":[185]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}