{"id":"https://openalex.org/W133339042","doi":null,"title":"Time course changes in [Ca2+]i, force, and protein content in hindlimb-suspended mouse soleus muscles.","display_name":"Time course changes in [Ca2+]i, force, and protein content in hindlimb-suspended mouse soleus muscles.","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W133339042","mag":"133339042","pmid":"https://pubmed.ncbi.nlm.nih.gov/11346014"},"language":"en","primary_location":{"id":"pmid:11346014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11346014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082837550","display_name":"Christopher Paul Ingalls","orcid":"https://orcid.org/0000-0002-7303-3167","observed_orcids":["https://orcid.org/0000-0002-7303-3167"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C P Ingalls","raw_affiliation_strings":["Department of Health & Kinesiology, Texas A&M University, College Station, USA. cingalls@gsu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health & Kinesiology, Texas A&M University, College Station, USA. cingalls@gsu.edu","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047948293","display_name":"Joseph C. Wenke","orcid":"https://orcid.org/0000-0003-0624-7998","observed_orcids":["https://orcid.org/0000-0003-0624-7998"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Wenke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103607926","display_name":"R. B. Armstrong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R B Armstrong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0458,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.72412935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"72","issue":"5","first_page":"471","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.972000002861023},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.7850000262260437},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.7120000123977661},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8450000286102295},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.871999979019165},{"id":"https://openalex.org/keywords/isometric-tetanic-force","display_name":"isometric tetanic force","score":0.8889999985694885},{"id":"https://openalex.org/keywords/disuse","display_name":"disuse","score":0.41499999165534973},{"id":"https://openalex.org/keywords/skeletal-muscle-mass","display_name":"skeletal muscle mass","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.8797194957733154},{"id":"https://openalex.org/C7301908","wikidata":"https://www.wikidata.org/wiki/Q318623","display_name":"Myofibril","level":2,"score":0.7388902902603149},{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.7370988130569458},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.716934084892273},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5990760922431946},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.548397421836853},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5425700545310974},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.5321114659309387},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4974100887775421},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.4832054376602173},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4419688880443573},{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.44091635942459106},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.39662355184555054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3141307234764099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11529400944709778},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007537","descriptor_name":"Isometric Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018472","descriptor_name":"Hypogravity","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11346014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11346014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},{"id":"mag:133339042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11346014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2078216883","https://openalex.org/W2129137736","https://openalex.org/W2325270866","https://openalex.org/W1990807335","https://openalex.org/W2129898693","https://openalex.org/W1986397883","https://openalex.org/W234063023","https://openalex.org/W2091405281","https://openalex.org/W1949818415","https://openalex.org/W833356967"],"abstract_inverted_index":{"BACKGROUND:":[0],"Exposure":[1],"to":[2,25,93,105],"reduced":[3,144],"gravitational":[4],"forces":[5],"during":[6],"spaceflight":[7],"is":[8,183],"associated":[9],"with":[10,118,134,158],"significant":[11],"reductions":[12,40],"in":[13,31,41,50,96,195,201],"skeletal":[14],"muscle":[15,53,90,102,137,161,204],"mass":[16],"and":[17,44,98,109,128,139,146,170,192],"strength.":[18],"The":[19],"purpose":[20],"of":[21,56,154,189],"this":[22],"study":[23],"was":[24,91,103,121,163],"test":[26],"the":[27,84,87,99,187],"hypothesis":[28],"that":[29,178],"increases":[30],"resting":[32,179],"cytosolic":[33,180],"free":[34],"calcium":[35],"concentration":[36],"([Ca2+]i)":[37],"would":[38],"precede":[39],"protein":[42,107,141],"content":[43,108],"maximal":[45],"isometric":[46],"tetanic":[47],"force":[48],"(Po)":[49],"mouse":[51],"soleus":[52,89,101,136,160,203],"after":[54,152,186],"initiation":[55,153,188],"hindlimb":[57,67,85,155,190],"suspension.":[58,156],"METHODS:":[59],"Female":[60],"ICR":[61],"mice":[62,78],"(n":[63],"=":[64],"42)":[65],"were":[66,79,143],"suspended":[68],"for":[69],"1,":[70],"2,":[71],"3,":[72],"5,":[73],"or":[74],"7":[75,131,173],"d;":[76],"weight-matched":[77],"used":[80,92,104],"as":[81],"controls.":[82],"Following":[83],"suspension,":[86,191],"left":[88],"determine":[94,106],"Po":[95,162],"vitro":[97],"right":[100],"[Ca2+]i":[110,120,196],"via":[111],"confocal":[112],"laser":[113],"scanning":[114],"microscopy.":[115],"RESULTS:":[116],"Compared":[117,133,157],"controls,":[119,135,159],"elevated":[122],"by":[123,165],"38%":[124,171],"at":[125,130,149,167,172],"2":[126],"d,":[127,169],"117%":[129],"d.":[132,174],"total":[138],"myofibrillar":[140],"contents":[142],"27-29%":[145],"30-34%,":[147],"respectively,":[148],"5-7":[150],"d":[151],"decreased":[164],"24%":[166],"3":[168],"CONCLUSION:":[175],"It":[176],"appears":[177],"Ca2+":[181],"homeostasis":[182],"disturbed":[184],"soon":[185],"these":[193],"elevations":[194],"may":[197],"play":[198],"a":[199],"role":[200],"initiating":[202],"atrophy.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}