{"id":"https://openalex.org/W133227232","doi":"https://doi.org/10.1177/172460089901400413","title":"The Role of the Thiol N-Acetylcysteine in the Prevention of Tumor Invasion and Angiogenesis","display_name":"The Role of the Thiol N-Acetylcysteine in the Prevention of Tumor Invasion and Angiogenesis","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W133227232","doi":"https://doi.org/10.1177/172460089901400413","mag":"133227232","pmid":"https://pubmed.ncbi.nlm.nih.gov/10669958"},"language":"en","primary_location":{"id":"doi:10.1177/172460089901400413","doi":"https://doi.org/10.1177/172460089901400413","is_oa":false,"landing_page_url":"https://doi.org/10.1177/172460089901400413","pdf_url":null,"source":{"id":"https://openalex.org/S155339466","display_name":"The International Journal of Biological Markers","issn_l":"0393-6155","issn":["0393-6155","1724-6008"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biological Markers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023894341","display_name":"Monica Morini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153145","display_name":"National Cancer Institute","ror":"https://ror.org/04w2jh416","country_code":"LT","type":"healthcare","lineage":["https://openalex.org/I4210153145"]},{"id":"https://openalex.org/I4387155507","display_name":"Instituto Nacional del C\u00e1ncer","ror":"https://ror.org/02vkzd588","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4387155507"]}],"countries":["AR","LT"],"is_corresponding":false,"raw_author_name":"M. Morini","raw_affiliation_strings":["National Institute for Cancer Research, Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Cancer Research, Genova","institution_ids":["https://openalex.org/I4210153145","https://openalex.org/I4387155507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026549250","display_name":"Tania Cai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Cai","raw_affiliation_strings":["Advanced Biotechnology Center, Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Biotechnology Center, Genova","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111736439","display_name":"Maria Grazia Aluigi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.G. Aluigi","raw_affiliation_strings":["Advanced Biotechnology Center, Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Biotechnology Center, Genova","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107301111","display_name":"Douglas McClain Noonan","orcid":"https://orcid.org/0000-0001-8058-0719","observed_orcids":["https://orcid.org/0000-0001-8058-0719"]},"institutions":[{"id":"https://openalex.org/I4210153145","display_name":"National Cancer Institute","ror":"https://ror.org/04w2jh416","country_code":"LT","type":"healthcare","lineage":["https://openalex.org/I4210153145"]},{"id":"https://openalex.org/I4387155507","display_name":"Instituto Nacional del C\u00e1ncer","ror":"https://ror.org/02vkzd588","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4387155507"]}],"countries":["AR","LT"],"is_corresponding":false,"raw_author_name":"D.M. Noonan","raw_affiliation_strings":["National Institute for Cancer Research, Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Cancer Research, Genova","institution_ids":["https://openalex.org/I4210153145","https://openalex.org/I4387155507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052689901","display_name":"Luciana Masiello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153145","display_name":"National Cancer Institute","ror":"https://ror.org/04w2jh416","country_code":"LT","type":"healthcare","lineage":["https://openalex.org/I4210153145"]},{"id":"https://openalex.org/I4387155507","display_name":"Instituto Nacional del C\u00e1ncer","ror":"https://ror.org/02vkzd588","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4387155507"]}],"countries":["AR","LT"],"is_corresponding":false,"raw_author_name":"L. Masiello","raw_affiliation_strings":["National Institute for Cancer Research, Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Cancer Research, Genova","institution_ids":["https://openalex.org/I4210153145","https://openalex.org/I4387155507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108080293","display_name":"Silvio De Flora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. de Flora","raw_affiliation_strings":["Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genova, Genova - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genova, Genova - Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066866844","display_name":"Francesco D\u2019Agostini","orcid":"https://orcid.org/0000-0002-6299-6873","observed_orcids":["https://orcid.org/0000-0002-6299-6873"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. D'Agostini","raw_affiliation_strings":["Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genova, Genova - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genova, Genova - Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031245175","display_name":"Adriana Albini","orcid":"https://orcid.org/0000-0002-9624-5103","observed_orcids":["https://orcid.org/0000-0002-9624-5103"]},"institutions":[{"id":"https://openalex.org/I4210153145","display_name":"National Cancer Institute","ror":"https://ror.org/04w2jh416","country_code":"LT","type":"healthcare","lineage":["https://openalex.org/I4210153145"]},{"id":"https://openalex.org/I4387155507","display_name":"Instituto Nacional del C\u00e1ncer","ror":"https://ror.org/02vkzd588","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4387155507"]}],"countries":["AR","LT"],"is_corresponding":false,"raw_author_name":"A. Albini","raw_affiliation_strings":["National Institute for Cancer Research, Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Cancer Research, Genova","institution_ids":["https://openalex.org/I4210153145","https://openalex.org/I4387155507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112085073","display_name":"Gianfranco Fassina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153145","display_name":"National Cancer Institute","ror":"https://ror.org/04w2jh416","country_code":"LT","type":"healthcare","lineage":["https://openalex.org/I4210153145"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4387155507","display_name":"Instituto Nacional del C\u00e1ncer","ror":"https://ror.org/02vkzd588","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4387155507"]}],"countries":["AR","IT","LT"],"is_corresponding":true,"raw_author_name":"G. Fassina","raw_affiliation_strings":["Center for the Study of Cerebral Neurophysiology, National Research Council (CNR), Genova - Italy","National Institute for Cancer Research, Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Cerebral Neurophysiology, National Research Council (CNR), Genova - Italy","institution_ids":["https://openalex.org/I4210155236"]},{"raw_affiliation_string":"National Institute for Cancer Research, Genova","institution_ids":["https://openalex.org/I4210153145","https://openalex.org/I4387155507"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5112085073"],"corresponding_institution_ids":["https://openalex.org/I4210153145","https://openalex.org/I4210155236","https://openalex.org/I4387155507"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":0.8774,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.70366305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"4","first_page":"268","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":1.0},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8330000042915344},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7689999938011169},{"id":"https://openalex.org/keywords/gelatinase-inhibition","display_name":"gelatinase inhibition","score":0.6940000057220459},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.8259999752044678},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7239999771118164},{"id":"https://openalex.org/keywords/endothelial-cell-invasion","display_name":"endothelial cell invasion","score":0.7799999713897705},{"id":"https://openalex.org/keywords/type-iv-collagen-degradation","display_name":"type IV collagen degradation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.675000011920929},{"id":"https://openalex.org/keywords/synergistic-cancer-therapy","display_name":"synergistic cancer therapy","score":0.5419999957084656},{"id":"https://openalex.org/keywords/thiols","display_name":"thiols","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7701337337493896},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7252160906791687},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6609084010124207},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6414728164672852},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.6385232210159302},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5307481288909912},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.4417327344417572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4139559864997864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3887481093406677},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32419300079345703},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2880392074584961},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2682431936264038},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2427651584148407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.159550279378891},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06498405337333679},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/172460089901400413","doi":"https://doi.org/10.1177/172460089901400413","is_oa":false,"landing_page_url":"https://doi.org/10.1177/172460089901400413","pdf_url":null,"source":{"id":"https://openalex.org/S155339466","display_name":"The International Journal of Biological Markers","issn_l":"0393-6155","issn":["0393-6155","1724-6008"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biological Markers","raw_type":"journal-article"},{"id":"pmid:10669958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10669958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of biological markers","raw_type":"Journal Article"},{"id":"pmh:oai:irinsubria.uninsubria.it:11383/1489420","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11383/1489420","pdf_url":null,"source":{"id":"https://openalex.org/S4377196351","display_name":"IrInSubria (University of Insubria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I115752224","host_organization_name":"University of Insubria","host_organization_lineage":["https://openalex.org/I115752224"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unige.it:11567/389328","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/389328","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W114435776","https://openalex.org/W594861935","https://openalex.org/W1518448777","https://openalex.org/W1576813285","https://openalex.org/W1680235302","https://openalex.org/W1938617858","https://openalex.org/W1945689998","https://openalex.org/W1989185371","https://openalex.org/W1995709950","https://openalex.org/W2018665136","https://openalex.org/W2026151657","https://openalex.org/W2035068715","https://openalex.org/W2042985786","https://openalex.org/W2046998348","https://openalex.org/W2049229455","https://openalex.org/W2068545625","https://openalex.org/W2109388796"],"related_works":["https://openalex.org/W2109388796","https://openalex.org/W1585205230","https://openalex.org/W2068545625","https://openalex.org/W1554860885","https://openalex.org/W2350526524","https://openalex.org/W2395416237","https://openalex.org/W2579163146","https://openalex.org/W2129761388","https://openalex.org/W7268420","https://openalex.org/W4287832689"],"abstract_inverted_index":{"We":[0],"have":[1,89],"extensively":[2],"studied":[3],"the":[4,42,60,79,95,116,130,143,167,191,201,207],"effects":[5,128],"of":[6,28,35,44,62,76,81,97,119,134,145,150,171,188,203,210],"N-acetylcysteine":[7],"(NAC),":[8],"a":[9,67,91],"cytoprotective":[10],"drug":[11],"that":[12,181],"can":[13],"prevent":[14],"in":[15,70,94,107,160,213],"vivo":[16,214],"carcinogenesis.":[17],"Here":[18],"we":[19,88],"review":[20],"our":[21],"findings":[22],"NAC":[23,40,57,77,106,123,151,165,182,189,204],"completely":[24,141],"inhibits":[25],"gelatinolytic":[26],"activity":[27,159,209],"metalloproteases":[29],"and":[30,32,65,105,112,121,132,137,140,169,215],"chemotactic":[31],"invasive":[33,158,208],"activities":[34],"tumor":[36,71,197],"cells.":[37],"In":[38,84,110],"addition,":[39],"reduces":[41,78,156,190],"number":[43,96],"lung":[45,98,146],"metastases":[46,99],"when":[47],"malignant":[48],"murine":[49],"melanoma":[50],"cells":[51,154,212],"are":[52],"injected":[53],"into":[54],"nude":[55,108],"mice.":[56,109],"treatment":[58,101],"decreases":[59],"weight":[61,133],"primary":[63,135],"tumors":[64,136],"produces":[66],"dose-related":[68],"increase":[69],"latency.":[72],"Moreover,":[73],"oral":[74,122],"administration":[75,118,187],"formation":[80,144],"spontaneous":[82,113],"metastases.":[83,147],"experimental":[85],"metastasis":[86,114],"assays,":[87,115],"found":[90],"synergistic":[92,127],"reduction":[93],"after":[100],"with":[102],"doxorubicin":[103],"(DOX)":[104],"tumorigenicity":[111],"combined":[117],"DOX":[120],"again":[124],"has":[125],"shown":[126],"on":[129],"frequency":[131],"local":[138],"recurrences":[139],"prevented":[142],"The":[148],"addition":[149],"to":[152,162,205],"endothelial":[153,178,211],"strongly":[155],"their":[157],"response":[161,193],"angiogenic":[163,192],"stimuli.":[164],"inhibited":[166],"degradation":[168],"release":[170],"radiolabeled":[172],"type":[173],"IV":[174],"collagen":[175],"by":[176,195],"activated":[177],"cells,":[179],"indicating":[180],"blocks":[183],"gelatinase":[184],"activity.":[185],"Oral":[186],"induced":[194],"KS":[196],"cell":[198],"products,":[199],"confirming":[200],"ability":[202],"inhibit":[206],"thereby":[216],"blocking":[217],"angiogenesis.":[218]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}