{"id":"https://openalex.org/W133178757","doi":null,"title":"Fetal bone marrow CD34+CD41+ cells are enriched for multipotent hematopoietic progenitors, but not for pluripotent stem cells.","display_name":"Fetal bone marrow CD34+CD41+ cells are enriched for multipotent hematopoietic progenitors, but not for pluripotent stem cells.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W133178757","mag":"133178757","pmid":"https://pubmed.ncbi.nlm.nih.gov/8641347"},"language":"en","primary_location":{"id":"pmid:8641347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8641347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059422518","display_name":"L J Murray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L J Murray","raw_affiliation_strings":["SyStemix Inc., Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SyStemix Inc., Palo Alto, CA 94304, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047743362","display_name":"Daniza Mandich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Mandich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058425712","display_name":"Edward Bruno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Bruno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061527234","display_name":"R DiGiusto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R K DiGiusto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109033364","display_name":"W C Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W C Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111390863","display_name":"DR Sutherland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Sutherland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006372952","display_name":"Ronald Hoffman","orcid":"https://orcid.org/0000-0001-6564-6732","observed_orcids":["https://orcid.org/0000-0001-6564-6732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Hoffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048743123","display_name":"Ann S. Tsukamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Tsukamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7451,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.93441273,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"2","first_page":"236","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-bone-marrow","display_name":"fetal bone marrow","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/megakaryocyte-progenitors","display_name":"megakaryocyte progenitors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cobblestone-area-forming-cells","display_name":"cobblestone area-forming cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cfu-mk","display_name":"CFU-MK","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cfu-mix","display_name":"CFU-Mix","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cfu-gm","display_name":"CFU-GM","score":0.7160000205039978},{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/myeloid-progenitor-cells","display_name":"myeloid progenitor cells","score":0.7580000162124634},{"id":"https://openalex.org/keywords/pluripotent-stem-cells","display_name":"pluripotent stem cells","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.7546857595443726},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7302271127700806},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6504935026168823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6126412749290466},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5840314030647278},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.583534836769104},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.5626632571220398},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5318289399147034},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4693259596824646},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4502637982368469},{"id":"https://openalex.org/C131665280","wikidata":"https://www.wikidata.org/wiki/Q14866169","display_name":"Interleukin 3","level":5,"score":0.4336327016353607},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4271605610847473},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.4253726005554199},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42459559440612793},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1386047899723053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07957708835601807},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.06087842583656311},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8641347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8641347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"mag:133178757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8641347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032740980","https://openalex.org/W2299362120","https://openalex.org/W2047798668","https://openalex.org/W1988065695","https://openalex.org/W287589543","https://openalex.org/W2141939565","https://openalex.org/W2249854218","https://openalex.org/W2011715678","https://openalex.org/W2007236006","https://openalex.org/W2404702471"],"abstract_inverted_index":{"We":[0],"have":[1],"investigated":[2],"the":[3,35,43,50,78,83,127,141,145,156,183],"expression":[4],"of":[5,11,59,69,90,115,135,147],"CD41a":[6],"(gpIIbIIIa)":[7],"on":[8],"a":[9,55,65,131,148],"subpopulation":[10,80],"human":[12,105],"fetal":[13,163],"bone":[14,124],"marrow":[15,125],"(FBM)":[16],"CD34+":[17],"progenitor":[18,72,170],"cells.":[19],"Human":[20],"FBM":[21],"CD34+Lin-":[22],"cells":[23,38,73,92,138,165,171],"were":[24,47,75],"subfractionated":[25],"into":[26],"CD41a+":[27,51],"and":[28,40,64,107,173,177],"CD41a-":[29],"subpopulations":[30],"by":[31,95],"flow":[32],"cytometry.":[33],"All":[34],"megakaryocyte":[36],"colony-forming":[37,61],"(CFU-MK)":[39],"almost":[41],"all":[42],"burst-forming":[44],"units-megakaryocyte":[45],"(BFU-MK)":[46],"found":[48],"within":[49,77,155],"subpopulation.":[52,85],"In":[53],"addition,":[54],"14-fold":[56],"greater":[57,67],"number":[58,68],"granulocyte-macrophage":[60],"units":[62],"(CFU-GM)":[63],"five-fold":[66],"mixed":[70],"lineage":[71],"(CFU-mix)":[74],"observed":[76],"CD34+Lin-CD41a+":[79,91,142,164],"compared":[81],"to":[82,98],"CD34+Lin-CD41a-":[84,128,157],"The":[86],"high":[87],"proliferative":[88],"potential":[89],"was":[93],"demonstrated":[94],"their":[96],"capacity":[97],"expand":[99],"in":[100,101,122],"vitro":[102],"culture":[103],"containing":[104],"plasma":[106],"recombinant":[108],"Mpl":[109],"ligand":[110],"(thrombopoietin":[111],"[Tpo])":[112],"with":[113],"production":[114],"over":[116],"80%":[117],"CD41b+":[118],"(gpIIb+)":[119],"MKs.":[120],"However,":[121],"long-term":[123],"cultures,":[126],"population":[129,154],"contained":[130],"significantly":[132],"higher":[133],"frequency":[134],"cobblestone":[136],"area-forming":[137],"(CAFC)":[139],"than":[140],"population,":[143],"indicating":[144],"presence":[146],"primitive":[149,185],"hematopoietic":[150],"stem":[151],"cell":[152],"(HSC)":[153],"subset.":[158],"These":[159],"data":[160],"suggest":[161],"that":[162],"are":[166],"enriched":[167],"for":[168],"MK":[169],"(CFU-MK":[172],"BFU-MK),":[174],"myeloid":[175],"progenitors,":[176],"CFU-mix":[178],"but":[179],"do":[180],"not":[181],"contain":[182],"more":[184],"CAFC.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
