{"id":"https://openalex.org/W132653936","doi":null,"title":"Molecular and Cellular Characterization of Dopamine Neuron Stimulating Peptides","display_name":"Molecular and Cellular Characterization of Dopamine Neuron Stimulating Peptides","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W132653936","mag":"132653936"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:neurobio_etds-1005","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/neurobio_etds/6","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Neuroscience","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001384716","display_name":"Kristen A. Kelps","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I249887453","display_name":"Alderson Broaddus University","ror":"https://ror.org/04wkwbq27","country_code":"US","type":"education","lineage":["https://openalex.org/I249887453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristen A. Kelps","raw_affiliation_strings":["Alderson-Broaddus University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alderson-Broaddus University","institution_ids":["https://openalex.org/I249887453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001384716"],"corresponding_institution_ids":["https://openalex.org/I249887453"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.12950000166893005,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8460000157356262},{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"glial cell line-derived neurotrophic factor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/trophic-factors","display_name":"trophic factors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/peptide-stability","display_name":"peptide stability","score":0.7049999833106995},{"id":"https://openalex.org/keywords/peptide-structure","display_name":"peptide structure","score":0.5149999856948853},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6349999904632568},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5619999766349792},{"id":"https://openalex.org/keywords/anti-apoptotic-mechanisms","display_name":"anti-apoptotic mechanisms","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase","display_name":"glyceraldehyde-3-phosphate dehydrogenase","score":0.8799999952316284},{"id":"https://openalex.org/keywords/binding-partners","display_name":"binding partners","score":0.7670000195503235},{"id":"https://openalex.org/keywords/substantia-nigra-dopaminergic-neurons","display_name":"substantia nigra dopaminergic neurons","score":0.8040000200271606},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.8232656717300415},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6997032165527344},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6262013912200928},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5599920749664307},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4854333996772766},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.45529961585998535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42231523990631104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3926110863685608},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2841630280017853},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:neurobio_etds-1005","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/neurobio_etds/6","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Neuroscience","raw_type":"text"},{"id":"mag:132653936","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1005&context=neurobio_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":226,"referenced_works":["https://openalex.org/W964655","https://openalex.org/W11847823","https://openalex.org/W26790817","https://openalex.org/W47087854","https://openalex.org/W90044925","https://openalex.org/W91777371","https://openalex.org/W141636555","https://openalex.org/W199354732","https://openalex.org/W327034261","https://openalex.org/W1033087388","https://openalex.org/W1484568938","https://openalex.org/W1501353578","https://openalex.org/W1504584187","https://openalex.org/W1507318381","https://openalex.org/W1527671059","https://openalex.org/W1550876205","https://openalex.org/W1577130619","https://openalex.org/W1583740060","https://openalex.org/W1590012920","https://openalex.org/W1638542732","https://openalex.org/W1821174618","https://openalex.org/W1830728982","https://openalex.org/W1900535849","https://openalex.org/W1902058987","https://openalex.org/W1941281848","https://openalex.org/W1965986364","https://openalex.org/W1966432826","https://openalex.org/W1968547636","https://openalex.org/W1969199506","https://openalex.org/W1969270873","https://openalex.org/W1969349734","https://openalex.org/W1969479602","https://openalex.org/W1969950937","https://openalex.org/W1970416276","https://openalex.org/W1971258758","https://openalex.org/W1971389338","https://openalex.org/W1972229214","https://openalex.org/W1973174174","https://openalex.org/W1973304468","https://openalex.org/W1975637203","https://openalex.org/W1977454957","https://openalex.org/W1977567629","https://openalex.org/W1979848970","https://openalex.org/W1983265620","https://openalex.org/W1984726522","https://openalex.org/W1984800697","https://openalex.org/W1986625112","https://openalex.org/W1988111175","https://openalex.org/W1988457275","https://openalex.org/W1988791308","https://openalex.org/W1989381407","https://openalex.org/W1989386072","https://openalex.org/W1991208841","https://openalex.org/W1991231955","https://openalex.org/W1991600275","https://openalex.org/W1992181345","https://openalex.org/W1992466885","https://openalex.org/W1993605428","https://openalex.org/W1993806602","https://openalex.org/W1994452959","https://openalex.org/W1995246942","https://openalex.org/W1995262469","https://openalex.org/W1996971085","https://openalex.org/W1997597731","https://openalex.org/W1997631088","https://openalex.org/W1998885927","https://openalex.org/W1999127620","https://openalex.org/W2002358648","https://openalex.org/W2002506451","https://openalex.org/W2003861040","https://openalex.org/W2004434463","https://openalex.org/W2007881147","https://openalex.org/W2009835677","https://openalex.org/W2013331421","https://openalex.org/W2014078232","https://openalex.org/W2015167814","https://openalex.org/W2017530051","https://openalex.org/W2019021459","https://openalex.org/W2019050557","https://openalex.org/W2019695510","https://openalex.org/W2020244870","https://openalex.org/W2020390006","https://openalex.org/W2021083387","https://openalex.org/W2022034337","https://openalex.org/W2022863957","https://openalex.org/W2023285758","https://openalex.org/W2023505129","https://openalex.org/W2024880736","https://openalex.org/W2027988197","https://openalex.org/W2028093783","https://openalex.org/W2028607742","https://openalex.org/W2029107495","https://openalex.org/W2030653104","https://openalex.org/W2031031932","https://openalex.org/W2031345305","https://openalex.org/W2032554568","https://openalex.org/W2033887763","https://openalex.org/W2033985997","https://openalex.org/W2034067256","https://openalex.org/W2034110115","https://openalex.org/W2035102064","https://openalex.org/W2036834043","https://openalex.org/W2037892763","https://openalex.org/W2038471328","https://openalex.org/W2038730603","https://openalex.org/W2041676728","https://openalex.org/W2042162774","https://openalex.org/W2044632073","https://openalex.org/W2046589157","https://openalex.org/W2047725093","https://openalex.org/W2050264451","https://openalex.org/W2051575011","https://openalex.org/W2054307806","https://openalex.org/W2054561574","https://openalex.org/W2054810445","https://openalex.org/W2055874717","https://openalex.org/W2056184820","https://openalex.org/W2057329581","https://openalex.org/W2058176457","https://openalex.org/W2058674503","https://openalex.org/W2061219878","https://openalex.org/W2061415409","https://openalex.org/W2061956914","https://openalex.org/W2062729163","https://openalex.org/W2063127941","https://openalex.org/W2063553747","https://openalex.org/W2063893203","https://openalex.org/W2064698772","https://openalex.org/W2065541320","https://openalex.org/W2065978481","https://openalex.org/W2066430727","https://openalex.org/W2071288931","https://openalex.org/W2071640504","https://openalex.org/W2072754507","https://openalex.org/W2073449985","https://openalex.org/W2073986062","https://openalex.org/W2074143108","https://openalex.org/W2076606989","https://openalex.org/W2077160573","https://openalex.org/W2077260129","https://openalex.org/W2082559815","https://openalex.org/W2084420014","https://openalex.org/W2084639084","https://openalex.org/W2084664833","https://openalex.org/W2085304524","https://openalex.org/W2085452364","https://openalex.org/W2085475378","https://openalex.org/W2085975745","https://openalex.org/W2086208850","https://openalex.org/W2086480069","https://openalex.org/W2087262420","https://openalex.org/W2089081665","https://openalex.org/W2089303587","https://openalex.org/W2089953140","https://openalex.org/W2091558304","https://openalex.org/W2091930637","https://openalex.org/W2093613378","https://openalex.org/W2094061170","https://openalex.org/W2098095284","https://openalex.org/W2099317052","https://openalex.org/W2099708534","https://openalex.org/W2100300726","https://openalex.org/W2100894616","https://openalex.org/W2101615317","https://openalex.org/W2102284349","https://openalex.org/W2103899142","https://openalex.org/W2104382960","https://openalex.org/W2105631970","https://openalex.org/W2106705545","https://openalex.org/W2107155103","https://openalex.org/W2107639627","https://openalex.org/W2108724455","https://openalex.org/W2109759840","https://openalex.org/W2114355876","https://openalex.org/W2116880223","https://openalex.org/W2117065100","https://openalex.org/W2119028277","https://openalex.org/W2119306020","https://openalex.org/W2123948067","https://openalex.org/W2124906403","https://openalex.org/W2125949705","https://openalex.org/W2129248872","https://openalex.org/W2129755489","https://openalex.org/W2129991279","https://openalex.org/W2135062838","https://openalex.org/W2135189917","https://openalex.org/W2135907949","https://openalex.org/W2135970444","https://openalex.org/W2136388422","https://openalex.org/W2138182618","https://openalex.org/W2138274734","https://openalex.org/W2138404407","https://openalex.org/W2138855318","https://openalex.org/W2139369185","https://openalex.org/W2139661803","https://openalex.org/W2142460292","https://openalex.org/W2145316942","https://openalex.org/W2149917767","https://openalex.org/W2150469601","https://openalex.org/W2150857721","https://openalex.org/W2150922307","https://openalex.org/W2151349288","https://openalex.org/W2151885529","https://openalex.org/W2153406820","https://openalex.org/W2153669485","https://openalex.org/W2155008473","https://openalex.org/W2159329523","https://openalex.org/W2160484806","https://openalex.org/W2164424529","https://openalex.org/W2165394592","https://openalex.org/W2166046424","https://openalex.org/W2166988918","https://openalex.org/W2167707649","https://openalex.org/W2168894386","https://openalex.org/W2169295394","https://openalex.org/W2200415975","https://openalex.org/W2203444202","https://openalex.org/W2260407561","https://openalex.org/W2280420202","https://openalex.org/W2317804643","https://openalex.org/W2403094776","https://openalex.org/W2403356157","https://openalex.org/W2415896524","https://openalex.org/W2464050648","https://openalex.org/W2885529494","https://openalex.org/W4298127727"],"related_works":["https://openalex.org/W2073986062","https://openalex.org/W2065541320","https://openalex.org/W7095455782","https://openalex.org/W2014798765","https://openalex.org/W1609269723","https://openalex.org/W90044925","https://openalex.org/W4225405871","https://openalex.org/W144517712","https://openalex.org/W2532644436","https://openalex.org/W2040905444"],"abstract_inverted_index":{"Parkinson\u2019s":[0],"disease,":[1,7],"the":[2,11,17,21,33,36,58,67,121,124,148,174,180,194,201,273,289,299,328,373,385],"second":[3],"most":[4],"common":[5],"neurodegenerative":[6],"is":[8,382],"characterized":[9],"by":[10],"loss":[12,59],"of":[13,35,60,66,123,129,139,151,167,193,260,275,291,339],"dopaminergic":[14],"neurons":[15,61,68],"within":[16],"substantia":[18],"nigra.":[19],"Currently,":[20],"treatments":[22,28],"available":[23],"for":[24,189,212,288,295],"PD":[25,296],"are":[26,78,100,135,264],"symptomatic":[27],"that":[29,55,69,179,200,251,263,327,337,353,384],"do":[30,183],"not":[31,184,369],"stop":[32,57],"progression":[34],"disease.":[37],"Trophic":[38],"molecules,":[39],"such":[40],"as":[41,51,159,284,307],"glial":[42],"cell-line":[43],"derived":[44,136],"neurotrophic":[45,276],"factor":[46,277],"(GDNF),":[47],"have":[48,70,270],"been":[49,72],"evaluated":[50,306],"potential":[52,113,160,237,309],"therapeutic":[53,114,161],"molecules":[54,77],"could":[56,335],"and":[62,85,94,102,126,132,165,210,227,236,303,333,343,397],"potentially":[63,219],"restore":[64],"some":[65],"already":[71],"lost.":[73],"However,":[74],"these":[75,152,168,399],"trophic":[76,293],"large":[79],"making":[80],"them":[81,110,216],"difficult":[82],"to":[83,96,107,111,146,155,217,232,245,255,316,371],"produce":[84],"delivery.":[86],"Here":[87],"we":[88],"characterize":[89],"three":[90,153,181],"peptides":[91,154,169,182,202],"(DNSP-5,":[92],"DNSP-11,":[93,131],"DNSP-17)":[95],"determine":[97,156,233],"it":[98,176,367,381],"they":[99],"stable":[101,204],"offer":[103],"protective":[104],"effects":[105],"similar":[106],"GNDF":[108],"allowing":[109,188,215],"be":[112,220,243,372,402],"molecules.":[115,162],"The":[116,163],"data":[117,175],"presented":[118],"here":[119],"involves":[120],"evaluation":[122],"molecular":[125],"cellular":[127],"mechanism":[128,375],"DNSP-5,":[130],"DNSP-17,":[133],"which":[134,240],"from":[137],"prosequence":[138,278],"GDNF.":[140],"Initial":[141],"studies":[142,269],"were":[143,170,203,230],"carried":[144],"out":[145],"evaluate":[147],"physical":[149],"characteristics":[150],"their":[157],"viability":[158],"structure":[164],"stability":[166],"evaluated.":[171,404],"Based":[172,377],"on":[173,378],"was":[177,197,249,253,305,325,351],"determined":[178,199,250],"interact":[185,256],"in":[186,266,272,320,341,363,393],"vitro,":[187],"further":[190,403],"individual":[191],"evaluations":[192],"peptides.":[195],"It":[196,248,324,350],"also":[198,282],"when":[205],"stored":[206,221],"at":[207],"both":[208,218],"-80\u00b0C":[209],"37\u00b0C":[211],"one":[213],"month,":[214],"during":[222],"treatment.":[223,297],"Cell":[224],"culture":[225],"assays":[226],"proteomic":[228],"profiling":[229],"utilized":[231],"binding":[234,261,388],"partners":[235,262,389],"mechanisms":[238,396],"through":[239],"DNSP-11":[241,252,302,332,345],"may":[242,359],"able":[244,254],"mediate":[246,336],"apoptosis.":[247],"with":[257,357],"a":[258,285,308,318,361,391],"variety":[259],"involved":[265],"metabolism.":[267],"These":[268],"aided":[271],"understanding":[274],"function,":[279],"but":[280],"will":[281],"serve":[283],"starting":[286],"point":[287],"development":[290],"novel":[292],"factors":[294],"Finally,":[298],"interaction":[300,330,356],"between":[301,331],"GAPDH":[304,312,334,340,358],"anti-apoptotic":[310,348,365,395],"mechanism.":[311],"has":[313],"previously":[314],"shown":[315],"play":[317,360,390],"role":[319,338,362,392],"mediating":[321],"apoptotic":[322],"pathways.":[323],"hypothesized":[326],"observed":[329,347,352],"apoptosis":[342],"afford":[344],"its":[346,364],"effects.":[349],"while":[354],"DNSP-11\u2019s":[355,394],"effects,":[366],"does":[368],"appear":[370],"only":[374],"involved.":[376],"this":[379],"data,":[380],"likely":[383],"other":[386],"metabolic":[387],"therefore,":[398],"interactions":[400],"should":[401]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
