{"id":"https://openalex.org/W132604487","doi":null,"title":"Interferon responses in HIV infection: from protection to disease.","display_name":"Interferon responses in HIV infection: from protection to disease.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W132604487","mag":"132604487","pmid":"https://pubmed.ncbi.nlm.nih.gov/24522779"},"language":"en","primary_location":{"id":"pmid:24522779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24522779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS reviews","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044279427","display_name":"Aida Sivro","orcid":"https://orcid.org/0000-0001-9215-5285","observed_orcids":["https://orcid.org/0000-0001-9215-5285"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aida Sivro","raw_affiliation_strings":["Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020486211","display_name":"Ruey\u2010Chyi Su","orcid":"https://orcid.org/0000-0001-9477-1073","observed_orcids":["https://orcid.org/0000-0001-9477-1073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruey-Chyi Su","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004563927","display_name":"Francis Allan Plummer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis A Plummer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102929988","display_name":"Terry Blake Ball","orcid":"https://orcid.org/0000-0001-7096-804X","observed_orcids":["https://orcid.org/0000-0001-7096-804X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Blake Ball","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4519,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.7933669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"43","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.3073999881744385,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hiv-1-pathogenesis","display_name":"HIV-1 pathogenesis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8619999885559082},{"id":"https://openalex.org/keywords/acute-hiv-infection","display_name":"acute HIV infection","score":0.6909999847412109},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.5440000295639038},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chronic-immune-activation","display_name":"chronic immune activation","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.747779130935669},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7431694865226746},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.720794141292572},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5988389849662781},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5071659088134766},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.46038201451301575},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.45987409353256226},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.438610702753067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43584197759628296},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4111570715904236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4006234109401703},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3825799524784088},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.20878544449806213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.057801008224487305}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:24522779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24522779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS reviews","raw_type":"Clinical Trial"},{"id":"mag:132604487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24522779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W1604946786","https://openalex.org/W1964271390","https://openalex.org/W1972924632","https://openalex.org/W1973826424","https://openalex.org/W1974415936","https://openalex.org/W1982203309","https://openalex.org/W1982280354","https://openalex.org/W1987480613","https://openalex.org/W1988025623","https://openalex.org/W1988571161","https://openalex.org/W1988941798","https://openalex.org/W1989277325","https://openalex.org/W1994980446","https://openalex.org/W1997909759","https://openalex.org/W1999742985","https://openalex.org/W2000461732","https://openalex.org/W2000794727","https://openalex.org/W2003051762","https://openalex.org/W2005311345","https://openalex.org/W2006721694","https://openalex.org/W2006772331","https://openalex.org/W2008219975","https://openalex.org/W2013202475","https://openalex.org/W2016620404","https://openalex.org/W2028648297","https://openalex.org/W2029677746","https://openalex.org/W2031913105","https://openalex.org/W2033856426","https://openalex.org/W2035309717","https://openalex.org/W2036384587","https://openalex.org/W2040580977","https://openalex.org/W2041178635","https://openalex.org/W2041442788","https://openalex.org/W2043064608","https://openalex.org/W2043579465","https://openalex.org/W2048662192","https://openalex.org/W2050326976","https://openalex.org/W2055111778","https://openalex.org/W2058321555","https://openalex.org/W2063858805","https://openalex.org/W2066989669","https://openalex.org/W2067547048","https://openalex.org/W2068366465","https://openalex.org/W2071553665","https://openalex.org/W2071692035","https://openalex.org/W2079295092","https://openalex.org/W2080587505","https://openalex.org/W2081441708","https://openalex.org/W2082510200","https://openalex.org/W2083112247","https://openalex.org/W2084938297","https://openalex.org/W2085237060","https://openalex.org/W2086509049","https://openalex.org/W2089027304","https://openalex.org/W2089589689","https://openalex.org/W2092580120","https://openalex.org/W2096106220","https://openalex.org/W2096753387","https://openalex.org/W2098529138","https://openalex.org/W2099080968","https://openalex.org/W2099242520","https://openalex.org/W2099470418","https://openalex.org/W2104586170","https://openalex.org/W2104808073","https://openalex.org/W2112651157","https://openalex.org/W2122483069","https://openalex.org/W2124847351","https://openalex.org/W2128306333","https://openalex.org/W2131152496","https://openalex.org/W2131327798","https://openalex.org/W2133299937","https://openalex.org/W2134252835","https://openalex.org/W2134559961","https://openalex.org/W2143875917","https://openalex.org/W2146674508","https://openalex.org/W2147880249","https://openalex.org/W2149492547","https://openalex.org/W2160403318","https://openalex.org/W2163345503","https://openalex.org/W2165070219","https://openalex.org/W2167917127","https://openalex.org/W2168475631","https://openalex.org/W2170019076","https://openalex.org/W2582398023","https://openalex.org/W2616715702"],"related_works":["https://openalex.org/W2783920963","https://openalex.org/W2143440342","https://openalex.org/W2103515427","https://openalex.org/W2767139768","https://openalex.org/W2031286781","https://openalex.org/W2046810464","https://openalex.org/W2914313859","https://openalex.org/W2028362497","https://openalex.org/W2793294042","https://openalex.org/W2063927115"],"abstract_inverted_index":{"Interferons,":[0],"induced":[1],"early":[2,52],"during":[3,89],"viral":[4],"infections,":[5],"represent":[6],"important":[7],"regulators":[8],"of":[9,24,57,64,83,96,148],"both":[10],"innate":[11],"and":[12,16,32,44,79,88,106,128,134],"adaptive":[13],"immune":[14,46,66,77,109],"responses,":[15],"provide":[17],"protective":[18],"effects":[19],"against":[20],"a":[21],"wide":[22],"range":[23],"pathogens,":[25],"including":[26],"HIV.":[27],"Several":[28],"in":[29,34,50,68,121,131,142],"vitro":[30],"studies":[31],"some":[33],"vivo":[35],"data":[36],"from":[37,123],"HIV-exposed":[38],"seronegative":[39],"cohorts":[40],"indicate":[41],"that":[42,118],"interferons":[43,119],"interferon-mediated":[45],"responses":[47,85,145],"are":[48],"crucial":[49],"preventing":[51],"HIV":[53,58,90,101,104,124,132,151],"replication.":[54],"Following":[55],"establishment":[56],"infection,":[59,105,125,127],"the":[60,65,116],"uncontrolled":[61],"(aberrant)":[62],"activation":[63,78],"system,":[67],"part":[69],"regulated":[70],"by":[71],"interferon":[72,84,144],"levels,":[73],"contributes":[74],"to":[75,87,99],"HIV-1-induced":[76],"disease":[80,135],"progression.":[81,136],"Modulation":[82],"prior":[86],"infection":[91],"shows":[92],"promise":[93],"for":[94,146],"development":[95],"novel":[97,150],"therapeutics":[98],"prevent":[100],"transmission,":[102],"clear":[103],"dampen":[107],"chronic":[108],"activation.":[110],"In":[111],"this":[112],"review":[113,139],"we":[114,138],"discuss":[115],"role":[117,130],"play":[120],"protection":[122],"acute":[126],"their":[129],"pathogenesis":[133],"Lastly,":[137],"recent":[140],"advances":[141],"modulating":[143],"purposes":[147],"developing":[149],"therapeutic":[152],"approaches.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
