{"id":"https://openalex.org/W1324698","doi":null,"title":"[Case of severe hypokalemia during emergency surgery caused by long-term administration of Shakuyaku-kanzo-to].","display_name":"[Case of severe hypokalemia during emergency surgery caused by long-term administration of Shakuyaku-kanzo-to].","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W1324698","mag":"1324698","pmid":"https://pubmed.ncbi.nlm.nih.gov/21384669"},"language":"ja","primary_location":{"id":"pmid:21384669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21384669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Masui. The Japanese journal of anesthesiology","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025249477","display_name":"Tadanobu Yasuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096554","display_name":"Tsukuba Memorial Hospital","ror":"https://ror.org/010bv4c75","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096554"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadanobu Yasuda","raw_affiliation_strings":["Department of Anesthesia, Tsukuba Memorial Hospital, Tsukuba 300-2622"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Tsukuba Memorial Hospital, Tsukuba 300-2622","institution_ids":["https://openalex.org/I4210096554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010671328","display_name":"Yuji Hirasaki","orcid":"https://orcid.org/0000-0002-4453-5547","observed_orcids":["https://orcid.org/0000-0002-4453-5547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuji Hirasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066316990","display_name":"Maiko Oguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maiko Oguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110470024","display_name":"Keiichi Tajima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiichi Tajima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"60","issue":"2","first_page":"244","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/shakuyaku-kanzo-to","display_name":"Shakuyaku-kanzo-to","score":0.9290000200271606},{"id":"https://openalex.org/keywords/kampo-medicine","display_name":"Kampo medicine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glycyrrhizin","display_name":"glycyrrhizin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pseudoaldosteronism","display_name":"pseudoaldosteronism","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metabolic-alkalosis","display_name":"metabolic alkalosis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/femoral-hernia","display_name":"femoral hernia","score":0.7599999904632568},{"id":"https://openalex.org/keywords/emergency-surgery","display_name":"emergency surgery","score":0.7289999723434448},{"id":"https://openalex.org/keywords/drug-induced-electrolyte-disorder","display_name":"drug-induced electrolyte imbalance","score":0.6240000128746033},{"id":"https://openalex.org/keywords/remifentanil","display_name":"remifentanil","score":0.7509999871253967},{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C2778242168","wikidata":"https://www.wikidata.org/wiki/Q794086","display_name":"Hypokalemia","level":2,"score":0.8332558274269104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7813161015510559},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.5346616506576538},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.506105363368988},{"id":"https://openalex.org/C2779539245","wikidata":"https://www.wikidata.org/wiki/Q1428362","display_name":"Metabolic alkalosis","level":2,"score":0.48594605922698975},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.4663988947868347},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.44808048009872437},{"id":"https://openalex.org/C2776138174","wikidata":"https://www.wikidata.org/wiki/Q2378552","display_name":"Hypoaldosteronism","level":4,"score":0.4421168267726898},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4293193221092224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39651012420654297},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3481060862541199},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077208","descriptor_name":"Remifentanil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004630","descriptor_name":"Emergencies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006035","descriptor_name":"Glycyrrhiza","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006550","descriptor_name":"Hernia, Femoral","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007008","descriptor_name":"Hypokalemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007431","descriptor_name":"Intraoperative Complications","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029596","descriptor_name":"Paeonia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056929","descriptor_name":"Liddle Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21384669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21384669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Masui. The Japanese journal of anesthesiology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3161917006","https://openalex.org/W2064608985","https://openalex.org/W7097317456","https://openalex.org/W2059036362","https://openalex.org/W2314361445","https://openalex.org/W71321137","https://openalex.org/W2042026105","https://openalex.org/W2065457931","https://openalex.org/W4281641473","https://openalex.org/W7144473555"],"abstract_inverted_index":{"An":[0],"82-year-old":[1],"female":[2],"underwent":[3],"emergency":[4],"surgery":[5],"for":[6,85,124],"right":[7],"femoral":[8],"incarcerated":[9],"hernia":[10],"under":[11],"general":[12],"anesthesia.":[13],"Anesthesia":[14],"was":[15,102,158],"induced":[16,159],"and":[17,21,33,68,108],"maintained":[18],"with":[19],"remifentanil":[20],"propofol.":[22],"Her":[23],"laboratory":[24],"data":[25],"showed":[26],"severe":[27,156],"hypokalemia":[28,157],"(1.83":[29],"mEq":[30],"x":[31,39],"l(-1))":[32],"metabolic":[34],"alkalosis":[35],"(HCO3":[36],"36.9":[37],"mmol":[38],"l(-1)).":[40],"We":[41],"suspected":[42],"that":[43,155],"the":[44,60,78,128,144],"causes":[45],"of":[46,65,80,131,140,165],"such":[47],"abnormalities":[48],"were":[49,83,98,111],"due":[50],"to":[51,72,136,148],"an":[52],"endocrinological":[53,96],"abnormality,":[54],"but":[55],"we":[56,153],"could":[57],"not":[58],"ascertain":[59],"actual":[61],"cause.":[62],"Drip":[63],"infusion":[64],"sodium":[66],"chloride":[67],"saline":[69],"solution":[70],"infusion,":[71],"avoid":[73],"supplying":[74],"lactate":[75],"or":[76],"acetate,":[77],"source":[79],"bicarbonate":[81],"ions,":[82],"chosen":[84],"palliative":[86],"treatment.":[87],"No":[88],"adverse":[89],"event":[90],"occurred":[91],"during":[92],"surgery.":[93],"After":[94],"surgery,":[95],"functions":[97],"examined.":[99],"Primary":[100],"aldosteronism":[101],"ruled":[103],"out":[104],"because":[105],"serum":[106],"aldosterone":[107],"rennin":[109],"activity":[110],"within":[112],"normal":[113],"ranges.":[114],"The":[115],"patient":[116],"had":[117],"been":[118,134],"taking":[119],"a":[120,138],"Kampo":[121],"preparation,":[122],"Shakuyaku-kanzo-to,":[123,132],"two":[125],"years.":[126],"Glycyrrhizin,":[127],"main":[129],"component":[130],"has":[133],"reported":[135],"be":[137],"cause":[139],"pseudoaldosteronism":[141,161],"by":[142,160,162],"inhibiting":[143],"enzyme":[145],"converting":[146],"cortisol":[147],"cortisone.":[149],"With":[150],"these":[151],"findings":[152],"confirmed":[154],"long-term":[163],"administration":[164],"Shakuyaku-kanzo-to.":[166]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
