{"id":"https://openalex.org/W132435561","doi":null,"title":"Novel radiation targets in the endothelium and heart muscle","display_name":"Novel radiation targets in the endothelium and heart muscle","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W132435561","mag":"132435561"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:su-90429","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-90429","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-90429","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044384328","display_name":"Venkata Ramesh Yentrapalli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Venkata Ramesh Yentrapalli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044384328"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/radiation-induced-cardiovascular-disease","display_name":"radiation-induced cardiovascular disease","score":0.9480000138282776},{"id":"https://openalex.org/keywords/endothelial-senescence","display_name":"endothelial cell senescence","score":0.8759999871253967},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.8479999899864197},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.5120000243186951},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cardiac-radiation-injury","display_name":"cardiac radiation injury","score":0.6650000214576721},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.625},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5049999952316284},{"id":"https://openalex.org/keywords/cytoskeleton-organization","display_name":"cytoskeletal organization","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5724060535430908},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4932960867881775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48378655314445496},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3846997320652008},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3392995595932007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3077053129673004}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:su-90429","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-90429","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:132435561","doi":null,"is_oa":false,"landing_page_url":"http://su.diva-portal.org/smash/get/diva2:645698/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:su-90429","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-90429","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":152,"referenced_works":["https://openalex.org/W197241240","https://openalex.org/W1482050526","https://openalex.org/W1483245334","https://openalex.org/W1489408430","https://openalex.org/W1493971026","https://openalex.org/W1526615021","https://openalex.org/W1553763991","https://openalex.org/W1573467049","https://openalex.org/W1805451181","https://openalex.org/W1964113973","https://openalex.org/W1972465598","https://openalex.org/W1974597332","https://openalex.org/W1976717056","https://openalex.org/W1981049819","https://openalex.org/W1983052307","https://openalex.org/W1983673827","https://openalex.org/W1984736455","https://openalex.org/W1989335335","https://openalex.org/W1989754990","https://openalex.org/W1990423201","https://openalex.org/W1990491149","https://openalex.org/W1992028388","https://openalex.org/W1992083500","https://openalex.org/W1992718632","https://openalex.org/W1992995768","https://openalex.org/W1994328569","https://openalex.org/W1994918016","https://openalex.org/W1994965095","https://openalex.org/W1995446858","https://openalex.org/W1995800029","https://openalex.org/W1999161967","https://openalex.org/W2003197058","https://openalex.org/W2004205775","https://openalex.org/W2008771785","https://openalex.org/W2009768911","https://openalex.org/W2010381456","https://openalex.org/W2011242979","https://openalex.org/W2012154384","https://openalex.org/W2018925169","https://openalex.org/W2019963243","https://openalex.org/W2020142830","https://openalex.org/W2020595943","https://openalex.org/W2021248788","https://openalex.org/W2022437563","https://openalex.org/W2022472106","https://openalex.org/W2025338451","https://openalex.org/W2026582235","https://openalex.org/W2027469221","https://openalex.org/W2027697410","https://openalex.org/W2027974713","https://openalex.org/W2028133290","https://openalex.org/W2028672296","https://openalex.org/W2032836182","https://openalex.org/W2033896075","https://openalex.org/W2034522366","https://openalex.org/W2035167332","https://openalex.org/W2036259410","https://openalex.org/W2038140014","https://openalex.org/W2039251341","https://openalex.org/W2040711370","https://openalex.org/W2042461504","https://openalex.org/W2044939971","https://openalex.org/W2045176723","https://openalex.org/W2045264627","https://openalex.org/W2047330128","https://openalex.org/W2047644498","https://openalex.org/W2048889617","https://openalex.org/W2050920743","https://openalex.org/W2051020893","https://openalex.org/W2052067242","https://openalex.org/W2052244692","https://openalex.org/W2054772521","https://openalex.org/W2055063265","https://openalex.org/W2056889415","https://openalex.org/W2059123383","https://openalex.org/W2060720812","https://openalex.org/W2061964403","https://openalex.org/W2065470651","https://openalex.org/W2066617715","https://openalex.org/W2066666191","https://openalex.org/W2068481474","https://openalex.org/W2068510084","https://openalex.org/W2070704336","https://openalex.org/W2072579454","https://openalex.org/W2074554135","https://openalex.org/W2076698575","https://openalex.org/W2077436902","https://openalex.org/W2078184649","https://openalex.org/W2079094767","https://openalex.org/W2085498425","https://openalex.org/W2085821308","https://openalex.org/W2086483797","https://openalex.org/W2091717519","https://openalex.org/W2092006388","https://openalex.org/W2094941678","https://openalex.org/W2095070954","https://openalex.org/W2095302857","https://openalex.org/W2097785509","https://openalex.org/W2100598040","https://openalex.org/W2104867280","https://openalex.org/W2104908670","https://openalex.org/W2105924489","https://openalex.org/W2107927756","https://openalex.org/W2108106334","https://openalex.org/W2109694775","https://openalex.org/W2111450457","https://openalex.org/W2114171855","https://openalex.org/W2116009473","https://openalex.org/W2116054786","https://openalex.org/W2116437342","https://openalex.org/W2116610563","https://openalex.org/W2120233136","https://openalex.org/W2120600243","https://openalex.org/W2123447775","https://openalex.org/W2124156250","https://openalex.org/W2124435581","https://openalex.org/W2124728262","https://openalex.org/W2128635872","https://openalex.org/W2129252797","https://openalex.org/W2132158199","https://openalex.org/W2132540714","https://openalex.org/W2132673369","https://openalex.org/W2134258634","https://openalex.org/W2135825767","https://openalex.org/W2138907209","https://openalex.org/W2140886363","https://openalex.org/W2141203325","https://openalex.org/W2144626763","https://openalex.org/W2147646689","https://openalex.org/W2148782878","https://openalex.org/W2149678754","https://openalex.org/W2149831203","https://openalex.org/W2150168442","https://openalex.org/W2152877944","https://openalex.org/W2153664885","https://openalex.org/W2154375587","https://openalex.org/W2155259064","https://openalex.org/W2158217645","https://openalex.org/W2158711047","https://openalex.org/W2158802190","https://openalex.org/W2160279897","https://openalex.org/W2163664863","https://openalex.org/W2164541151","https://openalex.org/W2165737207","https://openalex.org/W2166581295","https://openalex.org/W2168778421","https://openalex.org/W2170245430","https://openalex.org/W2171979690","https://openalex.org/W2172863736","https://openalex.org/W2405338592","https://openalex.org/W2912349604","https://openalex.org/W7095856360"],"related_works":["https://openalex.org/W649684690","https://openalex.org/W2017662317","https://openalex.org/W2094996937","https://openalex.org/W7096635716","https://openalex.org/W6949250576","https://openalex.org/W2210680022","https://openalex.org/W3158849401","https://openalex.org/W2463833592","https://openalex.org/W1768019826","https://openalex.org/W7017719321"],"abstract_inverted_index":{"Worldwide,":[0],"people":[1,65],"are":[2,66,308],"being":[3],"exposed":[4,27,64,109],"to":[5,28,43,110,137,185,204,277],"natural":[6],"and":[7,97,140,157,159,215,242,262,283,292,304],"man-made":[8],"sources":[9],"of":[10,19,37,46,56,82,84,167,188,198,202,223,245,254,273,280,313],"radiation.":[11,30,163,286,317],"Epidemiological":[12],"studies":[13,105,295],"have":[14,25],"shown":[15],"an":[16,220],"increased":[17,186],"risk":[18,187],"vascular":[20],"diseases":[21],"in":[22,60,94,100,148,231,259,267,290,293,302],"populations":[23],"that":[24,72,219,271,307],"been":[26,92],"ionizing":[29,77,316],"Vascular":[31],"endothelium":[32],"is":[33,229],"implicated":[34,171],"as":[35],"one":[36],"the":[38,44,50,54,80,165,173,195,205,224,233,240,251,278,300],"targets":[39],"for":[40],"radiation":[41,78,116,203,234,237],"leading":[42],"development":[45,55],"cardiovascular":[47,58,190],"diseases.":[48],"However,":[49],"molecular":[51],"mechanisms":[52],"behind":[53],"radiation-induced":[57,189],"disease":[59],"acute":[61],"or":[62],"chronic":[63,73,177],"not":[67],"fully":[68],"elucidated.":[69],"The":[70,211],"hypothesis":[71],"low":[74,112,178],"dose":[75,113,179],"rate":[76,114],"accelerates":[79],"onset":[81],"senescence":[83,121,174,182],"primary":[85],"human":[86],"umbilical":[87],"vein":[88],"endothelial":[89,181,305],"cells":[90,118,306],"has":[91],"tested":[93],"papers":[95],"I":[96],"II":[98],"presented":[99],"this":[101],"thesis.":[102],"In":[103],"vitro":[104,291],"show":[106],"that,":[107],"when":[108],"continuous":[111],"gamma":[115],"these":[117,289],"enter":[119],"premature":[120],"much":[122],"earlier":[123],"than":[124],"non-irradiated":[125],"control":[126],"cells.":[127],"Quantitative":[128],"proteomic":[129,214],"analysis":[130,145,217],"using":[131,207],"isotope":[132],"coded":[133],"protein":[134,143],"labeling":[135],"coupled":[136],"LC-ESI-mass":[138],"spectrometry":[139],"followed":[141],"by":[142,162,250,315],"network":[144],"identified":[146],"changes":[147],"senescence-related":[149],"biological":[150],"pathways":[151,301],"including":[152],"cytoskeletal":[153],"organisation,":[154],"cell-cell":[155],"communication":[156],"adhesion,":[158],"inflammation":[160],"influenced":[161],"Moreover,":[164],"role":[166],"PI3K/Akt/mTOR":[168],"pathway":[169],"was":[170,248],"during":[172],"process.":[175],"Thus,":[176],"rated":[180],"may":[183],"contribute":[184],"disease.":[191],"Paper":[192],"III":[193],"analyse":[194],"long-term":[196],"effects":[197],"local":[199],"high":[200],"doses":[201],"heart":[206,281,303],"a":[208],"mouse":[209],"model.":[210],"results":[212],"from":[213],"bioinformatics":[216],"indicated":[218],"impaired":[221],"activity":[222],"peroxisome":[225],"proliferator-activated":[226],"receptor-alpha":[227],"(PPARA)":[228],"involved":[230,258],"mediating":[232],"response.":[235],"Ionizing":[236],"markedly":[238],"changed":[239],"phosphorylation":[241],"ubiquitination":[243],"status":[244],"PPARA.":[246],"This":[247,266],"reflected":[249],"decreased":[252],"expression":[253],"PPARA":[255],"target":[256],"genes":[257],"energy":[260],"metabolism":[261,275],"mitochondrial":[263],"respiratory":[264],"chain.":[265],"vivo":[268,294],"study":[269],"suggests":[270],"alteration":[272],"cardiac":[274],"contributes":[276],"impairment":[279],"structure":[282],"function":[284],"after":[285],"Taken":[287],"together,":[288],"provide":[296],"novel":[297],"information":[298],"on":[299],"affected":[309],"over":[310],"longer":[311],"periods":[312],"time":[314]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
