{"id":"https://openalex.org/W132379779","doi":null,"title":"Inversion of chromosome 16 and dysplastic eosinophils in accelerated phase of chronic myeloid leukemia.","display_name":"Inversion of chromosome 16 and dysplastic eosinophils in accelerated phase of chronic myeloid leukemia.","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W132379779","mag":"132379779","pmid":"https://pubmed.ncbi.nlm.nih.gov/1593903"},"language":"en","primary_location":{"id":"pmid:1593903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1593903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060587210","display_name":"H Enright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Enright","raw_affiliation_strings":["Department of Medicine, University of Minnesota, Minneapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Minnesota, Minneapolis","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111508551","display_name":"Daniel J. Weisdorf","orcid":"https://orcid.org/0000-0001-8078-8579","observed_orcids":["https://orcid.org/0000-0001-8078-8579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Weisdorf","raw_affiliation_strings":["Medicine - Hematology, Oncology, Transplant"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine - Hematology, Oncology, Transplant","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109944044","display_name":"Lo Ann C. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Peterson","raw_affiliation_strings":["Hennepin County Medical Center","VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hennepin County Medical Center","institution_ids":["https://openalex.org/I2802288015"]},{"raw_affiliation_string":"VA Medical Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031466655","display_name":"Robert E. Rydell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R E Rydell","raw_affiliation_strings":["University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055660653","display_name":"Manuel E. Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M E Kaplan","raw_affiliation_strings":["University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110480067","display_name":"Diane C. Arthur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D C Arthur","raw_affiliation_strings":["University of Minnesota Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Twin Cities","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4934,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.80062105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"6","issue":"5","first_page":"381","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosome-16-inversion","display_name":"chromosome 16 inversion","score":0.8999999761581421},{"id":"https://openalex.org/keywords/inv-16-p13q22","display_name":"inv(16)(p13q22)","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/accelerated-phase","display_name":"accelerated phase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/blast-crisis","display_name":"blast crisis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/philadelphia-chromosome","display_name":"Philadelphia chromosome","score":0.7160000205039978},{"id":"https://openalex.org/keywords/monocytoid-cells","display_name":"monocytoid cells","score":0.6679999828338623},{"id":"https://openalex.org/keywords/bone-marrow-karyotype","display_name":"bone marrow karyotype","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6449174880981445},{"id":"https://openalex.org/C2778608605","wikidata":"https://www.wikidata.org/wiki/Q4677943","display_name":"Acute myelomonocytic leukemia","level":3,"score":0.6291991472244263},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6021367311477661},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.525102972984314},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5169360041618347},{"id":"https://openalex.org/C165984737","wikidata":"https://www.wikidata.org/wiki/Q1070877","display_name":"Chromosomal inversion","level":5,"score":0.4940634071826935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4824710190296173},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4574406147003174},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4517372250556946},{"id":"https://openalex.org/C163588314","wikidata":"https://www.wikidata.org/wiki/Q742870","display_name":"Chromosome 16","level":4,"score":0.43942055106163025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35072579979896545},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3322725296020508},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3065907061100006},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14128082990646362},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002885","descriptor_name":"Chromosomes, Human, Pair 16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007446","descriptor_name":"Chromosome Inversion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010677","descriptor_name":"Philadelphia Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1593903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1593903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Case Reports"},{"id":"mag:132379779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1593903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G1373161313","display_name":"MARROW TRANSPLANTATION PROGRAM PROJECT","funder_award_id":"5p01ca021737-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2049761272","https://openalex.org/W1970535782","https://openalex.org/W2148529524","https://openalex.org/W2067348375","https://openalex.org/W2328556759","https://openalex.org/W1893640915","https://openalex.org/W2427152190","https://openalex.org/W1492135380","https://openalex.org/W2091712107","https://openalex.org/W4233162543"],"abstract_inverted_index":{"Abnormalities":[0],"of":[1,52,55,62,66,77,95,98,105,119,139],"chromosome":[2,44,56],"16,":[3],"including":[4],"inv(16)(p13q22),":[5],"del(16)(q22),":[6],"and":[7,20,69,102,108,126],"t(16;16)(p13;q22),":[8],"have":[9],"been":[10],"reported":[11],"almost":[12],"exclusively":[13],"in":[14,30,38,73,111,144],"association":[15,94],"with":[16,27,41,60,70,123],"acute":[17],"myelomonocytic":[18],"leukemia":[19,48],"are":[21],"characteristically":[22],"accompanied":[23],"by":[24],"abnormal":[25,78],"eosinophils":[26,110],"dysplastic":[28,109],"granules":[29],"the":[31,53,71,74,83,92,96,99,103,112,117],"bone":[32,75,113],"marrow.":[33],"We":[34],"observed":[35],"an":[36,136],"inv(16)(p13q22)":[37],"two":[39,90],"patients":[40,91],"typical":[42],"Philadelphia":[43],"positive":[45],"chronic":[46],"myeloid":[47],"(CML).":[49],"The":[50],"appearance":[51,72,104],"abnormality":[54,122],"16":[57,101],"was":[58],"associated":[59],"acceleration":[61],"disease":[63,142],"or":[64],"onset":[65],"blast":[67],"crisis":[68],"marrow":[76,84,114],"eosinophils.":[79],"In":[80,88],"both":[81],"cases":[82],"karyotypes":[85],"were":[86],"46,XY,t(9;22)(q34;q11)/46,XY,inv(16)(p13q22),t(9;22)(q34;q11).":[87],"these":[89],"temporal":[93],"acquisition":[97],"inversion":[100],"monocytoid":[106,125],"cells":[107],"further":[115],"supports":[116],"relationship":[118],"this":[120],"karyotypic":[121],"leukemic":[124],"eosinophilic":[127],"evolution.":[128],"This":[129],"secondary":[130],"cytogenetic":[131],"change":[132],"appears":[133],"to":[134],"be":[135],"infrequent":[137],"manifestation":[138],"specific":[140],"phenotypic":[141],"progression":[143],"CML.":[145]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
