{"id":"https://openalex.org/W132370862","doi":null,"title":"Etude de la fonction mitochondriale et de l'expression du g\u00e8ne Nogo dans le muscle squelettique dans la scl\u00e9rose lat\u00e9rale amyotrophique sporadique chez l'homme","display_name":"Etude de la fonction mitochondriale et de l'expression du g\u00e8ne Nogo dans le muscle squelettique dans la scl\u00e9rose lat\u00e9rale amyotrophique sporadique chez l'homme","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W132370862","mag":"132370862"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/794274","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/794274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/794274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041504666","display_name":"Andoni Echaniz\u2010Laguna","orcid":"https://orcid.org/0000-0003-1012-9783","observed_orcids":["https://orcid.org/0000-0003-1012-9783"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andoni Echaniz\u2010Laguna","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1012-9783","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041504666"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sporadic-als","display_name":"sporadic ALS","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8370000123977661},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nogo-a","display_name":"Nogo-A","score":0.9679999947547913},{"id":"https://openalex.org/keywords/motor-neuron-disease","display_name":"motor neuron disease","score":0.5830000042915344},{"id":"https://openalex.org/keywords/early-diagnostic-markers","display_name":"early diagnostic markers","score":0.5830000042915344},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.6069999933242798},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6688401103019714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2614881992340088}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:hdl:10068/794274","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/794274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:hdl:10068/826485","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/826485","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:EPrintsUneraTest01:1109","doi":null,"is_oa":false,"landing_page_url":"http://scd-theses.u-strasbg.fr/1109/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400486","display_name":"Serveur des th\u00e8ses de l'Universit\u00e9 de Strasbourg (University of Strasbourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I68947357","host_organization_name":"Universit\u00e9 de Strasbourg","host_organization_lineage":["https://openalex.org/I68947357"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Th\u00e8se de doctorat"},{"id":"mag:132370862","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2006STR13033","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/794274","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/794274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":137,"referenced_works":["https://openalex.org/W179329376","https://openalex.org/W1544928020","https://openalex.org/W1565043637","https://openalex.org/W1593701703","https://openalex.org/W1615913434","https://openalex.org/W1894493322","https://openalex.org/W1970616435","https://openalex.org/W1971303004","https://openalex.org/W1972760525","https://openalex.org/W1974809155","https://openalex.org/W1977984194","https://openalex.org/W1978569326","https://openalex.org/W1979889627","https://openalex.org/W1980205755","https://openalex.org/W1980477780","https://openalex.org/W1987072487","https://openalex.org/W1988931872","https://openalex.org/W1992002234","https://openalex.org/W1999655515","https://openalex.org/W1999899839","https://openalex.org/W2001221763","https://openalex.org/W2002104055","https://openalex.org/W2002346436","https://openalex.org/W2003998247","https://openalex.org/W2007753040","https://openalex.org/W2009272245","https://openalex.org/W2011575330","https://openalex.org/W2012662246","https://openalex.org/W2012851706","https://openalex.org/W2013135033","https://openalex.org/W2013451725","https://openalex.org/W2015266340","https://openalex.org/W2017222498","https://openalex.org/W2017887810","https://openalex.org/W2020074935","https://openalex.org/W2020494120","https://openalex.org/W2020914812","https://openalex.org/W2023233287","https://openalex.org/W2023260832","https://openalex.org/W2026381663","https://openalex.org/W2027884698","https://openalex.org/W2029225256","https://openalex.org/W2030834826","https://openalex.org/W2031884895","https://openalex.org/W2038697027","https://openalex.org/W2038941603","https://openalex.org/W2039042963","https://openalex.org/W2040818153","https://openalex.org/W2041838043","https://openalex.org/W2042696383","https://openalex.org/W2045037535","https://openalex.org/W2046196001","https://openalex.org/W2048213086","https://openalex.org/W2049928909","https://openalex.org/W2052238208","https://openalex.org/W2052818103","https://openalex.org/W2053272214","https://openalex.org/W2053712580","https://openalex.org/W2054200021","https://openalex.org/W2056644558","https://openalex.org/W2057269950","https://openalex.org/W2057938774","https://openalex.org/W2059369366","https://openalex.org/W2064127993","https://openalex.org/W2064640860","https://openalex.org/W2064982871","https://openalex.org/W2066075373","https://openalex.org/W2067800077","https://openalex.org/W2068111737","https://openalex.org/W2069523418","https://openalex.org/W2069891325","https://openalex.org/W2072978915","https://openalex.org/W2075066181","https://openalex.org/W2076261058","https://openalex.org/W2076511886","https://openalex.org/W2076788657","https://openalex.org/W2079103750","https://openalex.org/W2079220414","https://openalex.org/W2080858750","https://openalex.org/W2081324081","https://openalex.org/W2081394977","https://openalex.org/W2081586704","https://openalex.org/W2082055400","https://openalex.org/W2082866274","https://openalex.org/W2083147357","https://openalex.org/W2083204774","https://openalex.org/W2083910157","https://openalex.org/W2084498842","https://openalex.org/W2085181791","https://openalex.org/W2085518652","https://openalex.org/W2085880812","https://openalex.org/W2086082571","https://openalex.org/W2088009451","https://openalex.org/W2092390300","https://openalex.org/W2093252881","https://openalex.org/W2093407929","https://openalex.org/W2093477805","https://openalex.org/W2098796119","https://openalex.org/W2098817643","https://openalex.org/W2099565072","https://openalex.org/W2101228340","https://openalex.org/W2104646363","https://openalex.org/W2107621770","https://openalex.org/W2108381339","https://openalex.org/W2110284480","https://openalex.org/W2110551795","https://openalex.org/W2110961285","https://openalex.org/W2113333419","https://openalex.org/W2113542630","https://openalex.org/W2115033587","https://openalex.org/W2115659695","https://openalex.org/W2116148276","https://openalex.org/W2121726351","https://openalex.org/W2123402756","https://openalex.org/W2124618499","https://openalex.org/W2124727655","https://openalex.org/W2131284986","https://openalex.org/W2131677871","https://openalex.org/W2134927966","https://openalex.org/W2135247160","https://openalex.org/W2137511299","https://openalex.org/W2137983766","https://openalex.org/W2141373151","https://openalex.org/W2141451746","https://openalex.org/W2147421435","https://openalex.org/W2149169654","https://openalex.org/W2149497936","https://openalex.org/W2152398366","https://openalex.org/W2157665412","https://openalex.org/W2162674881","https://openalex.org/W2163289722","https://openalex.org/W2166155593","https://openalex.org/W2168208715","https://openalex.org/W2169128738","https://openalex.org/W2314689571","https://openalex.org/W2323608496","https://openalex.org/W2426390322"],"related_works":["https://openalex.org/W7043775411","https://openalex.org/W147778978","https://openalex.org/W7015120014","https://openalex.org/W413874873","https://openalex.org/W7037664370","https://openalex.org/W7143895772","https://openalex.org/W7134683644","https://openalex.org/W2098817643","https://openalex.org/W2120353998","https://openalex.org/W2059468420"],"abstract_inverted_index":{"La":[0],"scl\u00e9rose":[1],"lat\u00e9rale":[2],"amyotrophique":[3],"(SLA)":[4],"est":[5,232],"une":[6,11,19,58,72,98,200,213,246],"affection":[7,20],"mortelle":[8],"caract\u00e9ris\u00e9e":[9],"par":[10,89],"d\u00e9g\u00e9n\u00e9rescence":[12],"des":[13,69,78,85,145,284],"motoneurones.":[14],"Il":[15,34],"s":[16],"agit":[17],"habituellement":[18],"sporadique":[21],"d'\u00e9tiologie":[22],"inconnue":[23],"et":[24,114,132,151,278],"pour":[25,167],"laquelle":[26],"il":[27,95],"n'existe":[28],"pas":[29,126],"de":[30,49,101,129,135,160,177,181,191,202,204,210,224,229,238,262,272],"marqueur":[31,188],"diagnostique":[32,189],"sp\u00e9cifique.":[33],"a":[35,256],"\u00e9t\u00e9":[36],"r\u00e9cemment":[37],"sugg\u00e9r\u00e9":[38],"qu":[39,94],"un":[40,157,233,253],"dysfonctionnement":[41],"mitochondrial":[42,63],"pourrait":[43,133],"\u00eatre":[44,127],"impliqu\u00e9":[45],"dans":[46,64,105,109,153,183,206,226,264],"la":[47,50,76,82,102,110,118,130,136,143,149,192,265,270],"physiopathologie":[48],"SLA.":[51,193,247],"Dans":[52,194],"ce":[53,195],"travail,":[54,196],"nous":[55,197],"avons":[56,92,198,249],"r\u00e9alis\u00e9":[57,199],"\u00e9tude":[59,201],"temporelle":[60],"du":[61,216,276],"fonctionnement":[62],"le":[65,106,207,227,280],"muscle":[66,107,208,228],"squelettique":[67,108,209],"chez":[68],"patients":[70,211,231],"avec":[71,212,269,279],"SLA":[73,111,131,266],"en":[74],"utilisant":[75],"technique":[77],"fibres":[79,285],"perm\u00e9abilis\u00e9es":[80],"\u00e0":[81,115,142,148,252],"saponine":[83],"sur":[84],"fragments":[86],"musculaires":[87,186],"obtenus":[88],"biopsie.":[90],"Nous":[91,248],"d\u00e9montr\u00e9":[93],"existe":[96],"bien":[97],"alt\u00e9ration":[99,123],"progressive":[100],"fonction":[103],"mitochondriale":[104],"au":[112],"fur":[113],"mesure":[116],"que":[117,222,258],"maladie":[119],"progresse.":[120],"N\u00e9anmoins,":[121],"cette":[122],"ne":[124],"semble":[125],"sp\u00e9cifique":[128,159],"r\u00e9sulter":[134],"d\u00e9nervation":[137],"musculaire.La":[138],"prot\u00e9ine":[139],"Nogo":[140,165],"appartient":[141],"superfamille":[144],"prot\u00e9ines":[146],"associ\u00e9es":[147],"my\u00e9line":[150],"poss\u00e8de":[152],"sa":[154],"r\u00e9gion":[155],"c-terminale":[156],"domaine":[158],"type":[161],"r\u00e9ticulon.":[162],"Le":[163],"g\u00e8ne":[164],"code":[166],"plusieurs":[168],"isoformes,":[169],"dont":[170],"Nogo-A.":[171],"Des":[172],"observations":[173],"r\u00e9centes":[174],"ont":[175],"permis":[176],"proposer":[178],"l":[179,259,273],"utilisation":[180],"Nogo-A":[182,205,225,263],"les":[184],"biopsies":[185],"comme":[187],"pr\u00e9coce":[190],"l'expression":[203,223],"atteinte":[214],"isol\u00e9e":[215],"motoneurone":[217],"spinal.":[218],"Nos":[219],"r\u00e9sultats":[220],"sugg\u00e8rent":[221],"ces":[230],"test":[234],"pr\u00e9dictif":[235],"qui":[236,255],"permet":[237],"d\u00e9terminer":[239],"lesquels":[240],"d":[241,282],"entre":[242],"eux":[243],"vont":[244],"d\u00e9velopper":[245],"\u00e9galement":[250],"contribu\u00e9":[251],"travail":[254],"montr\u00e9":[257],"expression":[260],"musculaire":[261],"\u00e9tait":[267],"corr\u00e9l\u00e9e":[268],"s\u00e9v\u00e9rit\u00e9":[271],"\u00e9tat":[274],"clinique":[275],"patient":[277],"degr\u00e9":[281],"atrophie":[283],"musculaires.":[286]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
