{"id":"https://openalex.org/W132362670","doi":"https://doi.org/10.1016/s0165-7208(98)80051-2","title":"The HIV Tat-TAR interaction, a novel target for drug discovery","display_name":"The HIV Tat-TAR interaction, a novel target for drug discovery","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W132362670","doi":"https://doi.org/10.1016/s0165-7208(98)80051-2","mag":"132362670"},"language":"en","primary_location":{"id":"doi:10.1016/s0165-7208(98)80051-2","doi":"https://doi.org/10.1016/s0165-7208(98)80051-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-7208(98)80051-2","pdf_url":null,"source":{"id":"https://openalex.org/S118118078","display_name":"Pharmacochemistry library","issn_l":"0165-7208","issn":["0165-7208","2212-0637"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacochemistry Library","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4239899237","display_name":"Trends in Drug Research II, Proceedings of the 11th Noordwijkerhout-Camerino Symposium"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049581015","display_name":"Jonathan Karn","orcid":"https://orcid.org/0000-0002-2900-094X","observed_orcids":["https://orcid.org/0000-0002-2900-094X"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Karn","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","Medical Research Council"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"Medical Research Council","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057024955","display_name":"Nicholas Keen","orcid":"https://orcid.org/0000-0003-0741-3716","observed_orcids":["https://orcid.org/0000-0003-0741-3716"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas J. Keen","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","Medical Research Council"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"Medical Research Council","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057198168","display_name":"Mark J. Churcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark J. Churcher","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","Medical Research Council"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"Medical Research Council","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072597347","display_name":"Fareed Aboul\u2010ela","orcid":"https://orcid.org/0000-0002-0027-260X","observed_orcids":["https://orcid.org/0000-0002-0027-260X"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fareed Aboul-ela","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","Medical Research Council"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"Medical Research Council","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067888733","display_name":"Gabriele Varani","orcid":"https://orcid.org/0000-0001-6642-7144","observed_orcids":["https://orcid.org/0000-0001-6642-7144"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gabriele Varani","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","Medical Research Council"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"Medical Research Council","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109318635","display_name":"Fran\u00e7ois Hamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Hamy","raw_affiliation_strings":["Novartis, Ltd. Pharmaceuticals, Pharma Research, CH-4002 Basle, Switzerland","#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis, Ltd. Pharmaceuticals, Pharma Research, CH-4002 Basle, Switzerland","institution_ids":["https://openalex.org/I1283582996"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061258831","display_name":"Eduard Rudolf Felder","orcid":"https://orcid.org/0000-0002-1428-4222","observed_orcids":["https://orcid.org/0000-0002-1428-4222"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Eduard R. Felder","raw_affiliation_strings":["Novartis, Ltd. Pharmaceuticals, Pharma Research, CH-4002 Basle, Switzerland","#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis, Ltd. Pharmaceuticals, Pharma Research, CH-4002 Basle, Switzerland","institution_ids":["https://openalex.org/I1283582996"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088996709","display_name":"Gerhard Heizmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gerhard Heizmann","raw_affiliation_strings":["Novartis, Ltd. Pharmaceuticals, Pharma Research, CH-4002 Basle, Switzerland","#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis, Ltd. Pharmaceuticals, Pharma Research, CH-4002 Basle, Switzerland","institution_ids":["https://openalex.org/I1283582996"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052780767","display_name":"Thomas Klimkait","orcid":"https://orcid.org/0000-0003-4945-6511","observed_orcids":["https://orcid.org/0000-0003-4945-6511"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Klimkait","raw_affiliation_strings":["Novartis, Ltd. Pharmaceuticals, Pharma Research, CH-4002 Basle, Switzerland","#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis, Ltd. Pharmaceuticals, Pharma Research, CH-4002 Basle, Switzerland","institution_ids":["https://openalex.org/I1283582996"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Novartis#N##TAB##TAB##TAB#","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.078125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"121","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.24709999561309814,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.675000011920929},{"id":"https://openalex.org/keywords/tat-protein","display_name":"Tat protein","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tar-rna","display_name":"TAR RNA","score":0.9409999847412109},{"id":"https://openalex.org/keywords/drug-discovery-targets","display_name":"drug discovery targets","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7478705048561096},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.667709469795227},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.510917603969574},{"id":"https://openalex.org/C192643346","wikidata":"https://www.wikidata.org/wiki/Q283579","display_name":"tar (computing)","level":2,"score":0.47222900390625},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42465081810951233},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3794286847114563},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3707919120788574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24569958448410034},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1794707179069519},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11936154961585999},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0165-7208(98)80051-2","doi":"https://doi.org/10.1016/s0165-7208(98)80051-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-7208(98)80051-2","pdf_url":null,"source":{"id":"https://openalex.org/S118118078","display_name":"Pharmacochemistry library","issn_l":"0165-7208","issn":["0165-7208","2212-0637"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacochemistry Library","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1978229923","https://openalex.org/W1994291007","https://openalex.org/W1996827828","https://openalex.org/W2002680288","https://openalex.org/W2023660186","https://openalex.org/W2035516686","https://openalex.org/W2040800446","https://openalex.org/W2041719513","https://openalex.org/W2054266435","https://openalex.org/W2057633014","https://openalex.org/W2070171685","https://openalex.org/W2080580242","https://openalex.org/W2107634357","https://openalex.org/W2142759234"],"related_works":["https://openalex.org/W4255127142","https://openalex.org/W2163886313","https://openalex.org/W2505261914","https://openalex.org/W4299429224","https://openalex.org/W7051890332","https://openalex.org/W2068341018","https://openalex.org/W881979899","https://openalex.org/W7015098647","https://openalex.org/W1468961","https://openalex.org/W3175874424"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}