{"id":"https://openalex.org/W131930822","doi":null,"title":"Administration of Bifidobacterium animalis subsp. lactis BB-12 and xylitol with a novel pacifier in early childhood","display_name":"Administration of Bifidobacterium animalis subsp. lactis BB-12 and xylitol with a novel pacifier in early childhood","publication_year":2012,"publication_date":"2012-11-23","ids":{"openalex":"https://openalex.org/W131930822","mag":"131930822"},"language":"en","primary_location":{"id":"pmh:oai:utupub.fi:11111/27324","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27324","pdf_url":"https://www.utupub.fi/bitstreams/18be9c3d-783e-4c47-b870-9291fabac3d1/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/85065","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.utupub.fi/bitstreams/18be9c3d-783e-4c47-b870-9291fabac3d1/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020489377","display_name":"Teemu J. Taipale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"T. Taipale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5020489377"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bifidobacterium-animalis-subsp-lactis-bb-12","display_name":"Bifidobacterium animalis subsp. lactis BB-12","score":0.9990000128746033},{"id":"https://openalex.org/keywords/xylitol","display_name":"xylitol","score":0.9869999885559082},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7379999756813049},{"id":"https://openalex.org/keywords/early-childhood","display_name":"early childhood","score":0.6480000019073486},{"id":"https://openalex.org/keywords/dental-caries-prevention","display_name":"dental caries prevention","score":0.703000009059906},{"id":"https://openalex.org/keywords/mutans-streptococci","display_name":"mutans streptococci","score":0.9390000104904175},{"id":"https://openalex.org/keywords/oral-colonization","display_name":"oral colonization","score":0.8999999761581421},{"id":"https://openalex.org/keywords/respiratory-tract-infections","display_name":"respiratory infections","score":0.9169999957084656},{"id":"https://openalex.org/keywords/breastfed-infants","display_name":"breast-fed infants","score":0.8080000281333923},{"id":"https://openalex.org/keywords/sorbitol","display_name":"sorbitol","score":0.6850000023841858},{"id":"https://openalex.org/keywords/probiotic-safety","display_name":"probiotic safety","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C202712171","wikidata":"https://www.wikidata.org/wiki/Q152596","display_name":"Pacifier","level":3,"score":0.8396075963973999},{"id":"https://openalex.org/C2776031079","wikidata":"https://www.wikidata.org/wiki/Q212093","display_name":"Xylitol","level":3,"score":0.7967938184738159},{"id":"https://openalex.org/C2777945686","wikidata":"https://www.wikidata.org/wiki/Q4904767","display_name":"Bifidobacterium animalis","level":5,"score":0.7830404043197632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3998258411884308},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.36644446849823},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.35240328311920166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3432254195213318},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.18672680854797363},{"id":"https://openalex.org/C2776283161","wikidata":"https://www.wikidata.org/wiki/Q174876","display_name":"Breastfeeding","level":2,"score":0.1590404510498047},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.1100822389125824},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:utupub.fi:11111/27324","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27324","pdf_url":"https://www.utupub.fi/bitstreams/18be9c3d-783e-4c47-b870-9291fabac3d1/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/85065","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"pmh:oai:www.utupub.fi:10024/85065","doi":null,"is_oa":true,"landing_page_url":"http://www.utupub.fi/handle/10024/85065","pdf_url":"http://www.utupub.fi/handle/10024/85065","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"pmh:oai:www.doria.fi:10024/85065","doi":null,"is_oa":false,"landing_page_url":"http://www.doria.fi/handle/10024/85065","pdf_url":null,"source":{"id":"https://openalex.org/S4377196760","display_name":"Doria (University of Helsinki)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133731052","host_organization_name":"University of Helsinki","host_organization_lineage":["https://openalex.org/I133731052"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis (article-based)"},{"id":"mag:131930822","doi":null,"is_oa":false,"landing_page_url":"https://www.doria.fi/bitstream/10024/85065/1/AnnalesD1039Taipale.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utupub.fi:11111/27324","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27324","pdf_url":"https://www.utupub.fi/bitstreams/18be9c3d-783e-4c47-b870-9291fabac3d1/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/85065","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W131930822.pdf","grobid_xml":"https://content.openalex.org/works/W131930822.grobid-xml"},"referenced_works_count":149,"referenced_works":["https://openalex.org/W137862955","https://openalex.org/W157286122","https://openalex.org/W160497574","https://openalex.org/W1512051242","https://openalex.org/W1515222417","https://openalex.org/W1521289157","https://openalex.org/W1533207100","https://openalex.org/W1574595621","https://openalex.org/W1601976432","https://openalex.org/W1832474145","https://openalex.org/W1859349932","https://openalex.org/W1870514323","https://openalex.org/W1906180864","https://openalex.org/W1952368292","https://openalex.org/W1963675072","https://openalex.org/W1964280940","https://openalex.org/W1964496404","https://openalex.org/W1967665214","https://openalex.org/W1970011484","https://openalex.org/W1971627353","https://openalex.org/W1973124071","https://openalex.org/W1975413371","https://openalex.org/W1975682996","https://openalex.org/W1975701143","https://openalex.org/W1977313258","https://openalex.org/W1977460807","https://openalex.org/W1981398992","https://openalex.org/W1982235730","https://openalex.org/W1986692540","https://openalex.org/W1991413820","https://openalex.org/W1992007782","https://openalex.org/W1992813781","https://openalex.org/W1995659452","https://openalex.org/W1996711110","https://openalex.org/W1997820137","https://openalex.org/W1999322567","https://openalex.org/W2001363243","https://openalex.org/W2004715234","https://openalex.org/W2007380246","https://openalex.org/W2008533823","https://openalex.org/W2009742962","https://openalex.org/W2012740625","https://openalex.org/W2014544748","https://openalex.org/W2017342366","https://openalex.org/W2017457530","https://openalex.org/W2024340152","https://openalex.org/W2025092369","https://openalex.org/W2026452335","https://openalex.org/W2027289914","https://openalex.org/W2029450198","https://openalex.org/W2030409548","https://openalex.org/W2030445848","https://openalex.org/W2032408979","https://openalex.org/W2032541700","https://openalex.org/W2033680899","https://openalex.org/W2039742324","https://openalex.org/W2040975361","https://openalex.org/W2043767347","https://openalex.org/W2045745337","https://openalex.org/W2045878113","https://openalex.org/W2046952596","https://openalex.org/W2047703546","https://openalex.org/W2048550695","https://openalex.org/W2049968213","https://openalex.org/W2050872989","https://openalex.org/W2052397988","https://openalex.org/W2053462361","https://openalex.org/W2056114628","https://openalex.org/W2057465010","https://openalex.org/W2059282351","https://openalex.org/W2059738008","https://openalex.org/W2059875807","https://openalex.org/W2060091880","https://openalex.org/W2061105210","https://openalex.org/W2061245499","https://openalex.org/W2064029939","https://openalex.org/W2064822931","https://openalex.org/W2065442466","https://openalex.org/W2065780614","https://openalex.org/W2068057434","https://openalex.org/W2068904931","https://openalex.org/W2071460319","https://openalex.org/W2074513558","https://openalex.org/W2074844839","https://openalex.org/W2077991901","https://openalex.org/W2078541454","https://openalex.org/W2079906849","https://openalex.org/W2080223747","https://openalex.org/W2080848705","https://openalex.org/W2081627469","https://openalex.org/W2083526518","https://openalex.org/W2088347903","https://openalex.org/W2092094143","https://openalex.org/W2093051483","https://openalex.org/W2093290488","https://openalex.org/W2093301681","https://openalex.org/W2099472596","https://openalex.org/W2100119754","https://openalex.org/W2100181567","https://openalex.org/W2101219158","https://openalex.org/W2104246257","https://openalex.org/W2104771379","https://openalex.org/W2104944380","https://openalex.org/W2105315699","https://openalex.org/W2105953626","https://openalex.org/W2115910508","https://openalex.org/W2116895579","https://openalex.org/W2117677124","https://openalex.org/W2117727476","https://openalex.org/W2119610831","https://openalex.org/W2121527198","https://openalex.org/W2125804981","https://openalex.org/W2127327761","https://openalex.org/W2128019757","https://openalex.org/W2128769815","https://openalex.org/W2129001596","https://openalex.org/W2133989806","https://openalex.org/W2138253380","https://openalex.org/W2139826974","https://openalex.org/W2139962100","https://openalex.org/W2140376572","https://openalex.org/W2142111019","https://openalex.org/W2142625234","https://openalex.org/W2143137348","https://openalex.org/W2143640539","https://openalex.org/W2146388306","https://openalex.org/W2147915055","https://openalex.org/W2148316079","https://openalex.org/W2148337956","https://openalex.org/W2148719195","https://openalex.org/W2150840120","https://openalex.org/W2150955458","https://openalex.org/W2151355163","https://openalex.org/W2152882634","https://openalex.org/W2153261438","https://openalex.org/W2154246859","https://openalex.org/W2155067387","https://openalex.org/W2155350519","https://openalex.org/W2158157679","https://openalex.org/W2158590657","https://openalex.org/W2159443921","https://openalex.org/W2162912605","https://openalex.org/W2169324675","https://openalex.org/W2169914280","https://openalex.org/W2171298882","https://openalex.org/W2315826456","https://openalex.org/W2404675086","https://openalex.org/W2407425396","https://openalex.org/W2614358146"],"related_works":["https://openalex.org/W1986357938","https://openalex.org/W2079289966","https://openalex.org/W2143949352","https://openalex.org/W2081651858","https://openalex.org/W2418372654","https://openalex.org/W2040588650","https://openalex.org/W7130509133","https://openalex.org/W2588046829","https://openalex.org/W1964280940","https://openalex.org/W2994799335"],"abstract_inverted_index":{"Probiotic":[0],"bifidobacteria":[1],"are":[2,18],"used":[3,57],"in":[4,58,62,114,139,154,174,188,222,236,269],"the":[5,13,27,85,111,115,119,122,132,135,161,183,198,210,216,244,249,259],"prevention":[6],"and":[7,45,47,54,149,157],"treatment":[8],"of":[9,26,87,106,110,121,128,134,167,178,185,200,204,212,220,232,248],"childhood":[10,238],"diseases.":[11],"On":[12],"other":[14],"hand,":[15],"these":[16],"bacteria":[17],"also":[19],"connected":[20],"to":[21,31,48,76,103,243,258],"dental":[22,246],"caries.":[23,201],"The":[24,126,141,164],"purpose":[25],"present":[28],"work":[29],"was":[30,137],"test":[32],"a":[33,59,66,94,97,155,223],"food":[34,142],"supplement":[35,143],"containing":[36,145],"Bifidobacterium":[37],"animalis":[38],"subsp.":[39],"lactis":[40,43,79,147,169,193,206,234,254],"BB-12":[41,148,170,194,207,235,255],"(B.":[42],"BB-12)":[44],"xylitol,":[46,81],"investigate":[49],"its":[50],"health":[51,247],"effects,":[52],"properties":[53],"safety":[55],"when":[56],"novel":[60,123,162],"pacifier":[61,95,136],"early":[63,165,189,237],"childhood.":[64,190],"In":[65,251],"double-blind,":[67],"placebo-controlled":[68],"trial,":[69],"newborn":[70],"infants":[71],"(n=163)":[72],"were":[73,100],"assigned":[74],"randomly":[75],"receive":[77],"B.":[78,146,168,192,205,233,253],"BB-12,":[80],"or":[82,96,181],"sorbitol":[83],"from":[84,131],"age":[86],"1\u2013":[88],"2":[89,91],"monthsto":[90],"years":[92,105],"with":[93,160,226,241],"spoon.":[98],"Children":[99],"followed":[101],"up":[102],"four":[104],"age.":[107],"A":[108],"part":[109],"parents":[112],"participating":[113],"clinical":[116],"trial":[117],"evaluated":[118],"feasibility":[120],"administration":[124,166,203,231],"method.":[125],"pattern":[127],"tablet":[129,144],"release":[130],"pouch":[133],"tested":[138],"adults.":[140],"xylitol":[150],"could":[151],"be":[152],"delivered":[153],"safe":[156,240],"controlled":[158],"way":[159],"pacifier.":[163],"did":[171,195],"not":[172,196],"result":[173],"permanent":[175],"oral":[176],"colonization":[177,184],"this":[179],"probiotic":[180],"affect":[182],"mutans":[186],"streptococci":[187],"Moreover,":[191],"increase":[197],"occurrence":[199],"Controlled":[202],"significantly":[208],"reduced":[209],"incidence":[211],"respiratory":[213,262],"infections":[214,263],"during":[215],"first":[217],"eight":[218],"months":[219],"life":[221],"Finnish":[224],"population":[225],"breastfed":[227],"infants.":[228],"To":[229],"conclude,":[230],"is":[239],"regard":[242],"future":[245],"child.":[250],"addition,":[252],"may":[256],"add":[257],"protection":[260],"against":[261],"provided":[264],"by":[265],"human":[266],"breast":[267],"milk":[268],"infancy.":[270]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}