{"id":"https://openalex.org/W131233735","doi":null,"title":"Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.","display_name":"Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W131233735","mag":"131233735","pmid":"https://pubmed.ncbi.nlm.nih.gov/1551688","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384703"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384703","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027618078","display_name":"Marie Cumberbatch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Cumberbatch","raw_affiliation_strings":["ICI Central Toxicology Laboratory, Macclesfield, Cheshire, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICI Central Toxicology Laboratory, Macclesfield, Cheshire, U.K","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085384594","display_name":"Ian Kimber","orcid":"https://orcid.org/0000-0002-3538-8581","observed_orcids":["https://orcid.org/0000-0002-3538-8581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Kimber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.3992,"has_fulltext":false,"cited_by_count":324,"citation_normalized_percentile":{"value":0.98745456,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"75","issue":"2","first_page":"257","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/langerhans-cells","display_name":"Langerhans cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/dendritic-cell-migration","display_name":"dendritic cell migration","score":0.9779999852180481},{"id":"https://openalex.org/keywords/draining-lymph-nodes","display_name":"draining lymph nodes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/epidermal-cytokines","display_name":"epidermal cytokines","score":0.843999981880188},{"id":"https://openalex.org/keywords/skin-sensitization","display_name":"skin sensitization","score":0.8510000109672546},{"id":"https://openalex.org/keywords/skin-immune-response","display_name":"skin immune response","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mhc-class-ii-expression","display_name":"MHC class II expression","score":0.7289999723434448},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.6498262882232666},{"id":"https://openalex.org/C2778379841","wikidata":"https://www.wikidata.org/wiki/Q1623344","display_name":"Langerhans cell","level":3,"score":0.6106847524642944},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5926896333694458},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5801799297332764},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5550925731658936},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5285847187042236},{"id":"https://openalex.org/C2778937273","wikidata":"https://www.wikidata.org/wiki/Q10302254","display_name":"Intradermal injection","level":2,"score":0.5248056650161743},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.517166793346405},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.47010892629623413},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4498521387577057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4443587362766266},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37300556898117065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27826792001724243},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26948797702789307}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007801","descriptor_name":"Langerhans Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1384703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:1551688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1551688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/3ebeecf7-0810-4858-8ac8-f7082fa0497f","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/3ebeecf7-0810-4858-8ac8-f7082fa0497f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cumberbatch, M & Kimber, I 1992, 'Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.', Immunology, vol. 75, no. 2.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:131233735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1551688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W64588568","https://openalex.org/W86131408","https://openalex.org/W154828795","https://openalex.org/W1497052861","https://openalex.org/W1510470032","https://openalex.org/W1527531781","https://openalex.org/W1559489634","https://openalex.org/W1650036545","https://openalex.org/W1982996351","https://openalex.org/W2010350911","https://openalex.org/W2019146519","https://openalex.org/W2027238003","https://openalex.org/W2036792358","https://openalex.org/W2053719727","https://openalex.org/W2057123987","https://openalex.org/W2067024450","https://openalex.org/W2077616126","https://openalex.org/W2083726090","https://openalex.org/W2088189897","https://openalex.org/W2090321465","https://openalex.org/W2095702450","https://openalex.org/W2096152012","https://openalex.org/W2101060955","https://openalex.org/W2101186488","https://openalex.org/W2111275724","https://openalex.org/W2122462682","https://openalex.org/W2127145932","https://openalex.org/W2135272173","https://openalex.org/W2164322090","https://openalex.org/W2168539583","https://openalex.org/W2397769233","https://openalex.org/W2402323954","https://openalex.org/W2413042403","https://openalex.org/W2423421345","https://openalex.org/W2429421599"],"related_works":["https://openalex.org/W2075541573","https://openalex.org/W2419622634","https://openalex.org/W21346515","https://openalex.org/W7073567202","https://openalex.org/W2053373021","https://openalex.org/W74360995","https://openalex.org/W49481626","https://openalex.org/W7098241707","https://openalex.org/W2165653830","https://openalex.org/W2096379150"],"abstract_inverted_index":{"Previous":[0],"studies":[1,128],"have":[2,175],"shown":[3],"that":[4,46,82,135,166,258,280,292],"following":[5,73],"skin":[6,74,93],"sensitization":[7,75],"there":[8],"is":[9,94,107,133],"an":[10,97,110,239],"accumulation":[11,194,245,284],"of":[12,22,27,39,86,113,129,149,153,163,181,184,195,215,224,234,242,261,264,273],"dendritic":[13],"cells":[14,53],"(DC)":[15],"in":[16,32,126,177,197,212,238,251,285],"lymph":[17,34,198,274,287],"nodes":[18,35,72],"draining":[19,71,218,286],"the":[20,28,33,42,64,83,92,161,164,171,179,193,213,221,271],"site":[21],"exposure.":[23],"A":[24],"significant":[25],"number":[26,214],"DC":[29,66,196,216,244,283],"which":[30,67,150],"arrive":[31],"bear":[36],"high":[37],"levels":[38],"antigen,":[40],"and":[41,106,145,209,246,289],"available":[43],"evidence":[44],"indicates":[45],"they":[47,89],"are":[48,59,68,76,138,151],"derived":[49],"from":[50,91],"epidermal":[51,154,190],"Langerhans'":[52],"(LC).":[54],"Although":[55],"freshly":[56],"isolated":[57],"LC":[58,87,130,168,300],"relatively":[60],"inefficient":[61],"antigen-presenting":[62],"cells,":[63],"antigen-bearing":[65],"found":[69,204],"within":[70,217],"highly":[77],"immunostimulatory.":[78],"Recent":[79],"investigations":[80],"indicate":[81],"functional":[84],"maturation":[85],"as":[88,159],"migrate":[90],"reflected":[95],"by":[96,140,250],"enhanced":[98],"capacity":[99],"to":[100,160,205,269],"form":[101],"stable":[102],"clusters":[103],"with":[104,109,125],"lymphocytes,":[105],"associated":[108],"increased":[111],"expression":[112],"membrane":[114],"major":[115],"histocompatibility":[116],"complex":[117],"(MHC)":[118],"class":[119],"II":[120],"(Ia)":[121],"antigen.":[122],"By":[123],"analogy":[124],"vitro":[127,252],"maturation,":[131],"it":[132],"possible":[134],"such":[136],"changes":[137],"effected":[139],"granulocyte/macrophage":[141],"colony-stimulating":[142],"factor":[143],"(GM-CSF)":[144],"interleukin-1":[146],"(IL-1),":[147],"both":[148,243],"products":[152],"cells.":[155],"The":[156],"question":[157],"remains":[158],"nature":[162],"stimulus":[165,298],"initiates":[167],"migration.":[169],"In":[170],"present":[172],"study":[173],"we":[174,290],"examined":[176],"mice":[178],"effects":[180],"intradermal":[182],"injection":[183],"tumour":[185],"necrosis":[186],"factor-alpha":[187],"(TNF-alpha),":[188],"another":[189],"cytokine,":[191],"on":[192],"nodes.":[199,219],"Murine":[200],"recombinant":[201,227],"TNF-alpha":[202,236,281],"was":[203,229,257],"cause":[206],"a":[207],"concentration-":[208],"time-dependent":[210],"increase":[211],"Under":[220],"same":[222],"conditions":[223],"exposure":[225],"murine":[226],"GM-CSF":[228],"without":[230],"effect.":[231],"Heat":[232],"treatment":[233],"mouse":[235],"resulted":[237],"equivalent":[240,265],"inhibition":[241],"cytotoxic":[247],"activity":[248],"measured":[249],"bioassay.":[253],"An":[254],"interesting":[255],"observation":[256],"equal":[259],"concentrations":[260],"human":[262],"TNF-alpha,":[263],"specific":[266],"activity,":[267],"failed":[268],"influence":[270],"frequency":[272],"node":[275],"DC.":[276],"These":[277],"data":[278],"demonstrate":[279],"induces":[282],"nodes,":[288],"propose":[291],"this":[293],"cytokine":[294],"may":[295],"provide":[296],"one":[297],"for":[299],"migration":[301],"during":[302],"cutaneous":[303],"immune":[304],"responses.":[305]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}