{"id":"https://openalex.org/W131209438","doi":null,"title":"Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing","display_name":"Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing","publication_year":2014,"publication_date":"2014-02-10","ids":{"openalex":"https://openalex.org/W131209438","mag":"131209438"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/34433","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/34433","pdf_url":"http://hdl.handle.net/2077/34433","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/34433","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035093231","display_name":"Anna Thorfve","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna Thorfve","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035093231"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.29420000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.972000002861023},{"id":"https://openalex.org/keywords/wnt5a","display_name":"Wnt5a","score":0.7799999713897705},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7910000085830688},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8130000233650208},{"id":"https://openalex.org/keywords/non-canonical-wnt-signaling","display_name":"non-canonical Wnt signaling","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hydroxyapatite","display_name":"hydroxyapatite","score":0.8090000152587891},{"id":"https://openalex.org/keywords/plga","display_name":"PLGA","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.3959999978542328},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.5889999866485596},{"id":"https://openalex.org/keywords/osteoinduction","display_name":"osteoinduction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.800402045249939},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.730104386806488},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6846932172775269},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48545581102371216},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.42180579900741577},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.41366496682167053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3740079998970032},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36573296785354614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3548213541507721},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.31862592697143555},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13562637567520142}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/34433","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/34433","pdf_url":"http://hdl.handle.net/2077/34433","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:131209438","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/handle/2077/34433","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/34433","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/34433","pdf_url":"http://hdl.handle.net/2077/34433","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W131209438.pdf","grobid_xml":"https://content.openalex.org/works/W131209438.grobid-xml"},"referenced_works_count":239,"referenced_works":["https://openalex.org/W44674334","https://openalex.org/W99133475","https://openalex.org/W151869475","https://openalex.org/W152831221","https://openalex.org/W345774991","https://openalex.org/W1494249446","https://openalex.org/W1498671062","https://openalex.org/W1531447386","https://openalex.org/W1548313769","https://openalex.org/W1550510223","https://openalex.org/W1574722884","https://openalex.org/W1696199194","https://openalex.org/W1763281581","https://openalex.org/W1964059429","https://openalex.org/W1965948654","https://openalex.org/W1966824782","https://openalex.org/W1967053032","https://openalex.org/W1968742787","https://openalex.org/W1969026751","https://openalex.org/W1971085650","https://openalex.org/W1971496705","https://openalex.org/W1972343960","https://openalex.org/W1974506260","https://openalex.org/W1974751612","https://openalex.org/W1974921930","https://openalex.org/W1975124078","https://openalex.org/W1975772787","https://openalex.org/W1975975525","https://openalex.org/W1976882531","https://openalex.org/W1979120368","https://openalex.org/W1980970428","https://openalex.org/W1981020155","https://openalex.org/W1981840362","https://openalex.org/W1982589867","https://openalex.org/W1983408213","https://openalex.org/W1985170649","https://openalex.org/W1985608961","https://openalex.org/W1986208864","https://openalex.org/W1986754406","https://openalex.org/W1987504060","https://openalex.org/W1987546158","https://openalex.org/W1988036581","https://openalex.org/W1988592246","https://openalex.org/W1990985899","https://openalex.org/W1991222088","https://openalex.org/W1991950326","https://openalex.org/W1992318751","https://openalex.org/W1993456710","https://openalex.org/W1993636553","https://openalex.org/W1995358650","https://openalex.org/W1996929913","https://openalex.org/W1997689572","https://openalex.org/W1999963870","https://openalex.org/W2001812470","https://openalex.org/W2002073678","https://openalex.org/W2002725330","https://openalex.org/W2003667436","https://openalex.org/W2003852585","https://openalex.org/W2005442458","https://openalex.org/W2006107446","https://openalex.org/W2006419043","https://openalex.org/W2008274313","https://openalex.org/W2009524387","https://openalex.org/W2010517016","https://openalex.org/W2010999937","https://openalex.org/W2011038175","https://openalex.org/W2011780004","https://openalex.org/W2012293496","https://openalex.org/W2012852001","https://openalex.org/W2013064709","https://openalex.org/W2013327874","https://openalex.org/W2013462509","https://openalex.org/W2013891209","https://openalex.org/W2014680491","https://openalex.org/W2014995450","https://openalex.org/W2016692464","https://openalex.org/W2017877350","https://openalex.org/W2019582558","https://openalex.org/W2020398834","https://openalex.org/W2022981155","https://openalex.org/W2025406984","https://openalex.org/W2026870310","https://openalex.org/W2027461314","https://openalex.org/W2027600661","https://openalex.org/W2028966995","https://openalex.org/W2029179236","https://openalex.org/W2029456301","https://openalex.org/W2030181973","https://openalex.org/W2034519258","https://openalex.org/W2035376760","https://openalex.org/W2035653490","https://openalex.org/W2036647569","https://openalex.org/W2038773696","https://openalex.org/W2040155058","https://openalex.org/W2040400629","https://openalex.org/W2041840159","https://openalex.org/W2042474003","https://openalex.org/W2043162569","https://openalex.org/W2043556491","https://openalex.org/W2043678950","https://openalex.org/W2044413297","https://openalex.org/W2045012301","https://openalex.org/W2045325788","https://openalex.org/W2045823512","https://openalex.org/W2051803999","https://openalex.org/W2053288021","https://openalex.org/W2053528675","https://openalex.org/W2054141235","https://openalex.org/W2055033726","https://openalex.org/W2055559862","https://openalex.org/W2055746941","https://openalex.org/W2057581154","https://openalex.org/W2060223628","https://openalex.org/W2060580189","https://openalex.org/W2061905797","https://openalex.org/W2061981944","https://openalex.org/W2062573880","https://openalex.org/W2064366726","https://openalex.org/W2064720410","https://openalex.org/W2066883399","https://openalex.org/W2069507839","https://openalex.org/W2070364826","https://openalex.org/W2070721758","https://openalex.org/W2071426236","https://openalex.org/W2072100512","https://openalex.org/W2072319964","https://openalex.org/W2072366127","https://openalex.org/W2073985168","https://openalex.org/W2077559627","https://openalex.org/W2077648724","https://openalex.org/W2078884339","https://openalex.org/W2078925876","https://openalex.org/W2081713864","https://openalex.org/W2083571191","https://openalex.org/W2084855813","https://openalex.org/W2085813125","https://openalex.org/W2089162996","https://openalex.org/W2092026744","https://openalex.org/W2092429962","https://openalex.org/W2092654616","https://openalex.org/W2092972754","https://openalex.org/W2093738019","https://openalex.org/W2095032932","https://openalex.org/W2095930129","https://openalex.org/W2096007284","https://openalex.org/W2096884368","https://openalex.org/W2096946805","https://openalex.org/W2099069920","https://openalex.org/W2099108227","https://openalex.org/W2099421249","https://openalex.org/W2100192772","https://openalex.org/W2101699812","https://openalex.org/W2103017472","https://openalex.org/W2103385297","https://openalex.org/W2103883679","https://openalex.org/W2104899280","https://openalex.org/W2104983126","https://openalex.org/W2105565758","https://openalex.org/W2105924489","https://openalex.org/W2106843715","https://openalex.org/W2107277218","https://openalex.org/W2108403721","https://openalex.org/W2108491719","https://openalex.org/W2109050104","https://openalex.org/W2110052568","https://openalex.org/W2110760944","https://openalex.org/W2112090160","https://openalex.org/W2115644765","https://openalex.org/W2117841258","https://openalex.org/W2118097656","https://openalex.org/W2118492754","https://openalex.org/W2119413986","https://openalex.org/W2121623622","https://openalex.org/W2121741972","https://openalex.org/W2122883560","https://openalex.org/W2123106337","https://openalex.org/W2123861916","https://openalex.org/W2124504432","https://openalex.org/W2124870028","https://openalex.org/W2125858131","https://openalex.org/W2125916510","https://openalex.org/W2125964134","https://openalex.org/W2126985179","https://openalex.org/W2127487576","https://openalex.org/W2128129938","https://openalex.org/W2128419950","https://openalex.org/W2129729644","https://openalex.org/W2131147498","https://openalex.org/W2131839286","https://openalex.org/W2132411378","https://openalex.org/W2132884161","https://openalex.org/W2133032095","https://openalex.org/W2133465414","https://openalex.org/W2133514604","https://openalex.org/W2133821161","https://openalex.org/W2135084900","https://openalex.org/W2135122709","https://openalex.org/W2135129121","https://openalex.org/W2135671879","https://openalex.org/W2136499741","https://openalex.org/W2139133092","https://openalex.org/W2139457077","https://openalex.org/W2139710747","https://openalex.org/W2141643479","https://openalex.org/W2142820105","https://openalex.org/W2144438594","https://openalex.org/W2144796426","https://openalex.org/W2145650199","https://openalex.org/W2145684243","https://openalex.org/W2146978818","https://openalex.org/W2147323639","https://openalex.org/W2147760020","https://openalex.org/W2150774373","https://openalex.org/W2152217106","https://openalex.org/W2152368417","https://openalex.org/W2152959321","https://openalex.org/W2154305744","https://openalex.org/W2155777036","https://openalex.org/W2155787208","https://openalex.org/W2158217645","https://openalex.org/W2158545941","https://openalex.org/W2159374159","https://openalex.org/W2159999899","https://openalex.org/W2160741817","https://openalex.org/W2161253076","https://openalex.org/W2161915238","https://openalex.org/W2162445773","https://openalex.org/W2163617266","https://openalex.org/W2164095252","https://openalex.org/W2164155071","https://openalex.org/W2166428507","https://openalex.org/W2168420558","https://openalex.org/W2169061872","https://openalex.org/W2169967945","https://openalex.org/W2170984819","https://openalex.org/W2170989872","https://openalex.org/W2188194996","https://openalex.org/W3009051599","https://openalex.org/W7095788404"],"related_works":["https://openalex.org/W2221099420","https://openalex.org/W1672213021","https://openalex.org/W3151447615","https://openalex.org/W3035677815","https://openalex.org/W4379876057","https://openalex.org/W2043985298","https://openalex.org/W1973442759","https://openalex.org/W2382746519","https://openalex.org/W2130929624","https://openalex.org/W2192641655"],"abstract_inverted_index":{"The":[0,51,155,211],"Wnt":[1,38,88,109,132,144,160,173,179,209,213,227,250,292],"signaling":[2,39,110,161,174,293],"pathway":[3,145,214],"plays":[4],"a":[5,120,126,169,233,269],"central":[6],"role":[7],"in":[8,21,72,76,91,105,165,191,294],"bone":[9,150],"and":[10,25,95,103,146,175,194,207,266,297],"cartilage":[11,77,94,201],"embryonic":[12],"development,":[13],"processes":[14],"that":[15,67,158,186,195,239],"are":[16],"recapitulated":[17],"during":[18],"regeneration.":[19],"Imbalance":[20],"such":[22],"well":[23],"conserved":[24],"complex":[26],"system":[27],"often":[28],"contributes":[29],"to":[30,59,69,184,260,279],"numerous":[31],"diseases,":[32],"whereas":[33],"controlled":[34,241],"modulation":[35,117],"of":[36,54,63,87,98,108,129,222,230,243,274,291],"the":[37,55,61,64,83,96,99,106,130,143,149,153,159,196,220,226,240,248,254,288],"activity":[40],"is":[41],"an":[42,176],"attractive":[43],"target":[44],"e.g.":[45],"for":[46,115,271],"improved":[47],"fracture":[48,280],"healing":[49],"therapies.":[50,118],"first":[52],"aim":[53],"present":[56,255],"thesis":[57,283],"was":[58,188,215],"increase":[60],"knowledge":[62],"underlying":[65],"mechanisms":[66,114],"lead":[68],"cellular":[70],"alterations":[71],"osteoarthritis":[73],"(OA),":[74],"resulting":[75],"degeneration.":[78],"In":[79,252],"particular,":[80],"we":[81,123],"investigated":[82],"genome-wide":[84],"expression":[85,236],"profile":[86],"related":[89],"markers":[90],"human":[92],"OA":[93,116,166,264],"effect":[97],"pro-inflammatory":[100,197],"cytokines":[101],"IL-1\u03b2":[102],"IL-6":[104,199],"context":[107],"pathway,":[111],"thereby":[112],"revealing":[113],"As":[119],"second":[121],"aim,":[122],"studied":[124],"if":[125],"local":[127],"release":[128,242],"canonical":[131,172,208,212,249],"activator":[133],"Li+":[134,244,275],"from":[135,245],"hydroxyapatite":[136],"(HA)":[137],"or":[138],"poly(lactic-co-glycolic":[139],"acid)":[140],"(PLGA)":[141],"modulated":[142],"subsequently":[147],"enhanced":[148],"regeneration":[151],"around":[152],"implants.":[154],"results":[156],"indicated":[157],"pathways":[162],"were":[163,182],"dysregulated":[164],"cartilage,":[167,193],"with":[168],"partly":[170],"inhibited":[171],"active":[177],"non-canonical":[178],"cascade.":[180],"We":[181],"able":[183],"demonstrate":[185],"WNT5A":[187],"excessively":[189],"expressed":[190],"degenerative":[192],"cytokine":[198],"possessed":[200],"protective":[202],"properties":[203],"by":[204,217],"reducing":[205],"\u03b2-catenin":[206],"signaling.":[210,251],"activated":[216,247],"HA":[218,223],"but":[219],"osteoinductivity":[221],"itself":[224],"overridden":[225],"modulating":[228],"capacity":[229],"Li+.":[231],"Finally,":[232],"global":[234],"gene":[235,262],"profiling":[237],"demonstrated":[238],"PLGA":[246],"conclusion,":[253],"findings":[256],"may":[257],"be":[258],"used":[259],"develop":[261],"targeted":[263],"treatments":[265],"serve":[267],"as":[268],"basis":[270],"further":[272,285],"improvement":[273],"based":[276],"therapies":[277],"associated":[278],"repair.":[281],"This":[282],"sheds":[284],"light":[286],"on":[287],"ambiguous":[289],"influence":[290],"osteochondral":[295],"homeostasis":[296],"repair":[298],"mechanisms.":[299]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}