{"id":"https://openalex.org/W131087644","doi":null,"title":"Implications for multiple sclerosis in the era of the Affordable Care Act: an evolving treatment paradigm.","display_name":"Implications for multiple sclerosis in the era of the Affordable Care Act: an evolving treatment paradigm.","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W131087644","mag":"131087644","pmid":"https://pubmed.ncbi.nlm.nih.gov/25734888"},"language":"en","primary_location":{"id":"pmid:25734888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25734888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003821899","display_name":"Luigi Brunetti","orcid":"https://orcid.org/0000-0003-0565-6167","observed_orcids":["https://orcid.org/0000-0003-0565-6167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luigi Brunetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009491836","display_name":"Samuel F. Hunter","orcid":"https://orcid.org/0000-0002-0542-1176","observed_orcids":["https://orcid.org/0000-0002-0542-1176"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel F Hunter","raw_affiliation_strings":["brunetti@pharmacy.rutgers.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"brunetti@pharmacy.rutgers.edu","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2112,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54018321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"20","issue":"11 Suppl","first_page":"S228","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/affordable-care-act","display_name":"Affordable Care Act","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/treatment-paradigm","display_name":"treatment paradigm","score":0.7540000081062317},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.8579999804496765},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.8209999799728394},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9440000057220459},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.4970000088214874},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9029388427734375},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7484241127967834},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6639111042022705},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5153736472129822},{"id":"https://openalex.org/C43540301","wikidata":"https://www.wikidata.org/wiki/Q689971","display_name":"Paradigm shift","level":2,"score":0.4879612326622009},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.44412940740585327},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18963775038719177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0790649950504303},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058991","descriptor_name":"Patient Protection and Affordable Care Act","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25734888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25734888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},{"id":"mag:131087644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25734888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W1497657664","https://openalex.org/W1512495229","https://openalex.org/W1538563548","https://openalex.org/W1563651942","https://openalex.org/W1657604788","https://openalex.org/W1884147825","https://openalex.org/W1943010815","https://openalex.org/W1967253329","https://openalex.org/W1967838438","https://openalex.org/W1970190011","https://openalex.org/W1970253268","https://openalex.org/W1973256647","https://openalex.org/W1977759475","https://openalex.org/W1983999022","https://openalex.org/W1986886966","https://openalex.org/W1989807224","https://openalex.org/W1992684718","https://openalex.org/W1992759422","https://openalex.org/W1996787636","https://openalex.org/W1997880566","https://openalex.org/W1998780160","https://openalex.org/W2002565768","https://openalex.org/W2003261346","https://openalex.org/W2013902612","https://openalex.org/W2015734871","https://openalex.org/W2019582599","https://openalex.org/W2020713709","https://openalex.org/W2023388602","https://openalex.org/W2024560671","https://openalex.org/W2024751773","https://openalex.org/W2025032404","https://openalex.org/W2033175786","https://openalex.org/W2034432056","https://openalex.org/W2037260636","https://openalex.org/W2037685514","https://openalex.org/W2040969396","https://openalex.org/W2043591841","https://openalex.org/W2044022462","https://openalex.org/W2046399137","https://openalex.org/W2051383271","https://openalex.org/W2056093715","https://openalex.org/W2056799009","https://openalex.org/W2060129459","https://openalex.org/W2061005334","https://openalex.org/W2061621344","https://openalex.org/W2062062486","https://openalex.org/W2063929317","https://openalex.org/W2069006533","https://openalex.org/W2072502495","https://openalex.org/W2077912231","https://openalex.org/W2088453744","https://openalex.org/W2089794196","https://openalex.org/W2090486083","https://openalex.org/W2093009907","https://openalex.org/W2095037231","https://openalex.org/W2095666175","https://openalex.org/W2103758700","https://openalex.org/W2103810134","https://openalex.org/W2104948944","https://openalex.org/W2105206040","https://openalex.org/W2106654138","https://openalex.org/W2109579417","https://openalex.org/W2114080475","https://openalex.org/W2115989506","https://openalex.org/W2119172537","https://openalex.org/W2122403539","https://openalex.org/W2122545833","https://openalex.org/W2123038985","https://openalex.org/W2124131839","https://openalex.org/W2126574528","https://openalex.org/W2129967156","https://openalex.org/W2131078277","https://openalex.org/W2132649527","https://openalex.org/W2133329597","https://openalex.org/W2136039452","https://openalex.org/W2137069829","https://openalex.org/W2138815518","https://openalex.org/W2140248886","https://openalex.org/W2140560855","https://openalex.org/W2143670330","https://openalex.org/W2144633544","https://openalex.org/W2146805380","https://openalex.org/W2151340435","https://openalex.org/W2156524094","https://openalex.org/W2159179436","https://openalex.org/W2160870257","https://openalex.org/W2165059791","https://openalex.org/W2166335159","https://openalex.org/W2166983650","https://openalex.org/W2168301183","https://openalex.org/W2168649763","https://openalex.org/W2181407021","https://openalex.org/W2313649737","https://openalex.org/W2318222824","https://openalex.org/W2326911230","https://openalex.org/W2327378102","https://openalex.org/W2471961368"],"related_works":["https://openalex.org/W2080458330","https://openalex.org/W1987934286","https://openalex.org/W2297963658","https://openalex.org/W2093005278","https://openalex.org/W2194445852","https://openalex.org/W3164364963","https://openalex.org/W2505361403","https://openalex.org/W2177688959","https://openalex.org/W2007302015","https://openalex.org/W1971547969"],"abstract_inverted_index":{"The":[0],"treatment":[1,17,49],"paradigm":[2],"for":[3,71,93],"multiple":[4,81],"sclerosis":[5],"(MS)":[6],"continues":[7],"to":[8,54,62,73,101],"evolve":[9],"as":[10,23],"additional":[11],"pharmacotherapeutic":[12,91],"options":[13,92],"become":[14,20],"available.":[15],"Furthermore,":[16],"individualization":[18],"has":[19],"more":[21],"feasible":[22],"new":[24],"medications":[25],"with":[26,46,76,114],"distinct":[27],"mechanisms":[28],"of":[29,80,88,99,107],"action":[30],"and":[31,58,103],"improved":[32],"adverse":[33],"event":[34],"profiles":[35],"have":[36],"reached":[37],"the":[38,47,77,89,97,105],"market.":[39],"As":[40],"such,":[41],"clinicians":[42,72],"should":[43],"familiarize":[44],"themselves":[45],"available":[48,90],"options,":[50],"paying":[51],"particular":[52],"attention":[53],"their":[55],"various":[56],"advantages":[57],"disadvantages.":[59],"In":[60],"order":[61],"offer":[63],"patients":[64,113],"optimal":[65],"MS":[66],"therapy,":[67,102],"it":[68],"is":[69],"crucial":[70],"stay":[74],"current":[75],"changing":[78],"landscape":[79],"sclerosis.":[82],"This":[83],"article":[84],"provides":[85],"a":[86],"review":[87],"treating":[94],"MS,":[95],"discusses":[96],"impact":[98],"adherence":[100],"describes":[104],"importance":[106],"managing":[108],"comorbidities":[109],"often":[110],"experienced":[111],"by":[112],"MS.":[115]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
