{"id":"https://openalex.org/W130942009","doi":null,"title":"The thiol redox system in glioma biology : clinical target and significance in resistance to glioma chemotherapy","display_name":"The thiol redox system in glioma biology : clinical target and significance in resistance to glioma chemotherapy","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W130942009","mag":"130942009"},"language":"en","primary_location":{"id":"pmh:http://www.rian.ie/63158/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10197/4488","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book chapter"},"volume":null,"type":"book-chapter","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10197/4488","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108085664","display_name":"Gethin J. McBean","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gethin J. McBean","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108085664"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.2842000126838684,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.10719999670982361,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.968999981880188},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cystine-glutamate-exchanger","display_name":"cystine/glutamate exchanger","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cysteine-synthesis","display_name":"cysteine biosynthesis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.7319999933242798},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.5910000205039978},{"id":"https://openalex.org/keywords/thiol-disulfide-oxidoreductase","display_name":"thiol-disulfide oxidoreductase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/thioredoxin","display_name":"thioredoxin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/glutaredoxin","display_name":"glutaredoxin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cystine-import","display_name":"cystine import","score":0.6039999723434448},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.625},{"id":"https://openalex.org/keywords/brain-tumor-treatment","display_name":"brain tumor therapy","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.871466875076294},{"id":"https://openalex.org/C2777608289","wikidata":"https://www.wikidata.org/wiki/Q408626","display_name":"Cystine","level":4,"score":0.849083423614502},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7672269344329834},{"id":"https://openalex.org/C125619963","wikidata":"https://www.wikidata.org/wiki/Q81984039","display_name":"Glutaredoxin","level":4,"score":0.761731743812561},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.720569372177124},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5712180137634277},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5278135538101196},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.48064935207366943},{"id":"https://openalex.org/C2779344277","wikidata":"https://www.wikidata.org/wiki/Q106950316","display_name":"Glutathione synthetase","level":4,"score":0.4780586063861847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46664977073669434},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4605106711387634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4056066870689392},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2551638185977936},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.240943044424057},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22975438833236694},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:http://www.rian.ie/63158/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10197/4488","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book chapter"},{"id":"pmh:oai:researchrepository.ucd.ie:10197/4488","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10197/4488","pdf_url":null,"source":{"id":"https://openalex.org/S4306402280","display_name":"Research Repository UCD (University College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100930933","host_organization_name":"University College Dublin","host_organization_lineage":["https://openalex.org/I100930933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Book Chapter"},{"id":"mag:130942009","doi":null,"is_oa":false,"landing_page_url":"https://researchrepository.ucd.ie/bitstream/10197/4488/1/McBean_%282013%29_The_thiol_redox_system_in_glioma_biology.docx","pdf_url":null,"source":{"id":"https://openalex.org/S4306463674","display_name":"Nova Science Publishers eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320144","host_organization_name":"Nova Publishers","host_organization_lineage":["https://openalex.org/P4310320144"],"host_organization_lineage_names":["Nova Publishers"],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Nova Science Publishers eBooks","raw_type":null}],"best_oa_location":{"id":"pmh:oai:researchrepository.ucd.ie:10197/4488","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10197/4488","pdf_url":null,"source":{"id":"https://openalex.org/S4306402280","display_name":"Research Repository UCD (University College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100930933","host_organization_name":"University College Dublin","host_organization_lineage":["https://openalex.org/I100930933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Book Chapter"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W120058826","https://openalex.org/W1536770091","https://openalex.org/W1563428629","https://openalex.org/W1957783567","https://openalex.org/W1964694971","https://openalex.org/W1969285749","https://openalex.org/W1970256894","https://openalex.org/W1973249583","https://openalex.org/W1974796205","https://openalex.org/W1976266411","https://openalex.org/W1976955003","https://openalex.org/W1977617936","https://openalex.org/W1979234150","https://openalex.org/W1980911765","https://openalex.org/W1985322186","https://openalex.org/W1988025172","https://openalex.org/W1988119693","https://openalex.org/W1989369955","https://openalex.org/W1990046461","https://openalex.org/W1991628500","https://openalex.org/W1994833789","https://openalex.org/W1995185113","https://openalex.org/W1999357946","https://openalex.org/W2001383156","https://openalex.org/W2005980540","https://openalex.org/W2014837633","https://openalex.org/W2014843089","https://openalex.org/W2015103984","https://openalex.org/W2016562224","https://openalex.org/W2016575029","https://openalex.org/W2021270810","https://openalex.org/W2022442271","https://openalex.org/W2023262010","https://openalex.org/W2025139724","https://openalex.org/W2026710021","https://openalex.org/W2027774159","https://openalex.org/W2032954490","https://openalex.org/W2034845317","https://openalex.org/W2040262826","https://openalex.org/W2042890278","https://openalex.org/W2049530712","https://openalex.org/W2052503745","https://openalex.org/W2052945482","https://openalex.org/W2055072764","https://openalex.org/W2063537428","https://openalex.org/W2069499701","https://openalex.org/W2069760615","https://openalex.org/W2070619895","https://openalex.org/W2072682750","https://openalex.org/W2073678040","https://openalex.org/W2073691912","https://openalex.org/W2079162384","https://openalex.org/W2080292234","https://openalex.org/W2084878154","https://openalex.org/W2086818932","https://openalex.org/W2090880672","https://openalex.org/W2091505318","https://openalex.org/W2094214540","https://openalex.org/W2096492418","https://openalex.org/W2097822945","https://openalex.org/W2103964183","https://openalex.org/W2107288975","https://openalex.org/W2108036781","https://openalex.org/W2113714326","https://openalex.org/W2120257621","https://openalex.org/W2122797923","https://openalex.org/W2130278697","https://openalex.org/W2143373379","https://openalex.org/W2144367399","https://openalex.org/W2155162140"],"related_works":["https://openalex.org/W4205850057","https://openalex.org/W1973249583","https://openalex.org/W2008302670","https://openalex.org/W1564605317","https://openalex.org/W1971210299","https://openalex.org/W2029501044","https://openalex.org/W2766510605","https://openalex.org/W6889934982","https://openalex.org/W1498424268","https://openalex.org/W2914493583"],"abstract_inverted_index":{"Sulfur-containing":[0],"compounds":[1],"play":[2],"an":[3,46],"essential":[4],"role":[5],"in":[6,10,104,112,129,164,202,242,269],"maintaining":[7],"redox":[8,248],"balance":[9,249],"glioma":[11,165,203,246],"cells.":[12,204],"Chief":[13],"amongst":[14],"these":[15,81],"are":[16],"the":[17,38,60,97,113,120,137,173,192,214,221,232,243,252,258],"reduced":[18],"and":[19,26,34,55,155,198,230,250,262,274],"oxidised":[20,106],"(disulfide)":[21],"forms":[22],"of":[23,37,53,65,73,90,92,99,145,158,191,195,199,209,228,234,245,260],"cysteine":[24,54,261],"(cysteine/cystine)":[25],"glutathione":[27],"(GSH":[28],"/GSSG)":[29],"as":[30,32,45,48,119],"well":[31],"thioredoxin":[33],"glutaredoxin,":[35],"members":[36],"thiol-disulfide":[39],"oxidoreductases.":[40],"GSH":[41,61,93,162,200,229,263],"is":[42,94,102,134,188],"also":[43],"important":[44],"antioxidant,":[47],"a":[49,70,207],"\u2018safe\u2019":[50],"storage":[51],"form":[52],"for":[56,131,183,254],"detoxification":[57],"reactions":[58],"involving":[59],"sulfur":[62],"transferase":[63],"family":[64],"enzymes.":[66],"Glioma":[67,140],"cells":[68,82,141,166],"contain":[69],"high":[71],"concentration":[72],"GSH,":[74],"compared":[75],"to":[76,85,169],"normal":[77],"astrocytes,":[78],"which":[79,101,133],"renders":[80],"particularly":[83],"resistant":[84],"chemotherapeutic":[86],"agents.":[87],"The":[88],"rate":[89],"synthesis":[91,163,201,227],"controlled":[95],"by":[96,125,147],"availability":[98],"cysteine,":[100],"imported":[103],"its":[105],"form,":[107],"cystine,":[108],"through":[109],"specialized":[110],"channels":[111],"plasma":[114],"membrane.":[115],"These":[116],"channels,":[117],"known":[118,190],"cystine-glutamate":[121,215],"xc-":[122],"exchanger,":[123],"operate":[124],"taking":[126],"up":[127],"cystine":[128,196],"exchange":[130],"glutamate,":[132],"released":[135],"into":[136],"extracellular":[138],"medium.":[139],"export":[142],"large":[143],"quantities":[144],"glutamate":[146,235],"this":[148,224],"mechanism,":[149],"which,":[150],"if":[151],"unchecked,":[152],"causes":[153],"damage":[154],"eventual":[156],"death":[157],"surrounding":[159,178],"neurones.":[160],"Thus,":[161],"fuels":[167],"resistance":[168],"chemotherapy":[170],"and,":[171],"at":[172,257],"same":[174],"time,":[175],"kills":[176],"off":[177],"neurones":[179],"thereby":[180],"providing":[181],"space":[182],"tumor":[184,272],"cell":[185,247],"growth.":[186],"Much":[187],"now":[189],"molecular":[193],"mechanism":[194],"import":[197],"In":[205],"particular,":[206],"number":[208],"therapeutic":[210],"strategies":[211],"that":[212,223,265],"target":[213],"exchanger":[216],"have":[217],"been":[218],"proposed":[219],"on":[220],"basis":[222],"would":[225],"inhibit":[226],"remove":[231],"source":[233],"release.":[236],"This":[237],"review":[238],"describes":[239],"new":[240],"developments":[241],"field":[244],"evaluates":[251],"potential":[253],"clinical":[255],"intervention":[256],"level":[259],"biosynthesis":[264],"may":[266],"prove":[267],"effective":[268],"combating":[270],"brain":[271],"growth":[273],"development.":[275]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
