{"id":"https://openalex.org/W130931187","doi":null,"title":"Towards the Understanding of Resistance Mutations in Dihydrofolate Reductase from Methicillin-resistant Staphylococcus aureus","display_name":"Towards the Understanding of Resistance Mutations in Dihydrofolate Reductase from Methicillin-resistant Staphylococcus aureus","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W130931187","mag":"130931187"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-5983","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI3504572","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038965754","display_name":"Kathleen Mary Frey","orcid":"https://orcid.org/0000-0002-7419-8633","observed_orcids":["https://orcid.org/0000-0002-7419-8633"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kathleen M. Frey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7419-8633","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038965754"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dihydrofolate-reductase","display_name":"dihydrofolate reductase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole-resistance","display_name":"trimethoprim-sulfamethoxazole resistance","score":0.8830000162124634},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.7559999823570251},{"id":"https://openalex.org/keywords/resistance-prediction","display_name":"resistance prediction","score":0.6359999775886536},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.5509999990463257},{"id":"https://openalex.org/keywords/inhibitor-selection","display_name":"inhibitor selection","score":0.4440000057220459},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8168123960494995},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6327496767044067},{"id":"https://openalex.org/C2781320022","wikidata":"https://www.wikidata.org/wiki/Q417149","display_name":"Dihydrofolate reductase","level":3,"score":0.5877790451049805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4318247139453888},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3772794008255005},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.25004851818084717},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23482397198677063}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-5983","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI3504572","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:opencommons.uconn.edu:dissertations-5983","doi":null,"is_oa":false,"landing_page_url":"http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3504572","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:130931187","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/AAI3504572/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099199184","https://openalex.org/W2073361034","https://openalex.org/W2048236910","https://openalex.org/W2123018247","https://openalex.org/W2559867338","https://openalex.org/W2609769211","https://openalex.org/W7099265156","https://openalex.org/W1994670783","https://openalex.org/W2977255626","https://openalex.org/W2151047172"],"abstract_inverted_index":{"Methicillin-resistant":[0],"Staphylococcus":[1],"aureus":[2],"(MRSA)":[3],"is":[4,32,68],"a":[5,33,97,105,186],"major":[6],"cause":[7],"of":[8,27,95,107,147,157,164,177,194,202,208],"hospital-acquired":[9],"infections,":[10,20,74],"most":[11],"frequently":[12],"associated":[13],"with":[14,79,120,182],"bacteremia,":[15],"skin":[16],"and":[17,21,114,141,174],"soft":[18],"tissue":[19],"ventilator-assisted":[22],"pneumonia.":[23],"The":[24],"increasing":[25,60],"frequency":[26],"infections":[28],"caused":[29],"by":[30,180],"MRSA":[31,73,113,131,170,187],"global":[34],"health":[35],"concern":[36],"not":[37],"only":[38],"in":[39,44,62,82,128,135,167,185,199],"hospital":[40],"settings,":[41],"but":[42],"also":[43],"the":[45,86,92,143,190,200],"community":[46],"where":[47],"even":[48],"healthy":[49],"individuals":[50],"are":[51],"at":[52],"risk.":[53],"Resistance":[54],"to":[55,103,137],"therapeutics":[56],"has":[57,100],"become":[58],"an":[59,69],"problem":[61],"treating":[63],"MRSA.":[64,209],"While":[65],"trimethoprim-sulfamethoxazole":[66],"(TMP-SMZ)":[67],"alternative":[70],"treatment":[71],"for":[72,89,150,205],"resistant":[75,206],"strains":[76,207],"have":[77,132],"arisen":[78],"point":[80],"mutations":[81,127,166],"dihydrofolate":[83],"reductase":[84],"(DHFR),":[85],"validated":[87],"target":[88],"TMP.":[90],"Given":[91],"rapid":[93],"emergence":[94],"resistance,":[96],"multi-disciplinary":[98],"effort":[99],"been":[101,133],"established":[102],"design":[104,138],"library":[106],"propargyl-linked":[108,148],"inhibitors":[109,140,149,184,204],"targeting":[110],"DHFR":[111,129,152,159,168],"from":[112,130,169,192],"other":[115],"TMP-resistant":[116,151,158],"pathogens.":[117],"In":[118],"parallel":[119],"this":[121],"initiative,":[122],"several":[123],"studies":[124,196],"elucidating":[125],"resistance":[126,165,178],"conducted":[134],"order":[136],"new":[139],"include":[142],"following:":[144],"(1)":[145],"evaluation":[146],"enzymes,":[153,160],"(2)":[154],"structural":[155],"elucidation":[156],"(3)":[161],"prospective":[162],"prediction":[163],"using":[171],"computational":[172],"methods,":[173],"(4)":[175],"determination":[176],"profiles":[179],"selection":[181],"lead":[183],"strain.":[188],"Concurrently,":[189],"conclusions":[191],"all":[193],"these":[195],"will":[197],"assist":[198],"development":[201],"efficacious":[203],"^":[210]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
