{"id":"https://openalex.org/W130895097","doi":"https://doi.org/10.1093/jaoac/88.4.1114","title":"A Simple Determination of Mizoribine in Human Plasma by Liquid Chromatography with UV Detection","display_name":"A Simple Determination of Mizoribine in Human Plasma by Liquid Chromatography with UV Detection","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W130895097","doi":"https://doi.org/10.1093/jaoac/88.4.1114","mag":"130895097","pmid":"https://pubmed.ncbi.nlm.nih.gov/16152929"},"language":"en","primary_location":{"id":"doi:10.1093/jaoac/88.4.1114","doi":"https://doi.org/10.1093/jaoac/88.4.1114","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jaoac/88.4.1114","pdf_url":null,"source":{"id":"https://openalex.org/S103486911","display_name":"Journal of AOAC International","issn_l":"1060-3271","issn":["1060-3271","1944-7922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AOAC INTERNATIONAL","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040636868","display_name":"Hiroaki Kaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129844524","display_name":"Shujitsu University","ror":"https://ror.org/03mezqr97","country_code":"JP","type":"education","lineage":["https://openalex.org/I129844524"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Kaji","raw_affiliation_strings":["Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516","institution_ids":["https://openalex.org/I129844524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081310242","display_name":"Takayoshi Maiguma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129844524","display_name":"Shujitsu University","ror":"https://ror.org/03mezqr97","country_code":"JP","type":"education","lineage":["https://openalex.org/I129844524"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayoshi Maiguma","raw_affiliation_strings":["Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516","institution_ids":["https://openalex.org/I129844524"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoko Inukai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129844524","display_name":"Shujitsu University","ror":"https://ror.org/03mezqr97","country_code":"JP","type":"education","lineage":["https://openalex.org/I129844524"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Inukai","raw_affiliation_strings":["Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516","institution_ids":["https://openalex.org/I129844524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020652746","display_name":"Hiroshige Ono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129844524","display_name":"Shujitsu University","ror":"https://ror.org/03mezqr97","country_code":"JP","type":"education","lineage":["https://openalex.org/I129844524"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshige Ono","raw_affiliation_strings":["Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516","institution_ids":["https://openalex.org/I129844524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053794252","display_name":"\u5f8b\u5b50 \u8c37\u53e3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129844524","display_name":"Shujitsu University","ror":"https://ror.org/03mezqr97","country_code":"JP","type":"education","lineage":["https://openalex.org/I129844524"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ritsuko Taniguchi","raw_affiliation_strings":["Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516","institution_ids":["https://openalex.org/I129844524"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazutaka Makino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129844524","display_name":"Shujitsu University","ror":"https://ror.org/03mezqr97","country_code":"JP","type":"education","lineage":["https://openalex.org/I129844524"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutaka Makino","raw_affiliation_strings":["Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516","institution_ids":["https://openalex.org/I129844524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025011348","display_name":"Yoshinobu Tagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinobu Tagawa","raw_affiliation_strings":["Fukuoka University, Faculty of Pharmaceutical Sciences, Fukuoka, Japan 814-0180"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fukuoka University, Faculty of Pharmaceutical Sciences, Fukuoka, Japan 814-0180","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007218728","display_name":"Daisuke Teshima","orcid":"https://orcid.org/0000-0002-0576-0645","observed_orcids":["https://orcid.org/0000-0002-0576-0645"]},"institutions":[{"id":"https://openalex.org/I129844524","display_name":"Shujitsu University","ror":"https://ror.org/03mezqr97","country_code":"JP","type":"education","lineage":["https://openalex.org/I129844524"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Daisuke Teshima","raw_affiliation_strings":["Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shujitsu University, Department of Clinical Pharmacy, School of Pharmacy, Okayama, Japan 703-8516","institution_ids":["https://openalex.org/I129844524"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007218728"],"corresponding_institution_ids":["https://openalex.org/I129844524"],"apc_list":{"value":1868,"currency":"USD","value_usd":1868},"apc_paid":null,"fwci":0.251,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52258875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"88","issue":"4","first_page":"1114","last_page":"1117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mizoribine","display_name":"mizoribine","score":1.0},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9860000014305115},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.7450000047683716},{"id":"https://openalex.org/keywords/perchloric-acid-protein-precipitation","display_name":"perchloric acid protein precipitation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6919999718666077},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.7480000257492065},{"id":"https://openalex.org/keywords/drug-excretion-in-urine","display_name":"drug excretion in urine","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2777882293","wikidata":"https://www.wikidata.org/wiki/Q6884708","display_name":"Mizoribine","level":2,"score":0.9468989372253418},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8051337003707886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5797164440155029},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.5504058003425598},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5098423361778259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08952823281288147},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0776420533657074}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002623","descriptor_name":"Chemistry Techniques, Analytical","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D002623","descriptor_name":"Chemistry Techniques, Analytical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jaoac/88.4.1114","doi":"https://doi.org/10.1093/jaoac/88.4.1114","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jaoac/88.4.1114","pdf_url":null,"source":{"id":"https://openalex.org/S103486911","display_name":"Journal of AOAC International","issn_l":"1060-3271","issn":["1060-3271","1944-7922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AOAC INTERNATIONAL","raw_type":"journal-article"},{"id":"pmid:16152929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16152929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AOAC International","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2362736786","https://openalex.org/W2356810575","https://openalex.org/W2321143528","https://openalex.org/W2050909094","https://openalex.org/W2759083088","https://openalex.org/W2465476925","https://openalex.org/W2047548575","https://openalex.org/W1967555923","https://openalex.org/W2032378343","https://openalex.org/W1979434439"],"abstract_inverted_index":{"A":[0],"simple":[1],"liquid":[2],"chromatography":[3],"(LC)":[4],"method":[5,155],"was":[6,29,41,59,67,86,109,150],"developed":[7],"for":[8,39,165],"determination":[9],"of":[10,14,21,57,81,94,99,118,146],"the":[11,55,79,105,113,115,130,139,144,153,161],"therapeutic":[12,162],"level":[13],"mizoribine":[15,28,40,100,108,119,131],"in":[16,78,112,126,133,160],"human":[17],"plasma.":[18],"After":[19],"precipitation":[20],"plasma":[22,97,116],"proteins":[23],"with":[24,33],"6%":[25],"perchloric":[26],"acid,":[27],"determined":[30],"by":[31,123],"LC":[32],"spectophotometric":[34],"detection.":[35],"The":[36,65,69,83,96],"peak":[37],"height":[38],"linearly":[42],"related":[43,103],"to":[44,51,61,104],"its":[45],"concentrations,":[46],"which":[47],"ranged":[48],"from":[49],"0.09":[50,63],"3.13":[52],"microg/mL.":[53,64],"Therefore,":[54,129],"limit":[56,85],"quantitation":[58],"considered":[60],"be":[62,121,136,157],"accuracy":[66],"104.96-107.37%.":[68],"intra-":[70],"and":[71,138],"interday":[72],"relative":[73],"standard":[74],"deviation":[75],"values":[76],"were":[77,101],"range":[80],"1.10-3.25%.":[82],"detection":[84],"0.025":[87],"microg/mL,":[88],"defined":[89],"as":[90],"a":[91,124],"signal-to-noise":[92],"ratio":[93],"3.":[95],"concentrations":[98,117],"not":[102],"dosage.":[106],"Because":[107],"mainly":[110],"excreted":[111],"urine,":[114],"might":[120],"affected":[122],"change":[125],"renal":[127,147],"function.":[128,148],"concentration":[132],"blood":[134],"should":[135],"monitored":[137],"dosage":[140],"adjusted,":[141],"depending":[142],"on":[143],"condition":[145],"It":[149],"suggested":[151],"that":[152],"present":[154],"may":[156],"applied":[158],"well":[159],"drug":[163],"monitoring":[164],"mizoribine.":[166]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}