{"id":"https://openalex.org/W13080709","doi":null,"title":"Role of interleukin-6 signaling via the Jak/Stat pathway in human myeloma and effects on mediators of cell survival and proliferation","display_name":"Role of interleukin-6 signaling via the Jak/Stat pathway in human myeloma and effects on mediators of cell survival and proliferation","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W13080709","mag":"13080709"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/284289","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/284289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation-Reproduction (electronic)"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110966507","display_name":"Marc M. Oshiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marc M. Oshiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110966507"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.6234999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.6234999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.3752000033855438,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9359999895095825},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.7870000004768372},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8370000123977661},{"id":"https://openalex.org/keywords/jak2","display_name":"JAK2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9779999852180481},{"id":"https://openalex.org/keywords/fas-mediated-apoptosis","display_name":"Fas-mediated apoptosis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.953000009059906},{"id":"https://openalex.org/keywords/ag490","display_name":"AG490","score":0.9110000133514404},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.796999990940094},{"id":"https://openalex.org/keywords/u266-cells","display_name":"U266 cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.49300000071525574},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.878000020980835},{"id":"https://openalex.org/keywords/drug-induced-apoptosis","display_name":"drug-induced apoptosis","score":0.6359999775886536},{"id":"https://openalex.org/keywords/dominant-negative-stat3","display_name":"dominant-negative STAT3","score":0.7250000238418579},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.598236083984375},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5444905757904053},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.5236325263977051},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.522722065448761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4591682553291321},{"id":"https://openalex.org/C2776789625","wikidata":"https://www.wikidata.org/wiki/Q4875408","display_name":"Bcl-xL","level":4,"score":0.4467410147190094},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43449151515960693},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42935997247695923},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.42411500215530396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2562025189399719},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2541844844818115},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.16011694073677063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/284289","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/284289","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation-Reproduction (electronic)"},{"id":"mag:13080709","doi":null,"is_oa":false,"landing_page_url":"https://arizona.openrepository.com/handle/10150/284289","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W29766578","https://openalex.org/W53629506","https://openalex.org/W72273961","https://openalex.org/W139500099","https://openalex.org/W159302622","https://openalex.org/W161930446","https://openalex.org/W1483201954","https://openalex.org/W1495457417","https://openalex.org/W1538172857","https://openalex.org/W1568956696","https://openalex.org/W1591166893","https://openalex.org/W1592205925","https://openalex.org/W1651860280","https://openalex.org/W1652716702","https://openalex.org/W1748388485","https://openalex.org/W1833723119","https://openalex.org/W1845790496","https://openalex.org/W1975225141","https://openalex.org/W1980279458","https://openalex.org/W1981799488","https://openalex.org/W1986785675","https://openalex.org/W1999375479","https://openalex.org/W2002503549","https://openalex.org/W2007000374","https://openalex.org/W2007119824","https://openalex.org/W2015066175","https://openalex.org/W2016705386","https://openalex.org/W2025559703","https://openalex.org/W2028111124","https://openalex.org/W2029275361","https://openalex.org/W2032674547","https://openalex.org/W2036822121","https://openalex.org/W2041466047","https://openalex.org/W2044991100","https://openalex.org/W2045843248","https://openalex.org/W2049110705","https://openalex.org/W2052853635","https://openalex.org/W2063176993","https://openalex.org/W2063777990","https://openalex.org/W2074356752","https://openalex.org/W2078001244","https://openalex.org/W2081003617","https://openalex.org/W2083802827","https://openalex.org/W2090202756","https://openalex.org/W2090421237","https://openalex.org/W2094334993","https://openalex.org/W2094934486","https://openalex.org/W2098452001","https://openalex.org/W2107468514","https://openalex.org/W2107631090","https://openalex.org/W2109585569","https://openalex.org/W2113999599","https://openalex.org/W2116344911","https://openalex.org/W2116401711","https://openalex.org/W2118111016","https://openalex.org/W2118310862","https://openalex.org/W2121619780","https://openalex.org/W2127048642","https://openalex.org/W2132084215","https://openalex.org/W2145106676","https://openalex.org/W2155103945","https://openalex.org/W2158946057","https://openalex.org/W2166278790","https://openalex.org/W2253172597","https://openalex.org/W2258341156","https://openalex.org/W2292808816","https://openalex.org/W2341205915","https://openalex.org/W2412273027","https://openalex.org/W2413207407","https://openalex.org/W2464590528"],"related_works":["https://openalex.org/W2118310862","https://openalex.org/W2165238462","https://openalex.org/W913477751","https://openalex.org/W2389310533","https://openalex.org/W2596686723","https://openalex.org/W2144322759","https://openalex.org/W2072493113","https://openalex.org/W2075262248","https://openalex.org/W7098783892","https://openalex.org/W7099413595"],"abstract_inverted_index":{"Multiple":[0],"myeloma":[1,36,72,78,100,163,309],"is":[2,30,60],"a":[3,19],"B-cell":[4],"malignancy":[5],"characterized":[6],"by":[7,136,191,255],"the":[8,31,43,75,94,106,130,137,182,217,226,243,278,282,316],"latent":[9],"accumulation":[10],"in":[11,63,74,133,150,211,266],"bone":[12,64],"marrow":[13,65],"of":[14,48,105,129,152,162,176,184,206,216,223,228,236,252,261,277,284,294,307,318],"monoclonal":[15],"plasma":[16],"cells":[17,38,67,83,113,135,213,230,239,310],"with":[18,70,166],"low":[20],"proliferative":[21],"index":[22],"and":[23,39,46,73,120,155,174,187,196,291,299],"an":[24],"extended":[25],"life":[26],"span.":[27],"Interleukin-6":[28],"(IL-6)":[29],"major":[32],"survival":[33],"factor":[34],"for":[35],"tumor":[37],"induces":[40],"signaling":[41],"through":[42],"Signal":[44],"Transducer":[45],"Activator":[47],"Transcription":[49],"(STAT)":[50],"proteins.":[51],"We":[52,200],"report":[53],"that":[54,111,203,273,287],"one":[55],"STAT":[56],"family":[57],"member":[58],"Stat3,":[59],"constitutively":[61,87],"activated":[62],"mononuclear":[66],"from":[68],"patients":[69],"multiple":[71],"IL-6-dependent":[76],"human":[77,99],"cell":[79,101,108,267,289],"line,":[80],"U266.":[81],"U266":[82,112,134,212,229,238,308],"are":[84,114,297],"shown":[85],"to":[86,93,117,125,158,170,231,240,259,311],"overexpress":[88],"Bcl-XL":[89,153,185,207,224,298],"protein":[90,188],"when":[91,123],"compared":[92,124],"IL-6":[95,274],"independent,":[96],"Stat3":[97,145,172,303],"negative,":[98],"line":[102],"8226.":[103],"Comparison":[104],"two":[107],"lines":[109],"reveals":[110],"inherently":[115],"resistant":[116],"Fas-mediated":[118,159,312],"apoptosis":[119,210,254,313],"cytotoxic":[121,321],"drugs":[122],"8226":[126],"cells.":[127],"Inhibition":[128],"IL-6/Jak2/Stat3":[131],"pathway":[132,280],"Jak":[138],"kinase":[139],"inhibitor,":[140],"AG490,":[141],"or":[142],"dominant":[143],"negative":[144],"expression":[146,183,264,283],"construct":[147],"(Stat3/3)":[148],"results":[149],"downregulation":[151],"expression,":[154],"enhanced":[156,305],"sensitivity":[157,306],"apoptosis.":[160,249],"Treatment":[161],"patient":[164],"specimens":[165],"AG490":[167,180,246,256],"was":[168,257],"sufficient":[169],"inhibit":[171],"phosphorylation":[173],"activation":[175,276,304],"Stat3.":[177],"In":[178],"addition,":[179],"downregulated":[181],"mRNA":[186],"as":[189],"determined":[190],"RNase":[192],"protection":[193],"assay":[194],"(RPA)":[195],"flow":[197],"cytometry,":[198],"respectively.":[199],"also":[201],"found":[202],"ectopic":[204],"overexpression":[205,222],"rescued":[208],"Fas-induced":[209],"following":[214],"inhibition":[215,251,260],"Jak2/Stat3":[218,279],"pathway.":[219],"Furthermore,":[220],"enforced":[221],"increased":[225],"resistance":[227],"chemotherapeutic":[232],"drugs.":[233,322],"However,":[234],"instead":[235],"sensitizing":[237],"drug-induced":[241,248,253],"apoptosis,":[242],"JAK":[244],"inhibitor":[245],"antagonized":[247],"The":[250],"due":[258],"cyclin":[262,300],"D1":[263],"resulting":[265],"cycle":[268],"arrest.":[269],"These":[270],"studies":[271],"demonstrate":[272],"induced":[275],"controls":[281],"several":[285],"genes":[286,296],"regulate":[288],"proliferation":[290],"survival.":[292],"Two":[293],"these":[295],"D1.":[301],"Blocking":[302],"but":[314],"reduced":[315],"efficacy":[317],"cell-cycle":[319],"dependent":[320]},"counts_by_year":[],"updated_date":"2026-08-08T07:41:36.138363","created_date":"2016-06-24T00:00:00"}