{"id":"https://openalex.org/W130664918","doi":null,"title":"The Regulation of Gene Expression During Memory Consolidation in the Hippocampus","display_name":"The Regulation of Gene Expression During Memory Consolidation in the Hippocampus","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W130664918","mag":"130664918"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-3220","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/1408","pdf_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=3220&context=edissertations","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=3220&context=edissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091317614","display_name":"Shane G. Poplawski","orcid":"https://orcid.org/0000-0002-2867-6032","observed_orcids":["https://orcid.org/0000-0002-2867-6032"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shane G. Poplawski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2867-6032","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091317614"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00981087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/memory-consolidation","display_name":"memory consolidation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/contextual-fear-conditioning","display_name":"contextual fear conditioning","score":0.8410000205039978},{"id":"https://openalex.org/keywords/object-location-memory","display_name":"object location memory","score":0.9369999766349792},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8669999837875366},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nucleosome-positioning","display_name":"nucleosome positioning","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/long-term-memory","display_name":"long-term memory","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6525167226791382},{"id":"https://openalex.org/C48455012","wikidata":"https://www.wikidata.org/wiki/Q2892593","display_name":"Memory consolidation","level":3,"score":0.5407336950302124},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.474787175655365},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42395707964897156},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4136629104614258},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34900951385498047},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24027583003044128},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2287406027317047},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repository.upenn.edu:edissertations-3220","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/1408","pdf_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=3220&context=edissertations","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},{"id":"pmh:oai:repository.upenn.edu:20.500.14332/28216","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/28216","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},{"id":"pmh:oai:repository.upenn.edu:dissertations-12610","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3670951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:130664918","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=12610&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-3220","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/1408","pdf_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=3220&context=edissertations","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W130664918.pdf","grobid_xml":"https://content.openalex.org/works/W130664918.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W1501817389","https://openalex.org/W1607671357","https://openalex.org/W1646199134","https://openalex.org/W1675950512","https://openalex.org/W1821495885","https://openalex.org/W1846838131","https://openalex.org/W1920542018","https://openalex.org/W1963551704","https://openalex.org/W1963944109","https://openalex.org/W1964337986","https://openalex.org/W1964362163","https://openalex.org/W1965726907","https://openalex.org/W1967769642","https://openalex.org/W1967872727","https://openalex.org/W1968931043","https://openalex.org/W1969140317","https://openalex.org/W1970693538","https://openalex.org/W1970709734","https://openalex.org/W1976507388","https://openalex.org/W1981030303","https://openalex.org/W1981364887","https://openalex.org/W1986098629","https://openalex.org/W1986648879","https://openalex.org/W1989842018","https://openalex.org/W1990645823","https://openalex.org/W1991660337","https://openalex.org/W1995820701","https://openalex.org/W1996151441","https://openalex.org/W1996908854","https://openalex.org/W1998532096","https://openalex.org/W1999270653","https://openalex.org/W2000269220","https://openalex.org/W2002008745","https://openalex.org/W2002140212","https://openalex.org/W2002698073","https://openalex.org/W2002802459","https://openalex.org/W2002839257","https://openalex.org/W2003378728","https://openalex.org/W2005065580","https://openalex.org/W2011029903","https://openalex.org/W2011331227","https://openalex.org/W2014108956","https://openalex.org/W2014496001","https://openalex.org/W2014872693","https://openalex.org/W2016469892","https://openalex.org/W2018128016","https://openalex.org/W2019005509","https://openalex.org/W2020949930","https://openalex.org/W2021402699","https://openalex.org/W2024684743","https://openalex.org/W2026589640","https://openalex.org/W2035871717","https://openalex.org/W2037412924","https://openalex.org/W2039521726","https://openalex.org/W2042966900","https://openalex.org/W2046244011","https://openalex.org/W2046459630","https://openalex.org/W2059648396","https://openalex.org/W2060471542","https://openalex.org/W2061733344","https://openalex.org/W2062640733","https://openalex.org/W2063733436","https://openalex.org/W2064874105","https://openalex.org/W2066378949","https://openalex.org/W2068194528","https://openalex.org/W2069545688","https://openalex.org/W2072924157","https://openalex.org/W2073123664","https://openalex.org/W2075067850","https://openalex.org/W2075930190","https://openalex.org/W2076782084","https://openalex.org/W2076813149","https://openalex.org/W2082235945","https://openalex.org/W2083245183","https://openalex.org/W2086778920","https://openalex.org/W2089689396","https://openalex.org/W2090760765","https://openalex.org/W2091791524","https://openalex.org/W2091868956","https://openalex.org/W2092020421","https://openalex.org/W2092390808","https://openalex.org/W2096034876","https://openalex.org/W2096441981","https://openalex.org/W2099088617","https://openalex.org/W2099441867","https://openalex.org/W2103238221","https://openalex.org/W2104010831","https://openalex.org/W2104076855","https://openalex.org/W2104102838","https://openalex.org/W2104643304","https://openalex.org/W2106193559","https://openalex.org/W2110776599","https://openalex.org/W2111198429","https://openalex.org/W2111442044","https://openalex.org/W2111648798","https://openalex.org/W2113505474","https://openalex.org/W2114104545","https://openalex.org/W2114874351","https://openalex.org/W2115155255","https://openalex.org/W2116223459","https://openalex.org/W2117272508","https://openalex.org/W2117757143","https://openalex.org/W2120042804","https://openalex.org/W2125252313","https://openalex.org/W2126170190","https://openalex.org/W2128354129","https://openalex.org/W2128685285","https://openalex.org/W2131404068","https://openalex.org/W2133465414","https://openalex.org/W2134044586","https://openalex.org/W2134526812","https://openalex.org/W2136706395","https://openalex.org/W2136827845","https://openalex.org/W2140450002","https://openalex.org/W2141878312","https://openalex.org/W2142654476","https://openalex.org/W2143524000","https://openalex.org/W2146070554","https://openalex.org/W2147270524","https://openalex.org/W2147875291","https://openalex.org/W2149369543","https://openalex.org/W2149591661","https://openalex.org/W2150626351","https://openalex.org/W2153274979","https://openalex.org/W2154431984","https://openalex.org/W2154806815","https://openalex.org/W2156864264","https://openalex.org/W2158074192","https://openalex.org/W2158217645","https://openalex.org/W2159726740","https://openalex.org/W2160431149","https://openalex.org/W2160769038","https://openalex.org/W2164198678","https://openalex.org/W2165828523","https://openalex.org/W2168057767","https://openalex.org/W2172149172","https://openalex.org/W2416140597","https://openalex.org/W2726651211","https://openalex.org/W4298026142","https://openalex.org/W7097323753","https://openalex.org/W7114945960"],"related_works":["https://openalex.org/W4405877889","https://openalex.org/W2146544873","https://openalex.org/W2604955607","https://openalex.org/W2013152269","https://openalex.org/W2008918150","https://openalex.org/W4415809115","https://openalex.org/W39727085","https://openalex.org/W2143082392","https://openalex.org/W2079381434","https://openalex.org/W2408355380"],"abstract_inverted_index":{"Memory":[0],"consolidation":[1],"is":[2,17,28],"the":[3,35,78,84,89,93,123,154,187],"process":[4,21],"through":[5],"which":[6],"short-term":[7],"memories":[8],"are":[9,43,167,190],"stabilized":[10],"for":[11,19,32,153],"long-term":[12,113],"retention.":[13],"New":[14],"gene":[15,26,41,96,124,164],"expression":[16,27,42,97,125,165],"required":[18],"this":[20,40,70],"to":[22,58,76,121,141,145,169,209,224,251],"occur":[23,128,221],"successfully.":[24],"Although":[25],"a":[29,55,243],"necessary":[30],"component":[31],"memory":[33,99,256],"consolidation,":[34],"targets":[36,80,189],"and":[37,148,207,217],"regulation":[38,94],"of":[39,49,81,95,245],"not":[44],"well":[45],"understood.":[46],"The":[47],"advent":[48],"next-generation":[50,74],"sequencing":[51,75],"technologies":[52],"has":[53,103],"provided":[54],"tremendous":[56],"resource":[57],"probe":[59],"important":[60],"questions":[61],"genome-wide":[62,152],"in":[63,83,212,222,231,236,249],"ways":[64],"that":[65,111,127,186,220,242],"were":[66],"previously":[67],"impossible.":[68],"In":[69,115,200],"dissertation,":[71],"I":[72,118,135,184,226],"use":[73,119,136,204],"investigate":[77,122],"transcriptional":[79,188],"learning":[82,178],"hippocampus.":[85],"Chapter":[86,116,159,201],"1":[87],"reviews":[88],"previous":[90],"research":[91],"on":[92],"during":[98,255],"consolidation.":[100,257],"Previous":[101],"work":[102],"implicated":[104],"histone":[105,213,246],"acetylation":[106],"as":[107,181],"an":[108],"epigenomic":[109],"modification":[110],"regulates":[112],"memory.":[114,183],"2,":[117],"RNA-seq":[120],"changes":[126,147,166,211,230,235],"30":[129],"minutes":[130],"after":[131,157],"contextual":[132,170],"fear":[133,171],"conditioning.":[134],"recently":[137],"developed":[138],"analysis":[139],"techniques":[140],"improve":[142],"our":[143],"ability":[144],"detect":[146],"study":[149],"alternative":[150],"splicing":[151],"first":[155],"time":[156],"learning.":[158,225],"3":[160],"investigates":[161],"whether":[162],"these":[163],"specific":[168],"conditioning":[172],"or":[173],"shared":[174],"with":[175],"other":[176],"hippocampus-dependent":[177],"tasks":[179],"such":[180],"object-location":[182],"find":[185,227],"similar":[191],"between":[192],"training":[193],"paradigms,":[194],"but":[195,233],"their":[196],"temporal":[197],"activation":[198],"differs.":[199],"4,":[202],"we":[203],"ChIP-seq,":[205],"Sono-seq":[206],"MNase-seq":[208],"determine":[210],"acetylation,":[214],"chromatin":[215,237,253],"accessibility":[216,254],"nucleosome":[218],"positioning":[219],"response":[223],"only":[228],"small":[229],"H3K9/14ac,":[232],"large":[234],"accessibility.":[238],"This":[239],"may":[240],"suggest":[241],"multitude":[244],"modifications":[247],"act":[248],"concert":[250],"regulate":[252]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
