{"id":"https://openalex.org/W130654113","doi":null,"title":"Therapeutic effect of ethanolic extract of Hygrophila spinosa T. Anders on gentamicin-induced nephrotoxicity in rats.","display_name":"Therapeutic effect of ethanolic extract of Hygrophila spinosa T. Anders on gentamicin-induced nephrotoxicity in rats.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W130654113","mag":"130654113","pmid":"https://pubmed.ncbi.nlm.nih.gov/21506499"},"language":"en","primary_location":{"id":"pmid:21506499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21506499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059301922","display_name":"K. J. Bibu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K J Bibu","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, Mannuthy, Thrissur 680 651, India. bibujohn@rediffmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, Mannuthy, Thrissur 680 651, India. bibujohn@rediffmail.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008206375","display_name":"Aleena Joy","orcid":"https://orcid.org/0000-0001-8264-3381","observed_orcids":["https://orcid.org/0000-0001-8264-3381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A D Joy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001993936","display_name":"K. A. Mercey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K A Mercey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3947,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.90437584,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"48","issue":"9","first_page":"911","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hygrophila-spinosa","display_name":"Hygrophila spinosa","score":1.0},{"id":"https://openalex.org/keywords/gentamicin-induced-nephrotoxicity","display_name":"gentamicin nephrotoxicity","score":0.8809999823570251},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.5410000085830688},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.6179999709129333},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6320000290870667},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8989999890327454},{"id":"https://openalex.org/keywords/proximal-tubular-necrosis","display_name":"proximal tubular necrosis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.7609999775886536},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.6980000138282776},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8209999799728394},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.8955825567245483},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7270997762680054},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.6997810006141663},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6610592603683472},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.6350935697555542},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5718242526054382},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5357441306114197},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5344350337982178},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.49360883235931396},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.4841788113117218},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.46679621934890747},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.45423975586891174},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.42551594972610474},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4101232886314392},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2534315288066864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2373364269733429},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20368650555610657},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.1898927092552185},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.175622820854187}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023382","descriptor_name":"Toxicity Tests, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027901","descriptor_name":"Acanthaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21506499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21506499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},{"id":"mag:130654113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21506499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W154635216","https://openalex.org/W365713858","https://openalex.org/W624824503","https://openalex.org/W1526956509","https://openalex.org/W1538764270","https://openalex.org/W1587747486","https://openalex.org/W1969369643","https://openalex.org/W1990078435","https://openalex.org/W2001088240","https://openalex.org/W2001156991","https://openalex.org/W2004079184","https://openalex.org/W2006370393","https://openalex.org/W2009061522","https://openalex.org/W2012484566","https://openalex.org/W2015537598","https://openalex.org/W2025339922","https://openalex.org/W2028960441","https://openalex.org/W2040134804","https://openalex.org/W2040282320","https://openalex.org/W2051663915","https://openalex.org/W2052415091","https://openalex.org/W2053634787","https://openalex.org/W2061485058","https://openalex.org/W2067441755","https://openalex.org/W2082136439","https://openalex.org/W2106342570","https://openalex.org/W2113177765","https://openalex.org/W2142292913","https://openalex.org/W2155560553","https://openalex.org/W2158992106","https://openalex.org/W2334676005","https://openalex.org/W2413264531","https://openalex.org/W2440248945","https://openalex.org/W2511416029","https://openalex.org/W2790472723"],"related_works":["https://openalex.org/W7097717842","https://openalex.org/W2426207310","https://openalex.org/W2686058687","https://openalex.org/W90016338","https://openalex.org/W2552271197","https://openalex.org/W2013034111","https://openalex.org/W2023133716","https://openalex.org/W2044834624","https://openalex.org/W2030932310","https://openalex.org/W2553713680"],"abstract_inverted_index":{"Therapeutic":[0],"effect":[1,128],"of":[2,5,12,29,74,108,119,122],"ethanolic":[3,87,117],"extract":[4,66,88,118],"Hygrophila":[6],"spinosa":[7,65,124],"in":[8,15,59,93],"gentamicin-induced":[9,131],"nephrotoxic":[10],"model":[11],"kidney":[13],"injury":[14],"male":[16],"Sprague-Dawley":[17],"rats":[18],"was":[19,39],"studied.":[20],"Rats":[21],"were":[22,56,101],"administered":[23],"with":[24,79],"gentamicin":[25],"at":[26,72,83],"a":[27,80,91],"dose":[28],"80":[30],"mg/kg":[31,78],"intraperitoneally":[32],"(ip)":[33],"to":[34,103],"induce":[35],"nephrotoxicity.":[36],"Kidney":[37,47],"function":[38],"assessed":[40],"by":[41],"measuring":[42],"serum":[43,94],"creatinine":[44,95],"and":[45,53,61,76,96,129],"urea.":[46],"superoxide":[48],"dismutase,":[49],"lipid":[50],"peroxidation,":[51],"catalase":[52],"reduced":[54],"glutathione":[55],"also":[57,89],"measured":[58],"control":[60],"treated":[62],"rats.":[63],"H.":[64,123],"showed":[67],"free":[68],"radical":[69],"scavenging":[70],"activities":[71],"doses":[73],"50":[75],"250":[77,84],"predominant":[81],"activity":[82],"mg/kg.":[85],"The":[86,112],"caused":[90],"reduction":[92],"urea":[97],"levels.":[98],"Histopathological":[99],"studies":[100],"conducted":[102],"confirm":[104],"the":[105,109,116,126],"therapeutic":[106,127],"action":[107],"plant":[110,121],"extract.":[111],"results":[113],"demonstrated":[114],"that":[115],"whole":[120],"evinced":[125],"inhibited":[130],"proximal":[132],"tubular":[133],"necrosis.":[134]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}