{"id":"https://openalex.org/W130613889","doi":"https://doi.org/10.1139/jpn.0540","title":"Stressed or stressed out: What is the difference?","display_name":"Stressed or stressed out: What is the difference?","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W130613889","doi":"https://doi.org/10.1139/jpn.0540","mag":"130613889","pmid":"https://pubmed.ncbi.nlm.nih.gov/16151535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1197275"},"language":"en","primary_location":{"id":"doi:10.1139/jpn.0540","doi":"https://doi.org/10.1139/jpn.0540","is_oa":false,"landing_page_url":"https://doi.org/10.1139/jpn.0540","pdf_url":null,"source":{"id":"https://openalex.org/S141047287","display_name":"Journal of Psychiatry and Neuroscience","issn_l":"1180-4882","issn":["1180-4882","1488-2434"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatry and Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1197275","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035103174","display_name":"Bruce S. McEwen","orcid":"https://orcid.org/0000-0002-5288-7892","observed_orcids":["https://orcid.org/0000-0002-5288-7892"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce S. McEwen","raw_affiliation_strings":["Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY","Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA","Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA. mcewen@rockefeller.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA. mcewen@rockefeller.edu","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035103174"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":5.8034,"has_fulltext":false,"cited_by_count":602,"citation_normalized_percentile":{"value":0.97974494,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"30","issue":"5","first_page":"315","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12947","display_name":"Health, psychology, and well-being","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11761","display_name":"Resilience and Mental Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allostasis","display_name":"allostasis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.6729999780654907},{"id":"https://openalex.org/keywords/homeostasis","display_name":"homeostasis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/allostatic-overload","display_name":"allostatic overload","score":0.9419999718666077},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.7850000262260437},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/stress-mediators","display_name":"stress mediators","score":0.6309999823570251},{"id":"https://openalex.org/keywords/adaptive-stress-response","display_name":"adaptive stress response","score":0.5830000042915344},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.5},{"id":"https://openalex.org/keywords/stress-related-disorders","display_name":"stress-related disorders","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C157541749","wikidata":"https://www.wikidata.org/wiki/Q3612637","display_name":"Allostasis","level":2,"score":0.9902431964874268},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.8224090337753296},{"id":"https://openalex.org/C187150481","wikidata":"https://www.wikidata.org/wiki/Q4733156","display_name":"Allostatic load","level":2,"score":0.7886016368865967},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6310185194015503},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5649248957633972},{"id":"https://openalex.org/C33507282","wikidata":"https://www.wikidata.org/wiki/Q4680759","display_name":"Adaptive response","level":2,"score":0.4996049404144287},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.41682517528533936},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41395390033721924},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.40038618445396423},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.33221983909606934},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3262171745300293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14898836612701416},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009626","descriptor_name":"Terminology as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1139/jpn.0540","doi":"https://doi.org/10.1139/jpn.0540","is_oa":false,"landing_page_url":"https://doi.org/10.1139/jpn.0540","pdf_url":null,"source":{"id":"https://openalex.org/S141047287","display_name":"Journal of Psychiatry and Neuroscience","issn_l":"1180-4882","issn":["1180-4882","1488-2434"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatry and Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1197275","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1197275","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},{"id":"pmid:16151535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16151535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychiatry & neuroscience : JPN","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.554.4751","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.554.4751","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.nordicriskgroup.com/riskmote2007/publik/filer/McEwen -Stressed or stress out 2005.pdf","raw_type":"text"},{"id":"mag:130613889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16151535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1197275","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1197275","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W26526780","https://openalex.org/W31659055","https://openalex.org/W197329041","https://openalex.org/W352261356","https://openalex.org/W1735142613","https://openalex.org/W1964518559","https://openalex.org/W1965486589","https://openalex.org/W1980578471","https://openalex.org/W1981748148","https://openalex.org/W1989416066","https://openalex.org/W1994048221","https://openalex.org/W2023522611","https://openalex.org/W2025483550","https://openalex.org/W2061263676","https://openalex.org/W2076241195","https://openalex.org/W2149915148","https://openalex.org/W2162312524","https://openalex.org/W2334787351"],"related_works":["https://openalex.org/W4253132094","https://openalex.org/W7603151","https://openalex.org/W4237547583","https://openalex.org/W112970541","https://openalex.org/W2546675275","https://openalex.org/W2071271451","https://openalex.org/W3161830335","https://openalex.org/W2094284063","https://openalex.org/W154040221","https://openalex.org/W2000344066"],"abstract_inverted_index":{"The":[0],"term":[1],"\"allostasis\"":[2],"has":[3,75,114],"been":[4],"coined":[5],"to":[6,16,54,79,82,90,117,137],"clarify":[7],"ambiguities":[8],"associated":[9],"with":[10,139],"the":[11,17,24,39,45,57,62,84,87,96,106,119,125,130,134,140],"word":[12],"\"stress\".":[13],"Allostasis":[14],"refers":[15],"adaptive":[18,88],"processes":[19],"that":[20,66],"maintain":[21],"homeostasis":[22],"through":[23],"production":[25],"of":[26,38,47,86,95,105,109,121,133],"mediators":[27,37],"such":[28,100],"as":[29,127,129,143],"adrenalin,":[30],"cortisol":[31],"and":[32,59,64],"other":[33],"chemical":[34],"messengers.":[35],"These":[36],"stress":[40,122],"response":[41,89],"promote":[42],"adaptation":[43],"in":[44,103],"aftermath":[46],"acute":[48],"stress,":[49],"but":[50],"they":[51],"also":[52,115],"contribute":[53],"allostatic":[55],"overload,":[56],"wear":[58],"tear":[60],"on":[61],"body":[63],"brain":[65],"result":[67],"from":[68],"being":[69],"\"stressed":[70],"out\".":[71],"This":[72,112],"conceptual":[73],"framework":[74,113],"created":[76],"a":[77],"need":[78],"know":[80],"how":[81],"improve":[83],"efficiency":[85],"stressors":[91],"while":[92],"minimizing":[93],"overactivity":[94,101],"same":[97],"systems,":[98],"since":[99],"results":[102],"many":[104],"common":[107],"diseases":[108],"modern":[110],"life.":[111],"helped":[116],"demystify":[118],"biology":[120],"by":[123],"emphasizing":[124],"protective":[126],"well":[128],"damaging":[131],"effects":[132],"body's":[135],"attempts":[136],"cope":[138],"challenges":[141],"known":[142],"stressors.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":42},{"year":2022,"cited_by_count":41},{"year":2021,"cited_by_count":71},{"year":2020,"cited_by_count":71},{"year":2019,"cited_by_count":33},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}