{"id":"https://openalex.org/W13014466","doi":null,"title":"How stress damages immune system and health.","display_name":"How stress damages immune system and health.","publication_year":2005,"publication_date":"2005-04-01","ids":{"openalex":"https://openalex.org/W13014466","mag":"13014466","pmid":"https://pubmed.ncbi.nlm.nih.gov/20704904"},"language":"en","primary_location":{"id":"pmid:20704904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20704904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108799529","display_name":"Ronald Glaser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Glaser","raw_affiliation_strings":["Institute for Behavioral Medicine Research; College of Medicine and Public Health; and Comprehensive Cancer Center; The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Behavioral Medicine Research; College of Medicine and Public Health; and Comprehensive Cancer Center; The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050148319","display_name":"Janice K. Kiecolt\u2010Glaser","orcid":"https://orcid.org/0000-0003-4900-9578","observed_orcids":["https://orcid.org/0000-0003-4900-9578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janice Kiecolt-Glaser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.00150038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"26","first_page":"165","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psychoneuroimmunology","display_name":"psychoneuroimmunology","score":0.9210000038146973},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.7839999794960022},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/sympathoadrenal-system","display_name":"sympathoadrenal system","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8759999871253967},{"id":"https://openalex.org/keywords/central-nervous-system-immune-system-interaction","display_name":"central nervous system-immune system interaction","score":0.6940000057220459},{"id":"https://openalex.org/keywords/stress-hormones","display_name":"stress hormones","score":0.7820000052452087},{"id":"https://openalex.org/keywords/sickness-behavior","display_name":"sickness behavior","score":0.8029999732971191},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.574999988079071},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.43700000643730164},{"id":"https://openalex.org/keywords/sleep-patterns","display_name":"sleep patterns","score":0.5120000243186951},{"id":"https://openalex.org/keywords/loss-of-appetite","display_name":"appetite loss","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8611983060836792},{"id":"https://openalex.org/C38042653","wikidata":"https://www.wikidata.org/wiki/Q1500332","display_name":"Psychoneuroimmunology","level":3,"score":0.7634906768798828},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.6056084036827087},{"id":"https://openalex.org/C138906646","wikidata":"https://www.wikidata.org/wiki/Q7507668","display_name":"Sickness behavior","level":3,"score":0.5795916318893433},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5491249561309814},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5253735780715942},{"id":"https://openalex.org/C2779146795","wikidata":"https://www.wikidata.org/wiki/Q1369123","display_name":"Hypothalamic\u2013pituitary\u2013adrenal axis","level":3,"score":0.49228182435035706},{"id":"https://openalex.org/C201934248","wikidata":"https://www.wikidata.org/wiki/Q2492999","display_name":"Neuroimmunology","level":3,"score":0.4402676224708557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38990673422813416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37322887778282166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3449186682701111},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26238352060317993}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:20704904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20704904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"mag:13014466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20704904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3041408801","https://openalex.org/W2038619826","https://openalex.org/W2057760285","https://openalex.org/W4406917492","https://openalex.org/W2411453691","https://openalex.org/W1965210540","https://openalex.org/W126282077","https://openalex.org/W6922464956","https://openalex.org/W7132367094","https://openalex.org/W2402439366"],"abstract_inverted_index":{"Extract:":[0],"There":[1],"is":[2,60,104,129],"an":[3],"extensive":[4],"body":[5,55],"of":[6,13,56,71,101,125,155,161,185,204,209,235],"scientific":[7],"literature":[8,57],"related":[9],"to":[10,83,194,214,216],"the":[11,29,36,72,84,141,144,149,159,165,170,183,217,222],"field":[12],"research":[14,103],"called":[15],"psychoneuroimmunology.":[16],"Clinical":[17],"studies,":[18,23],"backed":[19],"up":[20],"by":[21,148,164,192],"mechanism":[22],"have":[24,80,89],"provided":[25],"convincing":[26],"evidence":[27],"that":[28,42,62,105,112,133],"central":[30],"nervous":[31],"system":[32,146],"(CNS)":[33],"interacts":[34],"with":[35],"endocrine":[37,150],"and":[38,41,74,86,88,143,169,241],"immune":[39,66,76,107,145,177,190,205],"systems":[40],"these":[43,156],"interactions":[44,139,157,175],"are":[45,113,135,198],"bi-directional.":[46],"Stress":[47],"has":[48,211],"been":[49,212],"a":[50],"focal":[51],"point":[52],"in":[53,123,221,238],"this":[54,102],"because":[58],"it":[59],"known":[61],"stress":[63,162],"can":[64,109,188],"induce":[65],"dysregulation":[67,108],"across":[68],"many":[69],"aspects":[70,154],"humoral":[73],"cellular":[75],"responses.":[77],"These":[78],"studies":[79,94],"dated":[81],"back":[82],"1960s":[85],"1970s,":[87],"included":[90],"some":[91],"very":[92,136],"elegant":[93],"involving":[95],"animal":[96],"models.":[97],"The":[98,174,207],"important":[99,153],"outcome":[100],"stress-induced":[106],"produce":[110],"changes":[111,220,237],"not":[114],"only":[115],"statistically":[116],"significant":[117,122],"but,":[118],"most":[119],"importantly,":[120],"biologically":[121],"terms":[124],"health":[126],"risk.":[127],"It":[128],"now":[130],"well":[131,226],"established":[132],"there":[134],"complex":[137],"bi-directional":[138],"between":[140,176],"CNS":[142],"mediated":[147],"system.":[151],"Two":[152],"include":[158],"production":[160,184],"hormones":[163],"hypothalamic-pituitary-adrenal":[166],"(HPA)":[167],"axis":[168],"sympathetic-adrenal-medullary":[171],"(SAM)":[172],"axis.":[173],"cells":[178],"also":[179],"take":[180],"place":[181],"through":[182],"cytokines.":[186],"Hormones":[187],"modulate":[189],"function":[191],"binding":[193],"their":[195],"receptors,":[196],"which":[197],"expressed":[199],"on":[200],"virtually":[201],"every":[202],"type":[203],"cell.":[206],"modulation":[208],"cytokines":[210],"shown":[213],"feedback":[215],"brain,":[218],"producing":[219],"HPA":[223],"axis,":[224],"as":[225,227,232],"inducing":[228],"sickness":[229],"behavior":[230],"such":[231],"fever,":[233],"loss":[234],"appetite,":[236],"sleep":[239],"patterns":[240],"depression.":[242]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
