{"id":"https://openalex.org/W130124634","doi":null,"title":"Intra-tibial injection of human prostate cancer cell line CWR22 elicits osteoblastic response in immunodeficient rats.","display_name":"Intra-tibial injection of human prostate cancer cell line CWR22 elicits osteoblastic response in immunodeficient rats.","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W130124634","mag":"130124634","pmid":"https://pubmed.ncbi.nlm.nih.gov/15758355"},"language":"en","primary_location":{"id":"pmid:15758355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15758355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of musculoskeletal & neuronal interactions","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Andersen","raw_affiliation_strings":["Pfizer Inc., Global Research and Development, Drug Safety Evaluation, Groton, CT, USA. cedo_bagi@groton.pfizer.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc., Global Research and Development, Drug Safety Evaluation, Groton, CT, USA. cedo_bagi@groton.pfizer.com","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069044085","display_name":"Cedo M. Bagi","orcid":"https://orcid.org/0000-0002-3103-9755","observed_orcids":["https://orcid.org/0000-0002-3103-9755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C M Bagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"S W Adams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S W Adams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8333,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.71023664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"3","issue":"2","first_page":"148","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7990000247955322},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.921999990940094},{"id":"https://openalex.org/keywords/osteolytic-lesions","display_name":"osteolytic lesions","score":0.8450000286102295},{"id":"https://openalex.org/keywords/osteosclerosis","display_name":"osteosclerosis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tartrate-resistant-acid-phosphatase","display_name":"tartrate-resistant acid phosphatase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nude-rat-model","display_name":"nude rat model","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7306180596351624},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5771509408950806},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5747166872024536},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5607974529266357},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.4957979619503021},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4689089059829712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46477535367012024},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4495505094528198},{"id":"https://openalex.org/C2776490512","wikidata":"https://www.wikidata.org/wiki/Q21151790","display_name":"Prostatic acid phosphatase","level":4,"score":0.43527740240097046},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.4317973256111145},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3870057463645935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2757471799850464},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:15758355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15758355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of musculoskeletal & neuronal interactions","raw_type":"Journal Article"},{"id":"mag:130124634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15758355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1581074473","https://openalex.org/W1670027677","https://openalex.org/W1672290086","https://openalex.org/W1676754695","https://openalex.org/W1860286105","https://openalex.org/W2039181986","https://openalex.org/W2057218203","https://openalex.org/W2058860389","https://openalex.org/W2063699543","https://openalex.org/W2065444789","https://openalex.org/W2066470904","https://openalex.org/W2075451472","https://openalex.org/W2075733574","https://openalex.org/W2088469222","https://openalex.org/W2098181641","https://openalex.org/W2100531189","https://openalex.org/W2113554746","https://openalex.org/W2114394594","https://openalex.org/W2165580132","https://openalex.org/W2309414991","https://openalex.org/W2410844975","https://openalex.org/W2616256733"],"related_works":["https://openalex.org/W1999360473","https://openalex.org/W1545371816","https://openalex.org/W2012672965","https://openalex.org/W4393075020","https://openalex.org/W2146465225","https://openalex.org/W2080922688","https://openalex.org/W2055184276","https://openalex.org/W1993630937","https://openalex.org/W3180585735","https://openalex.org/W2052380701"],"abstract_inverted_index":{"We":[0,80,223],"investigated":[1],"the":[2,27,66,73,97,101,128,157,186,189,212,226,286,313],"utility":[3],"of":[4,75,96,104,118,131,150,172,188,214,255,265,315],"CWR22":[5,87,122,227],"human":[6,12,82,108,228],"prostate":[7,14,83,229,316],"cancer":[8,31,58,76,84,106,317],"cells":[9,123],"for":[10,39,68,275],"modeling":[11],"metastatic":[13,266,293],"cancer,":[15],"specifically":[16],"their":[17],"ability":[18,42],"to":[19,36,43,50,144,160,243,297,306,319],"induce":[20,44],"bone":[21,40,46,69,175,193,206,299],"formation":[22],"following":[23],"intra-tibial":[24,235],"injections":[25],"in":[26,34,78,107,233,247,256,268,288],"nude":[28,236],"rat.":[29],"Prostate":[30],"is":[32,72],"unique":[33],"regard":[35],"its":[37,90,289],"tropism":[38],"and":[41,62,116,137,164,180,201,249],"new":[45],"formation.":[47],"In":[48,295],"contrast":[49],"humans,":[51],"other":[52],"mammalian":[53],"species":[54],"rarely":[55],"develop":[56],"prostatic":[57,105],"spontaneously":[59],"upon":[60],"aging":[61],"do":[63],"not":[64],"have":[65],"propensity":[67],"metastasis":[70,318],"that":[71,99,225,259],"hallmark":[74],"malignancy":[77],"men.":[79],"chose":[81],"cell":[85,230],"line":[86,231],"based":[88],"on":[89,198,280],"properties,":[91],"which":[92],"closely":[93,260],"resemble":[94],"all":[95,262],"features":[98,139,264],"characterize":[100],"early":[102],"stages":[103],"patients":[109],"including":[110],"slow":[111],"growth":[112],"rate,":[113],"hormone":[114],"dependence/independence":[115],"secretion":[117],"prostate-specific":[119,152],"antigen.":[120,153],"When":[121],"were":[124],"injected":[125],"directly":[126],"into":[127],"proximal":[129],"tibia":[130],"immunodeficient":[132],"male":[133],"rats,":[134],"both":[135],"osteoblastic":[136,248],"osteolytic":[138,192,250],"became":[140],"evident":[141,197],"after":[142],"4":[143],"6":[145],"weeks,":[146],"with":[147,170],"elevated":[148],"levels":[149],"serum":[151],"However,":[154],"osteosclerosis":[155],"dominates":[156],"skeletal":[158],"response":[159],"tumor":[161,183,287],"burden.":[162],"Radiological":[163],"histological":[165],"evidence":[166],"revealed":[167,204],"osteosclerotic":[168],"lesions":[169,194],"trabeculae":[171],"newly":[173],"formed":[174],"lined":[176],"by":[177,182,211],"active":[178],"osteoblasts":[179],"surrounded":[181],"cells.":[184],"Toward":[185],"end":[187],"7-week":[190],"study,":[191],"become":[195],"more":[196],"X-rays.":[199],"Paraffin":[200],"immunohistochemical":[202],"evaluations":[203],"mature":[205],"matrix":[207],"resorption":[208],"as":[209],"evidenced":[210],"presence":[213],"many":[215],"tartrate":[216],"resistant":[217],"acid":[218],"phosphatase":[219],"positive":[220],"multinucleated":[221],"osteoclasts.":[222],"conclude":[224],"used":[232],"an":[234],"rat":[237],"model":[238,258],"provides":[239],"a":[240,272],"useful":[241],"system":[242],"study":[244],"mechanisms":[245],"involved":[246],"bony":[251],"metastases.":[252],"This":[253],"type":[254],"vivo":[257],"mimics":[261],"major":[263],"disease":[267],"humans":[269],"may":[270],"provide":[271],"critical":[273],"tool":[274],"drug":[276,309],"development":[277],"efforts":[278],"focused":[279],"developing":[281],"integrated":[282],"systemic":[283],"therapy":[284],"targeting":[285,298],"specific":[290],"primary":[291],"or/and":[292],"microenvironments.":[294],"addition":[296],"marrow":[300],"stroma,":[301],"this":[302],"strategy":[303],"will":[304],"help":[305],"overcome":[307],"classical":[308],"resistance":[310],"seen":[311],"at":[312],"sites":[314],"bones.":[320]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
