{"id":"https://openalex.org/W130078062","doi":null,"title":"Effects of Glucagon-like Peptide-1-(7-36)amide (GLP-1) on Gastric Motor Function in Health and Diabetes: Potential Mechanism of Action","display_name":"Effects of Glucagon-like Peptide-1-(7-36)amide (GLP-1) on Gastric Motor Function in Health and Diabetes: Potential Mechanism of Action","publication_year":2003,"publication_date":"2003-01-07","ids":{"openalex":"https://openalex.org/W130078062","mag":"130078062"},"language":"en","primary_location":{"id":"mag:130078062","doi":null,"is_oa":false,"landing_page_url":"https://ddd.uab.cat/pub/tesis/2003/tdx-1222103-153356/sda1de1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067518042","display_name":"S\u00edlvia Delgado Aros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S\u00edlvia Delgado Aros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067518042"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01276196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.263700008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gastric-accommodation","display_name":"gastric accommodation","score":0.5770000219345093},{"id":"https://openalex.org/keywords/gastric-emptying","display_name":"gastric emptying","score":0.7110000252723694},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"vagus nerve","score":0.7699999809265137},{"id":"https://openalex.org/keywords/postprandial-gastric-volume","display_name":"postprandial gastric volume","score":0.8100000023841858},{"id":"https://openalex.org/keywords/pancreatic-polypeptide","display_name":"pancreatic polypeptide","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gastric-acid-secretion","display_name":"gastric acid secretion","score":0.7059999704360962},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.49399998784065247},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.6919999718666077},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.5210000276565552},{"id":"https://openalex.org/keywords/proglucagon-processing","display_name":"proglucagon processing","score":0.671999990940094},{"id":"https://openalex.org/keywords/l-cells","display_name":"L cells","score":0.4869999885559082},{"id":"https://openalex.org/keywords/intragastric-pressure","display_name":"intragastric pressure","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.8126728534698486},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.47074493765830994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38015854358673096},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.2101457715034485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15167060494422913},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.09538739919662476}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:130078062","doi":null,"is_oa":false,"landing_page_url":"https://ddd.uab.cat/pub/tesis/2003/tdx-1222103-153356/sda1de1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2141362365","https://openalex.org/W1993903158","https://openalex.org/W2509586222","https://openalex.org/W2119670027","https://openalex.org/W2129501738","https://openalex.org/W2097325055","https://openalex.org/W49041740","https://openalex.org/W2071966058","https://openalex.org/W2082118938","https://openalex.org/W2080117844"],"abstract_inverted_index":{"El":[0,406],"Glucagon-like":[1],"peptide-1":[2,490],"(GLP-1),":[3,491],"un":[4,74,83,479],"peptid":[5],"derivat":[6],"del":[7,9,15,18,39,58,85,167,190,214,352,377,399,413,473],"processament":[8],"proglucago":[10],"en":[11,68,124,134,153,210,280,314,342,347,356,367,395,410,441,459,470],"les":[12,53,271],"ce_lules":[13],"L":[14,503],"jejunum":[16,507],"i":[17,25,120,151,175,212],"colon,":[19,509],"inhibeix":[20,115,199],"la":[21,33,50,71,94,126,129,162,185,225,230,255,305,450,453,466,484],"secrecio":[22,226],"acida":[23],"gastrica":[24,67,89,119,158,201,263,292,488],"el":[26,113,116,136,176,196,207,240,259,287,343,359,364,380,411,434],"buidament":[27],"gastric,":[28,417],"a":[29,70,82,238,465,492,566,660,698,792,919],"mes":[30],"de":[31,52,93,102,128,149,171,224,227,257,265,270,282,294,304,309,318,432,443,452,455,468,486],"reduir":[32],"capacitat":[34,88,130],"dingesta.":[35],"Els":[36,188],"mecanismes":[37,422],"daccio":[38],"GLP-1":[40,59,114,150,197,260,288,360,378,533,542,595,629,677,730,761,834,851],"no":[41,198,289,361],"estan":[42,60],"clars.":[43],"Hi":[44],"ha":[45,420,430],"dades":[46],"que":[47,49,79,90,107,112,121,132,195,239,258,333,353,375,423,433,449],"suggereixen":[48],"inhibicio":[51,223,269],"funcions":[54],"gastriques":[55],"per":[56,220,245,268,482],"part":[57,125],"mitjancades":[61],"pel":[62,77,385],"nervi":[63,386,407],"vagus.\nLacomodacio":[64],"o":[65,87,285,415],"relaxacio":[66,262,291,487],"resposta":[69,485],"ingesta":[72],"es":[73,217,477],"reflex":[75,117,474,568,600,948],"mitjancat":[76,384],"vagus":[78,408,552,873],"dona":[80],"lloc":[81],"increment":[84],"volum":[86,177,208,266,295,365,381,416],"impedeix":[91],"lincrement":[92,165],"pressio":[95],"intragastrica":[96],"quan":[97],"mengem,":[98],"evitant":[99],"aixi":[100],"laparicio":[101],"simptomes.":[103],"La":[104],"primera":[105],"hipotesi":[106,141,256,277],"varem":[108,142,301,354],"plantejar":[109],"va":[110,205,218,362],"ser":[111,438],"dacomodacio":[118],"aixo":[122],"explicaria":[123],"reduccio":[127],"dingesta":[131],"sobserva":[133],"administrar":[135],"GLP-1.":[137,613],"Per":[138],"provar":[139,297],"aquesta":[140,276,298,348],"comparar":[143,325],"els":[144,249,315,327,337],"efectes":[145],"duna":[146],"infusio":[147,307],"endovenosa":[148,308],"placebo,":[152,313,631,787],"voluntaris":[154],"sans,":[155,358],"sobre":[156,379],"lacomodacio":[157,200],"postprandial":[159,166,633,642,681,691,941],"(mesurada":[160],"amb":[161,254,312,320,336,370,461],"tecnica":[163],"SPECT),":[164],"polipeptid":[168,228],"pancreatic":[169,647,703],"(marcador":[170],"funcio":[172],"vagal":[173,235,284,322,445,463,653,709,718,741,757,800,843,858,907,926],"abdominal)":[174],"dun":[178],"nutrient":[179,661],"liquid":[180,662],"(Ensure(r))":[181],"ingerit":[182],"fins":[183],"atansar":[184],"sacietat":[186],"maxima.":[187],"resultats":[189,250],"primer":[191,344],"estudi":[192,345],"van":[193],"demostrar":[194],"postprandial;":[202],"al":[203],"contrari,":[204],"augmentar":[206,363],"gastric":[209,242,366,382,436,511,515,571,598,634,682,692,713,733,736,765,768,789,805,838,853,864,880,896,915,942],"deju":[211,396],"despres":[213,398],"menjar.":[215],"Aixo":[216,373],"acompanyar":[219],"una":[221],"marcada":[222],"pancreatic,":[229],"qual":[231],"esta":[232,243,383],"sota":[233],"control":[234,412,878],"colinergic.":[236],"Degut":[237],"to":[241,414,435,562,786,812,830,867,918,929],"mantingut":[244],"influencia":[246],"colinergica":[247],"vagal,":[248],"obtinguts":[251],"son":[252],"compatibles":[253],"indueix":[261],"(augment":[264,293],"gastric)":[267],"vies":[272],"colinergiques":[273],"vagals.":[274],"Si":[275],"fos":[278],"certa,":[279],"cas":[281,471],"disfuncio":[283],"vagotomia,":[286],"produiria":[290],"gastric).\nPer":[296],"segona":[299],"hipotesi,":[300],"estudiar":[302],"lefecte":[303,376],"mateixa":[306],"GLP-1,":[310,784],"comparada":[311],"volums":[316,328,392,456],"gastrics":[317,329,457],"subjectes":[319,339,357,404],"neuropatia":[321,371,462],"diabetica.":[323],"Varem":[324],"tambe":[326,424],"dels":[330,338,403],"malalts":[331,368,388,460],"diabetics":[332,369,389,841],"rebien":[334],"placebo":[335,811],"sans":[340],"estudiats":[341],"presentat":[346],"tesi.":[349],"Al":[350],"contrari":[351],"observar":[355],"vagal.":[372],"suggereix":[374],"vagus.\nEls":[387],"avaluats":[390],"presentaven":[391],"gastrics,":[393],"tan":[394],"com":[397],"menjar,":[400],"similars":[401],"als":[402],"sans.":[405],"participa":[409],"pero":[418],"hi":[419,425,429],"altres":[421],"participen.":[426],"Es":[427],"mes,":[428],"evidencia":[431,467],"pot":[437],"controlat":[439],"adequadament":[440],"absencia":[442],"innervacio":[444],"extrinseca.":[446],"De":[447],"manera":[448],"troballa":[451],"existencia":[454],"normals":[458],"safegeix":[464],"que,":[469],"dalteracio":[472],"principal":[475],"vago-vagal,":[476],"produeix":[478],"mecanisme":[480],"adaptatiu":[481],"preservar":[483],"postprandial.\nGlucagon-like":[489],"peptide":[493],"derived":[494],"from":[495],"the":[496,499,506,551,558,575,586,589,597,608,623,639,657,672,685,702,721,754,776,779,815,821,848,877,903,913,923,930,934,945],"processing":[497],"of":[498,505,532,544,557,591,625,628,644,652,659,671,701,740,756,778,783,794,850,869,879,905,925,933,936],"proglucagon":[500],"molecule":[501],"in":[502,560,577,585,620,724,753,791,807,814,820,825,832,840,876,902,922],"cells":[504],"and":[508,514,518,582,601,630,656,690],"inhibits":[510,596],"acid":[512],"secretion":[513],"emptying":[516],"rate":[517],"it":[519,687],"also":[520,803],"decreases":[521],"food":[522,581,610],"consumption.":[523],"It":[524],"is":[525,548,565,707,715,855,892,949],"still":[526],"not":[527,679,763,836],"clear":[528],"how":[529],"these":[530],"effects":[531,624,831],"are":[534,537,886],"mediated.":[535],"There":[536],"data":[538],"that":[539,541,569,594,602,676,729,752,847,895,912],"suggest":[540],"inhibition":[543,700,739],"upper":[545],"gastrointestinal":[546],"functions":[547],"mediated":[549],"through":[550],"nerve.\nThe":[553],"accommodation":[554,599,635],"or":[555,759,882],"relaxation":[556,734,766,943],"stomach":[559],"response":[561,643,917,939],"meal":[563,663,920],"ingestion":[564],"vagally-mediated":[567],"increases":[570],"volume.":[572],"This":[573,694,845],"prevents":[574],"increase":[576,837],"intragastric":[578],"pressure":[579],"when":[580,944],"fluid":[583],"enter":[584],"stomach,":[587],"avoiding":[588],"development":[590],"symptoms.\nWe":[592],"hypothesized":[593],"this":[603,616,745,771,826],"effect":[604,777,849],"could":[605,731],"partly":[606],"explain":[607],"reduced":[609],"consumption":[611],"with":[612,796,799,842],"To":[614],"test":[615,770],"hypothesis,":[617],"we":[618,774,910],"compared,":[619],"healthy":[621,816,870],"volunteers,":[622],"intravenous":[626,781],"infusion":[627,782],"on":[632,684,788,810,852,857],"(as":[636],"measured":[637],"by":[638,697,717,738],"SPECT":[640],"technique),":[641],"plasma":[645],"human":[646],"polypeptide":[648,704],"(a":[649],"surrogate":[650],"marker":[651],"abdominal":[654],"function)":[655],"volume":[658,839,854,881,916],"(Ensure_)":[664],"ingested":[665],"at":[666],"maximum":[667],"satiation.":[668],"The":[669,872],"results":[670,722],"first":[673,726,822],"study":[674,727,823],"showed":[675],"does":[678],"inhibit":[680],"accommodation;":[683],"contrary,":[686],"increased":[688],"fasting":[689],"volumes.":[693],"was":[695],"accompanied":[696],"marked":[699],"release,":[705],"which":[706],"under":[708],"cholinergic":[710,719,742],"control.":[711],"Since":[712],"tone":[714,897],"maintained":[716],"input,":[720],"observed":[723,921],"our":[725],"suggested":[728],"induce":[732,764],"(increase":[735,767],"volume)":[737],"pathways.":[743],"If":[744],"hypothesis":[746,773],"were":[747],"true,":[748],"one":[749],"would":[750,762],"predict":[751],"presence":[755,924],"dysfunction":[758],"vagotomy,":[760],"volume).\nTo":[769],"second":[772],"studied":[775],"same":[780],"compared":[785,804],"volumes":[790,806,865],"sample":[793],"subjects":[795,817],"diabetes":[797],"affected":[798],"neuropathy.":[801,844],"We":[802],"diabetic":[808,860],"patients":[809,861],"those":[813,868],"who":[818],"participated":[819],"presented":[824],"thesis.":[827],"In":[828],"contrast":[829],"health,":[833],"did":[835],"suggests":[846],"dependent":[856],"function.\nThe":[859],"evaluated":[862],"had":[863],"similar":[866],"controls.":[871],"nerve":[874],"participates":[875],"tone;":[883],"however,":[884],"there":[885,891],"other":[887],"mechanisms":[888],"involved.":[889],"Furthermore,":[890],"increasing":[893],"evidence":[894,932],"may":[898],"be":[899],"adequately":[900],"controlled":[901],"absence":[904],"extrinsic":[906],"innervation.":[908],"Thus,":[909],"believe":[911],"normal":[914],"neuropathy":[927],"adds":[928],"growing":[931],"existence":[935],"an":[937],"adaptive":[938],"preserving":[940],"main":[946],"vago-vagal":[947],"impaired.":[950]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
