{"id":"https://openalex.org/W12989601","doi":null,"title":"Nuclear receptor co-repressor functions in prostate cancer; in vitro, in vivo and in silico approaches","display_name":"Nuclear receptor co-repressor functions in prostate cancer; in vitro, in vivo and in silico approaches","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W12989601","mag":"12989601"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:961","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/961/1/Battaglia_10_PhD(2).pdf","pdf_url":"http://etheses.bham.ac.uk/961/1/Battaglia_10_PhD(2).pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk/961/1/Battaglia_10_PhD(2).pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035909488","display_name":"Sebastiano Battaglia","orcid":"https://orcid.org/0000-0002-0809-8925","observed_orcids":["https://orcid.org/0000-0002-0809-8925"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sebastiano Battaglia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0809-8925","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035909488"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ncor1","display_name":"NCOR1","score":0.8489999771118164},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9480000138282776},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9079999923706055},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.6370000243186951},{"id":"https://openalex.org/keywords/nuclear-receptor-ligands","display_name":"nuclear receptor ligands","score":0.6579999923706055},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.7110000252723694},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mir-106b","display_name":"miR-106b","score":0.9340000152587891},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8949999809265137},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.5379999876022339},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/rwpe-1-cells","display_name":"RWPE-1 cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.6499999761581421},{"id":"https://openalex.org/keywords/differential-equation-modeling","display_name":"differential equation modeling","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.7689002752304077},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.7139577269554138},{"id":"https://openalex.org/C71931279","wikidata":"https://www.wikidata.org/wiki/Q21163354","display_name":"Nuclear receptor co-repressor 1","level":5,"score":0.7119480967521667},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.6221957206726074},{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.5547463297843933},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5538166165351868},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5301500558853149},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5150024890899658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5080146789550781},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.44507819414138794},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.42596012353897095},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4010027050971985},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4006781578063965},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37650784850120544},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3245430588722229},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.22441095113754272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20664235949516296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16262882947921753}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:961","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/961/1/Battaglia_10_PhD(2).pdf","pdf_url":"http://etheses.bham.ac.uk/961/1/Battaglia_10_PhD(2).pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:39666","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/39666","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/39666","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/973920","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/973920","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:12989601","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/523248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.bham.ac.uk:961","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/961/1/Battaglia_10_PhD(2).pdf","pdf_url":"http://etheses.bham.ac.uk/961/1/Battaglia_10_PhD(2).pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W12989601.pdf","grobid_xml":"https://content.openalex.org/works/W12989601.grobid-xml"},"referenced_works_count":244,"referenced_works":["https://openalex.org/W13935827","https://openalex.org/W36644418","https://openalex.org/W45411047","https://openalex.org/W77403056","https://openalex.org/W105174845","https://openalex.org/W122685959","https://openalex.org/W260482935","https://openalex.org/W1500827124","https://openalex.org/W1501286679","https://openalex.org/W1555564331","https://openalex.org/W1589515559","https://openalex.org/W1595664534","https://openalex.org/W1602722523","https://openalex.org/W1603742465","https://openalex.org/W1774021084","https://openalex.org/W1930929720","https://openalex.org/W1964259728","https://openalex.org/W1964410726","https://openalex.org/W1965209245","https://openalex.org/W1965638835","https://openalex.org/W1965844075","https://openalex.org/W1969408132","https://openalex.org/W1969973975","https://openalex.org/W1970316586","https://openalex.org/W1974112332","https://openalex.org/W1974480729","https://openalex.org/W1974545855","https://openalex.org/W1975555167","https://openalex.org/W1976980117","https://openalex.org/W1977690815","https://openalex.org/W1978125779","https://openalex.org/W1978152488","https://openalex.org/W1978440962","https://openalex.org/W1979013814","https://openalex.org/W1979201752","https://openalex.org/W1980184187","https://openalex.org/W1980255372","https://openalex.org/W1980484736","https://openalex.org/W1981549228","https://openalex.org/W1983485363","https://openalex.org/W1984312216","https://openalex.org/W1985294723","https://openalex.org/W1986295047","https://openalex.org/W1986706724","https://openalex.org/W1986920308","https://openalex.org/W1988435907","https://openalex.org/W1989320965","https://openalex.org/W1989439170","https://openalex.org/W1991560250","https://openalex.org/W1992396112","https://openalex.org/W1994340334","https://openalex.org/W1994579379","https://openalex.org/W1994774468","https://openalex.org/W1996562417","https://openalex.org/W1997296963","https://openalex.org/W1998329483","https://openalex.org/W1999952815","https://openalex.org/W2000400490","https://openalex.org/W2001646335","https://openalex.org/W2002573435","https://openalex.org/W2003834271","https://openalex.org/W2003850828","https://openalex.org/W2003881043","https://openalex.org/W2004499293","https://openalex.org/W2005205814","https://openalex.org/W2005979791","https://openalex.org/W2006115709","https://openalex.org/W2006602286","https://openalex.org/W2007801101","https://openalex.org/W2009199987","https://openalex.org/W2010057554","https://openalex.org/W2011511955","https://openalex.org/W2011564579","https://openalex.org/W2011752009","https://openalex.org/W2012743472","https://openalex.org/W2013631206","https://openalex.org/W2014077252","https://openalex.org/W2014825118","https://openalex.org/W2014844101","https://openalex.org/W2014938226","https://openalex.org/W2015519364","https://openalex.org/W2021064276","https://openalex.org/W2023059525","https://openalex.org/W2026431475","https://openalex.org/W2026643140","https://openalex.org/W2028521239","https://openalex.org/W2029014149","https://openalex.org/W2029903254","https://openalex.org/W2032353251","https://openalex.org/W2033017094","https://openalex.org/W2035810647","https://openalex.org/W2035887348","https://openalex.org/W2036986058","https://openalex.org/W2037139350","https://openalex.org/W2037602187","https://openalex.org/W2038208040","https://openalex.org/W2038704446","https://openalex.org/W2040786715","https://openalex.org/W2041973176","https://openalex.org/W2042748226","https://openalex.org/W2042950613","https://openalex.org/W2044099516","https://openalex.org/W2044578262","https://openalex.org/W2045327167","https://openalex.org/W2045580211","https://openalex.org/W2045663280","https://openalex.org/W2045786960","https://openalex.org/W2047265005","https://openalex.org/W2047852384","https://openalex.org/W2047982128","https://openalex.org/W2048619491","https://openalex.org/W2050723217","https://openalex.org/W2052373759","https://openalex.org/W2052569390","https://openalex.org/W2053516868","https://openalex.org/W2053535373","https://openalex.org/W2053994646","https://openalex.org/W2054154194","https://openalex.org/W2054621094","https://openalex.org/W2054867367","https://openalex.org/W2059506882","https://openalex.org/W2061357909","https://openalex.org/W2063113345","https://openalex.org/W2064781419","https://openalex.org/W2066000490","https://openalex.org/W2066092624","https://openalex.org/W2066602623","https://openalex.org/W2066606290","https://openalex.org/W2067602854","https://openalex.org/W2068345721","https://openalex.org/W2068669347","https://openalex.org/W2069532898","https://openalex.org/W2069678913","https://openalex.org/W2069728007","https://openalex.org/W2072845271","https://openalex.org/W2074369446","https://openalex.org/W2077498188","https://openalex.org/W2080575646","https://openalex.org/W2081290486","https://openalex.org/W2081825803","https://openalex.org/W2082668371","https://openalex.org/W2084381245","https://openalex.org/W2084722787","https://openalex.org/W2084774843","https://openalex.org/W2085995080","https://openalex.org/W2085995738","https://openalex.org/W2086022508","https://openalex.org/W2086243404","https://openalex.org/W2086334687","https://openalex.org/W2087481253","https://openalex.org/W2087538939","https://openalex.org/W2087966689","https://openalex.org/W2088617756","https://openalex.org/W2089265203","https://openalex.org/W2090926709","https://openalex.org/W2091508315","https://openalex.org/W2091811407","https://openalex.org/W2092040814","https://openalex.org/W2092066950","https://openalex.org/W2092315209","https://openalex.org/W2094085100","https://openalex.org/W2094466137","https://openalex.org/W2094838095","https://openalex.org/W2095670338","https://openalex.org/W2096130703","https://openalex.org/W2097751554","https://openalex.org/W2098680943","https://openalex.org/W2100898329","https://openalex.org/W2100975741","https://openalex.org/W2102902397","https://openalex.org/W2103309832","https://openalex.org/W2103660187","https://openalex.org/W2106787323","https://openalex.org/W2107889588","https://openalex.org/W2107940486","https://openalex.org/W2108105541","https://openalex.org/W2112248146","https://openalex.org/W2113328569","https://openalex.org/W2114353725","https://openalex.org/W2115446838","https://openalex.org/W2115950918","https://openalex.org/W2116103211","https://openalex.org/W2117101063","https://openalex.org/W2117457278","https://openalex.org/W2117623267","https://openalex.org/W2118933841","https://openalex.org/W2119259534","https://openalex.org/W2119963896","https://openalex.org/W2121296685","https://openalex.org/W2121629705","https://openalex.org/W2121855055","https://openalex.org/W2122872071","https://openalex.org/W2126669746","https://openalex.org/W2132613286","https://openalex.org/W2134221701","https://openalex.org/W2135666845","https://openalex.org/W2136879986","https://openalex.org/W2137958038","https://openalex.org/W2137996608","https://openalex.org/W2138325394","https://openalex.org/W2139996974","https://openalex.org/W2140485864","https://openalex.org/W2141269411","https://openalex.org/W2141578914","https://openalex.org/W2141984537","https://openalex.org/W2144908726","https://openalex.org/W2146027649","https://openalex.org/W2149161400","https://openalex.org/W2149357952","https://openalex.org/W2150972506","https://openalex.org/W2151214732","https://openalex.org/W2151590954","https://openalex.org/W2153382986","https://openalex.org/W2153997114","https://openalex.org/W2154969680","https://openalex.org/W2156019168","https://openalex.org/W2157452165","https://openalex.org/W2158202559","https://openalex.org/W2158940923","https://openalex.org/W2160093177","https://openalex.org/W2161810908","https://openalex.org/W2162262059","https://openalex.org/W2162729480","https://openalex.org/W2163154029","https://openalex.org/W2163311832","https://openalex.org/W2166771233","https://openalex.org/W2169224393","https://openalex.org/W2169756968","https://openalex.org/W2169896733","https://openalex.org/W2170222722","https://openalex.org/W2171439874","https://openalex.org/W2171498534","https://openalex.org/W2172295707","https://openalex.org/W2181856912","https://openalex.org/W2312877617","https://openalex.org/W2315251287","https://openalex.org/W2322982840","https://openalex.org/W2410645982","https://openalex.org/W2605614532","https://openalex.org/W3063220799","https://openalex.org/W3196159008","https://openalex.org/W4214898406","https://openalex.org/W4235592864","https://openalex.org/W7217628649"],"related_works":["https://openalex.org/W183988001","https://openalex.org/W2134623198","https://openalex.org/W2293257570","https://openalex.org/W3043669410","https://openalex.org/W2890834051","https://openalex.org/W2167276745","https://openalex.org/W2009953806","https://openalex.org/W2122249887","https://openalex.org/W2765277266","https://openalex.org/W2050992957"],"abstract_inverted_index":{"Prostate":[0],"epithelial":[1,188],"cells":[2,18,23,61,84],"are":[3],"exquisitely":[4],"sensitive":[5],"to":[6,39,56,64,86,102,135,159],"Nuclear":[7,29],"Receptor":[8,30],"(NR)":[9],"ligands.":[10],"These":[11,172],"compounds":[12],"exert":[13],"anti-proliferative":[14],"effect":[15],"over":[16],"non-malignant":[17,65],"RWPE-1":[19,66],"while":[20],"malignant":[21],"PC-3":[22,60,83],"retain":[24],"their":[25,48],"proliferative":[26],"ability.":[27],"The":[28],"Co-Repressor":[31],"1":[32],"(NCOR1)":[33],"complexes":[34],"with":[35,89,130],"Histone":[36],"Deacetylases":[37],"(HDACs)":[38],"repress":[40],"the":[41,73,120,137,155,168,175],"action":[42],"of":[43,70,91,105,154,163,177],"unliganded":[44],"NRs,":[45],"hence,":[46],"inhibiting":[47],"transcriptional":[49,142],"and":[50,94,123],"phenotypical":[51],"effects.":[52],"NCOR1":[53,78],"was":[54,117,128],"found":[55],"be":[57],"over-expressed":[58],"in":[59,186],"when":[62],"compared":[63],"cells.":[67,189],"Chemical":[68],"inhibition":[69],"NCOR1,":[71],"via":[72,80,111,126,144],"HDAC":[74],"inhibitor":[75],"SAHA,":[76],"or":[77],"knock-down,":[79],"shRNA,":[81],"restored":[82],"sensitivity":[85],"NR":[87,184],"agonists":[88],"exception":[90],"Vitamin":[92],"D":[93],"Thyroid":[95],"Hormone":[96],"T3.":[97],"NCOR1-knock":[98],"down":[99,122],"led":[100],"also":[101],"a":[103,131,150,160,178],"re-expression":[104],"basally":[106],"repressed":[107],"genes,":[108],"as":[109],"measured":[110],"Microfluidic":[112],"Gene-Card":[113],"analysis":[114],"(Q-RTPCRm).":[115],"CDKN1A":[116,141,164],"de-repressed":[118],"by":[119],"knock":[121],"its":[124],"activation":[125],"VDR":[127],"modeled":[129],"systems":[132],"biology":[133],"approach":[134],"identify":[136],"mechanistic":[138],"events":[139],"behind":[140],"regulation":[143],"miRNAs.":[145],"Differential":[146],"equation":[147],"models":[148],"revealed":[149],"time-sensitive":[151],"activation,":[152],"VDR-dependent,":[153],"miRNA-miR106b":[156],"that":[157,182],"leads":[158],"steep":[161],"degradation":[162],"mRNA":[165],"levels":[166],"within":[167],"first":[169],"30":[170],"minutes.":[171],"results":[173],"support":[174],"idea":[176],"corrupted":[179],"regulatory":[180],"network":[181],"squelches":[183],"activity":[185],"prostate":[187]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}