{"id":"https://openalex.org/W12979833","doi":"https://doi.org/10.14670/hh-23.11","title":"Adrenomedullin expression in pituitary adenomas and nontumoral adenohypophyses.","display_name":"Adrenomedullin expression in pituitary adenomas and nontumoral adenohypophyses.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W12979833","doi":"https://doi.org/10.14670/hh-23.11","mag":"12979833","pmid":"https://pubmed.ncbi.nlm.nih.gov/17952853"},"language":"en","primary_location":{"id":"pmid:17952853","doi":"https://doi.org/10.14670/hh-23.11","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17952853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10201/29778","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049749614","display_name":"Matilde Lombardero","orcid":"https://orcid.org/0000-0003-2088-1207","observed_orcids":["https://orcid.org/0000-0003-2088-1207"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M Lombardero","raw_affiliation_strings":["Department of Anatomy and A.P., Faculty of Veterinary Sciences, University of Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and A.P., Faculty of Veterinary Sciences, University of Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110132096","display_name":"K\u00e1lm\u00e1n Kov\u00e1cs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kovacs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045003878","display_name":"\u00c9va Horv\u00e1th","orcid":"https://orcid.org/0009-0002-2526-7070","observed_orcids":["https://orcid.org/0009-0002-2526-7070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Horvath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110883848","display_name":"Bernd Walter Scheithauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B W Scheithauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040817691","display_name":"Fabio Rotondo","orcid":"https://orcid.org/0009-0003-6459-9147","observed_orcids":["https://orcid.org/0009-0003-6459-9147","https://orcid.org/0000-0002-5344-7311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Rotondo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000751475","display_name":"Fateme Salehi","orcid":"https://orcid.org/0000-0002-5866-5377","observed_orcids":["https://orcid.org/0000-0002-5866-5377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Salehi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110331817","display_name":"Ricardo V. Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["CA","ES","US"],"is_corresponding":false,"raw_author_name":"R V Lloyd","raw_affiliation_strings":["Mayo Clinic","St. Michael's Hospital","Universidade de Santiago de Compostela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"St. Michael's Hospital","institution_ids":["https://openalex.org/I1297363086"]},{"raw_affiliation_string":"Universidade de Santiago de Compostela","institution_ids":["https://openalex.org/I200284239"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.00253333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"23","issue":"1","first_page":"11","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenomedullin","display_name":"adrenomedullin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pituitary-adenoma","display_name":"pituitary adenoma","score":0.9079999923706055},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.9520000219345093},{"id":"https://openalex.org/keywords/gonadotrophs","display_name":"gonadotrophs","score":0.9409999847412109},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.7689999938011169},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nonfunctioning-pituitary-adenoma","display_name":"non-functioning pituitary adenoma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7139999866485596},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C2777152744","wikidata":"https://www.wikidata.org/wiki/Q366935","display_name":"Adrenomedullin","level":3,"score":0.8939350843429565},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.6694477796554565},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5928072333335876},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5827178359031677},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.550519585609436},{"id":"https://openalex.org/C197012351","wikidata":"https://www.wikidata.org/wiki/Q3099316","display_name":"Gonadotropic cell","level":4,"score":0.5166666507720947},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.51333087682724},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5075572729110718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45561230182647705},{"id":"https://openalex.org/C78795084","wikidata":"https://www.wikidata.org/wiki/Q5113900","display_name":"Chromophobe cell","level":4,"score":0.4466354250907898},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39643871784210205},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37603646516799927},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3444285988807678},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1510334014892578},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.07006096839904785}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053607","descriptor_name":"Adrenomedullin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053607","descriptor_name":"Adrenomedullin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmid:17952853","doi":"https://doi.org/10.14670/hh-23.11","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17952853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Journal Article"},{"id":"pmh:oai:digitum.um.es:10201/29778","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/29778","pdf_url":"http://hdl.handle.net/10201/29778","source":{"id":"https://openalex.org/S4306401267","display_name":"Digitum: Institutional Repository of the University of Murcia (University of Murcia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80180929","host_organization_name":"Universidad de Murcia","host_organization_lineage":["https://openalex.org/I80180929"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dnet:digitum_____::ec82920d13768514e910abcdc0809ca9","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/29778","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:hispana.mcu.es:61734731","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/29778","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:12979833","doi":"https://doi.org/10.14670/hh-23.11","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17952853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitum.um.es:10201/29778","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/29778","pdf_url":"http://hdl.handle.net/10201/29778","source":{"id":"https://openalex.org/S4306401267","display_name":"Digitum: Institutional Repository of the University of Murcia (University of Murcia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80180929","host_organization_name":"Universidad de Murcia","host_organization_lineage":["https://openalex.org/I80180929"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W12979833.pdf","grobid_xml":"https://content.openalex.org/works/W12979833.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W108727682","https://openalex.org/W1534165161","https://openalex.org/W1570659420","https://openalex.org/W1824926677","https://openalex.org/W1977794841","https://openalex.org/W1979773904","https://openalex.org/W1985488507","https://openalex.org/W1985833604","https://openalex.org/W1999772563","https://openalex.org/W2024660080","https://openalex.org/W2027578274","https://openalex.org/W2027815328","https://openalex.org/W2051143396","https://openalex.org/W2056803964","https://openalex.org/W2060028993","https://openalex.org/W2074295150","https://openalex.org/W2076820430","https://openalex.org/W2078164089","https://openalex.org/W2089893988","https://openalex.org/W2092419989","https://openalex.org/W2094405074","https://openalex.org/W2104583114","https://openalex.org/W2106987138","https://openalex.org/W2111646407","https://openalex.org/W2121353747","https://openalex.org/W2123033691","https://openalex.org/W2146182395","https://openalex.org/W2155728016","https://openalex.org/W2294638471","https://openalex.org/W2401084230","https://openalex.org/W2408087544","https://openalex.org/W2425015118"],"related_works":["https://openalex.org/W1824926677","https://openalex.org/W2027578274","https://openalex.org/W3147587856","https://openalex.org/W2160340521","https://openalex.org/W2060028993","https://openalex.org/W7101010887","https://openalex.org/W2083727742","https://openalex.org/W2415669212","https://openalex.org/W2134882935","https://openalex.org/W1979773904"],"abstract_inverted_index":{"Adrenomedullin":[0],"(ADM)":[1],"is":[2,14,131,146],"a":[3,76,153],"novel":[4],"peptide":[5],"originally":[6],"identified":[7],"in":[8,31,42,54,81,90,99,127,133,158],"extracts":[9],"of":[10,25,39,106,144],"human":[11,43],"pheochromocytoma.":[12],"It":[13],"produced":[15],"by":[16],"several":[17],"tissues,":[18],"including":[19],"the":[20,100,128,138,159],"pituitary":[21,33,44,61,130],"gland.":[22,140],"The":[23,141],"presence":[24],"ADM":[26,40,52,71,89,107,119,125,145],"has":[27,46],"been":[28,47],"immunohistochemically":[29],"demonstrated":[30],"pathologic":[32],"glands,":[34],"but":[35,148],"no":[36],"systematic":[37],"study":[38],"expression":[41,105,126],"adenomas":[45],"reported.":[48],"Thus,":[49],"we":[50],"investigated":[51],"immunoexpression":[53],"88":[55],"various":[56],"hormone-secreting":[57],"and":[58,96],"clinically":[59],"nonfunctioning":[60],"adenoma":[62],"types":[63,104],"as":[64,66,135,152],"well":[65],"30":[67],"nontumoral":[68],"adenohypophyses.":[69],"Furthermore,":[70],"immunoreactivity":[72],"was":[73,108],"assessed":[74],"on":[75],"0":[77],"to":[78,137],"+3":[79],"scale":[80],"all":[82],"samples.":[83],"We":[84],"found":[85],"strong":[86],"immunoreativity":[87],"for":[88,118],"normal":[91,113,139],"gonadotrophs":[92],"also":[93],"expressing":[94],"FSH":[95],"LH":[97],"whereas":[98],"other":[101],"adenohypophysial":[102],"cell":[103],"mild.":[109],"Results":[110],"showed":[111],"that":[112,124],"adenohypophyses":[114],"were":[115],"strongly":[116],"immunopositive":[117],"(2.18+/-0.11).":[120],"Our":[121],"findings":[122],"demonstrate":[123],"anterior":[129],"diminished":[132],"tumors":[134],"compared":[136],"physiologic":[142],"function":[143],"unknown,":[147],"it":[149],"could":[150],"act":[151],"paracrine":[154],"or":[155],"autocrine":[156],"factor":[157],"adenohypophysis.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}