{"id":"https://openalex.org/W129743878","doi":null,"title":"The primate spliceosomal snRNA transcriptome as revealed by deep sequencing","display_name":"The primate spliceosomal snRNA transcriptome as revealed by deep sequencing","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W129743878","mag":"129743878"},"language":"en","primary_location":{"id":"mag:129743878","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A514632","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087036768","display_name":"Lei Liu Conze","orcid":"https://orcid.org/0000-0001-8698-3842","observed_orcids":["https://orcid.org/0000-0001-8698-3842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Liu Conze","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8698-3842","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038814932","display_name":"Richard Edward Green","orcid":"https://orcid.org/0000-0003-0516-5827","observed_orcids":["https://orcid.org/0000-0003-0516-5827"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard E. Green","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0516-5827","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103332807","display_name":"Larsson Pontus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larsson Pontus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058502394","display_name":"Jens Schuster","orcid":"https://orcid.org/0000-0002-4383-9880","observed_orcids":["https://orcid.org/0000-0002-4383-9880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jens Schuster","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4383-9880","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008293185","display_name":"Matthias Meyer","orcid":"https://orcid.org/0000-0002-4760-558X","observed_orcids":["https://orcid.org/0000-0002-4760-558X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias Meyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044203404","display_name":"Adrian W. Briggs","orcid":"https://orcid.org/0009-0001-1644-658X","observed_orcids":["https://orcid.org/0009-0001-1644-658X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrian W. Briggs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039289441","display_name":"Anders Virtanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anders Virtanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00854015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8949999809265137},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.8349999785423279},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8059999942779541},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.35600000619888306},{"id":"https://openalex.org/keywords/chimpanzees","display_name":"chimpanzees","score":1.0},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.9039999842643738},{"id":"https://openalex.org/keywords/splicing-regulation","display_name":"splicing regulation","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7959810495376587},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7035936117172241},{"id":"https://openalex.org/C100299639","wikidata":"https://www.wikidata.org/wiki/Q284578","display_name":"Small nuclear RNA","level":5,"score":0.7006962299346924},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6386207342147827},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6008163690567017},{"id":"https://openalex.org/C68483431","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"snRNP","level":5,"score":0.5583006739616394},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5386782288551331},{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.49671393632888794},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49047109484672546},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.47498267889022827},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43832331895828247},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3658999800682068},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3610287308692932},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.2918992042541504},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.17967134714126587},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:129743878","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A514632","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.550000011920929,"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W108837255","https://openalex.org/W122536167","https://openalex.org/W3180739613","https://openalex.org/W2171805656","https://openalex.org/W2370988846","https://openalex.org/W2969538625","https://openalex.org/W7208737718","https://openalex.org/W1988352576","https://openalex.org/W4390263094","https://openalex.org/W2056403897"],"abstract_inverted_index":{"The":[0,37],"concept":[1],"of":[2,23,31,49,87,108,117,124,147,174,197,216,244,252,274],"the":[3,13,20,28,35,70,75,84,88,113,120,138,171,184,195,205,242,260,271],"gene":[4,181,206],"has":[5,39,158],"been":[6,41,256],"constantly":[7],"challenged":[8],"by":[9,82,247],"new":[10],"discoveries":[11],"in":[12,44,63,67,99,103,142,187,228,241,276],"life":[14],"sciences.":[15],"Recent":[16],"challenging":[17],"observations":[18],"include":[19],"high":[21,151],"frequency":[22],"alternative":[24,56,78,245],"splicing":[25,57,79,98,114,246,250,261],"events":[26],"and":[27,58,80,111,122,150,163,183,231,280],"common":[29],"transcription":[30],"non-protein-coding-RNAs":[32],"(ncRNAs)":[33],"from":[34,51,178],"genome.":[36],"latter":[38],"long":[40],"considered":[42],"noise":[43],"biological":[45,272],"systems.":[46],"Multiple":[47],"lines":[48],"evidence":[50],"genomic":[52],"studies":[53],"indicate":[54],"that":[55,160,204,208],"ncRNA":[59],"play":[60,238],"important":[61],"roles":[62],"expanding":[64],"proteome":[65],"diversity":[66,123],"eukaryotes.":[68,100],"Here,":[69],"aim":[71],"is":[72],"to":[73,129,194,258,269],"find":[74],"link":[76],"between":[77],"ncRNAs":[81],"studying":[83],"expression":[85],"profile":[86],"spliceosomal":[89],"snRNAs":[90,93,126,176,218,236],"(U":[91],"snRNA).Spliceosomal":[92],"are":[94,219],"essential":[95],"for":[96],"pre-mRNA":[97],"They":[101],"participate":[102],"splice":[104],"site":[105],"selection,":[106],"recruitment":[107],"protein":[109],"factors":[110],"catalyzing":[112],"reaction.":[115],"Because":[116],"this,":[118],"both":[119],"abundance":[121],"U":[125,139,167,175,188,217,253,277],"were":[127,226],"expected":[128],"be":[130],"large.":[131],"In":[132],"our":[133,229,264],"study":[134,265,270],"we":[135],"deeply":[136],"analyzed":[137],"snRNA":[140,168,189,254,278],"population":[141,215],"primates":[143],"using":[144],"a":[145,212,239,267],"combination":[146],"bioinformatical,":[148],"biochemical":[149],"throughput":[152],"sequencing":[153],"approaches.":[154],"This":[155],"transcriptome":[156],"profiling":[157],"revealed":[159],"human,":[161],"chimpanzee":[162],"rhesus":[164],"have":[165,255],"similar":[166],"populations,":[169],"i.e.":[170],"vast":[172],"majority":[173],"originate":[177],"few":[179,223],"well-defined":[180],"loci":[182,207],"heterogeneity":[185],"observed":[186],"populations":[190],"was":[191],"largely":[192],"due":[193],"presence":[196],"SNPs":[198,275],"at":[199],"these":[200],"loci.":[201],"It":[202],"seems":[203],"could":[209],"potentially":[210],"encode":[211],"significantly":[213],"heterogeneous":[214],"mostly":[220],"silent.":[221],"Only":[222],"minority":[224],"transcripts":[225],"detected":[227],"study,":[230],"among":[232],"them":[233],"three":[234],"U1-like":[235],"might":[237],"role":[240],"regulation":[243],"recognizing":[248],"non-canonical":[249],"sites.Mutations":[251],"shown":[257],"impact":[259],"process.":[262],"Therefore,":[263],"provides":[266],"reference":[268],"significance":[273],"genes":[279],"their":[281],"association":[282],"with":[283],"diseases.":[284]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
