{"id":"https://openalex.org/W129734052","doi":null,"title":"Does Rap1 mix and match","display_name":"Does Rap1 mix and match","publication_year":2009,"publication_date":"2009-06-02","ids":{"openalex":"https://openalex.org/W129734052","mag":"129734052"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/33847","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/33847","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.library.uu.nl:8080/handle/1874/33847","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086213785","display_name":"Arjan Post","orcid":"https://orcid.org/0000-0003-3838-011X","observed_orcids":["https://orcid.org/0000-0003-3838-011X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Arjan Post","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086213785"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.07069999724626541,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rap1","display_name":"Rap1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/raf-mek-erk-pathway","display_name":"Raf/MEK/ERK pathway","score":0.9330000281333923},{"id":"https://openalex.org/keywords/integrin-activation","display_name":"integrin activation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/raf-1","display_name":"Raf-1","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2776179587","wikidata":"https://www.wikidata.org/wiki/Q54461864","display_name":"Rap1","level":3,"score":0.5049193501472473},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33857351541519165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15389183163642883},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/33847","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/33847","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:129734052","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/handle/1874/33847/Rap1%20thesis%20A.%20Post.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/33847","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/33847","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W164957562","https://openalex.org/W1498760971","https://openalex.org/W1526383449","https://openalex.org/W1560618466","https://openalex.org/W1623614426","https://openalex.org/W1773465307","https://openalex.org/W1885709862","https://openalex.org/W1966386737","https://openalex.org/W1971241138","https://openalex.org/W1973568352","https://openalex.org/W1975131304","https://openalex.org/W1975345515","https://openalex.org/W1976849281","https://openalex.org/W1979565835","https://openalex.org/W1980676029","https://openalex.org/W1982349843","https://openalex.org/W1983575720","https://openalex.org/W1986185207","https://openalex.org/W1991590387","https://openalex.org/W1991930853","https://openalex.org/W1993230013","https://openalex.org/W1995404993","https://openalex.org/W1995553619","https://openalex.org/W1996645283","https://openalex.org/W1996830465","https://openalex.org/W1997098580","https://openalex.org/W1998868831","https://openalex.org/W1999141661","https://openalex.org/W2001640037","https://openalex.org/W2003229639","https://openalex.org/W2003879013","https://openalex.org/W2008575015","https://openalex.org/W2009080196","https://openalex.org/W2011098845","https://openalex.org/W2012806962","https://openalex.org/W2013549218","https://openalex.org/W2014606667","https://openalex.org/W2015341098","https://openalex.org/W2016095963","https://openalex.org/W2016775197","https://openalex.org/W2018884883","https://openalex.org/W2018888894","https://openalex.org/W2023969596","https://openalex.org/W2026769136","https://openalex.org/W2028188226","https://openalex.org/W2030282026","https://openalex.org/W2031178514","https://openalex.org/W2031446047","https://openalex.org/W2031872827","https://openalex.org/W2032140254","https://openalex.org/W2032629917","https://openalex.org/W2033160174","https://openalex.org/W2034900375","https://openalex.org/W2038063954","https://openalex.org/W2039712657","https://openalex.org/W2040750859","https://openalex.org/W2040865177","https://openalex.org/W2048580726","https://openalex.org/W2052438966","https://openalex.org/W2052750490","https://openalex.org/W2053713095","https://openalex.org/W2055737181","https://openalex.org/W2058325118","https://openalex.org/W2059300671","https://openalex.org/W2062604072","https://openalex.org/W2063193026","https://openalex.org/W2064712236","https://openalex.org/W2067711179","https://openalex.org/W2070564840","https://openalex.org/W2071337276","https://openalex.org/W2073304797","https://openalex.org/W2075099549","https://openalex.org/W2075158125","https://openalex.org/W2077754734","https://openalex.org/W2077788859","https://openalex.org/W2079541312","https://openalex.org/W2079562848","https://openalex.org/W2082889823","https://openalex.org/W2083063047","https://openalex.org/W2083268673","https://openalex.org/W2089169139","https://openalex.org/W2090115932","https://openalex.org/W2092207202","https://openalex.org/W2094080636","https://openalex.org/W2099853794","https://openalex.org/W2100999260","https://openalex.org/W2103746902","https://openalex.org/W2104235973","https://openalex.org/W2104310645","https://openalex.org/W2105651402","https://openalex.org/W2106435662","https://openalex.org/W2106993162","https://openalex.org/W2109016302","https://openalex.org/W2109319033","https://openalex.org/W2112281734","https://openalex.org/W2114857520","https://openalex.org/W2123586247","https://openalex.org/W2127144515","https://openalex.org/W2133683853","https://openalex.org/W2134484018","https://openalex.org/W2137373737","https://openalex.org/W2141277115","https://openalex.org/W2142203996","https://openalex.org/W2143086493","https://openalex.org/W2143563119","https://openalex.org/W2146946054","https://openalex.org/W2148417985","https://openalex.org/W2152561142","https://openalex.org/W2157838823","https://openalex.org/W2158293024","https://openalex.org/W2161057669","https://openalex.org/W2164097208","https://openalex.org/W2164227785","https://openalex.org/W2164767056","https://openalex.org/W2166455924","https://openalex.org/W2166606571","https://openalex.org/W2217357219","https://openalex.org/W2321031632","https://openalex.org/W2328366150","https://openalex.org/W2346147167","https://openalex.org/W2388163742"],"related_works":["https://openalex.org/W1974791474","https://openalex.org/W2047922419","https://openalex.org/W1983790767","https://openalex.org/W1974391453","https://openalex.org/W2083063047","https://openalex.org/W1494692540","https://openalex.org/W2625053490","https://openalex.org/W2023969596","https://openalex.org/W2558003740","https://openalex.org/W2159273977"],"abstract_inverted_index":{"Rap1":[0,15,27,51,77,95,109,120,203],"is":[1,82,121,154,199],"a":[2,18,23],"monomeric":[3],"G":[4,13],"protein":[5],"belonging":[6],"to":[7,31,42,99,133,144,150,168,191,200],"the":[8,33,48,55,67,79,88,92,124,142,145,159,209],"Ras":[9],"superfamily.":[10],"As":[11],"other":[12,160],"proteins,":[14],"cycles":[16],"between":[17],"GTP-bound,":[19],"active":[20],"state":[21],"and":[22,105,117,184,212],"GDP-bound,":[24],"inactive":[25,63],"state.":[26],"was":[28,40],"first":[29],"discovered":[30],"inhibit":[32,54,164,169],"transforming":[34],"properties":[35],"of":[36,76,126,196,221],"Ras.":[37],"Later":[38],"it":[39],"found":[41,98],"have":[43],"several":[44],"functions.":[45],"Depending":[46],"on":[47,87,141],"subcellular":[49,74],"context,":[50],"can":[52,110],"either":[53],"Raf/MEK/ERK":[56,68,89,93,210],"pathway":[57,69,211],"by":[58,70,113,129],"binding":[59],"Raf-1":[60],"in":[61,102,148,166,186],"an":[62],"complex,":[64],"or":[65],"activate":[66,111],"activating":[71,208],"B-Raf.":[72],"The":[73,194],"pool":[75],"at":[78],"plasma":[80],"membrane":[81],"responsible":[83,122],"for":[84,123,188],"its":[85,115],"effects":[86],"pathway.":[90],"\\nBesides":[91],"pathway,":[94],"has":[96],"been":[97],"be":[100],"involved":[101],"integrin":[103,213],"activation":[104,214],"adherens":[106,127,136,162,216],"junction":[107,217],"formation.":[108],"integrins":[112,183],"enhancing":[114],"affinity":[116],"avidity.":[118],"Furthermore,":[119],"maturation":[125],"junctions":[128,163],"inducing":[130],"cadherin":[131],"recruitment":[132],"newly":[134],"forming":[135],"junctions.":[137],"\\nAdherent":[138],"cells":[139],"depend":[140],"adherence":[143],"extracellular":[146,173],"matrix":[147],"order":[149,167,187],"allow":[151],"proliferation.":[152],"This":[153],"mediated":[155],"through":[156],"integrins.":[157],"On":[158],"hand,":[161],"proliferation":[165,190],"unchecked":[170],"growth.":[171],"Thus,":[172],"growth":[174,206],"signals":[175,181,207],"must":[176],"ne":[177],"well":[178],"coordinated":[179],"with":[180],"from":[182],"cadherins":[185],"proper":[189],"take":[192],"place.":[193],"scope":[195],"this":[197],"thesis":[198],"determine":[201],"whether":[202],"could":[204],"interconnect":[205],"and/or":[215],"formation,":[218],"allowing":[219],"coordination":[220],"these":[222],"separate":[223],"events.":[224]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
