{"id":"https://openalex.org/W129705372","doi":null,"title":"Islet Xenotransplantation: toward a cure for diabetes","display_name":"Islet Xenotransplantation: toward a cure for diabetes","publication_year":2011,"publication_date":"2011-06-21","ids":{"openalex":"https://openalex.org/W129705372","mag":"129705372"},"language":"en","primary_location":{"id":"mag:129705372","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/23681/110621_Windt-Dirk-Jan-van-der.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038140786","display_name":"Dirk J. van der Windt","orcid":"https://orcid.org/0000-0001-8839-577X","observed_orcids":["https://orcid.org/0000-0001-8839-577X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dirk J. van der Windt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038140786"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.5160999894142151,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.5160999894142151,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.4814000129699707,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet-xenotransplantation","display_name":"islet xenotransplantation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7279999852180481},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.7480000257492065},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.578000009059906},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7310000061988831},{"id":"https://openalex.org/keywords/exocrine-pancreas","display_name":"exocrine pancreas","score":0.6959999799728394},{"id":"https://openalex.org/keywords/pancreas-transplantation","display_name":"pancreas transplantation","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.7764952182769775},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.6673259735107422},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5797712802886963},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5587486028671265},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5261244773864746},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5164592266082764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5147511959075928},{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.4980285167694092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4920946955680847},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.48957809805870056},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4861840605735779},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.4591372311115265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3365795612335205}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:129705372","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/23681/110621_Windt-Dirk-Jan-van-der.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":290,"referenced_works":["https://openalex.org/W73107674","https://openalex.org/W198950289","https://openalex.org/W206701427","https://openalex.org/W297903042","https://openalex.org/W1485526722","https://openalex.org/W1496079450","https://openalex.org/W1511608972","https://openalex.org/W1517172525","https://openalex.org/W1519531812","https://openalex.org/W1531618550","https://openalex.org/W1547507373","https://openalex.org/W1550517269","https://openalex.org/W1552082712","https://openalex.org/W1556405737","https://openalex.org/W1562820093","https://openalex.org/W1580373248","https://openalex.org/W1585770671","https://openalex.org/W1606417387","https://openalex.org/W1608842679","https://openalex.org/W1696581921","https://openalex.org/W1698216789","https://openalex.org/W1752045965","https://openalex.org/W1752100137","https://openalex.org/W1811402656","https://openalex.org/W1826628219","https://openalex.org/W1849103171","https://openalex.org/W1864268059","https://openalex.org/W1965319363","https://openalex.org/W1966432380","https://openalex.org/W1966568879","https://openalex.org/W1966857537","https://openalex.org/W1968448831","https://openalex.org/W1969742343","https://openalex.org/W1969922813","https://openalex.org/W1970127550","https://openalex.org/W1970376329","https://openalex.org/W1970845404","https://openalex.org/W1971470814","https://openalex.org/W1972357761","https://openalex.org/W1972785772","https://openalex.org/W1974609577","https://openalex.org/W1975279687","https://openalex.org/W1975762253","https://openalex.org/W1976199229","https://openalex.org/W1976990715","https://openalex.org/W1978451233","https://openalex.org/W1979038362","https://openalex.org/W1981480494","https://openalex.org/W1981498160","https://openalex.org/W1983209431","https://openalex.org/W1983813529","https://openalex.org/W1985097433","https://openalex.org/W1985356825","https://openalex.org/W1985498833","https://openalex.org/W1985544303","https://openalex.org/W1986225549","https://openalex.org/W1986465331","https://openalex.org/W1987694689","https://openalex.org/W1987992258","https://openalex.org/W1988121754","https://openalex.org/W1988256776","https://openalex.org/W1989844646","https://openalex.org/W1990341094","https://openalex.org/W1990434622","https://openalex.org/W1990980573","https://openalex.org/W1991223923","https://openalex.org/W1991479231","https://openalex.org/W1993030810","https://openalex.org/W1993579114","https://openalex.org/W1994307941","https://openalex.org/W1995101370","https://openalex.org/W1995568445","https://openalex.org/W1996518807","https://openalex.org/W1996997425","https://openalex.org/W1998148424","https://openalex.org/W1998944797","https://openalex.org/W1999261642","https://openalex.org/W2001452398","https://openalex.org/W2002448034","https://openalex.org/W2003878418","https://openalex.org/W2004128160","https://openalex.org/W2005515353","https://openalex.org/W2005536112","https://openalex.org/W2005599815","https://openalex.org/W2006561389","https://openalex.org/W2006590912","https://openalex.org/W2006787694","https://openalex.org/W2006919788","https://openalex.org/W2007129817","https://openalex.org/W2007203700","https://openalex.org/W2007233326","https://openalex.org/W2007363285","https://openalex.org/W2009034832","https://openalex.org/W2009715480","https://openalex.org/W2010450410","https://openalex.org/W2012320162","https://openalex.org/W2012549523","https://openalex.org/W2014944668","https://openalex.org/W2016124159","https://openalex.org/W2018485187","https://openalex.org/W2020267609","https://openalex.org/W2021509402","https://openalex.org/W2021646109","https://openalex.org/W2022217630","https://openalex.org/W2024273144","https://openalex.org/W2024711583","https://openalex.org/W2025013227","https://openalex.org/W2025695769","https://openalex.org/W2025943017","https://openalex.org/W2026097978","https://openalex.org/W2026822923","https://openalex.org/W2028212562","https://openalex.org/W2028297024","https://openalex.org/W2029915395","https://openalex.org/W2032487978","https://openalex.org/W2034160312","https://openalex.org/W2034627511","https://openalex.org/W2034902726","https://openalex.org/W2035010412","https://openalex.org/W2035055926","https://openalex.org/W2036413946","https://openalex.org/W2036996065","https://openalex.org/W2038126534","https://openalex.org/W2038691484","https://openalex.org/W2038789463","https://openalex.org/W2039004105","https://openalex.org/W2040730133","https://openalex.org/W2042248138","https://openalex.org/W2044091791","https://openalex.org/W2044839499","https://openalex.org/W2045006713","https://openalex.org/W2045125356","https://openalex.org/W2045588775","https://openalex.org/W2046110140","https://openalex.org/W2046452166","https://openalex.org/W2047768051","https://openalex.org/W2048438191","https://openalex.org/W2049982658","https://openalex.org/W2052514340","https://openalex.org/W2052719306","https://openalex.org/W2052802056","https://openalex.org/W2053386318","https://openalex.org/W2054169358","https://openalex.org/W2054623041","https://openalex.org/W2055201358","https://openalex.org/W2057607651","https://openalex.org/W2057966927","https://openalex.org/W2058547069","https://openalex.org/W2058734603","https://openalex.org/W2059032931","https://openalex.org/W2059059809","https://openalex.org/W2059581409","https://openalex.org/W2060070176","https://openalex.org/W2061190448","https://openalex.org/W2061464382","https://openalex.org/W2061540320","https://openalex.org/W2061841135","https://openalex.org/W2063030983","https://openalex.org/W2063423653","https://openalex.org/W2063454151","https://openalex.org/W2063929679","https://openalex.org/W2065707431","https://openalex.org/W2065745112","https://openalex.org/W2065751770","https://openalex.org/W2066300564","https://openalex.org/W2066808970","https://openalex.org/W2067305414","https://openalex.org/W2069098685","https://openalex.org/W2069307627","https://openalex.org/W2071119322","https://openalex.org/W2071475464","https://openalex.org/W2071535279","https://openalex.org/W2072617248","https://openalex.org/W2074332806","https://openalex.org/W2074625649","https://openalex.org/W2075613131","https://openalex.org/W2076129653","https://openalex.org/W2076355973","https://openalex.org/W2080256413","https://openalex.org/W2081695157","https://openalex.org/W2082547072","https://openalex.org/W2083063864","https://openalex.org/W2084245368","https://openalex.org/W2084438950","https://openalex.org/W2085516849","https://openalex.org/W2085878243","https://openalex.org/W2086216240","https://openalex.org/W2086318157","https://openalex.org/W2088289399","https://openalex.org/W2089101299","https://openalex.org/W2092136358","https://openalex.org/W2093532675","https://openalex.org/W2095505431","https://openalex.org/W2097573911","https://openalex.org/W2099001943","https://openalex.org/W2101043709","https://openalex.org/W2101173482","https://openalex.org/W2101716510","https://openalex.org/W2102387814","https://openalex.org/W2102892562","https://openalex.org/W2103302057","https://openalex.org/W2103706790","https://openalex.org/W2106078708","https://openalex.org/W2106218580","https://openalex.org/W2108040825","https://openalex.org/W2108255115","https://openalex.org/W2108266187","https://openalex.org/W2108313671","https://openalex.org/W2108979344","https://openalex.org/W2110325792","https://openalex.org/W2111886083","https://openalex.org/W2112890973","https://openalex.org/W2113627614","https://openalex.org/W2113719877","https://openalex.org/W2114055381","https://openalex.org/W2114746698","https://openalex.org/W2115701666","https://openalex.org/W2116611386","https://openalex.org/W2117543456","https://openalex.org/W2118320592","https://openalex.org/W2118514868","https://openalex.org/W2119303704","https://openalex.org/W2119408313","https://openalex.org/W2121699757","https://openalex.org/W2122344882","https://openalex.org/W2122830690","https://openalex.org/W2124551895","https://openalex.org/W2127881971","https://openalex.org/W2128219297","https://openalex.org/W2129568900","https://openalex.org/W2130644929","https://openalex.org/W2132594405","https://openalex.org/W2132705610","https://openalex.org/W2132956587","https://openalex.org/W2133041135","https://openalex.org/W2133186034","https://openalex.org/W2133741976","https://openalex.org/W2134703404","https://openalex.org/W2134784775","https://openalex.org/W2135606708","https://openalex.org/W2136127635","https://openalex.org/W2137171012","https://openalex.org/W2137315507","https://openalex.org/W2139685116","https://openalex.org/W2140778701","https://openalex.org/W2143333559","https://openalex.org/W2143468368","https://openalex.org/W2143487734","https://openalex.org/W2144187890","https://openalex.org/W2144965623","https://openalex.org/W2145047873","https://openalex.org/W2145416905","https://openalex.org/W2146651194","https://openalex.org/W2149360034","https://openalex.org/W2151487860","https://openalex.org/W2152189447","https://openalex.org/W2152724745","https://openalex.org/W2153669290","https://openalex.org/W2153697534","https://openalex.org/W2154507669","https://openalex.org/W2155623284","https://openalex.org/W2155676759","https://openalex.org/W2156717841","https://openalex.org/W2157203184","https://openalex.org/W2158070939","https://openalex.org/W2162120036","https://openalex.org/W2164277825","https://openalex.org/W2165314607","https://openalex.org/W2165468650","https://openalex.org/W2165563030","https://openalex.org/W2167738785","https://openalex.org/W2168128391","https://openalex.org/W2169838924","https://openalex.org/W2169901386","https://openalex.org/W2170386768","https://openalex.org/W2171678230","https://openalex.org/W2273888401","https://openalex.org/W2288875579","https://openalex.org/W2294982637","https://openalex.org/W2322121630","https://openalex.org/W2328786770","https://openalex.org/W2400483822","https://openalex.org/W2403341575","https://openalex.org/W2415077403","https://openalex.org/W2416956206","https://openalex.org/W2433290023","https://openalex.org/W2474391416","https://openalex.org/W2769264260","https://openalex.org/W4313311481","https://openalex.org/W4320288060"],"related_works":["https://openalex.org/W2231594688","https://openalex.org/W3142248223","https://openalex.org/W2062707784","https://openalex.org/W4211199261","https://openalex.org/W4234195513","https://openalex.org/W4236047184","https://openalex.org/W207116702","https://openalex.org/W6999090579","https://openalex.org/W146632560","https://openalex.org/W4211066584"],"abstract_inverted_index":{"textabstractThe":[0],"pancreas":[1,87],"is":[2,33,57],"an":[3,52,90],"organ":[4],"with":[5],"a":[6,13,116,126],"central":[7,14],"anatomical":[8],"position":[9],"in":[10,16,97,105,121,143,154],"the":[11,17,76,86,106,155],"abdomen,\r\nand":[12],"role":[15,142],"processes":[18],"of":[19,27,39,59,85,108,136,152,157],"food":[20],"digestion":[21],"and":[22,37,49,67],"glucose":[23,80,144],"metabolism.\r\nThe":[24],"vast":[25],"majority":[26],"pancreatic":[28],"tissue":[29,110],"(more":[30],"than":[31],"98%)":[32],"dedicated":[34],"to":[35,78,163],"the\r\nproduction":[36],"secretion":[38],"digestive":[40],"enzymes":[41],"that":[42,72,131],"are":[43,73,95],"released":[44,74],"into":[45,75],"the\r\nproximal":[46],"small":[47,83,98],"intestine,":[48],"therefore":[50,88],"has":[51,89],"exocrine":[53,109],"function.":[54],"The":[55],"remaining\r\n1-2%":[56],"composed":[58],"cells":[60,94],"producing":[61],"mainly":[62],"insulin":[63],"(by":[64],"beta":[65],"cells)":[66],"glucagon\r\n(by":[68],"alpha":[69],"cells),":[70],"hormones":[71],"bloodstream":[77],"regulate\r\nblood":[79],"levels.":[81],"This":[82],"part":[84],"endocrine\r\nfunction.":[91],"Those":[92],"hormone-producing":[93],"organized":[96],"clusters":[99],"that\r\nappear":[100],"as":[101,150,164],"\u2018small":[102],"islands\u2019":[103],"(islets)":[104],"\u2018sea\u2019":[107],"(Figure":[111],"1),":[112],"as\r\nfirst":[113],"described":[114],"by":[115],"German":[117],"pathologist,":[118],"Paul":[119],"Langerhans,":[120,153],"1869":[122],"while":[123],"he\r\nwas":[124],"still":[125],"medical":[127],"student,":[128],"although":[129],"at":[130],"time":[132],"he":[133],"was":[134,146],"unaware":[135],"their\r\nfunction.":[137],"When":[138],"later":[139],"their":[140],"crucial":[141],"metabolism":[145],"discovered,\r\nthey":[147],"became":[148],"known":[149],"islets":[151],"fields":[156],"diabetes":[158],"and\r\ntransplantation":[159],"(Tx)":[160],"simply":[161],"referred":[162],"\u2018islets\u2019.":[165]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
