{"id":"https://openalex.org/W12950544","doi":"https://doi.org/10.1093/pch/15.2.69","title":"Langerhans cell histiocytosis: A complex recurrent disease","display_name":"Langerhans cell histiocytosis: A complex recurrent disease","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W12950544","doi":"https://doi.org/10.1093/pch/15.2.69","mag":"12950544","pmid":"https://pubmed.ncbi.nlm.nih.gov/21286293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2865937"},"language":"en","primary_location":{"id":"doi:10.1093/pch/15.2.69","doi":"https://doi.org/10.1093/pch/15.2.69","is_oa":true,"landing_page_url":"https://doi.org/10.1093/pch/15.2.69","pdf_url":"https://academic.oup.com/pch/article-pdf/15/2/69/11188692/pch15069.pdf","source":{"id":"https://openalex.org/S87934238","display_name":"Paediatrics & Child Health","issn_l":"1205-7088","issn":["1205-7088","1918-1485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatrics & Child Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/pch/article-pdf/15/2/69/11188692/pch15069.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085092449","display_name":"Bruce Crooks","orcid":"https://orcid.org/0000-0003-4715-4536","observed_orcids":["https://orcid.org/0000-0003-4715-4536"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I2800394539","display_name":"Izaak Walton Killam Health Centre","ror":"https://ror.org/0064zg438","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800394539"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bruce Crooks","raw_affiliation_strings":["IWK Health Centre, Dalhousie University, Halifax, Nova Scotia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IWK Health Centre, Dalhousie University, Halifax, Nova Scotia","institution_ids":["https://openalex.org/I129902397","https://openalex.org/I2800394539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072443585","display_name":"Danielle Grenier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800860928","display_name":"Canadian Paediatric Society","ror":"https://ror.org/037qnwq20","country_code":"CA","type":"other","lineage":["https://openalex.org/I2800860928"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Danielle Grenier","raw_affiliation_strings":["Canadian Paediatric Society, Ottawa, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canadian Paediatric Society, Ottawa, Ontario","institution_ids":["https://openalex.org/I2800860928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4981,"currency":"USD","value_usd":4981},"apc_paid":null,"fwci":0.3923,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.64611635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"2","first_page":"69","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/langerhans-cell-histiocytosis","display_name":"Langerhans cell histiocytosis","score":1.0},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.6759999990463257},{"id":"https://openalex.org/keywords/skull-lesions","display_name":"skull lesions","score":0.7149999737739563},{"id":"https://openalex.org/keywords/diabetes-insipidus","display_name":"diabetes insipidus","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cd1a","display_name":"CD1a","score":0.7720000147819519},{"id":"https://openalex.org/keywords/langerin","display_name":"Langerin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/s100-protein","display_name":"S-100 protein","score":0.9729999899864197},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":0.7960000038146973},{"id":"https://openalex.org/keywords/prednisone","display_name":"prednisone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/multidisciplinary-care","display_name":"multidisciplinary care","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2777484599","wikidata":"https://www.wikidata.org/wiki/Q374036","display_name":"Langerhans cell histiocytosis","level":3,"score":0.7225396633148193},{"id":"https://openalex.org/C2776958162","wikidata":"https://www.wikidata.org/wiki/Q220551","display_name":"Diabetes insipidus","level":2,"score":0.7191852927207947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7176722288131714},{"id":"https://openalex.org/C2778833550","wikidata":"https://www.wikidata.org/wiki/Q691762","display_name":"Birbeck granules","level":4,"score":0.5109726190567017},{"id":"https://openalex.org/C2780174970","wikidata":"https://www.wikidata.org/wiki/Q1411740","display_name":"Histiocytosis","level":3,"score":0.502525806427002},{"id":"https://openalex.org/C2780180277","wikidata":"https://www.wikidata.org/wiki/Q1124286","display_name":"Polyuria","level":3,"score":0.4247111678123474},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4060337245464325},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33370187878608704},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.33080488443374634},{"id":"https://openalex.org/C2778379841","wikidata":"https://www.wikidata.org/wiki/Q1623344","display_name":"Langerhans cell","level":3,"score":0.2320134937763214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2034793198108673},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18723908066749573},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1189093291759491},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.08507192134857178},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/pch/15.2.69","doi":"https://doi.org/10.1093/pch/15.2.69","is_oa":true,"landing_page_url":"https://doi.org/10.1093/pch/15.2.69","pdf_url":"https://academic.oup.com/pch/article-pdf/15/2/69/11188692/pch15069.pdf","source":{"id":"https://openalex.org/S87934238","display_name":"Paediatrics & Child Health","issn_l":"1205-7088","issn":["1205-7088","1918-1485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatrics & Child Health","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2033931","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2865937","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2865937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2865937","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatr Child Health","raw_type":"Text"},{"id":"pmid:21286293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21286293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatrics & child health","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/pch/15.2.69","doi":"https://doi.org/10.1093/pch/15.2.69","is_oa":true,"landing_page_url":"https://doi.org/10.1093/pch/15.2.69","pdf_url":"https://academic.oup.com/pch/article-pdf/15/2/69/11188692/pch15069.pdf","source":{"id":"https://openalex.org/S87934238","display_name":"Paediatrics & Child Health","issn_l":"1205-7088","issn":["1205-7088","1918-1485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatrics & Child Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W12950544.pdf","grobid_xml":"https://content.openalex.org/works/W12950544.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1974779668","https://openalex.org/W2107166045","https://openalex.org/W2161616892"],"related_works":["https://openalex.org/W2097276374","https://openalex.org/W2090848859","https://openalex.org/W3185637478","https://openalex.org/W1986268941","https://openalex.org/W2105031721","https://openalex.org/W7097796133","https://openalex.org/W4403903973","https://openalex.org/W4400050117","https://openalex.org/W2109858284","https://openalex.org/W7002320007"],"abstract_inverted_index":{"A":[0,45,153,160],"six-year-old":[1],"boy":[2,77],"was":[3,104],"referred":[4],"to":[5,208],"a":[6,28,79,123,185,220],"paediatric":[7,186],"hematologist/oncologist":[8],"with":[9,106,125,214],"recurrent,":[10],"painful":[11],"skull":[12,49,134],"masses.":[13],"Skeletal":[14],"survey":[15],"and":[16,27,62,64,120,137,151,168,195],"computed":[17],"tomography":[18,38],"revealed":[19],"lytic":[20],"lesions":[21,103],"in":[22,31,190],"his":[23,32,92,171],"calvarium":[24],"(Figure":[25],"1)":[26],"silent":[29],"lesion":[30],"right":[33],"humerus.":[34],"Positron":[35],"emission":[36],"tomography-computed":[37],"scan":[39,165],"confirmed":[40,157],"involvement":[41],"of":[42,47,53,91,101,127,170,176,181],"these":[43],"sites.":[44],"biopsy":[46],"the":[48,76,88,192,206],"mass":[50,82,135],"showed":[51,141,166],"infiltrates":[52],"pathogenic":[54,142],"Langerhans":[55,107,143],"cells,":[56],"staining":[57],"positive":[58],"for":[59,122],"CD1a,":[60],"Langerin":[61],"S100,":[63],"containing":[65],"Birbeck":[66],"granules":[67],"on":[68],"electron":[69],"microscopy.":[70],"Of":[71],"note,":[72],"14":[73],"months":[74],"earlier,":[75],"had":[78,147],"soft":[80],"tissue":[81],"removed":[83],"by":[84,219],"surgical":[85,138],"curettage":[86,139],"from":[87],"lateral":[89],"wall":[90],"left":[93],"orbit":[94],"but":[95],"no":[96],"adjuvant":[97],"therapy.":[98],"The":[99,112],"pathology":[100],"both":[102],"consistent":[105],"cell":[108],"histiocytosis":[109],"(LCH).":[110],"...":[111],"boy's":[113],"treatment":[114],"at":[115],"this":[116,182],"time":[117],"included":[118],"vinblastine":[119],"prednisone":[121],"year,":[124],"regression":[126],"all":[128],"lesions.":[129],"Three":[130],"years":[131],"later,":[132],"another":[133],"appeared":[136],"again":[140],"cells.":[144],"Meanwhile,":[145],"he":[146],"developed":[148],"excessive":[149],"thirst":[150],"polyuria.":[152],"water":[154],"deprivation":[155],"test":[156],"diabetes":[158,193],"insipidus.":[159],"brain":[161],"magnetic":[162],"resonance":[163],"imaging":[164],"enhancement":[167],"thickening":[169],"infundibular":[172],"pituitary":[173,201],"stalk,":[174],"suggestive":[175],"LCH":[177,204],"involvement.":[178],"In":[179],"view":[180],"new":[183],"development,":[184],"endocrinologist":[187],"became":[188],"involved":[189],"managing":[191],"insipidus":[194],"is":[196,224],"closely":[197],"observing":[198],"any":[199],"further":[200],"complications.":[202],"Because":[203],"has":[205],"potential":[207],"recur":[209],"despite":[210],"successful":[211],"therapies,":[212],"sometimes":[213],"significant":[215],"sequelae,":[216],"close":[217],"supervision":[218],"multidisciplinary":[221],"care":[222],"team":[223],"essential":[225],"(1).":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}