{"id":"https://openalex.org/W129463405","doi":"https://doi.org/10.1007/978-1-59745-373-8_16","title":"Roles of CYP1B1, Optineurin, and WDR36 Gene Mutations in Glaucoma","display_name":"Roles of CYP1B1, Optineurin, and WDR36 Gene Mutations in Glaucoma","publication_year":2008,"publication_date":"2008-06-04","ids":{"openalex":"https://openalex.org/W129463405","doi":"https://doi.org/10.1007/978-1-59745-373-8_16","mag":"129463405"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-373-8_16","doi":"https://doi.org/10.1007/978-1-59745-373-8_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-373-8_16","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology Research\u2122","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2493557466","display_name":"Mechanisms of the Glaucomas"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109128051","display_name":"Mansoor Sarfarazi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mansoor Sarfarazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004187305","display_name":"Sharareh Monemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharareh Monemi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102157339","display_name":"Dharamainder Choudhary","orcid":"https://orcid.org/0000-0002-9580-3265","observed_orcids":["https://orcid.org/0000-0002-9580-3265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dharamainder Choudhary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087118120","display_name":"Tayebeh Rezaie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tayebeh Rezaie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109119364","display_name":"John B. Schenkman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John B. Schenkman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.03440233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"233","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cyp1b1","display_name":"CYP1B1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/optineurin","display_name":"optineurin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/wdr36","display_name":"WDR36","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.9390000104904175},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.49799999594688416},{"id":"https://openalex.org/keywords/pigment-epithelium","display_name":"pigment epithelium","score":0.5289999842643738},{"id":"https://openalex.org/keywords/optic-neuropathy","display_name":"optic neuropathy","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2777801377","wikidata":"https://www.wikidata.org/wiki/Q18035056","display_name":"Optineurin","level":4,"score":0.9911156892776489},{"id":"https://openalex.org/C2781147369","wikidata":"https://www.wikidata.org/wiki/Q18029808","display_name":"Myocilin","level":4,"score":0.6168028116226196},{"id":"https://openalex.org/C155701950","wikidata":"https://www.wikidata.org/wiki/Q14905165","display_name":"CYP1B1","level":4,"score":0.5729486346244812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5205753445625305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.515884280204773},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.46896401047706604},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3887079954147339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36804407835006714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35726243257522583},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.21474140882492065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07740631699562073},{"id":"https://openalex.org/C2991803831","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Open angle glaucoma","level":3,"score":0.07123643159866333},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59745-373-8_16","doi":"https://doi.org/10.1007/978-1-59745-373-8_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-373-8_16","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology Research\u2122","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":190,"referenced_works":["https://openalex.org/W76478092","https://openalex.org/W126408028","https://openalex.org/W185419275","https://openalex.org/W259843108","https://openalex.org/W589292691","https://openalex.org/W983639949","https://openalex.org/W1000307566","https://openalex.org/W1004982523","https://openalex.org/W1124201089","https://openalex.org/W1177139862","https://openalex.org/W1197924390","https://openalex.org/W1200986400","https://openalex.org/W1449822855","https://openalex.org/W1453434871","https://openalex.org/W1499071374","https://openalex.org/W1501204944","https://openalex.org/W1503135238","https://openalex.org/W1506156615","https://openalex.org/W1507279315","https://openalex.org/W1508340757","https://openalex.org/W1527331090","https://openalex.org/W1539891712","https://openalex.org/W1577083025","https://openalex.org/W1578829416","https://openalex.org/W1590039198","https://openalex.org/W1660567315","https://openalex.org/W1752988765","https://openalex.org/W1761879732","https://openalex.org/W1802772100","https://openalex.org/W1885679187","https://openalex.org/W1921441038","https://openalex.org/W1951869808","https://openalex.org/W1954855504","https://openalex.org/W1955923360","https://openalex.org/W1963552002","https://openalex.org/W1965182896","https://openalex.org/W1965572841","https://openalex.org/W1965955778","https://openalex.org/W1967515141","https://openalex.org/W1971505731","https://openalex.org/W1973830306","https://openalex.org/W1975957761","https://openalex.org/W1977660995","https://openalex.org/W1978849123","https://openalex.org/W1979875819","https://openalex.org/W1981030684","https://openalex.org/W1984777537","https://openalex.org/W1986130387","https://openalex.org/W1987853136","https://openalex.org/W1988156393","https://openalex.org/W1988346768","https://openalex.org/W1988874966","https://openalex.org/W1989235067","https://openalex.org/W1991378074","https://openalex.org/W1995887719","https://openalex.org/W1995920709","https://openalex.org/W1996381116","https://openalex.org/W1998021510","https://openalex.org/W1999632927","https://openalex.org/W2000935238","https://openalex.org/W2001405429","https://openalex.org/W2003366894","https://openalex.org/W2004038195","https://openalex.org/W2005641281","https://openalex.org/W2006624258","https://openalex.org/W2007095157","https://openalex.org/W2007891766","https://openalex.org/W2008478558","https://openalex.org/W2009220945","https://openalex.org/W2009479752","https://openalex.org/W2011867384","https://openalex.org/W2016392505","https://openalex.org/W2017748328","https://openalex.org/W2023895471","https://openalex.org/W2027461539","https://openalex.org/W2028043138","https://openalex.org/W2028236635","https://openalex.org/W2029061535","https://openalex.org/W2029504488","https://openalex.org/W2029731237","https://openalex.org/W2030739854","https://openalex.org/W2034209104","https://openalex.org/W2035107735","https://openalex.org/W2043552254","https://openalex.org/W2046632616","https://openalex.org/W2048377181","https://openalex.org/W2048697469","https://openalex.org/W2048764470","https://openalex.org/W2050100864","https://openalex.org/W2050119992","https://openalex.org/W2051768682","https://openalex.org/W2052612945","https://openalex.org/W2052783288","https://openalex.org/W2054339614","https://openalex.org/W2059065455","https://openalex.org/W2059896584","https://openalex.org/W2060621059","https://openalex.org/W2061861305","https://openalex.org/W2064261105","https://openalex.org/W2065589829","https://openalex.org/W2065670354","https://openalex.org/W2068547598","https://openalex.org/W2069825816","https://openalex.org/W2070528158","https://openalex.org/W2071750789","https://openalex.org/W2072023151","https://openalex.org/W2074239537","https://openalex.org/W2075577390","https://openalex.org/W2078477574","https://openalex.org/W2078576043","https://openalex.org/W2083761568","https://openalex.org/W2084050360","https://openalex.org/W2084144722","https://openalex.org/W2084223366","https://openalex.org/W2084716741","https://openalex.org/W2085511966","https://openalex.org/W2096360847","https://openalex.org/W2097751246","https://openalex.org/W2100159037","https://openalex.org/W2101199309","https://openalex.org/W2101697006","https://openalex.org/W2104901407","https://openalex.org/W2105719984","https://openalex.org/W2108508026","https://openalex.org/W2108608295","https://openalex.org/W2109542778","https://openalex.org/W2111608717","https://openalex.org/W2112473106","https://openalex.org/W2114281295","https://openalex.org/W2116680353","https://openalex.org/W2117149624","https://openalex.org/W2117954469","https://openalex.org/W2118632977","https://openalex.org/W2118770845","https://openalex.org/W2119480737","https://openalex.org/W2119896129","https://openalex.org/W2119897520","https://openalex.org/W2121772417","https://openalex.org/W2122146446","https://openalex.org/W2124334570","https://openalex.org/W2125624761","https://openalex.org/W2128128647","https://openalex.org/W2128727932","https://openalex.org/W2130227581","https://openalex.org/W2132616272","https://openalex.org/W2132762752","https://openalex.org/W2133853402","https://openalex.org/W2135483029","https://openalex.org/W2136793746","https://openalex.org/W2138442205","https://openalex.org/W2141968323","https://openalex.org/W2142877387","https://openalex.org/W2144645229","https://openalex.org/W2146100842","https://openalex.org/W2146117101","https://openalex.org/W2147079380","https://openalex.org/W2147569875","https://openalex.org/W2147700133","https://openalex.org/W2147745171","https://openalex.org/W2149557979","https://openalex.org/W2149664489","https://openalex.org/W2150586495","https://openalex.org/W2150644839","https://openalex.org/W2154787125","https://openalex.org/W2154886355","https://openalex.org/W2155120918","https://openalex.org/W2157425662","https://openalex.org/W2159852067","https://openalex.org/W2160973540","https://openalex.org/W2162559303","https://openalex.org/W2162862482","https://openalex.org/W2163474244","https://openalex.org/W2164763690","https://openalex.org/W2165108884","https://openalex.org/W2166453083","https://openalex.org/W2168802470","https://openalex.org/W2184527515","https://openalex.org/W2329959507","https://openalex.org/W2337441744","https://openalex.org/W2340005443","https://openalex.org/W2342118129","https://openalex.org/W2342492425","https://openalex.org/W2387199893","https://openalex.org/W2395338647","https://openalex.org/W2399688417","https://openalex.org/W2412739496","https://openalex.org/W2991899867","https://openalex.org/W2992020108","https://openalex.org/W6628478413","https://openalex.org/W6678510518"],"related_works":["https://openalex.org/W891930275","https://openalex.org/W130774219","https://openalex.org/W7082064743","https://openalex.org/W1121947700","https://openalex.org/W2916327402","https://openalex.org/W1503663435","https://openalex.org/W863977614","https://openalex.org/W1044481526","https://openalex.org/W823402015","https://openalex.org/W7056457637"],"abstract_inverted_index":{"'Roles":[0],"of":[1,13],"CYP1B1,":[2],"Optineurin,":[3],"and":[4],"WDR36":[5],"Gene":[6],"Mutations":[7],"in":[8,11],"Glaucoma'":[9],"published":[10],"'Mechanisms":[12],"the":[14],"Glaucomas'":[15]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
