{"id":"https://openalex.org/W129458636","doi":null,"title":"Treatment of systemic hypertension.","display_name":"Treatment of systemic hypertension.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W129458636","mag":"129458636","pmid":"https://pubmed.ncbi.nlm.nih.gov/22937486","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3427981"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2430716","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3427981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3427981","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091070572","display_name":"Wilbert S. Aronow","orcid":"https://orcid.org/0000-0002-7945-9863","observed_orcids":["https://orcid.org/0000-0002-7945-9863"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wilbert S Aronow","raw_affiliation_strings":["Cardiology Division, Department of Medicine, New York Medical College Valhalla, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Department of Medicine, New York Medical College Valhalla, New York, USA","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091070572"],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":null,"apc_paid":null,"fwci":1.651,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84971925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"2","issue":"3","first_page":"160","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-hypertension","display_name":"systemic hypertension","score":0.984000027179718},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/blood-pressure-targets","display_name":"blood pressure targets","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5920000076293945},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5649999976158142},{"id":"https://openalex.org/keywords/lifestyle-modification","display_name":"lifestyle modification","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9990000128746033},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9980000257492065},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":1.0},{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9615364074707031},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.811737060546875},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7480899691581726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6081511974334717},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5932358503341675},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5781027674674988},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5710065960884094},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.565886378288269},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5232464671134949},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4785626232624054},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4628668427467346},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4245983958244324},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2855116128921509},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2430716","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3427981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3427981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3427981","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cardiovasc Dis","raw_type":"Text"},{"id":"pmid:22937486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22937486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cardiovascular disease","raw_type":"Journal Article"},{"id":"mag:129458636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22937486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2430716","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3427981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W42284190","https://openalex.org/W52877415","https://openalex.org/W60172896","https://openalex.org/W75245760","https://openalex.org/W81008224","https://openalex.org/W180946569","https://openalex.org/W1592471891","https://openalex.org/W1970749664","https://openalex.org/W1977352975","https://openalex.org/W1988716175","https://openalex.org/W1989722793","https://openalex.org/W1993753212","https://openalex.org/W1994729171","https://openalex.org/W1995547316","https://openalex.org/W1998617830","https://openalex.org/W2003594060","https://openalex.org/W2005749229","https://openalex.org/W2007138117","https://openalex.org/W2009198719","https://openalex.org/W2019388918","https://openalex.org/W2023515446","https://openalex.org/W2029436713","https://openalex.org/W2034724325","https://openalex.org/W2038527678","https://openalex.org/W2040888535","https://openalex.org/W2043704089","https://openalex.org/W2048695535","https://openalex.org/W2054796764","https://openalex.org/W2056976690","https://openalex.org/W2058542179","https://openalex.org/W2067868110","https://openalex.org/W2075061564","https://openalex.org/W2079961959","https://openalex.org/W2080269802","https://openalex.org/W2084827581","https://openalex.org/W2090975042","https://openalex.org/W2091744415","https://openalex.org/W2093242089","https://openalex.org/W2101700331","https://openalex.org/W2103418109","https://openalex.org/W2103881469","https://openalex.org/W2104316399","https://openalex.org/W2104565625","https://openalex.org/W2105034073","https://openalex.org/W2106343349","https://openalex.org/W2107899584","https://openalex.org/W2107910831","https://openalex.org/W2110759418","https://openalex.org/W2112427158","https://openalex.org/W2114634962","https://openalex.org/W2116552344","https://openalex.org/W2117992633","https://openalex.org/W2119369921","https://openalex.org/W2119507826","https://openalex.org/W2120418712","https://openalex.org/W2121870998","https://openalex.org/W2123946565","https://openalex.org/W2125866188","https://openalex.org/W2127418795","https://openalex.org/W2135473035","https://openalex.org/W2136145230","https://openalex.org/W2137978158","https://openalex.org/W2139398481","https://openalex.org/W2144537167","https://openalex.org/W2145144040","https://openalex.org/W2147304664","https://openalex.org/W2147804563","https://openalex.org/W2150732896","https://openalex.org/W2151080792","https://openalex.org/W2152094400","https://openalex.org/W2156121263","https://openalex.org/W2162680540","https://openalex.org/W2167142042","https://openalex.org/W2167760816","https://openalex.org/W2169859718","https://openalex.org/W2169982013","https://openalex.org/W2170831516","https://openalex.org/W2404970595","https://openalex.org/W2413081855","https://openalex.org/W2567187030","https://openalex.org/W2908737464","https://openalex.org/W2916392902","https://openalex.org/W4233061835","https://openalex.org/W4300559951"],"related_works":["https://openalex.org/W4236526766","https://openalex.org/W7126107325","https://openalex.org/W2087950978","https://openalex.org/W2040474096","https://openalex.org/W2401439200","https://openalex.org/W2997500023","https://openalex.org/W2702532009","https://openalex.org/W2050319785","https://openalex.org/W2408041675","https://openalex.org/W2464414783"],"abstract_inverted_index":{"Systemic":[0],"hypertension":[1,148],"is":[2,11],"a":[3,18,27,102,120],"major":[4],"risk":[5],"factor":[6],"for":[7],"cardiovascular":[8,58,173],"disease":[9],"and":[10,38,67,73,96,119,135,149,168,191],"present":[12],"in":[13,22,30,39,60,68,75,78,113,130,153,175],"69%":[14],"of":[15,24,32,41,124,147,180,188],"patients":[16,25,33,42,61,69,114,131,154],"with":[17,26,34,43,155],"first":[19,28],"myocardial":[20],"infarction,":[21],"77%":[23],"stroke,":[29],"74%":[31],"chronic":[35],"heart":[36],"failure,":[37],"60%":[40],"peripheral":[44],"arterial":[45],"disease.":[46],"Double-blind,":[47],"randomized,":[48],"placebo-controlled":[49],"trials":[50],"have":[51,170],"found":[52],"that":[53,101],"antihypertensive":[54],"drug":[55],"therapy":[56,152],"reduces":[57],"events":[59,174],"aged":[62,70,132],"younger":[63,115],"than":[64,116],"80":[65,71,117,133],"years":[66,72,118,134],"older":[74],"the":[76,79,84],"Hypertension":[77],"Very":[80],"Elderly":[81],"Trial.":[82],"Although":[83],"optimal":[85],"blood":[86,105,122],"pressure":[87,106,123],"treatment":[88],"goal":[89,107],"has":[90],"not":[91],"been":[92],"determined,":[93],"existing":[94],"epidemiologic":[95],"clinical":[97],"trial":[98],"data":[99],"suggest":[100],"reasonable":[103],"therapeutic":[104],"should":[108,140],"be":[109,141],"<140/90":[110],"mm":[111,126],"Hg":[112,127],"systolic":[121],"140-145":[125],"if":[128],"tolerated":[129],"older.":[136],"Non-pharmacologic":[137],"lifestyle":[138],"measures":[139],"encouraged":[142],"both":[143],"to":[144],"prevent":[145],"development":[146],"as":[150],"adjunctive":[151],"hypertension.":[156],"Angiotensin-converting":[157],"enzyme":[158],"inhibitors,":[159],"angiotensin":[160],"receptor":[161],"blockers,":[162,164,167],"beta":[163],"calcium":[165],"channel":[166],"diuretics":[169],"all":[171],"reduced":[172],"randomized":[176],"trials.":[177],"The":[178],"choice":[179],"specific":[181,189],"drugs":[182],"depends":[183],"on":[184],"efficacy,":[185],"tolerability,":[186],"presence":[187],"comorbidities,":[190],"cost.":[192]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}