{"id":"https://openalex.org/W129441804","doi":"https://doi.org/10.1016/b978-0-12-405926-9.00003-4","title":"Understanding Principles of the Dynamic Biochemical Networks of Life Through Systems Biology","display_name":"Understanding Principles of the Dynamic Biochemical Networks of Life Through Systems Biology","publication_year":2013,"publication_date":"2013-12-06","ids":{"openalex":"https://openalex.org/W129441804","doi":"https://doi.org/10.1016/b978-0-12-405926-9.00003-4","mag":"129441804"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-405926-9.00003-4","doi":"https://doi.org/10.1016/b978-0-12-405926-9.00003-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-405926-9.00003-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Systems Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2593316322","display_name":"Computational Systems Biology"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043470360","display_name":"Hans Victor Westerhoff","orcid":"https://orcid.org/0000-0002-0443-6114","observed_orcids":["https://orcid.org/0000-0002-0443-6114"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Hans V. Westerhoff","raw_affiliation_strings":["Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands","Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands","Manchester Centre for Integrative Systems Biology (MCISB), Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Manchester Centre for Integrative Systems Biology (MCISB), Manchester","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007234030","display_name":"Fei He","orcid":"https://orcid.org/0000-0001-9176-6674","observed_orcids":["https://orcid.org/0000-0001-9176-6674"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fei He","raw_affiliation_strings":["Department of Automatic Control and systems Engineering, The University of Sheffield, Sheffield, UK","Manchester Centre for Integrative Systems Biology (MCISB), Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Automatic Control and systems Engineering, The University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Manchester Centre for Integrative Systems Biology (MCISB), Manchester","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090410031","display_name":"Ettore Murabito","orcid":"https://orcid.org/0000-0002-9308-9889","observed_orcids":["https://orcid.org/0000-0002-9308-9889"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ettore Murabito","raw_affiliation_strings":["Manchester Centre for Integrative Systems Biology (MCISB), Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manchester Centre for Integrative Systems Biology (MCISB), Manchester","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032667232","display_name":"Fr\u00e9d\u00e9ric G. E. Cr\u00e9mazy","orcid":"https://orcid.org/0000-0002-9375-1588","observed_orcids":["https://orcid.org/0000-0002-9375-1588"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Cr\u00e9mazy","raw_affiliation_strings":["Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015344698","display_name":"Matteo Barberis","orcid":"https://orcid.org/0000-0001-5640-7422","observed_orcids":["https://orcid.org/0000-0001-5640-7422"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Matteo Barberis","raw_affiliation_strings":["Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4169,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56503537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"21","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-networks","display_name":"metabolic networks","score":0.8230000138282776},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.824999988079071},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9039999842643738},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.8640000224113464},{"id":"https://openalex.org/keywords/perfect-adaptation","display_name":"perfect adaptation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/network-design-principles","display_name":"network design principles","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.8697025775909424},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6814982891082764},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5388509631156921},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.47908979654312134},{"id":"https://openalex.org/C80191262","wikidata":"https://www.wikidata.org/wiki/Q5477668","display_name":"Fragility","level":2,"score":0.47606343030929565},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4747089445590973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4599441885948181},{"id":"https://openalex.org/C33276779","wikidata":"https://www.wikidata.org/wiki/Q1943363","display_name":"Design elements and principles","level":2,"score":0.43181443214416504},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37868523597717285},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3474184274673462},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.21046584844589233},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11648279428482056},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/b978-0-12-405926-9.00003-4","doi":"https://doi.org/10.1016/b978-0-12-405926-9.00003-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-405926-9.00003-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Systems Biology","raw_type":"book-chapter"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/351c9cb8-a648-4db1-995e-b7eb1773ee59","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/351c9cb8-a648-4db1-995e-b7eb1773ee59","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Westerhoff, H V, He, F, Murabito, E, Cremazy, F & Baberis, M 2014, Understanding principles of the dynamic biochemical networks of life through systems biology. in Computational Systems Biology.","raw_type":"info:eu-repo/semantics/bookPart"},{"id":"pmh:oai:alma.44SUR_INST:11140075410002346","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1016/B978-0-12-405926-9.00003-4","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"},{"id":"pmh:oai:epubs.surrey.ac.uk:851013","doi":null,"is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/851013/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1480307447","https://openalex.org/W1538631790","https://openalex.org/W1585179321","https://openalex.org/W1588504519","https://openalex.org/W1599846636","https://openalex.org/W1914839904","https://openalex.org/W1964015820","https://openalex.org/W1967039865","https://openalex.org/W1971094336","https://openalex.org/W1982324549","https://openalex.org/W1983117831","https://openalex.org/W1983120620","https://openalex.org/W1984216727","https://openalex.org/W1993239172","https://openalex.org/W1998664759","https://openalex.org/W2009990638","https://openalex.org/W2016238670","https://openalex.org/W2023749984","https://openalex.org/W2023899126","https://openalex.org/W2034354682","https://openalex.org/W2035040435","https://openalex.org/W2041042514","https://openalex.org/W2041605515","https://openalex.org/W2047632644","https://openalex.org/W2055621713","https://openalex.org/W2059370259","https://openalex.org/W2069899270","https://openalex.org/W2091107892","https://openalex.org/W2097189192","https://openalex.org/W2098199730","https://openalex.org/W2105361135","https://openalex.org/W2107757397","https://openalex.org/W2107940486","https://openalex.org/W2108195113","https://openalex.org/W2109110326","https://openalex.org/W2116766270","https://openalex.org/W2125496919","https://openalex.org/W2128869773","https://openalex.org/W2132218677","https://openalex.org/W2133254839","https://openalex.org/W2133403209","https://openalex.org/W2136417542","https://openalex.org/W2154061034","https://openalex.org/W2156036011","https://openalex.org/W2156975984","https://openalex.org/W2157036180","https://openalex.org/W2158584281","https://openalex.org/W2160079005","https://openalex.org/W2165970330","https://openalex.org/W2171001939","https://openalex.org/W2416110537"],"related_works":["https://openalex.org/W2509687359","https://openalex.org/W153352358","https://openalex.org/W4239380253","https://openalex.org/W1997916316","https://openalex.org/W2165987985","https://openalex.org/W4366351999","https://openalex.org/W7096567072","https://openalex.org/W2158584281","https://openalex.org/W2034122901","https://openalex.org/W2057769265"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
