{"id":"https://openalex.org/W129378365","doi":null,"title":"Apoptosis, necrosis, and proliferation: possible implications in the etiology of keloids.","display_name":"Apoptosis, necrosis, and proliferation: possible implications in the etiology of keloids.","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W129378365","mag":"129378365","pmid":"https://pubmed.ncbi.nlm.nih.gov/8909233","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865267"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1533320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865267","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865267","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027019379","display_name":"Ian Appleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I Appleton","raw_affiliation_strings":["Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London, United Kingdom","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016753393","display_name":"Nicola Jane Brown","orcid":"https://orcid.org/0000-0002-2100-1905","observed_orcids":["https://orcid.org/0000-0002-2100-1905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N J Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012696881","display_name":"D. A. Willoughby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Willoughby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2344,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.96695423,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"149","issue":"5","first_page":"1441","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keloids","display_name":"keloids","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.953000009059906},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.9520000219345093},{"id":"https://openalex.org/keywords/acridine-orange-staining","display_name":"acridine orange staining","score":0.8519999980926514},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.8500000238418579},{"id":"https://openalex.org/keywords/skin-fibrosis","display_name":"skin fibrosis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6000000238418579},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6660000085830688},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.9160572290420532},{"id":"https://openalex.org/C2777538232","wikidata":"https://www.wikidata.org/wiki/Q1131260","display_name":"Keloid","level":2,"score":0.8694727420806885},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.677153468132019},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6760365962982178},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6653043627738953},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5335137844085693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5277101397514343},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5135300755500793},{"id":"https://openalex.org/C3019965523","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Papillary dermis","level":3,"score":0.46070730686187744},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4416595995426178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2556779980659485},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2051810920238495},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.08275550603866577},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000165","descriptor_name":"Acridine Orange","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007627","descriptor_name":"Keloid","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007627","descriptor_name":"Keloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1533320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865267","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1865267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:8909233","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8909233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:129378365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8909233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1533320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1865267","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1963676681","https://openalex.org/W1978205611","https://openalex.org/W1986814930","https://openalex.org/W2013936027","https://openalex.org/W2015344488","https://openalex.org/W2026954329","https://openalex.org/W2027206667","https://openalex.org/W2029320522","https://openalex.org/W2046400474","https://openalex.org/W2052853635","https://openalex.org/W2058789249","https://openalex.org/W2083482862","https://openalex.org/W2094888206","https://openalex.org/W2184817776","https://openalex.org/W2222065266","https://openalex.org/W2339753260","https://openalex.org/W2427956945","https://openalex.org/W4231712510"],"related_works":["https://openalex.org/W1997159217","https://openalex.org/W2357771614","https://openalex.org/W2028260435","https://openalex.org/W2372570505","https://openalex.org/W2032233211","https://openalex.org/W2371922287","https://openalex.org/W2999301552","https://openalex.org/W2009765708","https://openalex.org/W2062252963","https://openalex.org/W2046222413"],"abstract_inverted_index":{"Keloids":[0],"are":[1],"collagenous":[2],"lesions":[3],"acquired":[4],"as":[5],"a":[6,130],"result":[7],"of":[8,21,53,63,82,96,116,129,133,143,166,179],"abnormal":[9],"wound":[10],"heating.":[11],"In":[12,85,99],"this":[13],"study":[14],"we":[15],"have":[16],"assessed":[17],"the":[18,50,54,59,61,64,79,83,93,97,108,112,123,137,149,172,177,183,187],"potential":[19],"role":[20],"proliferation,":[22],"apoptosis,":[23],"and":[24,56,110,114],"necrosis":[25,144],"in":[26,49,58,68,78,107,136,148,164,171],"keloids.":[27],"Samples":[28],"were":[29,47,76,90,105,139],"immunolabeled":[30],"for":[31],"proliferating":[32,74],"cell":[33,158],"nuclear":[34],"antigen":[35],"or":[36,40],"DNA":[37],"strand":[38],"breaks":[39],"stained":[41],"with":[42,70,155],"acridine":[43],"orange.":[44],"Proliferating":[45],"cells":[46,75,89,104,118,128],"observed":[48,77,106],"basal":[51,94],"layer":[52,95],"epidermis":[55,109],"fibroblasts":[57],"dermis,":[60],"numbers":[62],"latter":[65],"being":[66],"increased":[67],"comparison":[69],"normal":[71,86],"skin.":[72],"No":[73],"central":[80],"region":[81],"keloid.":[84],"skin,":[87],"apoptotic":[88,103],"restricted":[91],"to":[92,122],"epidermis.":[98],"keloid":[100,124,174],"samples,":[101],"numerous":[102],"dermis;":[111],"number":[113],"distribution":[115],"positive":[117],"decreased":[119],"more":[120],"distal":[121],"lesion.":[125,175],"Apoptotic":[126],"endothelial":[127],"small":[131],"proportion":[132],"blood":[134],"vessels":[135],"dermis":[138],"also":[140,146],"observed.":[141],"Evidence":[142],"was":[145],"seen":[147],"dermis.":[150],"These":[151],"results":[152,163],"suggest":[153],"that,":[154],"maturity,":[156],"progressive":[157],"degeneration":[159],"primarily":[160],"by":[161],"apoptosis":[162],"clearance":[165],"certain":[167],"cellular":[168],"populations":[169],"resulting":[170],"typical":[173],"However,":[176],"persistence":[178],"fibroblast":[180],"proliferation":[181],"at":[182],"dermal/keloid":[184],"interface":[185],"propagates":[186],"fibrosis.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}