{"id":"https://openalex.org/W129337127","doi":null,"title":"Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia","display_name":"Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W129337127","mag":"129337127"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-182440","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182440","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182440","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112221401","display_name":"Anna Eriksson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna Eriksson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112221401"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/flt3","display_name":"FLT3","score":0.7559999823570251},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.871999979019165},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5429999828338623},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":0.8339999914169312},{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myc-pathway","display_name":"MYC pathway","score":0.7870000004768372},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9390000104904175},{"id":"https://openalex.org/keywords/flt3-mutation","display_name":"FLT3 mutation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6110000014305115},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7299647331237793},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6697359681129456},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4058879017829895},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3842690885066986},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3632100522518158},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3434189260005951},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3360769748687744}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-182440","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182440","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:129337127","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:559974/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-182440","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182440","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":149,"referenced_works":["https://openalex.org/W619336080","https://openalex.org/W1234653855","https://openalex.org/W1492609361","https://openalex.org/W1534849470","https://openalex.org/W1539778282","https://openalex.org/W1552830208","https://openalex.org/W1567091232","https://openalex.org/W1574752843","https://openalex.org/W1605230984","https://openalex.org/W1744303272","https://openalex.org/W1769833382","https://openalex.org/W1964270831","https://openalex.org/W1964767673","https://openalex.org/W1965262464","https://openalex.org/W1967358345","https://openalex.org/W1969054252","https://openalex.org/W1969130273","https://openalex.org/W1971028883","https://openalex.org/W1971438689","https://openalex.org/W1972644623","https://openalex.org/W1977379434","https://openalex.org/W1977924848","https://openalex.org/W1979389466","https://openalex.org/W1979697113","https://openalex.org/W1980142183","https://openalex.org/W1981599507","https://openalex.org/W1982548489","https://openalex.org/W1984741306","https://openalex.org/W1988050012","https://openalex.org/W1988062934","https://openalex.org/W1989836942","https://openalex.org/W1990870968","https://openalex.org/W1991253663","https://openalex.org/W1992842669","https://openalex.org/W1993300766","https://openalex.org/W1993536389","https://openalex.org/W1994791499","https://openalex.org/W1997097621","https://openalex.org/W1997432260","https://openalex.org/W2007618242","https://openalex.org/W2007658220","https://openalex.org/W2007812119","https://openalex.org/W2008241551","https://openalex.org/W2009069027","https://openalex.org/W2009886857","https://openalex.org/W2011187792","https://openalex.org/W2011288773","https://openalex.org/W2012453076","https://openalex.org/W2012753533","https://openalex.org/W2013310673","https://openalex.org/W2013875870","https://openalex.org/W2015085004","https://openalex.org/W2016883830","https://openalex.org/W2018374960","https://openalex.org/W2018659869","https://openalex.org/W2022460737","https://openalex.org/W2022948223","https://openalex.org/W2023546573","https://openalex.org/W2023556472","https://openalex.org/W2024249739","https://openalex.org/W2026548544","https://openalex.org/W2026703785","https://openalex.org/W2026775820","https://openalex.org/W2026990179","https://openalex.org/W2028231895","https://openalex.org/W2033025320","https://openalex.org/W2036053185","https://openalex.org/W2036208429","https://openalex.org/W2038254125","https://openalex.org/W2040331428","https://openalex.org/W2040951450","https://openalex.org/W2041686632","https://openalex.org/W2042814209","https://openalex.org/W2043216151","https://openalex.org/W2046024621","https://openalex.org/W2046398696","https://openalex.org/W2046691959","https://openalex.org/W2048369203","https://openalex.org/W2049102376","https://openalex.org/W2054449135","https://openalex.org/W2056465113","https://openalex.org/W2058188142","https://openalex.org/W2063511018","https://openalex.org/W2067653691","https://openalex.org/W2068936693","https://openalex.org/W2070308429","https://openalex.org/W2070968982","https://openalex.org/W2073302269","https://openalex.org/W2075741861","https://openalex.org/W2076650991","https://openalex.org/W2077651394","https://openalex.org/W2077804275","https://openalex.org/W2077945404","https://openalex.org/W2078589933","https://openalex.org/W2078972833","https://openalex.org/W2080109272","https://openalex.org/W2080576274","https://openalex.org/W2080719056","https://openalex.org/W2082140471","https://openalex.org/W2084507055","https://openalex.org/W2086580946","https://openalex.org/W2088965961","https://openalex.org/W2090352304","https://openalex.org/W2090466206","https://openalex.org/W2092623151","https://openalex.org/W2094791588","https://openalex.org/W2096638244","https://openalex.org/W2098918424","https://openalex.org/W2103146352","https://openalex.org/W2104411649","https://openalex.org/W2105469447","https://openalex.org/W2107398329","https://openalex.org/W2109065151","https://openalex.org/W2109336877","https://openalex.org/W2112998845","https://openalex.org/W2115707319","https://openalex.org/W2116858301","https://openalex.org/W2120064876","https://openalex.org/W2121604817","https://openalex.org/W2123986795","https://openalex.org/W2127132180","https://openalex.org/W2127568389","https://openalex.org/W2129615499","https://openalex.org/W2130410032","https://openalex.org/W2131557977","https://openalex.org/W2132912591","https://openalex.org/W2137881702","https://openalex.org/W2139552156","https://openalex.org/W2140277442","https://openalex.org/W2142765738","https://openalex.org/W2144395887","https://openalex.org/W2144965236","https://openalex.org/W2146659244","https://openalex.org/W2147083172","https://openalex.org/W2151222524","https://openalex.org/W2153056550","https://openalex.org/W2155208683","https://openalex.org/W2155682111","https://openalex.org/W2155704762","https://openalex.org/W2161918920","https://openalex.org/W2163515240","https://openalex.org/W2164819148","https://openalex.org/W2164886552","https://openalex.org/W2166783527","https://openalex.org/W2180005201","https://openalex.org/W2254384777","https://openalex.org/W2409635443","https://openalex.org/W2440662239","https://openalex.org/W2546853358"],"related_works":["https://openalex.org/W2036176755","https://openalex.org/W2083174954","https://openalex.org/W2113101330","https://openalex.org/W2574883996","https://openalex.org/W2030990783","https://openalex.org/W2520830132","https://openalex.org/W2405270027","https://openalex.org/W2007812119","https://openalex.org/W3033064977","https://openalex.org/W3031699003"],"abstract_inverted_index":{"Acute":[0],"myeloid":[1],"leukemia":[2],"(AML)":[3],"is":[4,13,128,204,243],"a":[5,72,98,129,152,169,234,303,317,330],"life-threatening":[6],"malignant":[7],"disorder":[8],"with":[9,122,134,177,184,210,286,316,347],"dismal":[10],"prognosis.":[11],"AML":[12,63,156,278,284,311],"characterized":[14],"by":[15,214,220,274,307],"frequent":[16,37],"genetic":[17],"changes":[18],"involving":[19],"tyrosine":[20,43,50,111,298],"kinases,":[21],"normally":[22],"acting":[23],"as":[24,89,120],"important":[25],"mediators":[26],"in":[27,47,62,125,141,148,151,172,246,276,282,309,329,342],"many":[28],"basic":[29],"cellular":[30,83],"processes.":[31],"Due":[32],"to":[33,92,191,200,259,325],"the":[34,40,57,108,215,221,241,262,290,294],"overexpression":[35],"and":[36,81,107,115,227,240,281],"mutations":[38],"of":[39,56,74,102,132,138,154,159,264,266,289,333,345],"FMS-like":[41],"receptor":[42,52,106],"kinase":[44,51,112,299,305,320,335],"3":[45],"(FLT3)":[46],"AML,":[48],"this":[49,67],"has":[53],"become":[54],"one":[55],"most":[58],"sought":[59],"after":[60],"targets":[61],"drug":[64,236],"development.":[65],"In":[66,223],"thesis,":[68],"we":[69],"have":[70,117,231],"used":[71],"combination":[73],"high-throughput":[75],"screens,":[76,84],"direct":[77],"target":[78],"interaction":[79],"assays":[80],"sequential":[82],"including":[85],"primary":[86,155,283],"patient":[87],"samples,":[88,157,334],"an":[90,135,142,247,287],"approach":[91],"discover":[93],"new":[94],"targeted":[95],"therapies.":[96],"Gefitinib,":[97],"previously":[99],"known":[100],"inhibitor":[101,131],"epidermal":[103],"growth":[104],"factor":[105],"two":[109],"novel":[110],"inhibitors":[113],"AKN-032":[114],"AKN-028,":[116,211,267],"been":[118],"identified":[119],"compounds":[121],"cytotoxic":[123,179,225],"activity":[124,150,226,300,321,336],"AML.":[126,348],"AKN-028":[127,167,233,275,308],"potent":[130],"FLT3":[133,160,165],"IC50":[136],"value":[137],"6":[139],"nM":[140],"enzyme":[143],"assay,":[144],"but":[145],"also":[146],"displaying":[147],"vitro":[149,173],"variety":[153],"irrespective":[158],"mutation":[161],"status":[162],"or":[163,182,195],"quantitative":[164],"expression.":[166],"shows":[168,302],"sequence":[170],"dependent":[171],"synergy":[174],"when":[175,187,206],"combined":[176],"standard":[178,192],"agents":[180],"cytarabine":[181],"daunorubicin,":[183],"better":[185],"efficacy":[186],"cells":[188,207,315],"are":[189,208],"exposed":[190],"chemotherapy":[193],"simultaneously":[194],"for":[196,237],"24":[197],"hours":[198],"prior":[199],"adding":[201],"AKN-028.":[202,326],"Antagonism":[203],"observed":[205],"pre-treated":[209],"possibly":[212],"explained":[213],"cell":[216,279],"cycle":[217],"arrest":[218],"induced":[219,273],"compound.":[222],"vivo":[224],"good":[228],"oral":[229],"bioavailability":[230],"made":[232],"candidate":[235],"clinical":[238],"studies":[239,257],"compound":[242],"presently":[244],"investigated":[245],"international":[248],"two-part":[249],"multicenter":[250],"phase":[251],"I/II":[252],"study.":[253],"Results":[254],"from":[255],"microarray":[256],"performed":[258],"further":[260],"elucidate":[261],"mechanism":[263],"action":[265],"revealed":[268],"significantly":[269],"altered":[270],"gene":[271],"expression":[272],"both":[277],"lines":[280],"cells,":[285],"enrichment":[288],"Myc":[291],"pathway":[292],"among":[293],"downregulated":[295],"genes.":[296],"Furthermore,":[297],"profiling":[301,337],"dose-dependent":[304],"inhibition":[306],"all":[310],"samples":[312],"tested.":[313],"Interestingly,":[314],"high":[318],"overall":[319],"were":[322],"more":[323],"sensitive":[324],"Provided":[327],"conformation":[328],"larger":[331],"set":[332],"may":[338],"give":[339],"useful":[340],"information":[341],"individualizing":[343],"treatment":[344],"patients":[346]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}